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The map label for this gene is thrC [H]

Identifier: 148359178

GI number: 148359178

Start: 1884784

End: 1886052

Strand: Reverse

Name: thrC [H]

Synonym: LPC_1072

Alternate gene names: 148359178

Gene position: 1886052-1884784 (Counterclockwise)

Preceding gene: 148359179

Following gene: 148359177

Centisome position: 52.74

GC content: 36.56

Gene sequence:

>1269_bases
ATGAAAATTAGAATAAAGAGTACGAGAGGACAATATGTCTCCACAATAGACGAAGCGATACTGTCAGGCCTGGCAGGGGA
TGGTGGGGTATTTGTACCTGACAGGTTTCCCAATTTAACAATAAAAAAATTTTATGAATACGGTAATTTAATCGACTTTT
CTGTTAATTTACTCTCGCCATTTTTTTCAGATAGTAAAATTGATGTAAATAATGCTTTTTTTCAAAAATTCCTCACCTTC
TCCTTTCCGTTACATCATCTTTTTAAGAAAAGTTATGTACTGGAGTTGTTTCATGGCCCAACCCTGTCTTTCAAAGATTT
AGGAACTCAATTTTTCAGTGAATGTTTATTGCATCTGATAGAAAACAAGAGCGCCAAAGTCATGGTCGCAACATCTGGTG
ATACTGGCGCTGCGATTGCTCATGCTTTGCATGGGAAAAGAGACCTGGAAGGAATCATTTTATTTCCCAAAGATAAACTT
ACTTTCAGACAACAATCTCAAATTACTTGTTGGGGAGAGAATATTCGTGCATTGGCTATTAATGGCAGCTTTGATCAATG
TCAACAGCTGGTGAAGCTGGTATTTGCCAAAAGAGAACATAAAGGAGTATTGACTACAGCCAATAGCATGAATATAGCCA
GATTATTACCACAGATTATTTTCTATGCTTTTACCAGCATTCAACTGGCATTAAGACATAATCATTCTGTTAATTTTATA
GTTCCAGGCGGAAACCTGGGTAATGTTACGGCTTGTTATTGGGCAAAAATGCTGGGTTTTCCGATTGAGCAAATTTTAAT
AGCTAATAATACTAATAGTGCACTGGGCGAATTTTTGTTAACGGGAGCTTATCAAGCCAAATCGGTTACTAAAACATTGG
CAACAGCGATGGATGTAGGTGAGCCAAGCAATTTGGAGCGTTTATTCATTTTATTTAATAATTATTCTGAATGTAAAAAA
CAGATGAATGCAGAATCTGTTAGTGATGAGCAAATTAAGCAAGCTATCCTACATTGTTACAATAAATATCATTATATAAT
TTGCCCTCATACCGCCACAGCTTATCATCGTCTAAGTACAATCAATCAGGACAAACCTTGGGTTATTGTGGCACCAGGGC
ACCCGGCCAAATTTGAAGAGGTATTAGAGCCACTATTGAACAAAGAAATTCCTGTCCCGGAACAGCTGAAGGTCTTTTTA
GGCAGAAAACAACATTATTCAATTATAGAGCCAAACTATCATTCTTTGTATCATTTCTTAGTTGAATGA

Upstream 100 bases:

>100_bases
AATTAAATATTGATGTGAGCAATATACCGTGAAGCAATAGTTGTCTTTGAAAGTGATTTATTGGTTGCCAATATTTCATC
AGAAGGTGCAAAGGCTGCAG

Downstream 100 bases:

>100_bases
AGGCCATTACAGAAGCAAATTATTGTGATGGCATATAATAGCATCGGTTAATTATCACCATTGTCTTTGATTGGCTCAAA
CTCATAAGCTAAGTCAGCAT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKIRIKSTRGQYVSTIDEAILSGLAGDGGVFVPDRFPNLTIKKFYEYGNLIDFSVNLLSPFFSDSKIDVNNAFFQKFLTF
SFPLHHLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLIENKSAKVMVATSGDTGAAIAHALHGKRDLEGIILFPKDKL
TFRQQSQITCWGENIRALAINGSFDQCQQLVKLVFAKREHKGVLTTANSMNIARLLPQIIFYAFTSIQLALRHNHSVNFI
VPGGNLGNVTACYWAKMLGFPIEQILIANNTNSALGEFLLTGAYQAKSVTKTLATAMDVGEPSNLERLFILFNNYSECKK
QMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLSTINQDKPWVIVAPGHPAKFEEVLEPLLNKEIPVPEQLKVFL
GRKQHYSIIEPNYHSLYHFLVE

Sequences:

>Translated_422_residues
MKIRIKSTRGQYVSTIDEAILSGLAGDGGVFVPDRFPNLTIKKFYEYGNLIDFSVNLLSPFFSDSKIDVNNAFFQKFLTF
SFPLHHLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLIENKSAKVMVATSGDTGAAIAHALHGKRDLEGIILFPKDKL
TFRQQSQITCWGENIRALAINGSFDQCQQLVKLVFAKREHKGVLTTANSMNIARLLPQIIFYAFTSIQLALRHNHSVNFI
VPGGNLGNVTACYWAKMLGFPIEQILIANNTNSALGEFLLTGAYQAKSVTKTLATAMDVGEPSNLERLFILFNNYSECKK
QMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLSTINQDKPWVIVAPGHPAKFEEVLEPLLNKEIPVPEQLKVFL
GRKQHYSIIEPNYHSLYHFLVE
>Mature_422_residues
MKIRIKSTRGQYVSTIDEAILSGLAGDGGVFVPDRFPNLTIKKFYEYGNLIDFSVNLLSPFFSDSKIDVNNAFFQKFLTF
SFPLHHLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLIENKSAKVMVATSGDTGAAIAHALHGKRDLEGIILFPKDKL
TFRQQSQITCWGENIRALAINGSFDQCQQLVKLVFAKREHKGVLTTANSMNIARLLPQIIFYAFTSIQLALRHNHSVNFI
VPGGNLGNVTACYWAKMLGFPIEQILIANNTNSALGEFLLTGAYQAKSVTKTLATAMDVGEPSNLERLFILFNNYSECKK
QMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLSTINQDKPWVIVAPGHPAKFEEVLEPLLNKEIPVPEQLKVFL
GRKQHYSIIEPNYHSLYHFLVE

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=443, Percent_Identity=30.2483069977427, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI149193323, Length=437, Percent_Identity=29.9771167048055, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1786185, Length=386, Percent_Identity=35.2331606217617, Blast_Score=223, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6319901, Length=456, Percent_Identity=32.2368421052632, Blast_Score=206, Evalue=4e-54,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 47656; Mature: 47656

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRIKSTRGQYVSTIDEAILSGLAGDGGVFVPDRFPNLTIKKFYEYGNLIDFSVNLLSP
CEEEEECCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHCCCEEEEEHHHHHH
FFSDSKIDVNNAFFQKFLTFSFPLHHLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLI
CCCCCCEECHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
ENKSAKVMVATSGDTGAAIAHALHGKRDLEGIILFPKDKLTFRQQSQITCWGENIRALAI
CCCCCEEEEEECCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEEEECCCEEEEEE
NGSFDQCQQLVKLVFAKREHKGVLTTANSMNIARLLPQIIFYAFTSIQLALRHNHSVNFI
ECCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEEECCCCEEEE
VPGGNLGNVTACYWAKMLGFPIEQILIANNTNSALGEFLLTGAYQAKSVTKTLATAMDVG
ECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCC
EPSNLERLFILFNNYSECKKQMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLST
CCCCCEEEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
INQDKPWVIVAPGHPAKFEEVLEPLLNKEIPVPEQLKVFLGRKQHYSIIEPNYHSLYHFL
CCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEECCCHHHHHHHH
VE
CC
>Mature Secondary Structure
MKIRIKSTRGQYVSTIDEAILSGLAGDGGVFVPDRFPNLTIKKFYEYGNLIDFSVNLLSP
CEEEEECCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHCCCEEEEEHHHHHH
FFSDSKIDVNNAFFQKFLTFSFPLHHLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLI
CCCCCCEECHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
ENKSAKVMVATSGDTGAAIAHALHGKRDLEGIILFPKDKLTFRQQSQITCWGENIRALAI
CCCCCEEEEEECCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEEEECCCEEEEEE
NGSFDQCQQLVKLVFAKREHKGVLTTANSMNIARLLPQIIFYAFTSIQLALRHNHSVNFI
ECCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEEECCCCEEEE
VPGGNLGNVTACYWAKMLGFPIEQILIANNTNSALGEFLLTGAYQAKSVTKTLATAMDVG
ECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCC
EPSNLERLFILFNNYSECKKQMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLST
CCCCCEEEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
INQDKPWVIVAPGHPAKFEEVLEPLLNKEIPVPEQLKVFLGRKQHYSIIEPNYHSLYHFL
CCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEECCCHHHHHHHH
VE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]