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The map label for this gene is copA [H]

Identifier: 148358475

GI number: 148358475

Start: 366564

End: 368105

Strand: Reverse

Name: copA [H]

Synonym: LPC_0341

Alternate gene names: 148358475

Gene position: 368105-366564 (Counterclockwise)

Preceding gene: 148358477

Following gene: 148358472

Centisome position: 10.29

GC content: 38.85

Gene sequence:

>1542_bases
ATGACCAATACAACAGATTTTTATTCAATAACTCCTCTGGACAAAGCCCGTTGGCAAAAAATTCTAATTAATAAAATTAC
AGTGCGCACTTTGGGTAAAATATTCGTTTTTATCATGGCAATAACTATCATGATAACCCTTTTTAATTTCTCTTATGCAA
CAGATAGCAAACTTAAACCGACGGTCATAACCGTCAGTGAAGAGGAATTCCAGGTCGATGGTAAAGGAAAAAAGACAAAG
GAGTTTAAACTCACTTTTACCCACCCGGACGGCACAAAGGACAACAAAGGTTACTTTGCCAATAAAGGAGATATGTTTCA
TGTTTTAGTTGAAAATAAAAGTGCGTCACCAATAACTCTTCATTGGCATGGATTAATTGTCCCAAGCGATCAGGATGGAG
TACCTGGCGTGAGTCAAATCCTGATTCCACCAGGGCAAAATAAATTATTTAACTACAGATTATTGCAAGCCGGAACCTAT
TGGATGCACTCTCATCAAAAATTTCAAGAGCAAAAGCAACTTTCTGCCCCTTTGATTATTTATGACACGGATGACCCGCA
TAAAAACTTACAAGAAGTCATCCTGTTTTTAGAGGATTTTACTTACAAGGATCCCCAATTAATATTTGATCAGTTAAGAA
CCGCTAAAATGGACATGAAGAAAATGGATTCTGGAAACGATTTGAATGACGTGACCTATGATGCGTTTCTCGCCAACAAA
AAAACATTGGCAGCACCTGATGTGATTTCAGTTCAACCCTCTAAAAAAGTAAGGTTACGAATCATCAATGCGTCTTCCTC
CACCAATTTTAAAATTGATACCGGGAAACTATCAGCCACTTTGATTGCTGTTGATGGTGAAAACATTGAGCCGATCGTAG
ATAGTTCTTTCCCTATTGGCGTTGGTAATCGTATGGATTTGCTTGTTGAGATTCCTTCTGCAGGCGGGGCATTCCCTGTT
AAAGCCATGGCGGAAGGAACAAACAAACAAACCGGTTTGGTTCTAACAACAGATAACACACCTACCCCGATACTATCTCC
CAATACCACGAATAAAACGGGACGTGTCAACTACTATGAGTTGGAAAAAAAACTAAAAGGAAAAAATGCTTTAACCAATA
AAAAAATAAATGCTCGTTTGCACTATGTGCTTGATGGCCAGATGAATGGTTATATTTGGACCATGAACAAGCAAAGCTGG
CCAGATGTCACGCCAAAAGTAATCCATTTCGGTGATCGTGTTGAAATGATCTATGAAAATAAATCATCTATGTCTCACCC
CATGCATTTCCATGGTCATGTCTTTCAAGTAACCGAAATTGATGGTCAGCCATTGGATGGAGCCATGCGCGATACCCTGT
TAGTCCAACCGCATTCGACAGTGAAAGTACAGTTTGATGCGCTAAACCCTGGCATCTGGGCTAACCACTGCCATAATTTA
TATCATTTAAACGCAGGAATGTTTACAACGTTTGAATACCAACACTACCCAAAACCCGATTTTTATTTAAAAACTATAGG
ACAACCCAAAAGTAACAATTAA

Upstream 100 bases:

>100_bases
TTAAAACTAATTCTGATAACCTATAAATCAGAGATTTGCTTACTGTGCTATTAACTGATAAAAAGATTATAAATATCATG
GACATGGACAGATCATAAAA

Downstream 100 bases:

>100_bases
CAGCTAAACAGAAACTCCAACATACATTACCTGCGTAAGCGCCTATACTTTTACTTATGACGCAAGGACTAATTGTTTTA
CTTTTTTAACGAACGTTGGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MTNTTDFYSITPLDKARWQKILINKITVRTLGKIFVFIMAITIMITLFNFSYATDSKLKPTVITVSEEEFQVDGKGKKTK
EFKLTFTHPDGTKDNKGYFANKGDMFHVLVENKSASPITLHWHGLIVPSDQDGVPGVSQILIPPGQNKLFNYRLLQAGTY
WMHSHQKFQEQKQLSAPLIIYDTDDPHKNLQEVILFLEDFTYKDPQLIFDQLRTAKMDMKKMDSGNDLNDVTYDAFLANK
KTLAAPDVISVQPSKKVRLRIINASSSTNFKIDTGKLSATLIAVDGENIEPIVDSSFPIGVGNRMDLLVEIPSAGGAFPV
KAMAEGTNKQTGLVLTTDNTPTPILSPNTTNKTGRVNYYELEKKLKGKNALTNKKINARLHYVLDGQMNGYIWTMNKQSW
PDVTPKVIHFGDRVEMIYENKSSMSHPMHFHGHVFQVTEIDGQPLDGAMRDTLLVQPHSTVKVQFDALNPGIWANHCHNL
YHLNAGMFTTFEYQHYPKPDFYLKTIGQPKSNN

Sequences:

>Translated_513_residues
MTNTTDFYSITPLDKARWQKILINKITVRTLGKIFVFIMAITIMITLFNFSYATDSKLKPTVITVSEEEFQVDGKGKKTK
EFKLTFTHPDGTKDNKGYFANKGDMFHVLVENKSASPITLHWHGLIVPSDQDGVPGVSQILIPPGQNKLFNYRLLQAGTY
WMHSHQKFQEQKQLSAPLIIYDTDDPHKNLQEVILFLEDFTYKDPQLIFDQLRTAKMDMKKMDSGNDLNDVTYDAFLANK
KTLAAPDVISVQPSKKVRLRIINASSSTNFKIDTGKLSATLIAVDGENIEPIVDSSFPIGVGNRMDLLVEIPSAGGAFPV
KAMAEGTNKQTGLVLTTDNTPTPILSPNTTNKTGRVNYYELEKKLKGKNALTNKKINARLHYVLDGQMNGYIWTMNKQSW
PDVTPKVIHFGDRVEMIYENKSSMSHPMHFHGHVFQVTEIDGQPLDGAMRDTLLVQPHSTVKVQFDALNPGIWANHCHNL
YHLNAGMFTTFEYQHYPKPDFYLKTIGQPKSNN
>Mature_512_residues
TNTTDFYSITPLDKARWQKILINKITVRTLGKIFVFIMAITIMITLFNFSYATDSKLKPTVITVSEEEFQVDGKGKKTKE
FKLTFTHPDGTKDNKGYFANKGDMFHVLVENKSASPITLHWHGLIVPSDQDGVPGVSQILIPPGQNKLFNYRLLQAGTYW
MHSHQKFQEQKQLSAPLIIYDTDDPHKNLQEVILFLEDFTYKDPQLIFDQLRTAKMDMKKMDSGNDLNDVTYDAFLANKK
TLAAPDVISVQPSKKVRLRIINASSSTNFKIDTGKLSATLIAVDGENIEPIVDSSFPIGVGNRMDLLVEIPSAGGAFPVK
AMAEGTNKQTGLVLTTDNTPTPILSPNTTNKTGRVNYYELEKKLKGKNALTNKKINARLHYVLDGQMNGYIWTMNKQSWP
DVTPKVIHFGDRVEMIYENKSSMSHPMHFHGHVFQVTEIDGQPLDGAMRDTLLVQPHSTVKVQFDALNPGIWANHCHNLY
HLNAGMFTTFEYQHYPKPDFYLKTIGQPKSNN

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=451, Percent_Identity=24.1685144124169, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323703, Length=216, Percent_Identity=27.7777777777778, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24650186, Length=221, Percent_Identity=23.0769230769231, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 57934; Mature: 57803

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTTDFYSITPLDKARWQKILINKITVRTLGKIFVFIMAITIMITLFNFSYATDSKLKP
CCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TVITVSEEEFQVDGKGKKTKEFKLTFTHPDGTKDNKGYFANKGDMFHVLVENKSASPITL
EEEEEEHHHEEECCCCCCCEEEEEEEECCCCCCCCCCEEECCCCEEEEEEECCCCCEEEE
HWHGLIVPSDQDGVPGVSQILIPPGQNKLFNYRLLQAGTYWMHSHQKFQEQKQLSAPLII
EEEEEEEECCCCCCCCCCEEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCEEE
YDTDDPHKNLQEVILFLEDFTYKDPQLIFDQLRTAKMDMKKMDSGNDLNDVTYDAFLANK
ECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHEECCC
KTLAAPDVISVQPSKKVRLRIINASSSTNFKIDTGKLSATLIAVDGENIEPIVDSSFPIG
CCCCCCCEEEECCCCEEEEEEEECCCCCCEEEECCCEEEEEEEECCCCCCCEECCCCCCC
VGNRMDLLVEIPSAGGAFPVKAMAEGTNKQTGLVLTTDNTPTPILSPNTTNKTGRVNYYE
CCCCEEEEEECCCCCCCCCCHHHHCCCCCCCCEEEECCCCCCCEECCCCCCCCCCEEHEE
LEKKLKGKNALTNKKINARLHYVLDGQMNGYIWTMNKQSWPDVTPKVIHFGDRVEMIYEN
HHHHHCCCCCCCCCEECEEEEEEEECCCCCEEEEECCCCCCCCCHHEEEECCEEEEEEEC
KSSMSHPMHFHGHVFQVTEIDGQPLDGAMRDTLLVQPHSTVKVQFDALNPGIWANHCHNL
CCCCCCCEEECCEEEEEEECCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCHHHHCCCE
YHLNAGMFTTFEYQHYPKPDFYLKTIGQPKSNN
EEECCCEEEEEEECCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
TNTTDFYSITPLDKARWQKILINKITVRTLGKIFVFIMAITIMITLFNFSYATDSKLKP
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TVITVSEEEFQVDGKGKKTKEFKLTFTHPDGTKDNKGYFANKGDMFHVLVENKSASPITL
EEEEEEHHHEEECCCCCCCEEEEEEEECCCCCCCCCCEEECCCCEEEEEEECCCCCEEEE
HWHGLIVPSDQDGVPGVSQILIPPGQNKLFNYRLLQAGTYWMHSHQKFQEQKQLSAPLII
EEEEEEEECCCCCCCCCCEEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCEEE
YDTDDPHKNLQEVILFLEDFTYKDPQLIFDQLRTAKMDMKKMDSGNDLNDVTYDAFLANK
ECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHEECCC
KTLAAPDVISVQPSKKVRLRIINASSSTNFKIDTGKLSATLIAVDGENIEPIVDSSFPIG
CCCCCCCEEEECCCCEEEEEEEECCCCCCEEEECCCEEEEEEEECCCCCCCEECCCCCCC
VGNRMDLLVEIPSAGGAFPVKAMAEGTNKQTGLVLTTDNTPTPILSPNTTNKTGRVNYYE
CCCCEEEEEECCCCCCCCCCHHHHCCCCCCCCEEEECCCCCCCEECCCCCCCCCCEEHEE
LEKKLKGKNALTNKKINARLHYVLDGQMNGYIWTMNKQSWPDVTPKVIHFGDRVEMIYEN
HHHHHCCCCCCCCCEECEEEEEEEECCCCCEEEEECCCCCCCCCHHEEEECCEEEEEEEC
KSSMSHPMHFHGHVFQVTEIDGQPLDGAMRDTLLVQPHSTVKVQFDALNPGIWANHCHNL
CCCCCCCEEECCEEEEEEECCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCHHHHCCCE
YHLNAGMFTTFEYQHYPKPDFYLKTIGQPKSNN
EEECCCEEEEEEECCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]