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The map label for this gene is rmlA1 [C]

Identifier: 148358508

GI number: 148358508

Start: 405589

End: 406251

Strand: Reverse

Name: rmlA1 [C]

Synonym: LPC_0374

Alternate gene names: 148358508

Gene position: 406251-405589 (Counterclockwise)

Preceding gene: 148358509

Following gene: 148358505

Centisome position: 11.36

GC content: 41.48

Gene sequence:

>663_bases
ATGAAAACCGCTATGATTCTTGCAGCAGGACGTGGAGAACGATTACGCCCTTTAACCGACAAAATTCCTAAAGCACTTTG
TACGGTAAGAAACAAGCCGTTAATTGAACACCATATCATTAACCTGGCCAATGCCGGCTTTGACCGATTGATAATCAATC
ATGCCTACCTGGGCGGACAAATTCGCCAATATATAGGAAATGGAAAACAATGGGGCTTGAATGTTATCTATTCTCCAGAA
CCGCCAGGAGGCCTTGAAACAGGGGGTGGTATTGTGAACGCCTTGCCTTTGCTGGGCGAGGGGCCATTTTTAACAGTAAA
TGCCGACATTTACACTGATTTTGATTTTACCAAGCTCCAACTCAAAAATATTGATACATTTCATCTTATTTTAATACCAA
AAAATCCTTCTCTGCTTCATCATGGCGATTTTGGCTTAATCAATGGATCCCACTTAACCAATACAAATCAGGCTTACACT
TTTTCAGGTATTGCCTGCTATAACCCAAAGGTTTTTGCCAACTGCAGACAAGGAAGGTATTCTGTTACCCCTTTACTCAG
AAAATATGTGGAACAAAATAGTGCCACAGGCAGTGTTCACTCAGGAATTTGGTATGACATAGGCTCTTTCGATAGACTGC
ATGCAGCAAATCAATTCCCCTAA

Upstream 100 bases:

>100_bases
GGGACTTGCCTCTCACGTTAAAATATGCATTAGAATGCGCAGAAACCTATGAGGAATTACACCCATTTTTTAATTTTCTG
CAAAAACGAGTTTATTTACC

Downstream 100 bases:

>100_bases
AAACCAATCTTGGTTTTTAGGGGAACCAGTATATTCCTATCTGATGGATTGAGTGGTTGGGGCTTCAGCACCGGATTCAA
TTTCTTGCCTGATTTCTTCT

Product: mannose-1-phosphate guanyltransferase

Products: dTDPglucose; Diphosphate [C]

Alternate protein names: Nucleotidyltransferase Family Protein; Nucleoside-Diphosphate-Sugar Pyrophosphorylase; Nucleotidyl Transferase Family Protein; Mannose-1-Phosphate Guanyltransferase; Nucleotidyl Transferase Superfamily; Nucleotidyltransferase; Sugar-Phosphate Nucleotidyl Transferase; Mannose-1-Phosphate Guanyltransferase-Related Protein; Mannose-1-Phosphate Guanylyltransferase; Nucleotidyltransferase Protein; Transaldolase AB; Nucleotidyl Transferase Protein; ADP-Glucose Pyrophosphorylase; Mannose-1-Phosphate Guanyltransferase Protein; D-Glycero-D-Manno-Heptose 1-Phosphate Guanosyltransferase; Aminoglycoside Phosphotransferase; Glucose-1-Phosphate Thymidylyltransferase; Sugar-Phosphate Nucleotide Transferase; Glucose-1-Phosphate Nucleotidyltransferase; Phosphoglucomutase; Nucleotidyl Transferase Superfamily Protein

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MKTAMILAAGRGERLRPLTDKIPKALCTVRNKPLIEHHIINLANAGFDRLIINHAYLGGQIRQYIGNGKQWGLNVIYSPE
PPGGLETGGGIVNALPLLGEGPFLTVNADIYTDFDFTKLQLKNIDTFHLILIPKNPSLLHHGDFGLINGSHLTNTNQAYT
FSGIACYNPKVFANCRQGRYSVTPLLRKYVEQNSATGSVHSGIWYDIGSFDRLHAANQFP

Sequences:

>Translated_220_residues
MKTAMILAAGRGERLRPLTDKIPKALCTVRNKPLIEHHIINLANAGFDRLIINHAYLGGQIRQYIGNGKQWGLNVIYSPE
PPGGLETGGGIVNALPLLGEGPFLTVNADIYTDFDFTKLQLKNIDTFHLILIPKNPSLLHHGDFGLINGSHLTNTNQAYT
FSGIACYNPKVFANCRQGRYSVTPLLRKYVEQNSATGSVHSGIWYDIGSFDRLHAANQFP
>Mature_220_residues
MKTAMILAAGRGERLRPLTDKIPKALCTVRNKPLIEHHIINLANAGFDRLIINHAYLGGQIRQYIGNGKQWGLNVIYSPE
PPGGLETGGGIVNALPLLGEGPFLTVNADIYTDFDFTKLQLKNIDTFHLILIPKNPSLLHHGDFGLINGSHLTNTNQAYT
FSGIACYNPKVFANCRQGRYSVTPLLRKYVEQNSATGSVHSGIWYDIGSFDRLHAANQFP

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11761621, Length=239, Percent_Identity=28.4518828451883, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI11761619, Length=239, Percent_Identity=28.4518828451883, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1788351, Length=243, Percent_Identity=25.9259259259259, Blast_Score=64, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=119, Percent_Identity=36.1344537815126, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355443, Length=229, Percent_Identity=27.5109170305677, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644084, Length=229, Percent_Identity=27.5109170305677, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.7.24 [C]

Molecular weight: Translated: 24267; Mature: 24267

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAMILAAGRGERLRPLTDKIPKALCTVRNKPLIEHHIINLANAGFDRLIINHAYLGGQ
CCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHEEEEHHHHCHH
IRQYIGNGKQWGLNVIYSPEPPGGLETGGGIVNALPLLGEGPFLTVNADIYTDFDFTKLQ
HHHHHCCCCEECEEEEECCCCCCCCCCCCCCEEEHHCCCCCCEEEEECCEEECCCCEEEE
LKNIDTFHLILIPKNPSLLHHGDFGLINGSHLTNTNQAYTFSGIACYNPKVFANCRQGRY
EECCCEEEEEEEECCCCEEECCCEEEEECCEECCCCCEEEECCEEEECCCEEEECCCCCE
SVTPLLRKYVEQNSATGSVHSGIWYDIGSFDRLHAANQFP
EHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHCCCCCCC
>Mature Secondary Structure
MKTAMILAAGRGERLRPLTDKIPKALCTVRNKPLIEHHIINLANAGFDRLIINHAYLGGQ
CCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHEEEEHHHHCHH
IRQYIGNGKQWGLNVIYSPEPPGGLETGGGIVNALPLLGEGPFLTVNADIYTDFDFTKLQ
HHHHHCCCCEECEEEEECCCCCCCCCCCCCCEEEHHCCCCCCEEEEECCEEECCCCEEEE
LKNIDTFHLILIPKNPSLLHHGDFGLINGSHLTNTNQAYTFSGIACYNPKVFANCRQGRY
EECCCEEEEEEEECCCCEEECCCEEEEECCEECCCCCEEEECCEEEECCCEEEECCCCCE
SVTPLLRKYVEQNSATGSVHSGIWYDIGSFDRLHAANQFP
EHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dTTP; D-Glucose 1-phosphate; H+ [C]

Specific reaction: dTTP + D-Glucose 1-phosphate + H+ --> dTDPglucose + Diphosphate [C]

General reaction: Nucleotidyl group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA