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The map label for this gene is pyrD

Identifier: 148359367

GI number: 148359367

Start: 2119883

End: 2120884

Strand: Reverse

Name: pyrD

Synonym: LPC_1265

Alternate gene names: 148359367

Gene position: 2120884-2119883 (Counterclockwise)

Preceding gene: 148359368

Following gene: 148359366

Centisome position: 59.3

GC content: 38.22

Gene sequence:

>1002_bases
ATGTATTCACTGCTGCGCCCTTTACTTTTCAGATTGGATGCAGAAAAAGCCCATTCATTAACATTATCCTTATTACATTA
CCTCCCTGGTTTTTATTTTCGGAAAATAGCCGGTCAACCTGTTCATGCTATGGGTCTTGTATTCCCTCATCAAGTTGGAC
TGGCAGCTGGTTTAGATAAAAATGGCGAACATTTGGATGCATTAGCCAAATTGGGATTTTCATTCATTGAATTAGGGACA
GTAACACCTAAGGGACAAGCAGGTAATCCCAAACCAAGGCTTTTTCGTATTGCAGAGGCAAATGCGATTATCAACAGGAT
GGGTTTTAACAATTCGGGAGTTGATGTACTGGTAGAAAATGTAAAAAGAGCAAATTATAAAGGAATATTAGGGATAAATA
TTGGAAAAAATAAAGAGACTAATTTAAATCAAGCTGCAGAGGACTATCTTTATTGCTTCCGTAAAGTATATGATCATGCT
TCCTATGTCACTATCAATATTTCCTCTCCCAATACCCCTGATTTACGCCAGTTACAACAAGGAGATTATTTTGCTGAATT
ACTCACCCAGTTACAAAAAGAACAGATAAAATTAGCAGATCAATATGGACGCCATGTGCCTTTAGTGGTGAAAGTATCTC
CGGATGAAACAGATGAAACACTAAAACAAATGACAGATATCATTTTACAGTATGGAATCGAGGGTATTATTGCAACGAAT
ACCACCTGTTCTCGGGAAATGGTAAAAAATTTGCCTTGTTCTGAAGAACAGGGCGGATTAAGTGGTAGGCCACTGATGGA
ATTATCTACTCGCTGCTTGCGCTTGTTGAAACAATATGTTGGTAATGATGTGACATTGATAGGAGTGGGTGGTATTGACA
GTTTGGAGAGCGCCAAAGACAAGATCAATGCAGGAGCTTCGTTATTACAAGTATACAGTGGTTTAGTTTATAAGGGACCG
GAGTTGATTCACGATATTGTTTCAGGTTTAAATGCTATCTGA

Upstream 100 bases:

>100_bases
TCGCTTCCTATTAATCGTCAGTACGAAAATCATCACGAAAAATGTTATCATACCTCAATTGTTCTTTATTAATGATTCTC
CCTGCTTTAGGAGTAATTTT

Downstream 100 bases:

>100_bases
TCCTGGTGGTGAGGAAATCGATGTATATTACTAAGGAATTGGCTGTTCGCATGGAAGGGTGTATCAAGCAGAGTCACATT
GAGGTGACAAAGCGGTACTC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MYSLLRPLLFRLDAEKAHSLTLSLLHYLPGFYFRKIAGQPVHAMGLVFPHQVGLAAGLDKNGEHLDALAKLGFSFIELGT
VTPKGQAGNPKPRLFRIAEANAIINRMGFNNSGVDVLVENVKRANYKGILGINIGKNKETNLNQAAEDYLYCFRKVYDHA
SYVTINISSPNTPDLRQLQQGDYFAELLTQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATN
TTCSREMVKNLPCSEEQGGLSGRPLMELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKDKINAGASLLQVYSGLVYKGP
ELIHDIVSGLNAI

Sequences:

>Translated_333_residues
MYSLLRPLLFRLDAEKAHSLTLSLLHYLPGFYFRKIAGQPVHAMGLVFPHQVGLAAGLDKNGEHLDALAKLGFSFIELGT
VTPKGQAGNPKPRLFRIAEANAIINRMGFNNSGVDVLVENVKRANYKGILGINIGKNKETNLNQAAEDYLYCFRKVYDHA
SYVTINISSPNTPDLRQLQQGDYFAELLTQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATN
TTCSREMVKNLPCSEEQGGLSGRPLMELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKDKINAGASLLQVYSGLVYKGP
ELIHDIVSGLNAI
>Mature_333_residues
MYSLLRPLLFRLDAEKAHSLTLSLLHYLPGFYFRKIAGQPVHAMGLVFPHQVGLAAGLDKNGEHLDALAKLGFSFIELGT
VTPKGQAGNPKPRLFRIAEANAIINRMGFNNSGVDVLVENVKRANYKGILGINIGKNKETNLNQAAEDYLYCFRKVYDHA
SYVTINISSPNTPDLRQLQQGDYFAELLTQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATN
TTCSREMVKNLPCSEEQGGLSGRPLMELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKDKINAGASLLQVYSGLVYKGP
ELIHDIVSGLNAI

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=333, Percent_Identity=40.8408408408408, Blast_Score=229, Evalue=3e-60,
Organism=Escherichia coli, GI1787177, Length=332, Percent_Identity=50.9036144578313, Blast_Score=345, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI17509475, Length=337, Percent_Identity=36.2017804154303, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI281361352, Length=339, Percent_Identity=38.9380530973451, Blast_Score=230, Evalue=9e-61,
Organism=Drosophila melanogaster, GI17137316, Length=339, Percent_Identity=38.9380530973451, Blast_Score=230, Evalue=9e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_LEGPA (Q5X496)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_124102.1
- ProteinModelPortal:   Q5X496
- SMR:   Q5X496
- STRING:   Q5X496
- GeneID:   3116752
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp1784
- LegioList:   lpp1784
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- ProtClustDB:   PRK05286
- BioCyc:   LPNE297246:LPP1784-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 36659; Mature: 36659

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLLRPLLFRLDAEKAHSLTLSLLHYLPGFYFRKIAGQPVHAMGLVFPHQVGLAAGLDK
CHHHHHHHHHHHCHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
NGEHLDALAKLGFSFIELGTVTPKGQAGNPKPRLFRIAEANAIINRMGFNNSGVDVLVEN
CCHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCHHHHHHH
VKRANYKGILGINIGKNKETNLNQAAEDYLYCFRKVYDHASYVTINISSPNTPDLRQLQQ
HHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHC
GDYFAELLTQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATN
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECC
TTCSREMVKNLPCSEEQGGLSGRPLMELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKD
CHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHH
KINAGASLLQVYSGLVYKGPELIHDIVSGLNAI
HHHCCHHHHHHHHCHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MYSLLRPLLFRLDAEKAHSLTLSLLHYLPGFYFRKIAGQPVHAMGLVFPHQVGLAAGLDK
CHHHHHHHHHHHCHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
NGEHLDALAKLGFSFIELGTVTPKGQAGNPKPRLFRIAEANAIINRMGFNNSGVDVLVEN
CCHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCHHHHHHH
VKRANYKGILGINIGKNKETNLNQAAEDYLYCFRKVYDHASYVTINISSPNTPDLRQLQQ
HHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHC
GDYFAELLTQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATN
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECC
TTCSREMVKNLPCSEEQGGLSGRPLMELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKD
CHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHH
KINAGASLLQVYSGLVYKGPELIHDIVSGLNAI
HHHCCHHHHHHHHCHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA