Click here to switch to the map view.

The map label for this gene is ffh [H]

Identifier: 148284448

GI number: 148284448

Start: 762807

End: 764159

Strand: Direct

Name: ffh [H]

Synonym: OTBS_0785

Alternate gene names: 148284448

Gene position: 762807-764159 (Clockwise)

Preceding gene: 148284443

Following gene: 148284449

Centisome position: 35.86

GC content: 31.56

Gene sequence:

>1353_bases
ATGTTTCAAACTTTAACTCAAAAACTTAGTAATATTTTCGATAAGATTAAAGGTAGTACTGCTCTATCTGAACAACAAGT
TTTAACAATAGCACGGGAAGTAAGAATTGCATTATTAGAGGCAGATGTTTCATTAGTAGTTATTAAAGATTTTATTAATA
ATGTTGTAGAAAAAGCTAAAGGGCAGGAAGTTATTCGTTCTGTAACACCAGGCCAGATGGTTATTAAAATTATTAGCGAT
GAGATGATAAAGGTCCTTAGCAGCTCAGAAACAGAACAAGCACTGCGCATTGAGTTTGAGCCACCTGTAAACATTATGAT
GATTGGTCTACAAGGTAGCGGAAAAACAACTACAACGGCTAAATTAGCAATGAAGCTTGCTAAAAAAAATAAAAAAGTTA
TGGTTGTATCACTAGATATTTATAGACCAGCTGCTAGAGAACAGCTCGAAACATTAGTGCGAAATCACGAAACTATACTA
TCATTACCTATAGTTTCAAATGAGAATGTGTTTCAGATTATAGCACGAAGTACTAAGGAAGCTAAGTTGCTTGGTTGTGA
TGTAGTAATTTATGATACTGCAGGTCGTCTACATATTGATGAGACAATGTTGCAAGAGCTAAGTAATATAAAAGAAATAA
TTACCCCTAAAGAAATACTTTTAGTAGTTGATTCACTTATTGGTCAAGAATCAGTCAATGTAGCTAATCAATTTAATCAA
ACATTGAATATTTCTGGCGTAGTATTAACTAAAATTGACGGTGATTCAAGAGGAGGAGCAGCATTAAGTATTAAATATGT
TACTGGCAAGCCAATAAAATTTCTTGGCATAGGAGAAAAAACTAATGATTTAGAGGAATTTCATCCAGAAAGAATTGCTT
CACGGATATTAGGTAAAGGTGATATTGTTTCTCTAGTAGAGAAAGCAGCTGAAGTAATTAGTAAAGAGGATGCAGCTAAA
TCAGTTGAGAAATTAAAAAAAGGCAGTTTTAATCTTGAGGATTACTATCAACAGCTGCAAAACATTAATAAGATGGGAGG
AATTAGCTCAATACTTAATCTTATGCCTGGAATAAATAAACTATTGCCGAAAATTGATCAAAATCCATTTGATCAAAACA
GTGTAAAGTTACAACAGGCAATAATTTTATCAATGACAAGGCATGAAAAATTAAATCCAGATATAATTAATGGAAAACGA
AAAAAACGTATTGCAGCTGGCTCAGGAACATCAGTTCAAGAAGTCAATAAGCTATTGAAACAATTTCAAAATATTACTTC
TTTGCTTAAAAGTGGAATGAAAGGTAATAATATACTAAGAGATAAATTTAATAATTTGAAAAATTTTTTCTAA

Upstream 100 bases:

>100_bases
TCTTAATATAGATTATGTTATATATTTATAGGAATAAGTAAAAATCAACAATTTTTAGCAGTAAAATATTTAACCAATTT
CATGAACTTAAGATAGAAGT

Downstream 100 bases:

>100_bases
GTTATTTGAACAAAGGTTTTAATTTAGCAACTAAAGAGCTGCAAAATTTAAGTATATGATTGACTATGAAAATAATAGTT
CTAATACAGAAGATTATATC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MFQTLTQKLSNIFDKIKGSTALSEQQVLTIAREVRIALLEADVSLVVIKDFINNVVEKAKGQEVIRSVTPGQMVIKIISD
EMIKVLSSSETEQALRIEFEPPVNIMMIGLQGSGKTTTTAKLAMKLAKKNKKVMVVSLDIYRPAAREQLETLVRNHETIL
SLPIVSNENVFQIIARSTKEAKLLGCDVVIYDTAGRLHIDETMLQELSNIKEIITPKEILLVVDSLIGQESVNVANQFNQ
TLNISGVVLTKIDGDSRGGAALSIKYVTGKPIKFLGIGEKTNDLEEFHPERIASRILGKGDIVSLVEKAAEVISKEDAAK
SVEKLKKGSFNLEDYYQQLQNINKMGGISSILNLMPGINKLLPKIDQNPFDQNSVKLQQAIILSMTRHEKLNPDIINGKR
KKRIAAGSGTSVQEVNKLLKQFQNITSLLKSGMKGNNILRDKFNNLKNFF

Sequences:

>Translated_450_residues
MFQTLTQKLSNIFDKIKGSTALSEQQVLTIAREVRIALLEADVSLVVIKDFINNVVEKAKGQEVIRSVTPGQMVIKIISD
EMIKVLSSSETEQALRIEFEPPVNIMMIGLQGSGKTTTTAKLAMKLAKKNKKVMVVSLDIYRPAAREQLETLVRNHETIL
SLPIVSNENVFQIIARSTKEAKLLGCDVVIYDTAGRLHIDETMLQELSNIKEIITPKEILLVVDSLIGQESVNVANQFNQ
TLNISGVVLTKIDGDSRGGAALSIKYVTGKPIKFLGIGEKTNDLEEFHPERIASRILGKGDIVSLVEKAAEVISKEDAAK
SVEKLKKGSFNLEDYYQQLQNINKMGGISSILNLMPGINKLLPKIDQNPFDQNSVKLQQAIILSMTRHEKLNPDIINGKR
KKRIAAGSGTSVQEVNKLLKQFQNITSLLKSGMKGNNILRDKFNNLKNFF
>Mature_450_residues
MFQTLTQKLSNIFDKIKGSTALSEQQVLTIAREVRIALLEADVSLVVIKDFINNVVEKAKGQEVIRSVTPGQMVIKIISD
EMIKVLSSSETEQALRIEFEPPVNIMMIGLQGSGKTTTTAKLAMKLAKKNKKVMVVSLDIYRPAAREQLETLVRNHETIL
SLPIVSNENVFQIIARSTKEAKLLGCDVVIYDTAGRLHIDETMLQELSNIKEIITPKEILLVVDSLIGQESVNVANQFNQ
TLNISGVVLTKIDGDSRGGAALSIKYVTGKPIKFLGIGEKTNDLEEFHPERIASRILGKGDIVSLVEKAAEVISKEDAAK
SVEKLKKGSFNLEDYYQQLQNINKMGGISSILNLMPGINKLLPKIDQNPFDQNSVKLQQAIILSMTRHEKLNPDIINGKR
KKRIAAGSGTSVQEVNKLLKQFQNITSLLKSGMKGNNILRDKFNNLKNFF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=449, Percent_Identity=30.2895322939866, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI226371618, Length=341, Percent_Identity=33.4310850439883, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI23308697, Length=320, Percent_Identity=25.3125, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI295424842, Length=320, Percent_Identity=25.3125, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI89061728, Length=142, Percent_Identity=35.9154929577465, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=48.4777517564403, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1789874, Length=270, Percent_Identity=29.2592592592593, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17539958, Length=438, Percent_Identity=30.5936073059361, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI193206261, Length=289, Percent_Identity=28.719723183391, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=407, Percent_Identity=32.9238329238329, Blast_Score=216, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6320498, Length=263, Percent_Identity=26.2357414448669, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17647949, Length=447, Percent_Identity=30.2013422818792, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24641198, Length=305, Percent_Identity=26.8852459016393, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49878; Mature: 49878

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQTLTQKLSNIFDKIKGSTALSEQQVLTIAREVRIALLEADVSLVVIKDFINNVVEKAK
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHC
GQEVIRSVTPGQMVIKIISDEMIKVLSSSETEQALRIEFEPPVNIMMIGLQGSGKTTTTA
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCHHHH
KLAMKLAKKNKKVMVVSLDIYRPAAREQLETLVRNHETILSLPIVSNENVFQIIARSTKE
HHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCCC
AKLLGCDVVIYDTAGRLHIDETMLQELSNIKEIITPKEILLVVDSLIGQESVNVANQFNQ
CEEEECEEEEEECCCCEEECHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHCC
TLNISGVVLTKIDGDSRGGAALSIKYVTGKPIKFLGIGEKTNDLEEFHPERIASRILGKG
CEECCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCHHHHCHHHHHHHHCCCC
DIVSLVEKAAEVISKEDAAKSVEKLKKGSFNLEDYYQQLQNINKMGGISSILNLMPGINK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHH
LLPKIDQNPFDQNSVKLQQAIILSMTRHEKLNPDIINGKRKKRIAAGSGTSVQEVNKLLK
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHEEECCCCCCHHHHHHHHH
QFQNITSLLKSGMKGNNILRDKFNNLKNFF
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MFQTLTQKLSNIFDKIKGSTALSEQQVLTIAREVRIALLEADVSLVVIKDFINNVVEKAK
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHC
GQEVIRSVTPGQMVIKIISDEMIKVLSSSETEQALRIEFEPPVNIMMIGLQGSGKTTTTA
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCHHHH
KLAMKLAKKNKKVMVVSLDIYRPAAREQLETLVRNHETILSLPIVSNENVFQIIARSTKE
HHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCCC
AKLLGCDVVIYDTAGRLHIDETMLQELSNIKEIITPKEILLVVDSLIGQESVNVANQFNQ
CEEEECEEEEEECCCCEEECHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHCC
TLNISGVVLTKIDGDSRGGAALSIKYVTGKPIKFLGIGEKTNDLEEFHPERIASRILGKG
CEECCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCHHHHCHHHHHHHHCCCC
DIVSLVEKAAEVISKEDAAKSVEKLKKGSFNLEDYYQQLQNINKMGGISSILNLMPGINK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHH
LLPKIDQNPFDQNSVKLQQAIILSMTRHEKLNPDIINGKRKKRIAAGSGTSVQEVNKLLK
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHEEECCCCCCHHHHHHHHH
QFQNITSLLKSGMKGNNILRDKFNNLKNFF
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]