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The map label for this gene is proA [H]

Identifier: 148359143

GI number: 148359143

Start: 1842783

End: 1844036

Strand: Reverse

Name: proA [H]

Synonym: LPC_1035

Alternate gene names: 148359143

Gene position: 1844036-1842783 (Counterclockwise)

Preceding gene: 148359144

Following gene: 148359139

Centisome position: 51.56

GC content: 34.21

Gene sequence:

>1254_bases
ATGAATATTGATATTGCTAACCAATTAAGGGCCGCTAAAAAAGCAACTACTGATCTTAACTTAATACAAAGTGATACCCG
AACAATAATTTTGAAAACATTAGCGGCTAATTTAGAGAAGCACATTGAAAACATAATACAAGAAAATCAAAAAGATTTAA
GTTTAATGCTTGAGCAAGATCCCAGATATGATCGTTTATTGTTAAATAAAGAGAGAATTTTGTCATTGGCGAATGATGTG
AGAAAAGTAGCCGATTTACCTAACCCATTAGGAGTTAACCTCCTTGAAAAATCAATGCCAAATGGTTTGAGTATTAAGAA
AATCACAGTACCTTTAGGTGTCATCGCAGTCATTTATGAGTCAAGACCTAATGTAACTATTGATATCTTCAGTCTATGCT
TTAAATCTGGAAATGTTTGCATTTTAAAAGGTGGAAAAGAAGCACATTTTACTAATAGTTATCTGCTTTTATTAATTAAA
AATACATTAAAGAATTTTAATATAAACACAGATATTGTTTGTTTATTACCACCAGAAAGAGCATTGATGACTCAATTATT
AAATGCCACAGGTCTTGTTGATTTATGCATTCCAAGAGGGAGCCAGAATTTAATAAATTTTGTCAGAGACAATGCCAAAA
TACCTGTCATTGAAACAGGGGCAGGTATCGTGCATACCTATTTTGACAAAAGTGGAGATTTGGGAAAAGGTAAAAAAATT
ATTAACAACGCTAAAACCAGAAGAGTAAGTGTTTGCAATGCGCTGGATACTTTGATTATTCATGCTGATCGTTTAAAAGA
TTTGCCAGAACTTGTGGAGACCTTGTCTCAAAAGAATGTGATTATCTATGCCGACCAGGATGCATATCAGGTTTTAGATA
AGAATTATCCTAAACAACTTTTAATTAAGGCAAAACCACAAGACTTTGGCCATGAATTTCTGGACTATAAATTAGCAATA
AAAACAGTACCCAATATAAAAGCAGCTATTGATCATATTCAACAATTCAGTTCCCATCATAGTGAGGCTGTTATTGCTGA
AGATGAGTCTGCAATTGATAAATTTCTAACTGAAGTGGATGCCGCAGCTGTCTATGCCAATGCATCTACTTCATTTACAG
ATGGTGGGGAGTTCGGATTAGGGGCTGAAATTGGAATTAGTACGCAAAAGGTTCATGCGCGAGGGCCTATGGGATTAGAT
GCTTTAACAAGCTACAAATGGGTGATAAGAGGGACAGGACAAATTAGAAATTAA

Upstream 100 bases:

>100_bases
TCGCCAGATATGATTTCTTAAGATTAAAGGACTATCTTAGACTTCAAAATAAGCCTGCATTTATACATTACGATCATTTG
CATATTCTATAGGTATCAAA

Downstream 100 bases:

>100_bases
GCACAATTCTATTTTCCCAACGCCGTCTCCAATAATGACAACTGCAATAATCACCACTTTTCTGATATTGGATTGTTATC
AAAATATTCACCCAGTCTGC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MNIDIANQLRAAKKATTDLNLIQSDTRTIILKTLAANLEKHIENIIQENQKDLSLMLEQDPRYDRLLLNKERILSLANDV
RKVADLPNPLGVNLLEKSMPNGLSIKKITVPLGVIAVIYESRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIK
NTLKNFNINTDIVCLLPPERALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKNVIIYADQDAYQVLDKNYPKQLLIKAKPQDFGHEFLDYKLAI
KTVPNIKAAIDHIQQFSSHHSEAVIAEDESAIDKFLTEVDAAAVYANASTSFTDGGEFGLGAEIGISTQKVHARGPMGLD
ALTSYKWVIRGTGQIRN

Sequences:

>Translated_417_residues
MNIDIANQLRAAKKATTDLNLIQSDTRTIILKTLAANLEKHIENIIQENQKDLSLMLEQDPRYDRLLLNKERILSLANDV
RKVADLPNPLGVNLLEKSMPNGLSIKKITVPLGVIAVIYESRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIK
NTLKNFNINTDIVCLLPPERALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKNVIIYADQDAYQVLDKNYPKQLLIKAKPQDFGHEFLDYKLAI
KTVPNIKAAIDHIQQFSSHHSEAVIAEDESAIDKFLTEVDAAAVYANASTSFTDGGEFGLGAEIGISTQKVHARGPMGLD
ALTSYKWVIRGTGQIRN
>Mature_417_residues
MNIDIANQLRAAKKATTDLNLIQSDTRTIILKTLAANLEKHIENIIQENQKDLSLMLEQDPRYDRLLLNKERILSLANDV
RKVADLPNPLGVNLLEKSMPNGLSIKKITVPLGVIAVIYESRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIK
NTLKNFNINTDIVCLLPPERALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKNVIIYADQDAYQVLDKNYPKQLLIKAKPQDFGHEFLDYKLAI
KTVPNIKAAIDHIQQFSSHHSEAVIAEDESAIDKFLTEVDAAAVYANASTSFTDGGEFGLGAEIGISTQKVHARGPMGLD
ALTSYKWVIRGTGQIRN

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=419, Percent_Identity=34.1288782816229, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI21361368, Length=419, Percent_Identity=34.1288782816229, Blast_Score=231, Evalue=7e-61,
Organism=Escherichia coli, GI1786438, Length=413, Percent_Identity=40.4358353510896, Blast_Score=304, Evalue=8e-84,
Organism=Caenorhabditis elegans, GI17569967, Length=420, Percent_Identity=33.5714285714286, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17569969, Length=420, Percent_Identity=33.5714285714286, Blast_Score=225, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6324899, Length=424, Percent_Identity=37.0283018867925, Blast_Score=255, Evalue=9e-69,
Organism=Drosophila melanogaster, GI21357643, Length=407, Percent_Identity=33.4152334152334, Blast_Score=230, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: NA

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 46117; Mature: 46117

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDIANQLRAAKKATTDLNLIQSDTRTIILKTLAANLEKHIENIIQENQKDLSLMLEQD
CCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCC
PRYDRLLLNKERILSLANDVRKVADLPNPLGVNLLEKSMPNGLSIKKITVPLGVIAVIYE
CCHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCEEEEEEECCEEEEEEEE
SRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIKNTLKNFNINTDIVCLLPPER
CCCCEEEEHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEHHHHHCCCCCCCEEEEECCCH
ALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
HHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCCCHHH
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKNVIIYADQDAYQVLDKNYPKQL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHCCCCCEE
LIKAKPQDFGHEFLDYKLAIKTVPNIKAAIDHIQQFSSHHSEAVIAEDESAIDKFLTEVD
EEEECCHHHCHHHHHEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHH
AAAVYANASTSFTDGGEFGLGAEIGISTQKVHARGPMGLDALTSYKWVIRGTGQIRN
HHHEEECCCCCCCCCCCCCCCCEECCCCEEEECCCCCCHHHHHCCEEEEECCCCCCC
>Mature Secondary Structure
MNIDIANQLRAAKKATTDLNLIQSDTRTIILKTLAANLEKHIENIIQENQKDLSLMLEQD
CCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCC
PRYDRLLLNKERILSLANDVRKVADLPNPLGVNLLEKSMPNGLSIKKITVPLGVIAVIYE
CCHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCEEEEEEECCEEEEEEEE
SRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIKNTLKNFNINTDIVCLLPPER
CCCCEEEEHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEHHHHHCCCCCCCEEEEECCCH
ALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
HHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCCCHHH
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKNVIIYADQDAYQVLDKNYPKQL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHCCCCCEE
LIKAKPQDFGHEFLDYKLAIKTVPNIKAAIDHIQQFSSHHSEAVIAEDESAIDKFLTEVD
EEEECCHHHCHHHHHEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHH
AAAVYANASTSFTDGGEFGLGAEIGISTQKVHARGPMGLDALTSYKWVIRGTGQIRN
HHHEEECCCCCCCCCCCCCCCCEECCCCEEEECCCCCCHHHHHCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA