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The map label for this gene is lspA

Identifier: 148267687

GI number: 148267687

Start: 1300553

End: 1301044

Strand: Direct

Name: lspA

Synonym: SaurJH9_1255

Alternate gene names: 148267687

Gene position: 1300553-1301044 (Clockwise)

Preceding gene: 148267686

Following gene: 148267688

Centisome position: 44.74

GC content: 26.63

Gene sequence:

>492_bases
ATGCACAAAAAATATTTTATTGGCACTTCCATTTTAATAGCAGTATTTGTCGTTATATTTGACCAAGTTACTAAATATAT
TATAGCTACTACAATGAAAATTGGAGATTCATTTGAAGTGATACCGCACTTTTTAAACATAACATCACATCGAAATAATG
GTGCTGCATGGGGAATATTGAGTGGAAAAATGACATTTTTCTTTATTATTACCATTATTATATTAATAGCCTTAGTATAT
TTCTTTATTAAAGATGCTCAATATAATTTGTTTATGCAAGTTGCTATTAGTTTACTTTTTGCAGGTGCACTTGGAAACTT
TATTGATAGAATTTTAACAGGAGAAGTTGTTGACTTTATTGATACAAATATTTTTGGTTATGATTTTCCAATATTTAATA
TAGCAGATTCAAGTTTAACAATTGGTGTAATATTAATTATTATTGCCTTATTAAAGGATACTTCCAATAAAAAGGAGAAG
GAGGTTAAGTAA

Upstream 100 bases:

>100_bases
GTAACATTAGATTTAATGTAATATGCTTACTTTTTTTATTAGCAGGTGTAAGCTATAATATAAAGAGTTGTCTTATGGAC
GATTGATTGGAGGAACGAAA

Downstream 100 bases:

>100_bases
TGGAGACTTATGAATTTAACATTACAGATAAAGAACAAACAGGTATGCGTGTAGATAAGTTGCTGCCTGAATTAAATAAT
GATTGGTCTCGTAACCAGAT

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MHKKYFIGTSILIAVFVVIFDQVTKYIIATTMKIGDSFEVIPHFLNITSHRNNGAAWGILSGKMTFFFIITIIILIALVY
FFIKDAQYNLFMQVAISLLFAGALGNFIDRILTGEVVDFIDTNIFGYDFPIFNIADSSLTIGVILIIIALLKDTSNKKEK
EVK

Sequences:

>Translated_163_residues
MHKKYFIGTSILIAVFVVIFDQVTKYIIATTMKIGDSFEVIPHFLNITSHRNNGAAWGILSGKMTFFFIITIIILIALVY
FFIKDAQYNLFMQVAISLLFAGALGNFIDRILTGEVVDFIDTNIFGYDFPIFNIADSSLTIGVILIIIALLKDTSNKKEK
EVK
>Mature_163_residues
MHKKYFIGTSILIAVFVVIFDQVTKYIIATTMKIGDSFEVIPHFLNITSHRNNGAAWGILSGKMTFFFIITIIILIALVY
FFIKDAQYNLFMQVAISLLFAGALGNFIDRILTGEVVDFIDTNIFGYDFPIFNIADSSLTIGVILIIIALLKDTSNKKEK
EVK

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=155, Percent_Identity=32.9032258064516, Blast_Score=75, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_STAA1 (A7X1E3)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441776.1
- STRING:   A7X1E3
- EnsemblBacteria:   EBSTAT00000005313
- GeneID:   5561036
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1186
- eggNOG:   COG0597
- GeneTree:   EBGT00050000024886
- HOGENOM:   HBG724422
- OMA:   NFELRES
- ProtClustDB:   PRK00376
- BioCyc:   SAUR418127:SAHV_1186-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18342; Mature: 18342

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 109-109 ACT_SITE 136-136

Signals:

None

Transmembrane regions:

HASH(0xf46053c)-; HASH(0xf132b0c)-; HASH(0xed75bb8)-; HASH(0xe861c58)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKKYFIGTSILIAVFVVIFDQVTKYIIATTMKIGDSFEVIPHFLNITSHRNNGAAWGIL
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEC
SGKMTFFFIITIIILIALVYFFIKDAQYNLFMQVAISLLFAGALGNFIDRILTGEVVDFI
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTNIFGYDFPIFNIADSSLTIGVILIIIALLKDTSNKKEKEVK
HCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCH
>Mature Secondary Structure
MHKKYFIGTSILIAVFVVIFDQVTKYIIATTMKIGDSFEVIPHFLNITSHRNNGAAWGIL
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEC
SGKMTFFFIITIIILIALVYFFIKDAQYNLFMQVAISLLFAGALGNFIDRILTGEVVDFI
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTNIFGYDFPIFNIADSSLTIGVILIIIALLKDTSNKKEKEVK
HCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA