Click here to switch to the map view.

The map label for this gene is hemL1

Identifier: 148268148

GI number: 148268148

Start: 1823784

End: 1825070

Strand: Reverse

Name: hemL1

Synonym: SaurJH9_1725

Alternate gene names: 148268148

Gene position: 1825070-1823784 (Counterclockwise)

Preceding gene: 148268149

Following gene: 148268147

Centisome position: 62.79

GC content: 36.75

Gene sequence:

>1287_bases
ATGAGATATACGAAATCAGAAGAAGCAATGAAGGTTGCTGAAACTTTAATGCCTGGTGGTGTAAATAGTCCAGTACGCGC
ATTTAAATCAGTAGATACACCAGCAATTTTTATGGATCACGGTAAAGGCTCAAAAATTTATGATATCGATGGTAACGAGT
ATATCGACTATGTACTAAGTTGGGGGCCGCTTATTTTAGGACATAGAGACCCTCAAGTTATTAGTCATTTACATGAAGCA
ATTGATAAAGGTACAAGTTTTGGTGCATCAACATTACTTGAAAATAAATTGGCGCAGCTCGTTATTGACCGAGTACCTTC
AATAGAAAAAGTGCGTATGGTGTCATCTGGTACAGAAGCTACATTGGATACTTTAAGATTAGCACGTGGTTATACTGGCA
GAAATAAAATTGTGAAATTTGAAGGTTGCTATCATGGTCATAGTGATTCGTTATTAATCAAAGCTGGTTCTGGGGTGGCA
ACATTAGGATTGCCGGATTCTCCTGGTGTGCCTGAAGGTATTGCTAAAAATACAATTACAGTTCCATACAATGATTTAGA
TGCACTTAAAATCGCTTTCGAAAAATTTGGAGACGATATTGCTGGTGTAATCGTAGAACCTGTTGCTGGTAATATGGGTG
TCGTACCACCGATTGAAGGTTTTTTACAGGGATTAAGAGATATTACGACTGAATACGGCGCATTGCTAATTTTCGATGAA
GTAATGACTGGTTTCAGAGTCGGTTATCATTGTGCACAAGGTTACTTTGGTGTGACACCAGATTTAACTTGCTTAGGAAA
AGTTATCGGTGGAGGACTACCTGTAGGTGCTTTTGGTGGTAAAAAAGAAATCATGGATCATATAGCACCATTAGGAAATA
TTTATCAAGCGGGTACGTTATCAGGAAATCCTCTTGCAATGACAAGTGGTTATGAAACGTTAAGCCAATTAACGCCAGAG
ACATATGAGTATTTTAATATGTTAGGCGATATACTTGAAGACGGTTTAAAGCGTGTATTTGCTAAACACAATGTACCAAT
AACTGTAAATAGAGCAGGTTCAATGATTGGTTATTTCTTAAATGAAGGACCTGTAACTAATTTTGAACAAGCGAATAAAA
GTGATTTGAAATTATTTGCAGAAATGTATCGAGAAATGGCAAAAGAAGGTGTGTTTTTACCACCATCTCAATTTGAAGGT
ACATTCTTATCTACGGCACACACGAAAGAAGATATTGAAAAAACGATTCAAGCATTTGATACGGCTTTAAGTCGTATTGT
AAAATAA

Upstream 100 bases:

>100_bases
ATATGATTATTACGTATTTTGCAAAGGACATTTGTCGCTATTTAGATAAATAAGGTTTTATATGTATGATTTTCCATAAA
CTATAGGAGGAATTTACTTT

Downstream 100 bases:

>100_bases
ATATACGGACAAATTGAGAGCCTGAACTTTGTTCAGGCTCTTTTTAAATGTATATCAGGCATGGGCGGCGACTTGATAGT
GAAAGTCCATATATGCTTTG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MRYTKSEEAMKVAETLMPGGVNSPVRAFKSVDTPAIFMDHGKGSKIYDIDGNEYIDYVLSWGPLILGHRDPQVISHLHEA
IDKGTSFGASTLLENKLAQLVIDRVPSIEKVRMVSSGTEATLDTLRLARGYTGRNKIVKFEGCYHGHSDSLLIKAGSGVA
TLGLPDSPGVPEGIAKNTITVPYNDLDALKIAFEKFGDDIAGVIVEPVAGNMGVVPPIEGFLQGLRDITTEYGALLIFDE
VMTGFRVGYHCAQGYFGVTPDLTCLGKVIGGGLPVGAFGGKKEIMDHIAPLGNIYQAGTLSGNPLAMTSGYETLSQLTPE
TYEYFNMLGDILEDGLKRVFAKHNVPITVNRAGSMIGYFLNEGPVTNFEQANKSDLKLFAEMYREMAKEGVFLPPSQFEG
TFLSTAHTKEDIEKTIQAFDTALSRIVK

Sequences:

>Translated_428_residues
MRYTKSEEAMKVAETLMPGGVNSPVRAFKSVDTPAIFMDHGKGSKIYDIDGNEYIDYVLSWGPLILGHRDPQVISHLHEA
IDKGTSFGASTLLENKLAQLVIDRVPSIEKVRMVSSGTEATLDTLRLARGYTGRNKIVKFEGCYHGHSDSLLIKAGSGVA
TLGLPDSPGVPEGIAKNTITVPYNDLDALKIAFEKFGDDIAGVIVEPVAGNMGVVPPIEGFLQGLRDITTEYGALLIFDE
VMTGFRVGYHCAQGYFGVTPDLTCLGKVIGGGLPVGAFGGKKEIMDHIAPLGNIYQAGTLSGNPLAMTSGYETLSQLTPE
TYEYFNMLGDILEDGLKRVFAKHNVPITVNRAGSMIGYFLNEGPVTNFEQANKSDLKLFAEMYREMAKEGVFLPPSQFEG
TFLSTAHTKEDIEKTIQAFDTALSRIVK
>Mature_428_residues
MRYTKSEEAMKVAETLMPGGVNSPVRAFKSVDTPAIFMDHGKGSKIYDIDGNEYIDYVLSWGPLILGHRDPQVISHLHEA
IDKGTSFGASTLLENKLAQLVIDRVPSIEKVRMVSSGTEATLDTLRLARGYTGRNKIVKFEGCYHGHSDSLLIKAGSGVA
TLGLPDSPGVPEGIAKNTITVPYNDLDALKIAFEKFGDDIAGVIVEPVAGNMGVVPPIEGFLQGLRDITTEYGALLIFDE
VMTGFRVGYHCAQGYFGVTPDLTCLGKVIGGGLPVGAFGGKKEIMDHIAPLGNIYQAGTLSGNPLAMTSGYETLSQLTPE
TYEYFNMLGDILEDGLKRVFAKHNVPITVNRAGSMIGYFLNEGPVTNFEQANKSDLKLFAEMYREMAKEGVFLPPSQFEG
TFLSTAHTKEDIEKTIQAFDTALSRIVK

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=318, Percent_Identity=32.0754716981132, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI284507298, Length=238, Percent_Identity=34.453781512605, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI13994255, Length=328, Percent_Identity=25.609756097561, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI24119277, Length=357, Percent_Identity=27.1708683473389, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1786349, Length=425, Percent_Identity=52.2352941176471, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1789016, Length=378, Percent_Identity=30.952380952381, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1788044, Length=344, Percent_Identity=32.5581395348837, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI145693181, Length=321, Percent_Identity=31.1526479750779, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789759, Length=338, Percent_Identity=31.0650887573964, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1787560, Length=352, Percent_Identity=29.8295454545455, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1786991, Length=286, Percent_Identity=26.5734265734266, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI25144271, Length=313, Percent_Identity=29.3929712460064, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71992977, Length=337, Percent_Identity=28.1899109792285, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25144274, Length=161, Percent_Identity=37.888198757764, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=360, Percent_Identity=27.5, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323470, Length=329, Percent_Identity=27.9635258358663, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357415, Length=318, Percent_Identity=27.3584905660377, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356575, Length=341, Percent_Identity=27.5659824046921, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA1_STAA1 (A7X388)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442244.1
- ProteinModelPortal:   A7X388
- SMR:   A7X388
- STRING:   A7X388
- EnsemblBacteria:   EBSTAT00000004817
- GeneID:   5560892
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1654
- eggNOG:   COG0001
- GeneTree:   EBGT00050000024123
- HOGENOM:   HBG725944
- OMA:   VGCFGGK
- ProtClustDB:   PRK00062
- BioCyc:   SAUR418127:SAHV_1654-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46390; Mature: 46390

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYTKSEEAMKVAETLMPGGVNSPVRAFKSVDTPAIFMDHGKGSKIYDIDGNEYIDYVLS
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEECCCCCEEEECCCCHHHHHHHH
WGPLILGHRDPQVISHLHEAIDKGTSFGASTLLENKLAQLVIDRVPSIEKVRMVSSGTEA
CCCEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHH
TLDTLRLARGYTGRNKIVKFEGCYHGHSDSLLIKAGSGVATLGLPDSPGVPEGIAKNTIT
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCEEE
VPYNDLDALKIAFEKFGDDIAGVIVEPVAGNMGVVPPIEGFLQGLRDITTEYGALLIFDE
ECCCCHHHHHHHHHHHCCHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VMTGFRVGYHCAQGYFGVTPDLTCLGKVIGGGLPVGAFGGKKEIMDHIAPLGNIYQAGTL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHCCCCC
SGNPLAMTSGYETLSQLTPETYEYFNMLGDILEDGLKRVFAKHNVPITVNRAGSMIGYFL
CCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHH
NEGPVTNFEQANKSDLKLFAEMYREMAKEGVFLPPSQFEGTFLSTAHTKEDIEKTIQAFD
CCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
TALSRIVK
HHHHHHCC
>Mature Secondary Structure
MRYTKSEEAMKVAETLMPGGVNSPVRAFKSVDTPAIFMDHGKGSKIYDIDGNEYIDYVLS
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEECCCCCEEEECCCCHHHHHHHH
WGPLILGHRDPQVISHLHEAIDKGTSFGASTLLENKLAQLVIDRVPSIEKVRMVSSGTEA
CCCEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHH
TLDTLRLARGYTGRNKIVKFEGCYHGHSDSLLIKAGSGVATLGLPDSPGVPEGIAKNTIT
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCEEE
VPYNDLDALKIAFEKFGDDIAGVIVEPVAGNMGVVPPIEGFLQGLRDITTEYGALLIFDE
ECCCCHHHHHHHHHHHCCHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VMTGFRVGYHCAQGYFGVTPDLTCLGKVIGGGLPVGAFGGKKEIMDHIAPLGNIYQAGTL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHCCCCC
SGNPLAMTSGYETLSQLTPETYEYFNMLGDILEDGLKRVFAKHNVPITVNRAGSMIGYFL
CCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHH
NEGPVTNFEQANKSDLKLFAEMYREMAKEGVFLPPSQFEGTFLSTAHTKEDIEKTIQAFD
CCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
TALSRIVK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA