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The map label for this gene is guaB [H]

Identifier: 148359262

GI number: 148359262

Start: 1996342

End: 1997814

Strand: Reverse

Name: guaB [H]

Synonym: LPC_1157

Alternate gene names: 148359262

Gene position: 1997814-1996342 (Counterclockwise)

Preceding gene: 148359263

Following gene: 148359261

Centisome position: 55.86

GC content: 41.75

Gene sequence:

>1473_bases
ATGCCTCTATCCATTGTGCAACAGTCATTAACCTTTGACGATGTTTTGCTTGTCCCTGCCCACTCAACTATTTTACCCAA
AGACGTTTCATTGAAAACCAAATTAACCCGTGCAATCCACCTTAATATGCCTTTAATTTCGGCAGCAATGGATACAGTGA
CCGAAGCGAGGTTAGCTATCGCTTTAGCACAGGAAGGTGGTTTGGGGATTATTCATAAGAATATGAGTATCGCTGATCAA
GCAGAAGAAGTCAGAAAAGTAAAAAAATTTGAAAGCGGTATGGTGAAAGATCCTATTTCAGTAACTCCCGACTTGACAGT
TAAAGAATTGCTTGCAGTCATGACAAAATATAATTTTTCAGGGGTGCCGGTGGTTGATGGTAAGCATTTGGTAGGAATAG
TAACCAGTCGAGATATTCGTTTTGAAACCAATATGAATTTGACTGTGGCGCAAGTAATGACTCCCAAAGGGCGTTTGGTT
ACTGTAAAAGAAGGAGCAAGTAGAGAAGAAGTCAGAAGTTTGCTCCATAAGCACCGAATAGAAAAATTATTAGTAGTGAA
TGAGGATTTTGAGTTACGTGGACTCATTACAGTAAAAGACATACAAAAAGCAAAAGACAACCCTTATGCTTGTAAAGATA
GTTTTGAGCAGCTAAGAGTTGGGGCTGCTGTTGGTGTTGGTGAAGGGACCGATGAGCGAGTTGCAGCTCTTGTTGAATCC
GGAGTTGATGTCATAGTAGTGGATACAGCACATGGACATTCTCAGGGCGTATTAAATCGCGTGAAATGGATTAAAAAGAA
TTATCCTGATGTACAAGTCATAGGTGGTAATATTGCAACCGCTGCCGCCGCAAGAGATTTATATGAGGCGGGTGCTGATG
CAGTAAAAGTTGGAATTGGGCCAGGATCAATTTGTACCACTCGCATAGTGACCGGTGTTGGTATCCCGCAAATTAGCGCT
ATAGCAAATGTGGCACAAGAACTTAAAGGGATAATTCCTGTGATAGCTGATGGTGGGATACGTTTTTCAGGTGACGTTTG
TAAAGCGTTGGCCGCAGGTGCTGATACTGTAATGCTTGGTAGTATGTTTGCAGGTACGGAAGAATCTCCTGGTGAAATTG
AATTATATCAGGGGCGTACTTATAAAAATTACAGAGGTATGGGATCCATTGGAGCCATGTCATTAGCTCAGGGGTCAAGT
GACCGCTATTTTCAGGATGCTTCTCTTGGTACAGAAAAGCTGGTTCCTGAAGGTATTGAGGGGAGAGTACCTTATAAAGG
ACCGGTTCAAACAATTATTCATCAATTATTAGGTGGTTTACGCTCCTGTATGGGCTATACCGGTTGTGCTACTATTGAGG
AATTGCATTCTAAAACTGAATTTGTGCAAGTGACCAATGCTGGTATGCGTGAGTCACATGTGCATGATGTGAGTATTACT
AAGCAAGCCCCCAATTATCAGGTGGATAATTAA

Upstream 100 bases:

>100_bases
GTATTTTGTCCAGTACAGAGAAATTTATACATTAAATGTTTAAAATTTTTAAAGTTTGTAGTAAACTATTTGGTTATTTA
ATTACTGGAGTGAGATAAAA

Downstream 100 bases:

>100_bases
TAATGAATGATTTGAAAAAAAGCCCATTATTAATATTAGATTTTGGTTCTCAATACACCCAATTAATTGCAAGACGCGTT
CGAGAAATGGGGGTTTATTG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MPLSIVQQSLTFDDVLLVPAHSTILPKDVSLKTKLTRAIHLNMPLISAAMDTVTEARLAIALAQEGGLGIIHKNMSIADQ
AEEVRKVKKFESGMVKDPISVTPDLTVKELLAVMTKYNFSGVPVVDGKHLVGIVTSRDIRFETNMNLTVAQVMTPKGRLV
TVKEGASREEVRSLLHKHRIEKLLVVNEDFELRGLITVKDIQKAKDNPYACKDSFEQLRVGAAVGVGEGTDERVAALVES
GVDVIVVDTAHGHSQGVLNRVKWIKKNYPDVQVIGGNIATAAAARDLYEAGADAVKVGIGPGSICTTRIVTGVGIPQISA
IANVAQELKGIIPVIADGGIRFSGDVCKALAAGADTVMLGSMFAGTEESPGEIELYQGRTYKNYRGMGSIGAMSLAQGSS
DRYFQDASLGTEKLVPEGIEGRVPYKGPVQTIIHQLLGGLRSCMGYTGCATIEELHSKTEFVQVTNAGMRESHVHDVSIT
KQAPNYQVDN

Sequences:

>Translated_490_residues
MPLSIVQQSLTFDDVLLVPAHSTILPKDVSLKTKLTRAIHLNMPLISAAMDTVTEARLAIALAQEGGLGIIHKNMSIADQ
AEEVRKVKKFESGMVKDPISVTPDLTVKELLAVMTKYNFSGVPVVDGKHLVGIVTSRDIRFETNMNLTVAQVMTPKGRLV
TVKEGASREEVRSLLHKHRIEKLLVVNEDFELRGLITVKDIQKAKDNPYACKDSFEQLRVGAAVGVGEGTDERVAALVES
GVDVIVVDTAHGHSQGVLNRVKWIKKNYPDVQVIGGNIATAAAARDLYEAGADAVKVGIGPGSICTTRIVTGVGIPQISA
IANVAQELKGIIPVIADGGIRFSGDVCKALAAGADTVMLGSMFAGTEESPGEIELYQGRTYKNYRGMGSIGAMSLAQGSS
DRYFQDASLGTEKLVPEGIEGRVPYKGPVQTIIHQLLGGLRSCMGYTGCATIEELHSKTEFVQVTNAGMRESHVHDVSIT
KQAPNYQVDN
>Mature_489_residues
PLSIVQQSLTFDDVLLVPAHSTILPKDVSLKTKLTRAIHLNMPLISAAMDTVTEARLAIALAQEGGLGIIHKNMSIADQA
EEVRKVKKFESGMVKDPISVTPDLTVKELLAVMTKYNFSGVPVVDGKHLVGIVTSRDIRFETNMNLTVAQVMTPKGRLVT
VKEGASREEVRSLLHKHRIEKLLVVNEDFELRGLITVKDIQKAKDNPYACKDSFEQLRVGAAVGVGEGTDERVAALVESG
VDVIVVDTAHGHSQGVLNRVKWIKKNYPDVQVIGGNIATAAAARDLYEAGADAVKVGIGPGSICTTRIVTGVGIPQISAI
ANVAQELKGIIPVIADGGIRFSGDVCKALAAGADTVMLGSMFAGTEESPGEIELYQGRTYKNYRGMGSIGAMSLAQGSSD
RYFQDASLGTEKLVPEGIEGRVPYKGPVQTIIHQLLGGLRSCMGYTGCATIEELHSKTEFVQVTNAGMRESHVHDVSITK
QAPNYQVDN

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=478, Percent_Identity=42.0502092050209, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI156616279, Length=478, Percent_Identity=42.0502092050209, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI34328930, Length=478, Percent_Identity=42.0502092050209, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI34328928, Length=478, Percent_Identity=42.0502092050209, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI66933016, Length=481, Percent_Identity=39.9168399168399, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI217035152, Length=474, Percent_Identity=41.9831223628692, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI217035148, Length=478, Percent_Identity=41.0041841004184, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI217035150, Length=478, Percent_Identity=39.1213389121339, Blast_Score=315, Evalue=9e-86,
Organism=Homo sapiens, GI50541954, Length=268, Percent_Identity=41.044776119403, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI50541952, Length=268, Percent_Identity=41.044776119403, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI50541948, Length=268, Percent_Identity=41.044776119403, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI50541956, Length=268, Percent_Identity=41.044776119403, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI156104880, Length=251, Percent_Identity=40.6374501992032, Blast_Score=172, Evalue=9e-43,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=64.7540983606557, Blast_Score=596, Evalue=1e-171,
Organism=Escherichia coli, GI1786293, Length=226, Percent_Identity=39.3805309734513, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=476, Percent_Identity=36.5546218487395, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=39.0476190476191, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17560440, Length=257, Percent_Identity=35.408560311284, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323585, Length=489, Percent_Identity=40.4907975460123, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6322012, Length=489, Percent_Identity=39.6728016359918, Blast_Score=334, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=41.2008281573499, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=344, Percent_Identity=40.406976744186, Blast_Score=254, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6319353, Length=114, Percent_Identity=41.2280701754386, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=39.9585921325052, Blast_Score=325, Evalue=4e-89,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=39.9585921325052, Blast_Score=325, Evalue=4e-89,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=40.8163265306122, Blast_Score=294, Evalue=1e-79,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52536; Mature: 52405

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSIVQQSLTFDDVLLVPAHSTILPKDVSLKTKLTRAIHLNMPLISAAMDTVTEARLAI
CCHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHHEE
ALAQEGGLGIIHKNMSIADQAEEVRKVKKFESGMVKDPISVTPDLTVKELLAVMTKYNFS
EEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
GVPVVDGKHLVGIVTSRDIRFETNMNLTVAQVMTPKGRLVTVKEGASREEVRSLLHKHRI
CCEEECCCEEEEEEECCCEEEECCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHH
EKLLVVNEDFELRGLITVKDIQKAKDNPYACKDSFEQLRVGAAVGVGEGTDERVAALVES
HEEEEECCCCCEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHC
GVDVIVVDTAHGHSQGVLNRVKWIKKNYPDVQVIGGNIATAAAARDLYEAGADAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGIPQISAIANVAQELKGIIPVIADGGIRFSGDVCKALAAGADTVMLG
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCEEECHHHHHHHHCCCCCEEEH
SMFAGTEESPGEIELYQGRTYKNYRGMGSIGAMSLAQGSSDRYFQDASLGTEKLVPEGIE
HHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCCEEECCCCCHHHCCCCCCC
GRVPYKGPVQTIIHQLLGGLRSCMGYTGCATIEELHSKTEFVQVTNAGMRESHVHDVSIT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHEEEEECCCCCCCCCCEEEEE
KQAPNYQVDN
CCCCCCCCCC
>Mature Secondary Structure 
PLSIVQQSLTFDDVLLVPAHSTILPKDVSLKTKLTRAIHLNMPLISAAMDTVTEARLAI
CHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHHEE
ALAQEGGLGIIHKNMSIADQAEEVRKVKKFESGMVKDPISVTPDLTVKELLAVMTKYNFS
EEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
GVPVVDGKHLVGIVTSRDIRFETNMNLTVAQVMTPKGRLVTVKEGASREEVRSLLHKHRI
CCEEECCCEEEEEEECCCEEEECCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHH
EKLLVVNEDFELRGLITVKDIQKAKDNPYACKDSFEQLRVGAAVGVGEGTDERVAALVES
HEEEEECCCCCEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHC
GVDVIVVDTAHGHSQGVLNRVKWIKKNYPDVQVIGGNIATAAAARDLYEAGADAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGIPQISAIANVAQELKGIIPVIADGGIRFSGDVCKALAAGADTVMLG
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCEEECHHHHHHHHCCCCCEEEH
SMFAGTEESPGEIELYQGRTYKNYRGMGSIGAMSLAQGSSDRYFQDASLGTEKLVPEGIE
HHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCCEEECCCCCHHHCCCCCCC
GRVPYKGPVQTIIHQLLGGLRSCMGYTGCATIEELHSKTEFVQVTNAGMRESHVHDVSIT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHEEEEECCCCCCCCCCEEEEE
KQAPNYQVDN
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA