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The map label for this gene is pepA [H]

Identifier: 148267376

GI number: 148267376

Start: 986260

End: 987735

Strand: Direct

Name: pepA [H]

Synonym: SaurJH9_0942

Alternate gene names: 148267376

Gene position: 986260-987735 (Clockwise)

Preceding gene: 148267375

Following gene: 148267377

Centisome position: 33.93

GC content: 33.94

Gene sequence:

>1476_bases
ATGAATTTTAAATTAAATAACACACTAAGCAACGAAATAAATACATTGATTATTGGTATACCAGAACATTTAAATCAGTT
AGAGCGCATTAGTTTTAATCATATCGATATTACAGAATCACTTGAAAGACTAAAACATCAACATATTATTGGTAGTAAAG
TTGGGAAGATTTATACAACTGCATTTGATGTACAAGATCAAACATATCGTTTAATTACAGTTGGTTTAGGAAACTTAAAA
GCACGTAGTTATCAAGATATGTTGAAAATATGGGGACATCTTTTCCAATACATAAAGTCAGAACATATTGAAGATACTTA
TTTACTTATGGATTCATTTATTTCAAAATATGATCAGTTATCAGATGTATTAATGGCATGCGGTATTCAAAGTGAGCGTG
CAACATATGAATTCGATCATTATAAATCAAGTAAGAAGGCACCGTTTAAGACGAATTTAAACCTTATTAGTGAATCATTA
ATTGAATTAGATTTCATTCATGAGGGTATCAGTATTGGCCAATCCATTAATTTGGCAAGAGACTTTAGTAATATGCCACC
GAATGTATTAACACCACAAACATTTGCAGAAGATATTGTTAATCATTTTAAAAATACAAAGGTCAAAGTAGATGTTAAAG
ATTATGACACTTTAGTTTCTGAAGGATTCGGACTTTTACAAGCAGTAGGTAAAGGTAGTAAGCATAAACCGAGATTAGTA
ACCATCACATATAATGGCAAAGACAAAGATGTAGCACCAATTGCCTTAGTTGGTAAAGGTATAACGTATGATTCTGGTGG
TTATAGTATTAAAACGAAGAATGGCATGGCTACAATGAAGTTTGACATGTGTGGCGCTGCGAATGTCGTTGGTATCATTG
AAGCGGCTAGTCGTTTACAACTGCCTGTAAATATTGTCGGAGTGCTTGCTTGTGCTGAAAATATGATAAATGAAGCATCA
ATGAAGCCAGATGATGTATTTACAGCATTAAGTGGTGAAACTGTAGAAGTAATGAATACAGACGCTGAAGGTAGATTAGT
CCTTGCAGATGCTGTGTATTATGCAAATCAATATCAGCCTAGTGTGATTATGGACTTTGCTACATTAACGGGTGCAGCCA
TCGTTGCACTAGGCGATGATAAAGCTGCTGCATTTGAATCGAATAGTAAAGTGATATTAAACGATATATTACAAATAAGT
TCTAAAGTCGATGAAATGGTATTTGAATTACCGATTACTGCAACCGAACGTGCAAGTATTAATCACAGTGATATCGCTGA
TTTAGTTAACCATACGAATGGACAAGGTAAAGCGCTATTTGCGGCAAGTTTTGTAACACATTTTAGTGGTCAAACACCTC
ACATTCATTTCGATATTGCAGGTCCAGCAACGACTAATAAAGCTTCATATAATGGTCCAAAAGGGCCAACAGGATTTATG
ATTCCGACGATAGTACAATGGTTAAAACAACAATAA

Upstream 100 bases:

>100_bases
AAATTAAATTATTCATTTATAAAGTCCTTCAGTGTCACTGAAGGGCTTTATTGTTGTACAATTTGAAGTGAGTAACATAT
CAAATCTAAGGAGGTACATT

Downstream 100 bases:

>100_bases
TTTAATTATTTGCCTGATACAACTTGTGTCTTGTTATACATTTCTAATTTAACTCTTGAAAGTATAAAGGATCGCATTGT
ATCAGGCATTTTCATTGTTG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNFKLNNTLSNEINTLIIGIPEHLNQLERISFNHIDITESLERLKHQHIIGSKVGKIYTTAFDVQDQTYRLITVGLGNLK
ARSYQDMLKIWGHLFQYIKSEHIEDTYLLMDSFISKYDQLSDVLMACGIQSERATYEFDHYKSSKKAPFKTNLNLISESL
IELDFIHEGISIGQSINLARDFSNMPPNVLTPQTFAEDIVNHFKNTKVKVDVKDYDTLVSEGFGLLQAVGKGSKHKPRLV
TITYNGKDKDVAPIALVGKGITYDSGGYSIKTKNGMATMKFDMCGAANVVGIIEAASRLQLPVNIVGVLACAENMINEAS
MKPDDVFTALSGETVEVMNTDAEGRLVLADAVYYANQYQPSVIMDFATLTGAAIVALGDDKAAAFESNSKVILNDILQIS
SKVDEMVFELPITATERASINHSDIADLVNHTNGQGKALFAASFVTHFSGQTPHIHFDIAGPATTNKASYNGPKGPTGFM
IPTIVQWLKQQ

Sequences:

>Translated_491_residues
MNFKLNNTLSNEINTLIIGIPEHLNQLERISFNHIDITESLERLKHQHIIGSKVGKIYTTAFDVQDQTYRLITVGLGNLK
ARSYQDMLKIWGHLFQYIKSEHIEDTYLLMDSFISKYDQLSDVLMACGIQSERATYEFDHYKSSKKAPFKTNLNLISESL
IELDFIHEGISIGQSINLARDFSNMPPNVLTPQTFAEDIVNHFKNTKVKVDVKDYDTLVSEGFGLLQAVGKGSKHKPRLV
TITYNGKDKDVAPIALVGKGITYDSGGYSIKTKNGMATMKFDMCGAANVVGIIEAASRLQLPVNIVGVLACAENMINEAS
MKPDDVFTALSGETVEVMNTDAEGRLVLADAVYYANQYQPSVIMDFATLTGAAIVALGDDKAAAFESNSKVILNDILQIS
SKVDEMVFELPITATERASINHSDIADLVNHTNGQGKALFAASFVTHFSGQTPHIHFDIAGPATTNKASYNGPKGPTGFM
IPTIVQWLKQQ
>Mature_491_residues
MNFKLNNTLSNEINTLIIGIPEHLNQLERISFNHIDITESLERLKHQHIIGSKVGKIYTTAFDVQDQTYRLITVGLGNLK
ARSYQDMLKIWGHLFQYIKSEHIEDTYLLMDSFISKYDQLSDVLMACGIQSERATYEFDHYKSSKKAPFKTNLNLISESL
IELDFIHEGISIGQSINLARDFSNMPPNVLTPQTFAEDIVNHFKNTKVKVDVKDYDTLVSEGFGLLQAVGKGSKHKPRLV
TITYNGKDKDVAPIALVGKGITYDSGGYSIKTKNGMATMKFDMCGAANVVGIIEAASRLQLPVNIVGVLACAENMINEAS
MKPDDVFTALSGETVEVMNTDAEGRLVLADAVYYANQYQPSVIMDFATLTGAAIVALGDDKAAAFESNSKVILNDILQIS
SKVDEMVFELPITATERASINHSDIADLVNHTNGQGKALFAASFVTHFSGQTPHIHFDIAGPATTNKASYNGPKGPTGFM
IPTIVQWLKQQ

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=357, Percent_Identity=35.2941176470588, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI47155554, Length=294, Percent_Identity=36.0544217687075, Blast_Score=145, Evalue=7e-35,
Organism=Escherichia coli, GI1790710, Length=364, Percent_Identity=35.4395604395604, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI87082123, Length=323, Percent_Identity=37.4613003095975, Blast_Score=172, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17556903, Length=341, Percent_Identity=31.3782991202346, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=215, Percent_Identity=33.4883720930233, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21355725, Length=329, Percent_Identity=33.1306990881459, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24661038, Length=307, Percent_Identity=33.5504885993485, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20129969, Length=368, Percent_Identity=29.3478260869565, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI161077148, Length=361, Percent_Identity=28.2548476454294, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI20130057, Length=361, Percent_Identity=28.2548476454294, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI21357381, Length=310, Percent_Identity=36.1290322580645, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI221379063, Length=310, Percent_Identity=36.1290322580645, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI221379062, Length=310, Percent_Identity=36.1290322580645, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24662227, Length=361, Percent_Identity=27.4238227146814, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI20129963, Length=333, Percent_Identity=30.9309309309309, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21355645, Length=327, Percent_Identity=27.5229357798165, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24662223, Length=327, Percent_Identity=27.5229357798165, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI19922386, Length=299, Percent_Identity=27.4247491638796, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24646701, Length=325, Percent_Identity=31.3846153846154, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24646703, Length=325, Percent_Identity=31.3846153846154, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21358201, Length=325, Percent_Identity=31.3846153846154, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54070; Mature: 54070

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFKLNNTLSNEINTLIIGIPEHLNQLERISFNHIDITESLERLKHQHIIGSKVGKIYTT
CCEEECCCCCCCCCEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEE
AFDVQDQTYRLITVGLGNLKARSYQDMLKIWGHLFQYIKSEHIEDTYLLMDSFISKYDQL
EEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
SDVLMACGIQSERATYEFDHYKSSKKAPFKTNLNLISESLIELDFIHEGISIGQSINLAR
HHHHHHCCCCCCCCEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
DFSNMPPNVLTPQTFAEDIVNHFKNTKVKVDVKDYDTLVSEGFGLLQAVGKGSKHKPRLV
HHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCHHHHHHHCCCCCCCCEEE
TITYNGKDKDVAPIALVGKGITYDSGGYSIKTKNGMATMKFDMCGAANVVGIIEAASRLQ
EEEECCCCCCCCEEEEEECCCEECCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCC
LPVNIVGVLACAENMINEASMKPDDVFTALSGETVEVMNTDAEGRLVLADAVYYANQYQP
CCHHHHHHHHHHHHHHHHCCCCCCHHEEECCCCEEEEEECCCCCCEEEEEHHHHHCCCCC
SVIMDFATLTGAAIVALGDDKAAAFESNSKVILNDILQISSKVDEMVFELPITATERASI
HHEEHHHHHCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NHSDIADLVNHTNGQGKALFAASFVTHFSGQTPHIHFDIAGPATTNKASYNGPKGPTGFM
CHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
IPTIVQWLKQQ
HHHHHHHHHCC
>Mature Secondary Structure
MNFKLNNTLSNEINTLIIGIPEHLNQLERISFNHIDITESLERLKHQHIIGSKVGKIYTT
CCEEECCCCCCCCCEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEE
AFDVQDQTYRLITVGLGNLKARSYQDMLKIWGHLFQYIKSEHIEDTYLLMDSFISKYDQL
EEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
SDVLMACGIQSERATYEFDHYKSSKKAPFKTNLNLISESLIELDFIHEGISIGQSINLAR
HHHHHHCCCCCCCCEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
DFSNMPPNVLTPQTFAEDIVNHFKNTKVKVDVKDYDTLVSEGFGLLQAVGKGSKHKPRLV
HHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCHHHHHHHCCCCCCCCEEE
TITYNGKDKDVAPIALVGKGITYDSGGYSIKTKNGMATMKFDMCGAANVVGIIEAASRLQ
EEEECCCCCCCCEEEEEECCCEECCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCC
LPVNIVGVLACAENMINEASMKPDDVFTALSGETVEVMNTDAEGRLVLADAVYYANQYQP
CCHHHHHHHHHHHHHHHHCCCCCCHHEEECCCCEEEEEECCCCCCEEEEEHHHHHCCCCC
SVIMDFATLTGAAIVALGDDKAAAFESNSKVILNDILQISSKVDEMVFELPITATERASI
HHEEHHHHHCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NHSDIADLVNHTNGQGKALFAASFVTHFSGQTPHIHFDIAGPATTNKASYNGPKGPTGFM
CHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
IPTIVQWLKQQ
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA