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The map label for this gene is nahM [H]

Identifier: 148358583

GI number: 148358583

Start: 3205565

End: 3206452

Strand: Direct

Name: nahM [H]

Synonym: LPC_0455

Alternate gene names: 148358583

Gene position: 3205565-3206452 (Clockwise)

Preceding gene: 148358584

Following gene: 148358582

Centisome position: 89.63

GC content: 35.59

Gene sequence:

>888_bases
ATGAATCCTGTATCGATTTTAGATGCCTCATTAAGAGATGGTGGACATAGAACTAATTTTCATTTTAAGGATGATGATTT
AAAAAAAATACTACTTCCTCTTGATAATTCAGGTATTGAATACATTGAAATTGGCTACCGTAATGGTTCACTTCACCCTA
TTGAAAATATAGGGAAAGCTGGAATGTGTCCCCAAGATTATCTCCTGTATTGCCAATCTCTAATAAAAAAAGCAAAAATT
GCAGTGATGGTTCATCCTCATAATGTAAACGAACAGGATCTGTTCGAGCTAAAAAATTGCGGTGTGAAATTAATAAGAAT
ATGTATAGCAAAAGGTGATCTTGTAACCGCTGTCCCTTTAATTAAACTGGCTAAGAATTTGAATTTTGAAACCTCAGTGA
ATATTATCCATATTTCTTATTATACGGAAAGCGAACTGGATAGTTTGATTGAGGAAGTAAGCAAACACGAACCGGATATG
ATCTATTTTGCTGATTCTAACGGAAGCCTATTTCCTGACAAGATAAATAACCTATATAAAAAATACACCAGCCGATATAA
AATTTCTTTTGGATTTCATGCTCATGACAACCTTGGGTTGGCGCAAGCCAACGCTCTTGCAGCGGTAAAGGCCGGGGTTC
ATTTTATTGATGCCTCACTGGCAGGAATGGGCAAAGGAACAGGTAATCTAAAAACTGAATTTTTTATCGCTTATTTACAT
GCGAACAATATAAAAAAATATAATTTGGAAGATGTGTTGGCAGCAGCTAATTATGTAAGAGATGCCTTGAAAATAGGACA
AGAACCTATTGAAATGAGTGAATTCATAAGGGGAATTTCTGATCTGTCTACAGCAGACCTGAAAAGCTATAAACCAGGCA
AGCTCTAG

Upstream 100 bases:

>100_bases
GCTTAATTGAACAACATATTGAACATGCTCATTTTGCAAGTGGTCTTTTAAAGTTTATACTTAATAATAATGAGGTTAAA
TTATTATTACGAGGTATTAA

Downstream 100 bases:

>100_bases
AAAATGCGTATATTTCCAATATAGGAATATAAGGCTGGGACACCTTGATTCCCCAAGATTTGATGCTCCAGAAAGCAACG
TACTTTCAAAATTAAGCTGG

Product: 4-hydroxy-2-oxovalerate aldolase

Products: NA

Alternate protein names: HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MNPVSILDASLRDGGHRTNFHFKDDDLKKILLPLDNSGIEYIEIGYRNGSLHPIENIGKAGMCPQDYLLYCQSLIKKAKI
AVMVHPHNVNEQDLFELKNCGVKLIRICIAKGDLVTAVPLIKLAKNLNFETSVNIIHISYYTESELDSLIEEVSKHEPDM
IYFADSNGSLFPDKINNLYKKYTSRYKISFGFHAHDNLGLAQANALAAVKAGVHFIDASLAGMGKGTGNLKTEFFIAYLH
ANNIKKYNLEDVLAAANYVRDALKIGQEPIEMSEFIRGISDLSTADLKSYKPGKL

Sequences:

>Translated_295_residues
MNPVSILDASLRDGGHRTNFHFKDDDLKKILLPLDNSGIEYIEIGYRNGSLHPIENIGKAGMCPQDYLLYCQSLIKKAKI
AVMVHPHNVNEQDLFELKNCGVKLIRICIAKGDLVTAVPLIKLAKNLNFETSVNIIHISYYTESELDSLIEEVSKHEPDM
IYFADSNGSLFPDKINNLYKKYTSRYKISFGFHAHDNLGLAQANALAAVKAGVHFIDASLAGMGKGTGNLKTEFFIAYLH
ANNIKKYNLEDVLAAANYVRDALKIGQEPIEMSEFIRGISDLSTADLKSYKPGKL
>Mature_295_residues
MNPVSILDASLRDGGHRTNFHFKDDDLKKILLPLDNSGIEYIEIGYRNGSLHPIENIGKAGMCPQDYLLYCQSLIKKAKI
AVMVHPHNVNEQDLFELKNCGVKLIRICIAKGDLVTAVPLIKLAKNLNFETSVNIIHISYYTESELDSLIEEVSKHEPDM
IYFADSNGSLFPDKINNLYKKYTSRYKISFGFHAHDNLGLAQANALAAVKAGVHFIDASLAGMGKGTGNLKTEFFIAYLH
ANNIKKYNLEDVLAAANYVRDALKIGQEPIEMSEFIRGISDLSTADLKSYKPGKL

Specific function: Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4-hydroxy-2-oxovalerate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1786548, Length=235, Percent_Identity=29.7872340425532, Blast_Score=85, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017629
- InterPro:   IPR013785
- InterPro:   IPR012425
- InterPro:   IPR000891
- ProDom:   PD005364 [H]

Pfam domain/function: PF07836 DmpG_comm; PF00682 HMGL-like [H]

EC number: =4.1.3.39 [H]

Molecular weight: Translated: 32852; Mature: 32852

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPVSILDASLRDGGHRTNFHFKDDDLKKILLPLDNSGIEYIEIGYRNGSLHPIENIGKA
CCCHHHEEHHHHCCCCCCCCCCCCCCHHEEEEECCCCCCEEEEEECCCCCCCCHHHCCCC
GMCPQDYLLYCQSLIKKAKIAVMVHPHNVNEQDLFELKNCGVKLIRICIAKGDLVTAVPL
CCCHHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHH
IKLAKNLNFETSVNIIHISYYTESELDSLIEEVSKHEPDMIYFADSNGSLFPDKINNLYK
HHHHHCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
KYTSRYKISFGFHAHDNLGLAQANALAAVKAGVHFIDASLAGMGKGTGNLKTEFFIAYLH
HHHCCEEEEEEEECCCCCCHHHHHHHHHHHHCHHHEEHHHHCCCCCCCCCCEEEEEEEEE
ANNIKKYNLEDVLAAANYVRDALKIGQEPIEMSEFIRGISDLSTADLKSYKPGKL
ECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCCCCCCC
>Mature Secondary Structure
MNPVSILDASLRDGGHRTNFHFKDDDLKKILLPLDNSGIEYIEIGYRNGSLHPIENIGKA
CCCHHHEEHHHHCCCCCCCCCCCCCCHHEEEEECCCCCCEEEEEECCCCCCCCHHHCCCC
GMCPQDYLLYCQSLIKKAKIAVMVHPHNVNEQDLFELKNCGVKLIRICIAKGDLVTAVPL
CCCHHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHH
IKLAKNLNFETSVNIIHISYYTESELDSLIEEVSKHEPDMIYFADSNGSLFPDKINNLYK
HHHHHCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
KYTSRYKISFGFHAHDNLGLAQANALAAVKAGVHFIDASLAGMGKGTGNLKTEFFIAYLH
HHHCCEEEEEEEECCCCCCHHHHHHHHHHHHCHHHEEHHHHCCCCCCCCCCEEEEEEEEE
ANNIKKYNLEDVLAAANYVRDALKIGQEPIEMSEFIRGISDLSTADLKSYKPGKL
ECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA