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The map label for this gene is yfeW [C]

Identifier: 148359457

GI number: 148359457

Start: 2220770

End: 2222032

Strand: Reverse

Name: yfeW [C]

Synonym: LPC_1364

Alternate gene names: 148359457

Gene position: 2222032-2220770 (Counterclockwise)

Preceding gene: 148359458

Following gene: 148359456

Centisome position: 62.13

GC content: 38.24

Gene sequence:

>1263_bases
ATGAAAATAAATAACTTAGTTAGTTTTCTGCTTGCCTTCTGCCTGGCTTCTTTATCTTATAATATCAGCGCAGCTGAATC
TCCTGTTGTATCTCATCATAAAATTCAAAAGGAAATGAGCAAGTACTTCAAGGTTTATCATAACAAAGAAAAATTTACTG
CCACTGCTGTCTCAGTGTTTATTCCTCAAGAGAAAAATAAGGATGTATTGGATGTTGCCACTTTTGTCAAAGGAACTATG
GGATATCCTCCACTGTCTCAGGAAATTACCCCATTGAATTTGTTTGATATTGGAAGCATTACCAAATCATTCACTTCATT
GATTTTGCTTCAATTGCAGACTGAGGGCAAATTGTCACTGGATGATCCTTTGGGTAAATGGCTGCCTCAATACAAAGAGT
GGAAAGATGTAAAATTAAGACAATTATTGAATATGACCAGTGGCATCCCCAATTATTCCGAAGATCCTGAATTTGCAAAA
AAGATGGAGGATAATTTTGCGGCAATCTGGGGCGATGAGGAGTTGTTAGGTTATGCTCATCCAGAAAAGCCAATAGAAAC
CGACAGAGCAAACAGGTATGAGTATTCCAATTCTAATTATATTCTTGCTGGAATGGTTATTGAAAAAGTGACTCAAGATA
CTTTCGAAAATCAGTTAAAACAGAGGATTATTAATACAAACAATGGATTAAACAATTCATTTTATCCTGCAGGACCACAT
GGTCCAGAAGTCGAAAAATCAATCAGGGATAGACGAGTCCATGGTTATTTTTACGATGAGGACAACAAAAAACTAATTGA
TACTATAAGCAATGATTTATCCTGGGCTGGCGCAGCAGGTGCTGTTATCGCAAATACTGAAGACGTCGGTCGTTGGGTGC
AGCTGCTATATCATGGGTTACTGATAGAGCCTGCTTTTAGAGACGAGGCTTTATCCGAATTGGAGTCAGTGGTTTCAATA
AAAACAGGGTTACCTATCCCTTCAGTCACAGAAGATGAGCCCTACGGTTTTGGATTGGGAGTTGGTTTTTATTATGATAA
AAATTCCAGGCAGCGCTTTTGGACTTACCAGGGCAGTACTTTAGGTTACAGGGTGATGTATTTGTGGAATCCTTGTAATG
ATGTAACGGTTGTTGTGGCTTTGAATGGGAAAGGTGGCTCAGGCAATGAGAAATCAAAAATGGGCAACCATATCCATGAG
CTTTGTTTGAATATACATAAAGTTATCGTTAAAAACCATCCACACTTACAATGTGCAAGCTAA

Upstream 100 bases:

>100_bases
ATTCAACAGAACATCTCCTGTTTTTTTTATTTTATGGATCTATTTGAGTCTATCAGGTTAAAATGGCCAATTTTCTACTT
AACTTGATGTATTTTTCGCC

Downstream 100 bases:

>100_bases
TTTATTATTTATCATTATTGGTTGTTAAGGACTGAATCACATGGCAATCTGTATTAATAAAGAAACAGATCACTTTTTTA
TTTCGATAGGTAAAATCAAT

Product: D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MKINNLVSFLLAFCLASLSYNISAAESPVVSHHKIQKEMSKYFKVYHNKEKFTATAVSVFIPQEKNKDVLDVATFVKGTM
GYPPLSQEITPLNLFDIGSITKSFTSLILLQLQTEGKLSLDDPLGKWLPQYKEWKDVKLRQLLNMTSGIPNYSEDPEFAK
KMEDNFAAIWGDEELLGYAHPEKPIETDRANRYEYSNSNYILAGMVIEKVTQDTFENQLKQRIINTNNGLNNSFYPAGPH
GPEVEKSIRDRRVHGYFYDEDNKKLIDTISNDLSWAGAAGAVIANTEDVGRWVQLLYHGLLIEPAFRDEALSELESVVSI
KTGLPIPSVTEDEPYGFGLGVGFYYDKNSRQRFWTYQGSTLGYRVMYLWNPCNDVTVVVALNGKGGSGNEKSKMGNHIHE
LCLNIHKVIVKNHPHLQCAS

Sequences:

>Translated_420_residues
MKINNLVSFLLAFCLASLSYNISAAESPVVSHHKIQKEMSKYFKVYHNKEKFTATAVSVFIPQEKNKDVLDVATFVKGTM
GYPPLSQEITPLNLFDIGSITKSFTSLILLQLQTEGKLSLDDPLGKWLPQYKEWKDVKLRQLLNMTSGIPNYSEDPEFAK
KMEDNFAAIWGDEELLGYAHPEKPIETDRANRYEYSNSNYILAGMVIEKVTQDTFENQLKQRIINTNNGLNNSFYPAGPH
GPEVEKSIRDRRVHGYFYDEDNKKLIDTISNDLSWAGAAGAVIANTEDVGRWVQLLYHGLLIEPAFRDEALSELESVVSI
KTGLPIPSVTEDEPYGFGLGVGFYYDKNSRQRFWTYQGSTLGYRVMYLWNPCNDVTVVVALNGKGGSGNEKSKMGNHIHE
LCLNIHKVIVKNHPHLQCAS
>Mature_420_residues
MKINNLVSFLLAFCLASLSYNISAAESPVVSHHKIQKEMSKYFKVYHNKEKFTATAVSVFIPQEKNKDVLDVATFVKGTM
GYPPLSQEITPLNLFDIGSITKSFTSLILLQLQTEGKLSLDDPLGKWLPQYKEWKDVKLRQLLNMTSGIPNYSEDPEFAK
KMEDNFAAIWGDEELLGYAHPEKPIETDRANRYEYSNSNYILAGMVIEKVTQDTFENQLKQRIINTNNGLNNSFYPAGPH
GPEVEKSIRDRRVHGYFYDEDNKKLIDTISNDLSWAGAAGAVIANTEDVGRWVQLLYHGLLIEPAFRDEALSELESVVSI
KTGLPIPSVTEDEPYGFGLGVGFYYDKNSRQRFWTYQGSTLGYRVMYLWNPCNDVTVVVALNGKGGSGNEKSKMGNHIHE
LCLNIHKVIVKNHPHLQCAS

Specific function: Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e., a D-alanyl-D-alanine- terminated peptide), it becomes im

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S12 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 47417; Mature: 47417

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINNLVSFLLAFCLASLSYNISAAESPVVSHHKIQKEMSKYFKVYHNKEKFTATAVSVF
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEE
IPQEKNKDVLDVATFVKGTMGYPPLSQEITPLNLFDIGSITKSFTSLILLQLQTEGKLSL
ECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCC
DDPLGKWLPQYKEWKDVKLRQLLNMTSGIPNYSEDPEFAKKMEDNFAAIWGDEELLGYAH
CCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCEEEEECCHHHHCCCC
PEKPIETDRANRYEYSNSNYILAGMVIEKVTQDTFENQLKQRIINTNNGLNNSFYPAGPH
CCCCCCCCCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GPEVEKSIRDRRVHGYFYDEDNKKLIDTISNDLSWAGAAGAVIANTEDVGRWVQLLYHGL
CCHHHHHHHHCEEEEEEEECCCCHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHH
LIEPAFRDEALSELESVVSIKTGLPIPSVTEDEPYGFGLGVGFYYDKNSRQRFWTYQGST
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCC
LGYRVMYLWNPCNDVTVVVALNGKGGSGNEKSKMGNHIHELCLNIHKVIVKNHPHLQCAS
CCEEEEEEECCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure
MKINNLVSFLLAFCLASLSYNISAAESPVVSHHKIQKEMSKYFKVYHNKEKFTATAVSVF
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEE
IPQEKNKDVLDVATFVKGTMGYPPLSQEITPLNLFDIGSITKSFTSLILLQLQTEGKLSL
ECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCC
DDPLGKWLPQYKEWKDVKLRQLLNMTSGIPNYSEDPEFAKKMEDNFAAIWGDEELLGYAH
CCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCEEEEECCHHHHCCCC
PEKPIETDRANRYEYSNSNYILAGMVIEKVTQDTFENQLKQRIINTNNGLNNSFYPAGPH
CCCCCCCCCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GPEVEKSIRDRRVHGYFYDEDNKKLIDTISNDLSWAGAAGAVIANTEDVGRWVQLLYHGL
CCHHHHHHHHCEEEEEEEECCCCHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHH
LIEPAFRDEALSELESVVSIKTGLPIPSVTEDEPYGFGLGVGFYYDKNSRQRFWTYQGST
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCC
LGYRVMYLWNPCNDVTVVVALNGKGGSGNEKSKMGNHIHELCLNIHKVIVKNHPHLQCAS
CCEEEEEEECCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3830154; 7925404; 3030739; 2175384; 2386365; 3997832; 7490745 [H]