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The map label for this gene is hpd

Identifier: 148359822

GI number: 148359822

Start: 2696966

End: 2698012

Strand: Direct

Name: hpd

Synonym: LPC_1747

Alternate gene names: 148359822

Gene position: 2696966-2698012 (Clockwise)

Preceding gene: 148359821

Following gene: 148359823

Centisome position: 75.41

GC content: 41.07

Gene sequence:

>1047_bases
ATGCAAAATAACAACCCCTGCGGATTAGATGGCTTTGCCTTTTTAGAGTTTTCAGGCCCTGATAGGAATAAATTACATCA
ACAATTTTCTGAGATGGGGTTTCAGGCCGTTGCCCACCATAAAAATCAAGACATTACTCTTTTCAAACAAGGGGAAATAC
AATTTATAGTGAATGCGGCTTCCCATTGTCAGGCAGAAGCGCATGCTTCAACTCATGGTCCAGGCGCTTGTGCAATGGGC
TTTAAAGTAAAAGATGCCAAAGCCGCATTTCAACACGCTATCGCGCATGGCGGTATAGCATTTCAGGATGCACCTCATGC
CAATCACGGCTTGCCAGCCATCCAGGCTATTGGTGGTAGTGTTATTTATTTTGTCGATGAAGAACACCAACCCTTCTCTC
ATGAATGGAATATTACCTCATCAGAACCCGTAGTTGGAAATGGTCTGACCGCAATCGACCATCTCACCCATAACGTTTAT
CGCGGTAATATGGATAAATGGGCTAGTTTTTATGCTTCCATTTTTAACTTCCAGGAAATTCGTTTTTTCAATATCAAAGG
AAAAATGACTGGTTTGGTCAGTCGAGCATTAGGTAGCCCTTGTGGCAAAATCAAAATTCCTTTAAACGAATCCAAAGATG
ATTTATCACAAATTGAAGAGTTTCTTCATGAATATCATGGCGAGGGCATTCAACACATCGCTCTCAATACCAATGATATT
TATAAGACAGTCAACGGCTTAAGAAAACAAGGGGTCAAATTCCTGGATGTGCCGGATACTTACTATGAGATGATTAATGA
CCGCCTCCCATGGCACAAGGAGCCACTGAATCAACTCCATGCTGAGAAAATTTTAATTGATGGAGAAGCAGATCCCAAAG
ACGGCTTGTTACTGCAAATATTTACTGAAAACATATTTGGACCAGTCTTTTTTGAAATTATTCAACGCAAAGGCAATCAG
GGGTTTGGTGAAGGGAATTTCCAGGCTCTATTCGAAGCCATTGAAAGAGATCAAGTTCGACGTGGTACTTTAAAAGAATT
AACCTAG

Upstream 100 bases:

>100_bases
AGCTGATGGAATGTTTCTGGTGCAACCCATTTAATCTTTAAAATCCCCAGCAAGCAATACACTGCATTGCTATGTAAATA
AGTACAAGGAGAATCTGATA

Downstream 100 bases:

>100_bases
ACAAACAGTTGAAATGTAATGATGCTGTTTTTCAGGCATAAGCCAGGAGATCTATATGAAACTCGCCAGTTTGAAATCAA
CTCGTTCTCGGGATGGAGAG

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase; Legiolysin

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITLFKQGEIQFIVNAASHCQAEAHASTHGPGACAMG
FKVKDAKAAFQHAIAHGGIAFQDAPHANHGLPAIQAIGGSVIYFVDEEHQPFSHEWNITSSEPVVGNGLTAIDHLTHNVY
RGNMDKWASFYASIFNFQEIRFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHGEGIQHIALNTNDI
YKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILIDGEADPKDGLLLQIFTENIFGPVFFEIIQRKGNQ
GFGEGNFQALFEAIERDQVRRGTLKELT

Sequences:

>Translated_348_residues
MQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITLFKQGEIQFIVNAASHCQAEAHASTHGPGACAMG
FKVKDAKAAFQHAIAHGGIAFQDAPHANHGLPAIQAIGGSVIYFVDEEHQPFSHEWNITSSEPVVGNGLTAIDHLTHNVY
RGNMDKWASFYASIFNFQEIRFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHGEGIQHIALNTNDI
YKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILIDGEADPKDGLLLQIFTENIFGPVFFEIIQRKGNQ
GFGEGNFQALFEAIERDQVRRGTLKELT
>Mature_348_residues
MQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITLFKQGEIQFIVNAASHCQAEAHASTHGPGACAMG
FKVKDAKAAFQHAIAHGGIAFQDAPHANHGLPAIQAIGGSVIYFVDEEHQPFSHEWNITSSEPVVGNGLTAIDHLTHNVY
RGNMDKWASFYASIFNFQEIRFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHGEGIQHIALNTNDI
YKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILIDGEADPKDGLLLQIFTENIFGPVFFEIIQRKGNQ
GFGEGNFQALFEAIERDQVRRGTLKELT

Specific function: Catalyzes the transformation of p-hydroxyphenylpyruvate into HGA. Has hemolytic and brown pigment production activity

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family

Homologues:

Organism=Homo sapiens, GI4504477, Length=352, Percent_Identity=29.2613636363636, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI285002264, Length=350, Percent_Identity=29.1428571428571, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI14249394, Length=347, Percent_Identity=26.8011527377522, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17555220, Length=346, Percent_Identity=30.635838150289, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17550752, Length=207, Percent_Identity=34.2995169082126, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24667510, Length=325, Percent_Identity=32.9230769230769, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356105, Length=299, Percent_Identity=33.7792642140468, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LLY_LEGPC (P69053)

Other databases:

- EMBL:   AJ001357
- EMBL:   CP000675
- RefSeq:   YP_001251029.1
- ProteinModelPortal:   P69053
- SMR:   P69053
- STRING:   P69053
- GeneID:   5181555
- GenomeReviews:   CP000675_GR
- KEGG:   lpc:LPC_1747
- eggNOG:   COG3185
- HOGENOM:   HBG680392
- OMA:   PDTYYEK
- ProtClustDB:   CLSK833301
- BioCyc:   LPNE400673:LPC_1747-MONOMER
- GO:   GO:0019835
- GO:   GO:0009405
- InterPro:   IPR005956
- InterPro:   IPR004360
- PIRSF:   PIRSF009283
- TIGRFAMs:   TIGR01263

Pfam domain/function: PF00903 Glyoxalase

EC number: =1.13.11.27

Molecular weight: Translated: 38927; Mature: 38927

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITLFKQGEIQFIVNAA
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECH
SHCQAEAHASTHGPGACAMGFKVKDAKAAFQHAIAHGGIAFQDAPHANHGLPAIQAIGGS
HHHHHHHCCCCCCCCEEEECEEECHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHCCCE
VIYFVDEEHQPFSHEWNITSSEPVVGNGLTAIDHLTHNVYRGNMDKWASFYASIFNFQEI
EEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEE
RFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHGEGIQHIALNTNDI
EEEEECCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHH
YKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILIDGEADPKDGLLLQI
HHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCCHHHHHHHHEEEECCCCCCCCCEEEEE
FTENIFGPVFFEIIQRKGNQGFGEGNFQALFEAIERDQVRRGTLKELT
EHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure
MQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITLFKQGEIQFIVNAA
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECH
SHCQAEAHASTHGPGACAMGFKVKDAKAAFQHAIAHGGIAFQDAPHANHGLPAIQAIGGS
HHHHHHHCCCCCCCCEEEECEEECHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHCCCE
VIYFVDEEHQPFSHEWNITSSEPVVGNGLTAIDHLTHNVYRGNMDKWASFYASIFNFQEI
EEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEE
RFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHGEGIQHIALNTNDI
EEEEECCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHH
YKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILIDGEADPKDGLLLQI
HHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCCHHHHHHHHEEEECCCCCCCCCEEEEE
FTENIFGPVFFEIIQRKGNQGFGEGNFQALFEAIERDQVRRGTLKELT
EHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA