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The map label for this gene is obgE

Identifier: 148284519

GI number: 148284519

Start: 899134

End: 900123

Strand: Direct

Name: obgE

Synonym: OTBS_0924

Alternate gene names: 148284519

Gene position: 899134-900123 (Clockwise)

Preceding gene: 148284518

Following gene: 148284520

Centisome position: 42.27

GC content: 31.72

Gene sequence:

>990_bases
ATGCAATTTATAGATGAAGCAAAGATTTTTATAAAAGGTGGTAATGGAGGAGATGGGTGTGTAAGTTTCAGGCGAGAAAA
ATTTGTTCCTAATGGTGGACCTGATGGTGGAAATGGAGGTTGTGGCGGAGATATTATTTTTATTGGTGATCGCCACCTAA
ACACTCTTATAAATTTTAAATTCAAGCAACATTTTCTAGCACAAAATGGTAGAGCTGGGGCAGGAAATAATAGAACTGGT
AAATCTGGACAAAATTTAGTACTAAAAGTACCTGTTGGCACTCAAATTTTAAGTAATAATAAAGAACACGTAATCTTTGA
TTTAACTAAAGATGGACAAGAATTTATAATTATTAGAGGAGGAAAAGGTGGTTTAGGAAACACTTATTTTAAATCATCGA
TTAATCAAAAACCTAGAAAAAATACTGTAGGCGAGATTGGTGATTCGATGTGGGTATGGTTGCATTTAAAATTGCTTTCT
GATGTTGGATTAGTAGGACTACCTAATGCAGGCAAGTCTACTTTTTTATCAGCAATTACTTCTGCTAAACCTAAAATTGC
TGATTATCCATTTACTACATTAACTCCGAATTTAGGAGTAGTTTATATTAATAATAATAGTTTTGTTGTTGCTGATATTC
CAGGTTTAATTGCTGGAGCACACCTTGGGCAAGGTTTAGGAGATAAATTCTTGAAACATATTGAACGATGTCGCATAATA
GTTCATTTGCTTGATATTACTGCAGAGAATTTGCTGCAAAACTATTATACTATTCGTGATGAACTGTCATCATATTCTTT
ATCTCTTAAAGATAAGACAGAAATTTTATGTTTTACCAAAACTGATACGCAATCTAACGAAGTAATAATGTCTAAGCTAT
TAGAACTACAGCCAGTAATTAATAGGGTAATATATCCAATATCATCTTATACTAAATATGGAATAAAAAAGTTACTAGCG
AATATTTTATCAGAGTTACAAAAATCATAA

Upstream 100 bases:

>100_bases
ATATCGGTATTCCTTACTAAAGTTGTTCCGTGGATGTTTATTACTTTTAGTTTAGCGTGGGTATATTTAAACTTTGTTTA
AGGTTTTACTTGATTAAATG

Downstream 100 bases:

>100_bases
TAGAAAAAATAGCTTATTAATTACAATCGTATTTTTAGATATTTTTCATTCGCTCTAATATGTCTTAAATCATCACTTAT
TATACCTTCAGCAAAACGGC

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQFIDEAKIFIKGGNGGDGCVSFRREKFVPNGGPDGGNGGCGGDIIFIGDRHLNTLINFKFKQHFLAQNGRAGAGNNRTG
KSGQNLVLKVPVGTQILSNNKEHVIFDLTKDGQEFIIIRGGKGGLGNTYFKSSINQKPRKNTVGEIGDSMWVWLHLKLLS
DVGLVGLPNAGKSTFLSAITSAKPKIADYPFTTLTPNLGVVYINNNSFVVADIPGLIAGAHLGQGLGDKFLKHIERCRII
VHLLDITAENLLQNYYTIRDELSSYSLSLKDKTEILCFTKTDTQSNEVIMSKLLELQPVINRVIYPISSYTKYGIKKLLA
NILSELQKS

Sequences:

>Translated_329_residues
MQFIDEAKIFIKGGNGGDGCVSFRREKFVPNGGPDGGNGGCGGDIIFIGDRHLNTLINFKFKQHFLAQNGRAGAGNNRTG
KSGQNLVLKVPVGTQILSNNKEHVIFDLTKDGQEFIIIRGGKGGLGNTYFKSSINQKPRKNTVGEIGDSMWVWLHLKLLS
DVGLVGLPNAGKSTFLSAITSAKPKIADYPFTTLTPNLGVVYINNNSFVVADIPGLIAGAHLGQGLGDKFLKHIERCRII
VHLLDITAENLLQNYYTIRDELSSYSLSLKDKTEILCFTKTDTQSNEVIMSKLLELQPVINRVIYPISSYTKYGIKKLLA
NILSELQKS
>Mature_329_residues
MQFIDEAKIFIKGGNGGDGCVSFRREKFVPNGGPDGGNGGCGGDIIFIGDRHLNTLINFKFKQHFLAQNGRAGAGNNRTG
KSGQNLVLKVPVGTQILSNNKEHVIFDLTKDGQEFIIIRGGKGGLGNTYFKSSINQKPRKNTVGEIGDSMWVWLHLKLLS
DVGLVGLPNAGKSTFLSAITSAKPKIADYPFTTLTPNLGVVYINNNSFVVADIPGLIAGAHLGQGLGDKFLKHIERCRII
VHLLDITAENLLQNYYTIRDELSSYSLSLKDKTEILCFTKTDTQSNEVIMSKLLELQPVINRVIYPISSYTKYGIKKLLA
NILSELQKS

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=321, Percent_Identity=35.5140186915888, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI111955139, Length=349, Percent_Identity=33.2378223495702, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI111955063, Length=246, Percent_Identity=35.3658536585366, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI58761500, Length=138, Percent_Identity=37.6811594202899, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4557537, Length=88, Percent_Identity=39.7727272727273, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4758796, Length=121, Percent_Identity=33.8842975206612, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789574, Length=330, Percent_Identity=47.8787878787879, Blast_Score=278, Evalue=4e-76,
Organism=Escherichia coli, GI1787454, Length=99, Percent_Identity=37.3737373737374, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=329, Percent_Identity=39.209726443769, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17552324, Length=328, Percent_Identity=31.4024390243902, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17509631, Length=172, Percent_Identity=29.0697674418605, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71981008, Length=113, Percent_Identity=34.5132743362832, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=163, Percent_Identity=38.6503067484663, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321612, Length=122, Percent_Identity=31.1475409836066, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319281, Length=88, Percent_Identity=36.3636363636364, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI20129375, Length=322, Percent_Identity=36.9565217391304, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24585318, Length=307, Percent_Identity=35.1791530944625, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24640873, Length=164, Percent_Identity=32.3170731707317, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24640877, Length=164, Percent_Identity=32.3170731707317, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24640875, Length=164, Percent_Identity=32.3170731707317, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21356473, Length=113, Percent_Identity=32.7433628318584, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_ORITB (A5CDM6)

Other databases:

- EMBL:   AM494475
- RefSeq:   YP_001248609.1
- STRING:   A5CDM6
- GeneID:   5219511
- GenomeReviews:   AM494475_GR
- KEGG:   ots:OTBS_0924
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   ATCEHAG
- ProtClustDB:   PRK12299
- BioCyc:   OTSU357244:OTBS_0924-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 36001; Mature: 36001

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFIDEAKIFIKGGNGGDGCVSFRREKFVPNGGPDGGNGGCGGDIIFIGDRHLNTLINFK
CCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHH
FKQHFLAQNGRAGAGNNRTGKSGQNLVLKVPVGTQILSNNKEHVIFDLTKDGQEFIIIRG
HHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCEEEEEEECCCCEEEEEEC
GKGGLGNTYFKSSINQKPRKNTVGEIGDSMWVWLHLKLLSDVGLVGLPNAGKSTFLSAIT
CCCCCCCHHHHHHCCCCCCCCCHHHCCCCEEEEHHHHHHHCCCEEECCCCCHHHHHHHHH
SAKPKIADYPFTTLTPNLGVVYINNNSFVVADIPGLIAGAHLGQGLGDKFLKHIERCRII
CCCCCCCCCCCEEECCCCEEEEECCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHH
VHLLDITAENLLQNYYTIRDELSSYSLSLKDKTEILCFTKTDTQSNEVIMSKLLELQPVI
HHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
NRVIYPISSYTKYGIKKLLANILSELQKS
HHHHHCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQFIDEAKIFIKGGNGGDGCVSFRREKFVPNGGPDGGNGGCGGDIIFIGDRHLNTLINFK
CCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHH
FKQHFLAQNGRAGAGNNRTGKSGQNLVLKVPVGTQILSNNKEHVIFDLTKDGQEFIIIRG
HHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCEEEEEEECCCCEEEEEEC
GKGGLGNTYFKSSINQKPRKNTVGEIGDSMWVWLHLKLLSDVGLVGLPNAGKSTFLSAIT
CCCCCCCHHHHHHCCCCCCCCCHHHCCCCEEEEHHHHHHHCCCEEECCCCCHHHHHHHHH
SAKPKIADYPFTTLTPNLGVVYINNNSFVVADIPGLIAGAHLGQGLGDKFLKHIERCRII
CCCCCCCCCCCEEECCCCEEEEECCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHH
VHLLDITAENLLQNYYTIRDELSSYSLSLKDKTEILCFTKTDTQSNEVIMSKLLELQPVI
HHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
NRVIYPISSYTKYGIKKLLANILSELQKS
HHHHHCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA