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The map label for this gene is norG [H]

Identifier: 148266535

GI number: 148266535

Start: 112144

End: 113472

Strand: Direct

Name: norG [H]

Synonym: SaurJH9_0095

Alternate gene names: 148266535

Gene position: 112144-113472 (Clockwise)

Preceding gene: 148266531

Following gene: 148266536

Centisome position: 3.86

GC content: 29.42

Gene sequence:

>1329_bases
ATGAAGATACCTCCACAGAGGCAGTTGGCGATACAATACAACGTAAATAGAGTGACGATTATTAAAAGTATTGAGTTATT
AGAGGCTGAAGGATTTATCTATACTAAAGTGGGGAGTGGAACATATGTTAATGACTATTTGAATGAAGCACATATTACAA
ATAAGTGGTCTGAAATGATGTTATGGTCCTCTCAACAAAGAAGTCAGTATACGGTGCAATTAATTAATAAAATTGAGACA
GATGATTCGTATATACATATAAGTAAAGGTGAATTGGGTATATCGTTAATGCCACATATTCAATTGAAAAAAGCCATGTC
TAATACAGCCAGTCATATTGAAGACTTATCTTTTGGTTATAATAATGGCTATGGTTATATCAAGTTAAGAGATATTATCG
TTGAACGAATGTCAAAGCAAGGTATAAATGTAGGTAGAGAAAATGTAATGATCACTTCAGGCGCTTTACATGCCATTCTA
CTTTTATCTATTGGGTTTTTAGGTCAAGATGCCATAATAATTTCGAATACACCATCATATATTCACTCTACAAATGTTTT
TGAGCAATTGAATTTTAGACATATTGATGTTCCTTATAATCAAATTAATGAAATTAATACCATCATTGATAGATTTATTA
ATTTTAAAAATAAAGCGATTTATATAGAACCTAGGTTTAATAACCCGACAGGTCGTTCTTTAACGAATGAGCAAAAGAAA
AATATAATTACTTATAGCGAAAGACATAATATTCCTATCATTGAAGATGATATCTTTAGAGATATTTTCTTTAGCGATCC
AACTCCTGCTATCAAAACTTATGATAAATTGGGAAAAGTTATACATATAAGCAGTTTTTCAAAAACGATTGCACCAGCAA
TAAGAATAGGTTGGATTGTTGCTTCTGAAAAAATAATAGAGCAATTGGCAGATGTAAGAATGCAAATTGACTATGGATCC
AGTATTTTGTCACAAATGGTTGTATATGAGATGTTGAAAAATAAGTCTTATGATAAACACTTAGTAAAGTTAAGGTATGT
TTTAAAAGATAAACGAGACTTTATGTTAAACATCCTCAATAATTTATTTAAGGATATAGCACATTGGGAGGTTCCAAGTG
GAGGTTATTTTGTATGGTTAGTCTTTAAAATAGATATAGATATTAAATATTTATTTTACGAATTGTTAAGTAAAGAAAAA
ATATTAATCAATCCGGGTTACATTTATGGCAGTAAAGAAAAGAGTATAAGGCTATCTTTTGCCTTTGAATCAAATGAAAA
TATTAAGCATGCGCTCTATAAAATTTATACATATGTGAAAAAGGTTTAA

Upstream 100 bases:

>100_bases
TACCTATCCAATTTTAAAAGGGAGGGAGAAGATGGCTAAATATTAAGATATTGCTAGTGACATAAGAGATAAAATAATCA
CAGGGGATTGGTTTTATGGA

Downstream 100 bases:

>100_bases
TTAAAACAATAATTCGAATCATTATGTGGCATGTTAAACAGCTAAATATAAGCTATGCACATTTAACAAGCGGATACTCC
TGACGCAATTATAGTATCAT

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MKIPPQRQLAIQYNVNRVTIIKSIELLEAEGFIYTKVGSGTYVNDYLNEAHITNKWSEMMLWSSQQRSQYTVQLINKIET
DDSYIHISKGELGISLMPHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERMSKQGINVGRENVMITSGALHAIL
LLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDVPYNQINEINTIIDRFINFKNKAIYIEPRFNNPTGRSLTNEQKK
NIITYSERHNIPIIEDDIFRDIFFSDPTPAIKTYDKLGKVIHISSFSKTIAPAIRIGWIVASEKIIEQLADVRMQIDYGS
SILSQMVVYEMLKNKSYDKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVPSGGYFVWLVFKIDIDIKYLFYELLSKEK
ILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV

Sequences:

>Translated_442_residues
MKIPPQRQLAIQYNVNRVTIIKSIELLEAEGFIYTKVGSGTYVNDYLNEAHITNKWSEMMLWSSQQRSQYTVQLINKIET
DDSYIHISKGELGISLMPHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERMSKQGINVGRENVMITSGALHAIL
LLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDVPYNQINEINTIIDRFINFKNKAIYIEPRFNNPTGRSLTNEQKK
NIITYSERHNIPIIEDDIFRDIFFSDPTPAIKTYDKLGKVIHISSFSKTIAPAIRIGWIVASEKIIEQLADVRMQIDYGS
SILSQMVVYEMLKNKSYDKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVPSGGYFVWLVFKIDIDIKYLFYELLSKEK
ILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV
>Mature_442_residues
MKIPPQRQLAIQYNVNRVTIIKSIELLEAEGFIYTKVGSGTYVNDYLNEAHITNKWSEMMLWSSQQRSQYTVQLINKIET
DDSYIHISKGELGISLMPHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERMSKQGINVGRENVMITSGALHAIL
LLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDVPYNQINEINTIIDRFINFKNKAIYIEPRFNNPTGRSLTNEQKK
NIITYSERHNIPIIEDDIFRDIFFSDPTPAIKTYDKLGKVIHISSFSKTIAPAIRIGWIVASEKIIEQLADVRMQIDYGS
SILSQMVVYEMLKNKSYDKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVPSGGYFVWLVFKIDIDIKYLFYELLSKEK
ILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV

Specific function: Positively regulates the expression of the NorB efflux pump and negatively regulates the expression of the AbcA efflux pump. Binds specifically to the promoters of norA, norB and norC and abcA genes. Could also have an aminotransferase activity [H]

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=318, Percent_Identity=25.4716981132075, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI33469970, Length=318, Percent_Identity=25.4716981132075, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1787710, Length=461, Percent_Identity=24.0780911062907, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1790797, Length=444, Percent_Identity=23.4234234234234, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321000, Length=181, Percent_Identity=23.7569060773481, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=276, Percent_Identity=25.7246376811594, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356535, Length=336, Percent_Identity=22.0238095238095, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000524
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00155 Aminotran_1_2; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 51273; Mature: 51273

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS50949 HTH_GNTR ; PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIPPQRQLAIQYNVNRVTIIKSIELLEAEGFIYTKVGSGTYVNDYLNEAHITNKWSEMM
CCCCCCCCEEEEECCCEEEEEEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCHHHHHH
LWSSQQRSQYTVQLINKIETDDSYIHISKGELGISLMPHIQLKKAMSNTASHIEDLSFGY
HHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHCCCC
NNGYGYIKLRDIIVERMSKQGINVGRENVMITSGALHAILLLSIGFLGQDAIIISNTPSY
CCCEEEEEHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEEECCCCH
IHSTNVFEQLNFRHIDVPYNQINEINTIIDRFINFKNKAIYIEPRFNNPTGRSLTNEQKK
HCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHC
NIITYSERHNIPIIEDDIFRDIFFSDPTPAIKTYDKLGKVIHISSFSKTIAPAIRIGWIV
CEEEEECCCCCCEECHHHHHHHHCCCCCCHHHHHHHCCCEEEEECHHHHHHHHHHHEEEE
ASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSYDKHLVKLRYVLKDKRDFMLNILN
HHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHH
NLFKDIAHWEVPSGGYFVWLVFKIDIDIKYLFYELLSKEKILINPGYIYGSKEKSIRLSF
HHHHHHHHCCCCCCCEEEEEEEEEECCHHHHHHHHHCCCEEEECCCEEECCCCCEEEEEE
AFESNENIKHALYKIYTYVKKV
EECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIPPQRQLAIQYNVNRVTIIKSIELLEAEGFIYTKVGSGTYVNDYLNEAHITNKWSEMM
CCCCCCCCEEEEECCCEEEEEEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCHHHHHH
LWSSQQRSQYTVQLINKIETDDSYIHISKGELGISLMPHIQLKKAMSNTASHIEDLSFGY
HHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHCCCC
NNGYGYIKLRDIIVERMSKQGINVGRENVMITSGALHAILLLSIGFLGQDAIIISNTPSY
CCCEEEEEHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEEECCCCH
IHSTNVFEQLNFRHIDVPYNQINEINTIIDRFINFKNKAIYIEPRFNNPTGRSLTNEQKK
HCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHC
NIITYSERHNIPIIEDDIFRDIFFSDPTPAIKTYDKLGKVIHISSFSKTIAPAIRIGWIV
CEEEEECCCCCCEECHHHHHHHHCCCCCCHHHHHHHCCCEEEEECHHHHHHHHHHHEEEE
ASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSYDKHLVKLRYVLKDKRDFMLNILN
HHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHH
NLFKDIAHWEVPSGGYFVWLVFKIDIDIKYLFYELLSKEKILINPGYIYGSKEKSIRLSF
HHHHHHHHCCCCCCCEEEEEEEEEECCHHHHHHHHHCCCEEEECCCEEECCCCCEEEEEE
AFESNENIKHALYKIYTYVKKV
EECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA