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The map label for this gene is map-1 [H]

Identifier: 148358374

GI number: 148358374

Start: 252126

End: 252887

Strand: Reverse

Name: map-1 [H]

Synonym: LPC_0238

Alternate gene names: 148358374

Gene position: 252887-252126 (Counterclockwise)

Preceding gene: 148358375

Following gene: 148358373

Centisome position: 7.07

GC content: 42.13

Gene sequence:

>762_bases
ATGTTAGTGAAGACGTCTGAAGAAATAAAAAAAATGCGCGTTGCGGGGCAGTTGGCAGCATCCGTACTTGAAATGATAGA
GCCTTATGTCATTGCAGGTACCAGTACCAGGGAGCTTGAACAAATTTGTCGTCAGTATATTGTCGAGGATTTGAAAGCGA
TTCCCTCGACGTTAAACCACTATGGGTTTCCCGCATGCGTTTGCACTTCGATAAATCACGTGGTATGCCATGGCATCCCC
TCAGAGAAAAAACTTAAAAATGGCGACATCATTAATATTGATGTGACTGTACAAAAGGACGGTTATATTGGGGATACCAG
CAAAATGTTTCTCGTTGGCAACATAAAGCCATTTGCTAAAAAGTTAGTAGAAGTTACCCAGGAGTGCCTATACAAAGCTA
TTTCAATAGTTCGCCCAGGGGCTTATCTCGGAGACATCGGAAACATAATCCAAACACACGCAGAACAACATGGATATTCA
ATAGTACGAGAGTTTGGTGGGCATGGAATTGGTAAATCCATGTGGGAAGATCCTCACATTATGCACTTCGGTAAACCAAA
TACCGGATTACGATTACAAGCAGGAATGACTTTCACTATTGAGCCAATGCTCAATTTGGGTCGTAAAGAGGTCAAGACTT
TAGGGGATGGTTGGACTGTTGTCACAAAAGACCATAAATTATCCGCACAATGGGAGCACACCATTTTAGTGACCGATAAT
GGACATGAGATACTTACATTAAGAGCGGATGAGCACTTTTAG

Upstream 100 bases:

>100_bases
TGGATTAGAATAGGAAAATTGGCGGAAGAGAATCCATCCATTACCTATACTGACATTCTTAAAATTTTAGTCCATCAAGC
TTCACTAGGTGAAATATACG

Downstream 100 bases:

>100_bases
ACATCTGCCCTCTTGTTCACTAATTACTGTTCCCCCAAGCCTCTCGGCGGAAAACATATACTATAATCAAACTAAAGGAA
ATCTAGTCAATCAAGGGAAA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MLVKTSEEIKKMRVAGQLAASVLEMIEPYVIAGTSTRELEQICRQYIVEDLKAIPSTLNHYGFPACVCTSINHVVCHGIP
SEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIKPFAKKLVEVTQECLYKAISIVRPGAYLGDIGNIIQTHAEQHGYS
IVREFGGHGIGKSMWEDPHIMHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTILVTDN
GHEILTLRADEHF

Sequences:

>Translated_253_residues
MLVKTSEEIKKMRVAGQLAASVLEMIEPYVIAGTSTRELEQICRQYIVEDLKAIPSTLNHYGFPACVCTSINHVVCHGIP
SEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIKPFAKKLVEVTQECLYKAISIVRPGAYLGDIGNIIQTHAEQHGYS
IVREFGGHGIGKSMWEDPHIMHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTILVTDN
GHEILTLRADEHF
>Mature_253_residues
MLVKTSEEIKKMRVAGQLAASVLEMIEPYVIAGTSTRELEQICRQYIVEDLKAIPSTLNHYGFPACVCTSINHVVCHGIP
SEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIKPFAKKLVEVTQECLYKAISIVRPGAYLGDIGNIIQTHAEQHGYS
IVREFGGHGIGKSMWEDPHIMHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTILVTDN
GHEILTLRADEHF

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=252, Percent_Identity=44.047619047619, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI40385867, Length=244, Percent_Identity=44.672131147541, Blast_Score=204, Evalue=6e-53,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=58, Blast_Score=301, Evalue=3e-83,
Organism=Escherichia coli, GI1788728, Length=256, Percent_Identity=26.953125, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71996291, Length=247, Percent_Identity=43.7246963562753, Blast_Score=210, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6323273, Length=243, Percent_Identity=42.798353909465, Blast_Score=200, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=44.672131147541, Blast_Score=216, Evalue=8e-57,
Organism=Drosophila melanogaster, GI21355531, Length=250, Percent_Identity=44.4, Blast_Score=216, Evalue=1e-56,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28166; Mature: 28166

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVKTSEEIKKMRVAGQLAASVLEMIEPYVIAGTSTRELEQICRQYIVEDLKAIPSTLNH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
YGFPACVCTSINHVVCHGIPSEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIKPFAK
CCCHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEECCCHHHH
KLVEVTQECLYKAISIVRPGAYLGDIGNIIQTHAEQHGYSIVREFGGHGIGKSMWEDPHI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCE
MHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTILVTDN
EEECCCCCCEEEECCCEEEEHHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECC
GHEILTLRADEHF
CCEEEEEECCCCC
>Mature Secondary Structure
MLVKTSEEIKKMRVAGQLAASVLEMIEPYVIAGTSTRELEQICRQYIVEDLKAIPSTLNH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
YGFPACVCTSINHVVCHGIPSEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIKPFAK
CCCHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEECCCHHHH
KLVEVTQECLYKAISIVRPGAYLGDIGNIIQTHAEQHGYSIVREFGGHGIGKSMWEDPHI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCE
MHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTILVTDN
EEECCCCCCEEEECCCEEEEHHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECC
GHEILTLRADEHF
CCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]