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The map label for this gene is tktA [H]

Identifier: 148358298

GI number: 148358298

Start: 175485

End: 177491

Strand: Reverse

Name: tktA [H]

Synonym: LPC_0160

Alternate gene names: 148358298

Gene position: 177491-175485 (Counterclockwise)

Preceding gene: 148358303

Following gene: 148358297

Centisome position: 4.96

GC content: 45.59

Gene sequence:

>2007_bases
ATGAACAGTTTTACAGAATTAGCTAATGCAGTACGCATGTTAAGCATCGATGCAGTAAACCAGGCTCAATCAGGCCACCC
TGGCATGCCCTTGGGTATGGCTGATATTGCCACCGTTTTATGGAAAAAATTTCTAAAATTCAACCCCAAAAACCCGCACT
GGTTTAACAGAGACCGTTTTGTATTATCTAATGGCCATGGTTCCATGCTTCTCTATTCTTTACTGCATTTGACCGGATAC
AATTTGGATATTAACGAGCTTAAAAATTTCCGCCAATTGCACTCAAAAACACCAGGGCATCCGGAACATGGGCACACTCC
CGGTGTCGAAACCACAACGGGGCCATTAGGTCAAGGTTTGGCCAATTCAGTCGGGATGGCATTGGCAGAGCGTGTACTGG
CCAGTCACTTCAACCACGATCACTATAACCTCGTTGATCATTATACTTATACTTTTGCCGGCGATGGATGCCTGATGGAA
GGCATTTCTCATGAAGCGTGCTCTCTGGCTGGCACTCTTGGTTTGGGAAAACTCATTGTATTTTATGACGACAATGGGAT
ATCTATTGATGGCAAGGTAGAATCCTGGTTTACGGACGATACCACGTCTCGCTTTAAAGCCTACAACTGGCAAGTCATAG
GCCCCATCGATGGCCACGACGCAGCTCAAATTGAGCAAGCCATATCAGCAGCACGCGAGAACACGACTCAACCTTCATTA
ATTATCTGTAAAACCGTCATAGGACTGGGTTCCTCTGTAGCCGGTAGCGAAAAAGCGCACGGCTCTCCATTGAGTGCCCA
AGACATAAATAATGTCCGTGAATTTTTTAATTGGAAACATGCTCCCTTCGAAATTCCAGATTCGATATACAAGCAATGGG
ATCATAGAGAGCAAGGAGAAAAAGAAGAGCAACAATGGCTGCAGCTCCTGCATGAATACCGGCAACAACATCCATCGGAA
CACGATGAGTTTTTGCGTCGTGCCAATGGCGACCTGCCCGATGATTGGCAAGAAATATCGGCTGGATTCCTAAAACAATG
CCTGAACAATGAGAAAGCCATAGCAACGCGTAAAGCATCGCAGCAATGCATAGAGTTTTTCGCGCCAATATTACCGGAAA
TGTTTGGCGGCTCAGCGGATTTGACTGGTTCCAATAATACTGACTGGTCAGGCAGCAAAGCCATCACGGCCCATAATTTT
TCCGGAAATTACCTTTATTATGGAGTGAGGGAATTTGCCATGGCAGCCATCATGAATGGACTTGCTGTTCATGGAGGATT
CATTCCCTACGGCGGAACATTCCTTGTTTTCGCAGATTATGCAAGAAATGCCATCCGTTTAAGCGCTTTAATGAAACAAA
GAGTGATATACGTATTGACTCATGATTCTATCGGTTTAGGGGAAGATGGCCCGACACACCAACCTATAGAACATATCGCT
ATGTTAAGAATGACCCCTGGCATGACGGTCTGGCGCCCTGCTGATTTGATGGAAACCGCTGTTGCATGGCAACAATCGTT
AGAACATCATAATGGACCCTCTGCATTGTTACTCTCAAGACAAAATCTGCCCGCTTTAGCCCATGGCGCCGATGCGGCTG
ACTTGATTAAGAAAGGTGGATATATTATTGCAGATTGTGAAGGGAAGCCTGATGCTATCCTGATAGCCACTGGTTCAGAA
GTTCAACTGGCTATAACCGCAGCAGAAAAGGCAAAAGCAAGAGGTCTCCAGGTCAGGGTGGTATCCATGCCCTGTGCTGA
GCGATTCCTTGCCCAGAGTGATGCTTACAAAAACCAGGTATTACCTGGTCAGGTTCGCACACGTATTGCGATAGAAGCAG
CTAGCAGTGCCTATTGGCACCAATTTGTTGGCTTTGACGGCGCTGTCATTGGGCTGGATTGTTTTGGGGTATCAGCTCCT
GCTACAGATGCTTTTAATTACCTTGGAATTACAGTAGAAAAAATTATCAATACTCTAGATACATTAACCAAACAAACAAT
GGTGTAA

Upstream 100 bases:

>100_bases
CTAATATTGTCATTATTTTCAACTAAAAATGAATGGTCTTCTTGCCGATTTATGCCTTCTGAGCGACAATAGTGCCTCAG
TTAAATGCAAAAGAGTAGGC

Downstream 100 bases:

>100_bases
CCCATACCCCTTCTGAAGTTTCAAGAAGGCCTGTATTCAGTATAACTGAGTATGGAGGTTACCCTAACTCGGAGAAGTAG
TATGACAATACGAGTCGCGA

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADIATVLWKKFLKFNPKNPHWFNRDRFVLSNGHGSMLLYSLLHLTGY
NLDINELKNFRQLHSKTPGHPEHGHTPGVETTTGPLGQGLANSVGMALAERVLASHFNHDHYNLVDHYTYTFAGDGCLME
GISHEACSLAGTLGLGKLIVFYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPIDGHDAAQIEQAISAARENTTQPSL
IICKTVIGLGSSVAGSEKAHGSPLSAQDINNVREFFNWKHAPFEIPDSIYKQWDHREQGEKEEQQWLQLLHEYRQQHPSE
HDEFLRRANGDLPDDWQEISAGFLKQCLNNEKAIATRKASQQCIEFFAPILPEMFGGSADLTGSNNTDWSGSKAITAHNF
SGNYLYYGVREFAMAAIMNGLAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVIYVLTHDSIGLGEDGPTHQPIEHIA
MLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSALLLSRQNLPALAHGADAADLIKKGGYIIADCEGKPDAILIATGSE
VQLAITAAEKAKARGLQVRVVSMPCAERFLAQSDAYKNQVLPGQVRTRIAIEAASSAYWHQFVGFDGAVIGLDCFGVSAP
ATDAFNYLGITVEKIINTLDTLTKQTMV

Sequences:

>Translated_668_residues
MNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADIATVLWKKFLKFNPKNPHWFNRDRFVLSNGHGSMLLYSLLHLTGY
NLDINELKNFRQLHSKTPGHPEHGHTPGVETTTGPLGQGLANSVGMALAERVLASHFNHDHYNLVDHYTYTFAGDGCLME
GISHEACSLAGTLGLGKLIVFYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPIDGHDAAQIEQAISAARENTTQPSL
IICKTVIGLGSSVAGSEKAHGSPLSAQDINNVREFFNWKHAPFEIPDSIYKQWDHREQGEKEEQQWLQLLHEYRQQHPSE
HDEFLRRANGDLPDDWQEISAGFLKQCLNNEKAIATRKASQQCIEFFAPILPEMFGGSADLTGSNNTDWSGSKAITAHNF
SGNYLYYGVREFAMAAIMNGLAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVIYVLTHDSIGLGEDGPTHQPIEHIA
MLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSALLLSRQNLPALAHGADAADLIKKGGYIIADCEGKPDAILIATGSE
VQLAITAAEKAKARGLQVRVVSMPCAERFLAQSDAYKNQVLPGQVRTRIAIEAASSAYWHQFVGFDGAVIGLDCFGVSAP
ATDAFNYLGITVEKIINTLDTLTKQTMV
>Mature_668_residues
MNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADIATVLWKKFLKFNPKNPHWFNRDRFVLSNGHGSMLLYSLLHLTGY
NLDINELKNFRQLHSKTPGHPEHGHTPGVETTTGPLGQGLANSVGMALAERVLASHFNHDHYNLVDHYTYTFAGDGCLME
GISHEACSLAGTLGLGKLIVFYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPIDGHDAAQIEQAISAARENTTQPSL
IICKTVIGLGSSVAGSEKAHGSPLSAQDINNVREFFNWKHAPFEIPDSIYKQWDHREQGEKEEQQWLQLLHEYRQQHPSE
HDEFLRRANGDLPDDWQEISAGFLKQCLNNEKAIATRKASQQCIEFFAPILPEMFGGSADLTGSNNTDWSGSKAITAHNF
SGNYLYYGVREFAMAAIMNGLAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVIYVLTHDSIGLGEDGPTHQPIEHIA
MLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSALLLSRQNLPALAHGADAADLIKKGGYIIADCEGKPDAILIATGSE
VQLAITAAEKAKARGLQVRVVSMPCAERFLAQSDAYKNQVLPGQVRTRIAIEAASSAYWHQFVGFDGAVIGLDCFGVSAP
ATDAFNYLGITVEKIINTLDTLTKQTMV

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=590, Percent_Identity=26.6101694915254, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI4507521, Length=590, Percent_Identity=26.6101694915254, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI133778974, Length=582, Percent_Identity=23.7113402061856, Blast_Score=119, Evalue=9e-27,
Organism=Escherichia coli, GI48994911, Length=657, Percent_Identity=59.0563165905632, Blast_Score=833, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=655, Percent_Identity=57.8625954198473, Blast_Score=812, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=593, Percent_Identity=23.7774030354132, Blast_Score=149, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6325331, Length=669, Percent_Identity=45.8893871449925, Blast_Score=568, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6319593, Length=672, Percent_Identity=44.7916666666667, Blast_Score=555, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24666278, Length=273, Percent_Identity=30.7692307692308, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI45551847, Length=292, Percent_Identity=29.1095890410959, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45550715, Length=292, Percent_Identity=29.1095890410959, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24645119, Length=267, Percent_Identity=28.8389513108614, Blast_Score=93, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73405; Mature: 73405

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADIATVLWKKFLKFNPKNPHWFNRDRF
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
VLSNGHGSMLLYSLLHLTGYNLDINELKNFRQLHSKTPGHPEHGHTPGVETTTGPLGQGL
EEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHH
ANSVGMALAERVLASHFNHDHYNLVDHYTYTFAGDGCLMEGISHEACSLAGTLGLGKLIV
HHHHHHHHHHHHHHHHCCCCCCCHHHCEEEEEECCCHHHHCCCHHHHHHHHHCCCCEEEE
FYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPIDGHDAAQIEQAISAARENTTQPSL
EECCCCEEECCCCCCEECCCCHHHHEEECCEEECCCCCCCHHHHHHHHHHHHCCCCCCHH
IICKTVIGLGSSVAGSEKAHGSPLSAQDINNVREFFNWKHAPFEIPDSIYKQWDHREQGE
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHCCC
KEEQQWLQLLHEYRQQHPSEHDEFLRRANGDLPDDWQEISAGFLKQCLNNEKAIATRKAS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
QQCIEFFAPILPEMFGGSADLTGSNNTDWSGSKAITAHNFSGNYLYYGVREFAMAAIMNG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHH
LAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVIYVLTHDSIGLGEDGPTHQPIEHIA
HHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHH
MLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSALLLSRQNLPALAHGADAADLIKKGG
HHHCCCCCCEECCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHCCCCHHHHHHCCC
YIIADCEGKPDAILIATGSEVQLAITAAEKAKARGLQVRVVSMPCAERFLAQSDAYKNQV
EEEEECCCCCCEEEEEECCCEEEEEEEHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCC
LPGQVRTRIAIEAASSAYWHQFVGFDGAVIGLDCFGVSAPATDAFNYLGITVEKIINTLD
CCCHHHHEEEEEECCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
TLTKQTMV
HHHHHHCC
>Mature Secondary Structure
MNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADIATVLWKKFLKFNPKNPHWFNRDRF
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
VLSNGHGSMLLYSLLHLTGYNLDINELKNFRQLHSKTPGHPEHGHTPGVETTTGPLGQGL
EEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHH
ANSVGMALAERVLASHFNHDHYNLVDHYTYTFAGDGCLMEGISHEACSLAGTLGLGKLIV
HHHHHHHHHHHHHHHHCCCCCCCHHHCEEEEEECCCHHHHCCCHHHHHHHHHCCCCEEEE
FYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPIDGHDAAQIEQAISAARENTTQPSL
EECCCCEEECCCCCCEECCCCHHHHEEECCEEECCCCCCCHHHHHHHHHHHHCCCCCCHH
IICKTVIGLGSSVAGSEKAHGSPLSAQDINNVREFFNWKHAPFEIPDSIYKQWDHREQGE
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHCCC
KEEQQWLQLLHEYRQQHPSEHDEFLRRANGDLPDDWQEISAGFLKQCLNNEKAIATRKAS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
QQCIEFFAPILPEMFGGSADLTGSNNTDWSGSKAITAHNFSGNYLYYGVREFAMAAIMNG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHH
LAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVIYVLTHDSIGLGEDGPTHQPIEHIA
HHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHH
MLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSALLLSRQNLPALAHGADAADLIKKGG
HHHCCCCCCEECCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHCCCCHHHHHHCCC
YIIADCEGKPDAILIATGSEVQLAITAAEKAKARGLQVRVVSMPCAERFLAQSDAYKNQV
EEEEECCCCCCEEEEEECCCEEEEEEEHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCC
LPGQVRTRIAIEAASSAYWHQFVGFDGAVIGLDCFGVSAPATDAFNYLGITVEKIINTLD
CCCHHHHEEEEEECCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
TLTKQTMV
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]