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The map label for this gene is cysG [H]

Identifier: 148268834

GI number: 148268834

Start: 2557913

End: 2558890

Strand: Reverse

Name: cysG [H]

Synonym: SaurJH9_2422

Alternate gene names: 148268834

Gene position: 2558890-2557913 (Counterclockwise)

Preceding gene: 148268835

Following gene: 148268833

Centisome position: 88.03

GC content: 37.83

Gene sequence:

>978_bases
ATGTCTGTAGATAAATATGGCAAGGTTTACTTGATAGGTGCGGGACCAGGTAATCCGAATTATTTGACTAAAAAGGCTGA
GCGTTTAATACGTGAAGCGGATGTTATACTATATGATCGATTAGTGAATCCGTTAATTTTACAATATGCGAATTTGACTA
CTGAAATTATCGATGTTGGTAAAAAGCCGTATGCAAAACACATTCAGCAAGAAAAAATAAATGAATGTATCGTGGAAGCA
GCACGTCGATATAACAAGGTTGTGAGGCTTAAAGGTGGCGACCCAGCAATATTTGGACGAGTTCAAGAAGAAGTTGACAC
ACTAAACAACTTTAATATTGCGTTTGAAATTGTACCTGGTGTGACATCTGCGAGTGCTGCAGTTGCTACGATGCAAACAG
GATTAACGATGCGTGCTGTTGCTAAGAGTGTGACATTTTCTACAGGTCACTTTAAAGATTCAGAAGAAAATGAAGTAGAT
GTCAACGCTTTAGTAAATGGTGGTACGTTGGCGATATATATGGGAGTTAAACGTTTAGGGAAAATTATCGCCCAGATACA
ACAGTACACAGATATTGATTATCCGATAGCGATTGTCTTTCAAGCATCGTGTTTTAACGAGTTTGTTGTTAAGGGGCGTT
TAAGTAATATTGTTGGGAAACTGGAGCATTACGCAATTGAGGCGAAACCAGGTATATGTATTATAGGCGAAGTAGTGGGT
TATACTGAAAATGTCTCAACAACTTCTAATCCGACTCAGCAATTTTATGTAGTAAGTGGTTCTAGACATGACGCCCTTAT
GCTCTGTGAACATTTATATGACGAAGGTTATGGCTGTTTGCTAAACCCAAATGATACATCGAATGGCACATATCATTCGT
CGCAATATGATTACTATGATGCATTTATTAAGCAGCAAGAAAATGTAACATATATTTCAACCGATCGTGCAGATGCTAAT
ACAGTGTTATGTCACTAA

Upstream 100 bases:

>100_bases
ATGATCAAAAGATTGATTTAAATACTGGGATTGTACAAGAACCTGATGAAGGTTGTGTAGATGTTTATGAGGTAGAAGTT
ACAGACGGGAACGTATATAT

Downstream 100 bases:

>100_bases
TTTATAAAAAATAAATGAATAAGTAAGGTTTCAACCGAGAGAATATATTCGTGTTGAAGCCTTATTTGTCGTTGTGCCAA
ATTTGAACGATTTAGATTGG

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSVDKYGKVYLIGAGPGNPNYLTKKAERLIREADVILYDRLVNPLILQYANLTTEIIDVGKKPYAKHIQQEKINECIVEA
ARRYNKVVRLKGGDPAIFGRVQEEVDTLNNFNIAFEIVPGVTSASAAVATMQTGLTMRAVAKSVTFSTGHFKDSEENEVD
VNALVNGGTLAIYMGVKRLGKIIAQIQQYTDIDYPIAIVFQASCFNEFVVKGRLSNIVGKLEHYAIEAKPGICIIGEVVG
YTENVSTTSNPTQQFYVVSGSRHDALMLCEHLYDEGYGCLLNPNDTSNGTYHSSQYDYYDAFIKQQENVTYISTDRADAN
TVLCH

Sequences:

>Translated_325_residues
MSVDKYGKVYLIGAGPGNPNYLTKKAERLIREADVILYDRLVNPLILQYANLTTEIIDVGKKPYAKHIQQEKINECIVEA
ARRYNKVVRLKGGDPAIFGRVQEEVDTLNNFNIAFEIVPGVTSASAAVATMQTGLTMRAVAKSVTFSTGHFKDSEENEVD
VNALVNGGTLAIYMGVKRLGKIIAQIQQYTDIDYPIAIVFQASCFNEFVVKGRLSNIVGKLEHYAIEAKPGICIIGEVVG
YTENVSTTSNPTQQFYVVSGSRHDALMLCEHLYDEGYGCLLNPNDTSNGTYHSSQYDYYDAFIKQQENVTYISTDRADAN
TVLCH
>Mature_324_residues
SVDKYGKVYLIGAGPGNPNYLTKKAERLIREADVILYDRLVNPLILQYANLTTEIIDVGKKPYAKHIQQEKINECIVEAA
RRYNKVVRLKGGDPAIFGRVQEEVDTLNNFNIAFEIVPGVTSASAAVATMQTGLTMRAVAKSVTFSTGHFKDSEENEVDV
NALVNGGTLAIYMGVKRLGKIIAQIQQYTDIDYPIAIVFQASCFNEFVVKGRLSNIVGKLEHYAIEAKPGICIIGEVVGY
TENVSTTSNPTQQFYVVSGSRHDALMLCEHLYDEGYGCLLNPNDTSNGTYHSSQYDYYDAFIKQQENVTYISTDRADANT
VLCH

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=249, Percent_Identity=37.7510040160643, Blast_Score=151, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6322922, Length=262, Percent_Identity=30.5343511450382, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 36009; Mature: 35878

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDKYGKVYLIGAGPGNPNYLTKKAERLIREADVILYDRLVNPLILQYANLTTEIIDVG
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KKPYAKHIQQEKINECIVEAARRYNKVVRLKGGDPAIFGRVQEEVDTLNNFNIAFEIVPG
CCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECC
VTSASAAVATMQTGLTMRAVAKSVTFSTGHFKDSEENEVDVNALVNGGTLAIYMGVKRLG
CCCHHHHHHHHHCCCHHHHHHHHHEECCCCCCCCCCCCEEEEEEECCCEEEEEHHHHHHH
KIIAQIQQYTDIDYPIAIVFQASCFNEFVVKGRLSNIVGKLEHYAIEAKPGICIIGEVVG
HHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEHHHC
YTENVSTTSNPTQQFYVVSGSRHDALMLCEHLYDEGYGCLLNPNDTSNGTYHSSQYDYYD
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEECCCCHHHH
AFIKQQENVTYISTDRADANTVLCH
HHHHCCCCEEEEEECCCCCCEEECC
>Mature Secondary Structure 
SVDKYGKVYLIGAGPGNPNYLTKKAERLIREADVILYDRLVNPLILQYANLTTEIIDVG
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KKPYAKHIQQEKINECIVEAARRYNKVVRLKGGDPAIFGRVQEEVDTLNNFNIAFEIVPG
CCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECC
VTSASAAVATMQTGLTMRAVAKSVTFSTGHFKDSEENEVDVNALVNGGTLAIYMGVKRLG
CCCHHHHHHHHHCCCHHHHHHHHHEECCCCCCCCCCCCEEEEEEECCCEEEEEHHHHHHH
KIIAQIQQYTDIDYPIAIVFQASCFNEFVVKGRLSNIVGKLEHYAIEAKPGICIIGEVVG
HHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEHHHC
YTENVSTTSNPTQQFYVVSGSRHDALMLCEHLYDEGYGCLLNPNDTSNGTYHSSQYDYYD
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEECCCCHHHH
AFIKQQENVTYISTDRADANTVLCH
HHHHCCCCEEEEEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA