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The map label for this gene is nadA [H]

Identifier: 148360554

GI number: 148360554

Start: 978973

End: 980316

Strand: Reverse

Name: nadA [H]

Synonym: LPC_2496

Alternate gene names: 148360554

Gene position: 980316-978973 (Counterclockwise)

Preceding gene: 148360553

Following gene: 148360558

Centisome position: 27.41

GC content: 40.4

Gene sequence:

>1344_bases
ATGTTTAAAAATTCAACTACTTACCAACCCGAAGCGACCCTCATGGCTATTCGTAATGATATGGCTATATGTCAAAGCGA
TTATCCATTAGATTGGTATCAAGAAGATTTTATTCCTTATGCCCAGGAATATCAGGCTTTACCCGATAGAAAGCTTACGA
CTGTTTTAAATTGGATGAAACCTTATCTTGCTAAAGCCCAAAATCATTTCGGTAACAAACTGTTACTTCTTGCCCATTAT
TATATGGGTGGAGAAATTGTTCGATTAATTGAACAGTTTGGGGGTAAAATCGGTGACTCCTACCAATTGGCTTTGATGGC
TGCGAATAACCCTGAAAAATCAGTCATAGTGGAATCAGCAGTTCATTTTATGGCGGAATCCATAAGCATTTTGGCTAATG
AAAATCAACACGTCTACATCACCAATCCCAAGTCAGGCTGCACCATGGAAATGCTTGCCAAAGACTTTATGGTCGAGCCT
GCTTTCCTTGATTTAAATGAGCGTTATGGTGCTGAAAATATTTTACCTGTGTGCTACATGAATACCTCTGGTCGTGTGAA
AGCCATGACCGGTGCCCAGGGAGGTGCGGTTTGTACAAGTTCCAATGTCAAAAAAATTTTTCAATGGGCTCAAAAACAAA
ACAAGAAAATCCTGTTTATTCCTGATCAACACATGGGAGAAAATGTCGCTTACTGGTTAGGAATTAAAAATCTCGCTTAT
TGGCCTGGAGGAACTGCCGGCGCTAATTATTCACTACCAGCGCAAGACAAAAAAACACTCAAGCAATTTGATAAAGCAGA
GTTGATTTTATTCGCAAGTCAATGCGCGGTTCATACCCATTATCAACCTGAAATGTGTGATTATTGGAAAAGCCTGGGAT
ACACTACCATTGTACATCCAGAGTGCCGTAATGATGTCATCAAAGTGGCTGATTACTCAGGTTCTACTGCATTCATATGG
GATCTGGTAGTCCATGACAAAGCAGGTACAAAAAGTTATGCCATCGGAACTGAAAACCACATGGTAGAAAACTTAAAGCA
ATATTGTAAAAATCTTGGAATTCGTGTTGTAAATCTTGCTGAAGCCCCTCAAAAAGACACTGAAAAAGGAGTTGGATGTG
GTTGTGCTACCATGTCTCGCAATGATCCGCCACATCTGGTCGCTCTCCTCGATTTACTTCGCCAGGGCAAATCGATGCCT
TACAATGAAGTAAAAGCAGGTGATGTGGTCAACGAATTCACAGGAACCAGAAACAGACTCCCAGTCAACGATCAACAATG
GGTTATTAATAATGCCAAAAAAGCCCTGGAAATGATGATTAATATCACTGAAGACAGGGTTTAA

Upstream 100 bases:

>100_bases
GACAGGCAGACAGTTCATTAGGATAGCCTGGCAAAGCTATCCCATTAACAATAATGAAAGAATCCTTCCCAAAAATCCCT
AATGACTAGAGGTAGATTTA

Downstream 100 bases:

>100_bases
TACGTGTTAGCTAGTGTGTTGTCCGCTTCCTTATGGTCGCGGCTCGGGTTTGCATCAACAGTGCTTATCAAATCCGAGCC
GCGACCGTAAGGAAGCGGGT

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MFKNSTTYQPEATLMAIRNDMAICQSDYPLDWYQEDFIPYAQEYQALPDRKLTTVLNWMKPYLAKAQNHFGNKLLLLAHY
YMGGEIVRLIEQFGGKIGDSYQLALMAANNPEKSVIVESAVHFMAESISILANENQHVYITNPKSGCTMEMLAKDFMVEP
AFLDLNERYGAENILPVCYMNTSGRVKAMTGAQGGAVCTSSNVKKIFQWAQKQNKKILFIPDQHMGENVAYWLGIKNLAY
WPGGTAGANYSLPAQDKKTLKQFDKAELILFASQCAVHTHYQPEMCDYWKSLGYTTIVHPECRNDVIKVADYSGSTAFIW
DLVVHDKAGTKSYAIGTENHMVENLKQYCKNLGIRVVNLAEAPQKDTEKGVGCGCATMSRNDPPHLVALLDLLRQGKSMP
YNEVKAGDVVNEFTGTRNRLPVNDQQWVINNAKKALEMMINITEDRV

Sequences:

>Translated_447_residues
MFKNSTTYQPEATLMAIRNDMAICQSDYPLDWYQEDFIPYAQEYQALPDRKLTTVLNWMKPYLAKAQNHFGNKLLLLAHY
YMGGEIVRLIEQFGGKIGDSYQLALMAANNPEKSVIVESAVHFMAESISILANENQHVYITNPKSGCTMEMLAKDFMVEP
AFLDLNERYGAENILPVCYMNTSGRVKAMTGAQGGAVCTSSNVKKIFQWAQKQNKKILFIPDQHMGENVAYWLGIKNLAY
WPGGTAGANYSLPAQDKKTLKQFDKAELILFASQCAVHTHYQPEMCDYWKSLGYTTIVHPECRNDVIKVADYSGSTAFIW
DLVVHDKAGTKSYAIGTENHMVENLKQYCKNLGIRVVNLAEAPQKDTEKGVGCGCATMSRNDPPHLVALLDLLRQGKSMP
YNEVKAGDVVNEFTGTRNRLPVNDQQWVINNAKKALEMMINITEDRV
>Mature_447_residues
MFKNSTTYQPEATLMAIRNDMAICQSDYPLDWYQEDFIPYAQEYQALPDRKLTTVLNWMKPYLAKAQNHFGNKLLLLAHY
YMGGEIVRLIEQFGGKIGDSYQLALMAANNPEKSVIVESAVHFMAESISILANENQHVYITNPKSGCTMEMLAKDFMVEP
AFLDLNERYGAENILPVCYMNTSGRVKAMTGAQGGAVCTSSNVKKIFQWAQKQNKKILFIPDQHMGENVAYWLGIKNLAY
WPGGTAGANYSLPAQDKKTLKQFDKAELILFASQCAVHTHYQPEMCDYWKSLGYTTIVHPECRNDVIKVADYSGSTAFIW
DLVVHDKAGTKSYAIGTENHMVENLKQYCKNLGIRVVNLAEAPQKDTEKGVGCGCATMSRNDPPHLVALLDLLRQGKSMP
YNEVKAGDVVNEFTGTRNRLPVNDQQWVINNAKKALEMMINITEDRV

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate [H]

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 3 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786964, Length=247, Percent_Identity=25.5060728744939, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003473 [H]

Pfam domain/function: PF02445 NadA [H]

EC number: =2.5.1.72 [H]

Molecular weight: Translated: 50307; Mature: 50307

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKNSTTYQPEATLMAIRNDMAICQSDYPLDWYQEDFIPYAQEYQALPDRKLTTVLNWMK
CCCCCCCCCCCHHEEEHHCCHHHHCCCCCCCHHHHHCCCHHHHHHCCCCHHHHHHHHHHH
PYLAKAQNHFGNKLLLLAHYYMGGEIVRLIEQFGGKIGDSYQLALMAANNPEKSVIVESA
HHHHHHHHHCCCEEEEEEHHHHCHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHH
VHFMAESISILANENQHVYITNPKSGCTMEMLAKDFMVEPAFLDLNERYGAENILPVCYM
HHHHHHHHHHEECCCCEEEEECCCCCCHHHHHHHHHHCCCCEECCHHHCCCCCCCEEEEE
NTSGRVKAMTGAQGGAVCTSSNVKKIFQWAQKQNKKILFIPDQHMGENVAYWLGIKNLAY
CCCCCEEEEECCCCCEEECCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCEEE
WPGGTAGANYSLPAQDKKTLKQFDKAELILFASQCAVHTHYQPEMCDYWKSLGYTTIVHP
CCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECHHHEECCCCCHHHHHHHHCCCEEEECC
ECRNDVIKVADYSGSTAFIWDLVVHDKAGTKSYAIGTENHMVENLKQYCKNLGIRVVNLA
HHCCCEEEEECCCCCEEEEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHCCEEEEEEC
EAPQKDTEKGVGCGCATMSRNDPPHLVALLDLLRQGKSMPYNEVKAGDVVNEFTGTRNRL
CCCCCHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCC
PVNDQQWVINNAKKALEMMINITEDRV
CCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFKNSTTYQPEATLMAIRNDMAICQSDYPLDWYQEDFIPYAQEYQALPDRKLTTVLNWMK
CCCCCCCCCCCHHEEEHHCCHHHHCCCCCCCHHHHHCCCHHHHHHCCCCHHHHHHHHHHH
PYLAKAQNHFGNKLLLLAHYYMGGEIVRLIEQFGGKIGDSYQLALMAANNPEKSVIVESA
HHHHHHHHHCCCEEEEEEHHHHCHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHH
VHFMAESISILANENQHVYITNPKSGCTMEMLAKDFMVEPAFLDLNERYGAENILPVCYM
HHHHHHHHHHEECCCCEEEEECCCCCCHHHHHHHHHHCCCCEECCHHHCCCCCCCEEEEE
NTSGRVKAMTGAQGGAVCTSSNVKKIFQWAQKQNKKILFIPDQHMGENVAYWLGIKNLAY
CCCCCEEEEECCCCCEEECCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCEEE
WPGGTAGANYSLPAQDKKTLKQFDKAELILFASQCAVHTHYQPEMCDYWKSLGYTTIVHP
CCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECHHHEECCCCCHHHHHHHHCCCEEEECC
ECRNDVIKVADYSGSTAFIWDLVVHDKAGTKSYAIGTENHMVENLKQYCKNLGIRVVNLA
HHCCCEEEEECCCCCEEEEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHCCEEEEEEC
EAPQKDTEKGVGCGCATMSRNDPPHLVALLDLLRQGKSMPYNEVKAGDVVNEFTGTRNRL
CCCCCHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCC
PVNDQQWVINNAKKALEMMINITEDRV
CCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA