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The map label for this gene is htpB [H]

Identifier: 148360660

GI number: 148360660

Start: 849465

End: 851111

Strand: Direct

Name: htpB [H]

Synonym: LPC_2606

Alternate gene names: 148360660

Gene position: 849465-851111 (Clockwise)

Preceding gene: 148360661

Following gene: 148360659

Centisome position: 23.75

GC content: 42.38

Gene sequence:

>1647_bases
ATGGCTAAAGAATTACGTTTTGGTGATGACGCTCGCCTACAAATGCTTGCTGGTGTTAATGCATTAGCAGATGCGGTTCA
AGTTACTATGGGTCCACGTGGCCGTAATGTTGTATTGGAAAAATCTTATGGCGCTCCTACTGTAACTAAAGACGGTGTGT
CTGTTGCCAAAGAAATTGAATTTGAGCATCGTTTCATGAACATGGGCGCTCAAATGGTTAAAGAAGTGGCTTCTAAAACT
TCTGATACTGCTGGTGATGGTACTACTACTGCAACAGTATTGGCTCGTTCTATTCTTGTTGAAGGTCACAAAGCAGTTGC
TGCTGGTATGAATCCAATGGATCTCAAACGCGGTATTGATAAAGCAGTATTAGCAGTTACCAAAAAATTACAAGCTATGT
CTAAGCCATGCAAAGACAGCAAAGCTATTGCTCAAGTTGGAACTATTTCTGCTAATTCTGATGAAGCGATTGGTGCTATC
ATTGCTGAAGCAATGGAAAAAGTTGGTAAAGAGGGTGTTATTACCGTTGAAGATGGTAATGGATTGGAAAATGAGCTTTC
TGTTGTTGAAGGTATGCAATTTGATCGCGGTTACATTTCTCCATACTTCATCAACAACCAGCAAAACATGAGCTGTGAAC
TTGAGCATCCATTCATTTTATTGGTTGACAAAAAAGTTTCCAGTATTCGTGAAATGTTGTCCGTATTGGAAGGTGTTGCA
AAATCTGGCCGTCCTTTATTGATCATCGCAGAAGATGTTGAAGGCGAAGCTTTAGCTACTCTGGTAGTTAACAACATGCG
CGGTATTGTAAAAGTATGTGCTGTCAAAGCGCCTGGTTTTGGTGATCGTCGCAAAGCGATGCTGCAAGACATTGCTATTT
TGACTAAAGGTCAAGTGATTTCTGAAGAAATTGGCAAGAGCCTGGAAGGTGCTACTCTGGAAGATCTTGGTAGTGCTAAG
CGAATCGTTGTTACCAAAGAAAACACCACTGTCATTGATGGTGAAGGAAAGGCAACTGAAATTAATGCTCGTATTGCTCA
AATTCGTGCACAAATGGAAGAAACCACTTCTGATTACGATAGAGAAAAATTACAAGAGCGCGTTGCTAAGTTAGCTGGTG
GTGTTGCTGTTATCAAAGTTGGCGCTGCCACAGAAGTTGAAATGAAAGAGAAGAAAGCACGTGTTGAAGATGCTCTTCAT
GCTACTCGCGCTGCAGTAGAAGAAGGTATCGTTGCCGGTGGTGGCGTTGCCTTGATTCGTGCTCAGAAAGCTCTTGATTC
ATTGAAAGGCGATAATGACGATCAAAATATGGGTATCAATATTTTACGTCGCGCTATTGAATCTCCAATGCGTCAAATTG
TTACTAACGCAGGATATGAAGCTTCTGTTGTAGTAAACAAGGTAGCTGAGCACAAAGACAACTATGGTTTCAACGCTGCA
ACTGGTGAATACGGTGATATGGTTGAGATGGGTATTCTTGATCCAACCAAAGTAACCCGTATGGCTCTGCAAAATGCAGC
TTCTGTAGCCAGTTTGATGTTGACTACTGAATGTATGGTTGCTGATCTGCCTAAGAAAGAAGAAGGTGTTGGTGCCGGCG
ATATGGGCGGCATGGGCGGAATGGGTGGCATGGGCGGAATGATGTAA

Upstream 100 bases:

>100_bases
TGAAGTTAAAGTTGATGGAAAAGAATTAGTTGTGATGCGCGAAGACGACATCATGGGTGTAATCGAGAAGTAATCTAATT
GTTTAAAGGAGACAATGATA

Downstream 100 bases:

>100_bases
TTTTCTCCCGGTTATCCAATAAAAAACCCGCTGTAAAGGCGGGTTTTTTATTAATGTTTATTTTGTTCTTTGACTGTTTT
GAACTATCCTTAATAACGTG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MAKELRFGDDARLQMLAGVNALADAVQVTMGPRGRNVVLEKSYGAPTVTKDGVSVAKEIEFEHRFMNMGAQMVKEVASKT
SDTAGDGTTTATVLARSILVEGHKAVAAGMNPMDLKRGIDKAVLAVTKKLQAMSKPCKDSKAIAQVGTISANSDEAIGAI
IAEAMEKVGKEGVITVEDGNGLENELSVVEGMQFDRGYISPYFINNQQNMSCELEHPFILLVDKKVSSIREMLSVLEGVA
KSGRPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIAILTKGQVISEEIGKSLEGATLEDLGSAK
RIVVTKENTTVIDGEGKATEINARIAQIRAQMEETTSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGIVAGGGVALIRAQKALDSLKGDNDDQNMGINILRRAIESPMRQIVTNAGYEASVVVNKVAEHKDNYGFNAA
TGEYGDMVEMGILDPTKVTRMALQNAASVASLMLTTECMVADLPKKEEGVGAGDMGGMGGMGGMGGMM

Sequences:

>Translated_548_residues
MAKELRFGDDARLQMLAGVNALADAVQVTMGPRGRNVVLEKSYGAPTVTKDGVSVAKEIEFEHRFMNMGAQMVKEVASKT
SDTAGDGTTTATVLARSILVEGHKAVAAGMNPMDLKRGIDKAVLAVTKKLQAMSKPCKDSKAIAQVGTISANSDEAIGAI
IAEAMEKVGKEGVITVEDGNGLENELSVVEGMQFDRGYISPYFINNQQNMSCELEHPFILLVDKKVSSIREMLSVLEGVA
KSGRPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIAILTKGQVISEEIGKSLEGATLEDLGSAK
RIVVTKENTTVIDGEGKATEINARIAQIRAQMEETTSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGIVAGGGVALIRAQKALDSLKGDNDDQNMGINILRRAIESPMRQIVTNAGYEASVVVNKVAEHKDNYGFNAA
TGEYGDMVEMGILDPTKVTRMALQNAASVASLMLTTECMVADLPKKEEGVGAGDMGGMGGMGGMGGMM
>Mature_547_residues
AKELRFGDDARLQMLAGVNALADAVQVTMGPRGRNVVLEKSYGAPTVTKDGVSVAKEIEFEHRFMNMGAQMVKEVASKTS
DTAGDGTTTATVLARSILVEGHKAVAAGMNPMDLKRGIDKAVLAVTKKLQAMSKPCKDSKAIAQVGTISANSDEAIGAII
AEAMEKVGKEGVITVEDGNGLENELSVVEGMQFDRGYISPYFINNQQNMSCELEHPFILLVDKKVSSIREMLSVLEGVAK
SGRPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIAILTKGQVISEEIGKSLEGATLEDLGSAKR
IVVTKENTTVIDGEGKATEINARIAQIRAQMEETTSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHA
TRAAVEEGIVAGGGVALIRAQKALDSLKGDNDDQNMGINILRRAIESPMRQIVTNAGYEASVVVNKVAEHKDNYGFNAAT
GEYGDMVEMGILDPTKVTRMALQNAASVASLMLTTECMVADLPKKEEGVGAGDMGGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=52.4621212121212, Blast_Score=547, Evalue=1e-155,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=52.4621212121212, Blast_Score=547, Evalue=1e-155,
Organism=Homo sapiens, GI38455427, Length=144, Percent_Identity=28.4722222222222, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=75.6653992395437, Blast_Score=801, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=50.1893939393939, Blast_Score=532, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=52.3809523809524, Blast_Score=225, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=54.5801526717557, Blast_Score=561, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6322524, Length=163, Percent_Identity=25.7668711656442, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=51.4231499051233, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=51.4231499051233, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=50.2846299810247, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=50.2846299810247, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=50.2846299810247, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI17864606, Length=551, Percent_Identity=43.557168784029, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24584129, Length=529, Percent_Identity=37.4291115311909, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI19921262, Length=529, Percent_Identity=37.4291115311909, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24645179, Length=528, Percent_Identity=21.4015151515152, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58122; Mature: 57991

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKELRFGDDARLQMLAGVNALADAVQVTMGPRGRNVVLEKSYGAPTVTKDGVSVAKEIE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCCCCCCCCHHHHHHHHH
FEHRFMNMGAQMVKEVASKTSDTAGDGTTTATVLARSILVEGHKAVAAGMNPMDLKRGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHH
KAVLAVTKKLQAMSKPCKDSKAIAQVGTISANSDEAIGAIIAEAMEKVGKEGVITVEDGN
HHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCC
GLENELSVVEGMQFDRGYISPYFINNQQNMSCELEHPFILLVDKKVSSIREMLSVLEGVA
CCHHHHHHHHCCCCCCCCCCCEEECCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHH
KSGRPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIAILTKGQVI
HCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHH
SEEIGKSLEGATLEDLGSAKRIVVTKENTTVIDGEGKATEINARIAQIRAQMEETTSDYD
HHHHCCCCCCCCHHHCCCCCEEEEEECCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHH
REKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALIR
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AQKALDSLKGDNDDQNMGINILRRAIESPMRQIVTNAGYEASVVVNKVAEHKDNYGFNAA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCC
TGEYGDMVEMGILDPTKVTRMALQNAASVASLMLTTECMVADLPKKEEGVGAGDMGGMGG
CCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCC
MGGMGGMM
CCCCCCCC
>Mature Secondary Structure 
AKELRFGDDARLQMLAGVNALADAVQVTMGPRGRNVVLEKSYGAPTVTKDGVSVAKEIE
CCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCCCCCCCCHHHHHHHHH
FEHRFMNMGAQMVKEVASKTSDTAGDGTTTATVLARSILVEGHKAVAAGMNPMDLKRGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHH
KAVLAVTKKLQAMSKPCKDSKAIAQVGTISANSDEAIGAIIAEAMEKVGKEGVITVEDGN
HHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCC
GLENELSVVEGMQFDRGYISPYFINNQQNMSCELEHPFILLVDKKVSSIREMLSVLEGVA
CCHHHHHHHHCCCCCCCCCCCEEECCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHH
KSGRPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIAILTKGQVI
HCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHH
SEEIGKSLEGATLEDLGSAKRIVVTKENTTVIDGEGKATEINARIAQIRAQMEETTSDYD
HHHHCCCCCCCCHHHCCCCCEEEEEECCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHH
REKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALIR
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AQKALDSLKGDNDDQNMGINILRRAIESPMRQIVTNAGYEASVVVNKVAEHKDNYGFNAA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCC
TGEYGDMVEMGILDPTKVTRMALQNAASVASLMLTTECMVADLPKKEEGVGAGDMGGMGG
CCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCC
MGGMGGMM
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA