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The map label for this gene is metC [H]

Identifier: 148360464

GI number: 148360464

Start: 1069542

End: 1070693

Strand: Reverse

Name: metC [H]

Synonym: LPC_2403

Alternate gene names: 148360464

Gene position: 1070693-1069542 (Counterclockwise)

Preceding gene: 148360457

Following gene: 148360465

Centisome position: 29.94

GC content: 42.36

Gene sequence:

>1152_bases
ATGAATAAGACTCATTTCGATACACGTGCAATTCATGCTGGGCAAGAACCATGTCAAAGTACAGGGGCCGTGATGACCCC
TATTTATGCTACCTCCACCTATAAGCAAATTGCCCCTGGCGAACATCTTGGCTATGAATACTCACGCACCCAAAACCCCA
CCAGAAAAGCCTATGAGGATTGCATAGCAAGCCTTGAATCAGGCCAAAAAGGATTTGCGTTTGCTTCGGGCATGGCTGCA
ATCAATACGGTTATTGATTTATTAGATTCAGGAGATCACGTCGTTGCCATGGATGATCTTTATGGAGGAACTTTCCGGCT
TTTTGATAAAGTAAAAACCCGAACTTCTAATTTATCCTTTTCTTTTATTGATATGTCAGTACCCGAGAATATTGAGGCTG
CAATAACTCCGAAGACAAAATTACTATGGCTGGAAACCCCTTCCAATCCCATGCTAAAGCTAGCTAATTTACGAAAAATC
GCCGCTATTGCAAAAAAACATAATTTGATTACAGTTGCCGATAACACCTTTGCAACTCCCTGGATTCAGCGCCCGCTTGA
ACTCGGATTTGACATTGTACTTCATTCAGCAACCAAATATCTGAACGGACATTCTGATGTAGTCAGTGGTGTCGTTGTGG
TCGGTGACAATTCAGTGTTGTCTGATAAAATTGCTTTTTTGCAAAATTCATGCGGCGCTGTAGCTGGCCCTTTCGACAGT
TTCCTGGTTCTGAGAAGCTTAAAAACATTATCCGTTCGTATGCAAAGGCACTGTGAAAACGCTAACCATCTGGCTAACTG
GCTTAGCAGCCACCCCAAGATTGAAAAAGTCATTTATCCCGGATTAAAAAGTCATCCGCAATATTCTCTTGCCAAGGAAC
AAATGAACGATTTCGGTGGTATGATATCTTTGGTACTTAAAGGTAGTCTTGAAGATGCCAAACGATTTTTAGCTCGCTGC
GAATTATTTACTTTGGCTGAAAGCCTGGGGGGTGTAGAAAGTTTAATTGAGCATCCTGCAATTATGACCCATGCCTCTAT
TCCAGTCGAACAACGCAAAGCCCTGGGCATAGAAGATGGTTTCATAAGATTATCAGTTGGTATTGAACACATTGATGATC
TGCGTGCCGATCTGGAGCATGCTTTAGGTTAA

Upstream 100 bases:

>100_bases
GAACTTTAGCAAAAAAAGCACCGAAAGTATATTTTTTAATCAATACTCTGATTGCTTATTGGTATTTCTTTGAATTTAAA
TATTTTTATGGGAATAAAAA

Downstream 100 bases:

>100_bases
AAGATGTAAATCCTGGTTCTGACTGTTAAAAAGAACCAGGGCAGATGTGTATAGGAGAAGTATTTCATGCAAAAAAATAA
ACAAAATGGCGGGCAACTCC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MNKTHFDTRAIHAGQEPCQSTGAVMTPIYATSTYKQIAPGEHLGYEYSRTQNPTRKAYEDCIASLESGQKGFAFASGMAA
INTVIDLLDSGDHVVAMDDLYGGTFRLFDKVKTRTSNLSFSFIDMSVPENIEAAITPKTKLLWLETPSNPMLKLANLRKI
AAIAKKHNLITVADNTFATPWIQRPLELGFDIVLHSATKYLNGHSDVVSGVVVVGDNSVLSDKIAFLQNSCGAVAGPFDS
FLVLRSLKTLSVRMQRHCENANHLANWLSSHPKIEKVIYPGLKSHPQYSLAKEQMNDFGGMISLVLKGSLEDAKRFLARC
ELFTLAESLGGVESLIEHPAIMTHASIPVEQRKALGIEDGFIRLSVGIEHIDDLRADLEHALG

Sequences:

>Translated_383_residues
MNKTHFDTRAIHAGQEPCQSTGAVMTPIYATSTYKQIAPGEHLGYEYSRTQNPTRKAYEDCIASLESGQKGFAFASGMAA
INTVIDLLDSGDHVVAMDDLYGGTFRLFDKVKTRTSNLSFSFIDMSVPENIEAAITPKTKLLWLETPSNPMLKLANLRKI
AAIAKKHNLITVADNTFATPWIQRPLELGFDIVLHSATKYLNGHSDVVSGVVVVGDNSVLSDKIAFLQNSCGAVAGPFDS
FLVLRSLKTLSVRMQRHCENANHLANWLSSHPKIEKVIYPGLKSHPQYSLAKEQMNDFGGMISLVLKGSLEDAKRFLARC
ELFTLAESLGGVESLIEHPAIMTHASIPVEQRKALGIEDGFIRLSVGIEHIDDLRADLEHALG
>Mature_383_residues
MNKTHFDTRAIHAGQEPCQSTGAVMTPIYATSTYKQIAPGEHLGYEYSRTQNPTRKAYEDCIASLESGQKGFAFASGMAA
INTVIDLLDSGDHVVAMDDLYGGTFRLFDKVKTRTSNLSFSFIDMSVPENIEAAITPKTKLLWLETPSNPMLKLANLRKI
AAIAKKHNLITVADNTFATPWIQRPLELGFDIVLHSATKYLNGHSDVVSGVVVVGDNSVLSDKIAFLQNSCGAVAGPFDS
FLVLRSLKTLSVRMQRHCENANHLANWLSSHPKIEKVIYPGLKSHPQYSLAKEQMNDFGGMISLVLKGSLEDAKRFLARC
ELFTLAESLGGVESLIEHPAIMTHASIPVEQRKALGIEDGFIRLSVGIEHIDDLRADLEHALG

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=365, Percent_Identity=53.1506849315069, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI299473759, Length=365, Percent_Identity=48.2191780821918, Blast_Score=319, Evalue=2e-87,
Organism=Homo sapiens, GI25453487, Length=364, Percent_Identity=47.8021978021978, Blast_Score=313, Evalue=1e-85,
Organism=Escherichia coli, GI1790375, Length=376, Percent_Identity=42.2872340425532, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1789383, Length=398, Percent_Identity=27.3869346733668, Blast_Score=151, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17538055, Length=368, Percent_Identity=49.4565217391304, Blast_Score=368, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17560056, Length=368, Percent_Identity=47.8260869565217, Blast_Score=357, Evalue=8e-99,
Organism=Caenorhabditis elegans, GI71980708, Length=391, Percent_Identity=37.0843989769821, Blast_Score=256, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6319307, Length=385, Percent_Identity=46.7532467532467, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6321254, Length=404, Percent_Identity=34.1584158415842, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323333, Length=435, Percent_Identity=34.7126436781609, Blast_Score=193, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6321170, Length=340, Percent_Identity=28.2352941176471, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6321904, Length=343, Percent_Identity=30.6122448979592, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322970, Length=350, Percent_Identity=25.1428571428571, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI19922554, Length=380, Percent_Identity=48.9473684210526, Blast_Score=382, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42009; Mature: 42009

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTHFDTRAIHAGQEPCQSTGAVMTPIYATSTYKQIAPGEHLGYEYSRTQNPTRKAYED
CCCCCCCHHHHHCCCCHHHHCCCEECCEEECCCHHHCCCCCCCCCCHHCCCCHHHHHHHH
CIASLESGQKGFAFASGMAAINTVIDLLDSGDHVVAMDDLYGGTFRLFDKVKTRTSNLSF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEE
SFIDMSVPENIEAAITPKTKLLWLETPSNPMLKLANLRKIAAIAKKHNLITVADNTFATP
EEEECCCCCCCCEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCH
WIQRPLELGFDIVLHSATKYLNGHSDVVSGVVVVGDNSVLSDKIAFLQNSCGAVAGPFDS
HHHHHHHCCHHHHHHHHHHHHCCCHHHHCCEEEECCCCHHHHHHHHHHHCCCCCCCCHHH
FLVLRSLKTLSVRMQRHCENANHLANWLSSHPKIEKVIYPGLKSHPQYSLAKEQMNDFGG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHH
MISLVLKGSLEDAKRFLARCELFTLAESLGGVESLIEHPAIMTHASIPVEQRKALGIEDG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEECCCCHHHHHHCCCCCC
FIRLSVGIEHIDDLRADLEHALG
EEEEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKTHFDTRAIHAGQEPCQSTGAVMTPIYATSTYKQIAPGEHLGYEYSRTQNPTRKAYED
CCCCCCCHHHHHCCCCHHHHCCCEECCEEECCCHHHCCCCCCCCCCHHCCCCHHHHHHHH
CIASLESGQKGFAFASGMAAINTVIDLLDSGDHVVAMDDLYGGTFRLFDKVKTRTSNLSF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEE
SFIDMSVPENIEAAITPKTKLLWLETPSNPMLKLANLRKIAAIAKKHNLITVADNTFATP
EEEECCCCCCCCEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCH
WIQRPLELGFDIVLHSATKYLNGHSDVVSGVVVVGDNSVLSDKIAFLQNSCGAVAGPFDS
HHHHHHHCCHHHHHHHHHHHHCCCHHHHCCEEEECCCCHHHHHHHHHHHCCCCCCCCHHH
FLVLRSLKTLSVRMQRHCENANHLANWLSSHPKIEKVIYPGLKSHPQYSLAKEQMNDFGG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHH
MISLVLKGSLEDAKRFLARCELFTLAESLGGVESLIEHPAIMTHASIPVEQRKALGIEDG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEECCCCHHHHHHCCCCCC
FIRLSVGIEHIDDLRADLEHALG
EEEEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]