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The map label for this gene is rnc

Identifier: 148359410

GI number: 148359410

Start: 2170904

End: 2171578

Strand: Reverse

Name: rnc

Synonym: LPC_1314

Alternate gene names: 148359410

Gene position: 2171578-2170904 (Counterclockwise)

Preceding gene: 148359411

Following gene: 148359407

Centisome position: 60.72

GC content: 39.11

Gene sequence:

>675_bases
GTGAAAATTAATTTAGAAAGATTGTGCAGACGTTTAAACTATCATTTTAATAACATAGCCTATTTGAAGCAGGCTTTGAC
GCATTGCAGTGCTGGTAGCGATAATTATGAACGCTTTGAGTTTCTTGGAGACTCGATATTAAGTTTTGTTATTGCCAATG
AGCTATTCAATCGTTTTCCACTTCACAGTGAAGGGCAATTAAGTCGATTGCGCTCTTTTCTTGTTAAAGGTGAAATGTTA
GCAGAAATAGCCAGAGAAATAGGTTTGGGTGATTATCTATTTCTTGGGCAAGGTGAGTTAAGGAGCGGTGGATTTCGCCG
CACATCTATATTAGCAGATGCCCTTGAGGCTATATTGGCAGCCATTTATTTGGATGGAGGAATGACTGCTGCAAAACAGA
TTATTTTAATGCTTTATAGTTCACGATTAGATGATCCGGATTTAAATCATTGTTTAAAGGATGCAAAGACACAATTACAG
GAGTTTTTGCAAGCATCAAAATTCGCTTTACCTGAATACGTCCTAACCAAGATTGAGGGGGATGAGCACGCTCAAATCTT
CCATGTAACATGCACAATTGAGGGAGTAAGTCAGGTAGCTTATGGCACAGGGCCTAATAGAAGAAAAGCTGAGCAGTTGG
CAGCAAAAGCCATGTTGGAACAGTTACAAGGTTAA

Upstream 100 bases:

>100_bases
AAATTTAAAATTAAGTTAAAATATCAAGTCATCAAACCTCTAATTTATAATATGAGCTTATTATTTAATTTTGAAGATAA
TTTTGAGGTAATAACAGGTA

Downstream 100 bases:

>100_bases
ATGGTATTGATCAGCAGAACCTATTACTTACTCTAGGCTTTCCAGGGCATGACATATTTCTAACCACTCTTCTTCTGTCT
TAATTAAAGCGGAATGAGCG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKINLERLCRRLNYHFNNIAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFPLHSEGQLSRLRSFLVKGEML
AEIAREIGLGDYLFLGQGELRSGGFRRTSILADALEAILAAIYLDGGMTAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQ
EFLQASKFALPEYVLTKIEGDEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG

Sequences:

>Translated_224_residues
MKINLERLCRRLNYHFNNIAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFPLHSEGQLSRLRSFLVKGEML
AEIAREIGLGDYLFLGQGELRSGGFRRTSILADALEAILAAIYLDGGMTAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQ
EFLQASKFALPEYVLTKIEGDEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG
>Mature_224_residues
MKINLERLCRRLNYHFNNIAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFPLHSEGQLSRLRSFLVKGEML
AEIAREIGLGDYLFLGQGELRSGGFRRTSILADALEAILAAIYLDGGMTAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQ
EFLQASKFALPEYVLTKIEGDEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=216, Percent_Identity=31.9444444444444, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI155030236, Length=216, Percent_Identity=31.9444444444444, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI29294649, Length=257, Percent_Identity=27.2373540856031, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI29294651, Length=257, Percent_Identity=27.2373540856031, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788920, Length=221, Percent_Identity=50.2262443438914, Blast_Score=212, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI193202651, Length=225, Percent_Identity=28.4444444444444, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17506883, Length=225, Percent_Identity=28.4444444444444, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137682, Length=202, Percent_Identity=29.2079207920792, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_LEGPA (Q5X446)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_124152.1
- ProteinModelPortal:   Q5X446
- SMR:   Q5X446
- STRING:   Q5X446
- GeneID:   3119653
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp1834
- LegioList:   lpp1834
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- BioCyc:   LPNE297246:LPP1834-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25136; Mature: 25136

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINLERLCRRLNYHFNNIAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFP
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
LHSEGQLSRLRSFLVKGEMLAEIAREIGLGDYLFLGQGELRSGGFRRTSILADALEAILA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHH
AIYLDGGMTAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQEFLQASKFALPEYVLTKIEG
HHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
DEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG
CCCCEEEEEEEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKINLERLCRRLNYHFNNIAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFP
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
LHSEGQLSRLRSFLVKGEMLAEIAREIGLGDYLFLGQGELRSGGFRRTSILADALEAILA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHH
AIYLDGGMTAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQEFLQASKFALPEYVLTKIEG
HHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
DEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG
CCCCEEEEEEEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA