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The map label for this gene is hmrR [H]

Identifier: 148243759

GI number: 148243759

Start: 152615

End: 153028

Strand: Direct

Name: hmrR [H]

Synonym: Acry_3237

Alternate gene names: 148243759

Gene position: 152615-153028 (Clockwise)

Preceding gene: 148243753

Following gene: 148243762

Centisome position: 74.96

GC content: 60.14

Gene sequence:

>414_bases
TTGGCAATCGGCGAACTCGGTCGGCAGACCGCAACCAGGGTCGAGACCATCCGCTACTACGAACGTATAGGGCTATTGCC
GGCTCCAGCGCGAACCGCCGGCAACTATCGGGCATACGGCCCTGAGCATCTGAACCGATTGAGCTTCATTCGCAGGTCAC
GCGATCTGGGTTTTTCACTCGATCAGGTCCGTGCTTTGCTGGATCTTGCCGATGAGCGCGCCCGCTCTTGTGAAGCTGTC
GACGCAATTGCCCGCGATCATCTGGCGGAGATCGATCGCAAGATCGCCGATCTGCGTGCTCTGCGGCGCGAACTCGGCAA
CATGATCAGTCAGTGCCGCCAGGGGACGGTTGCCGAATGCCGGATTATCGACGCGCTATCCCCTGGAGCCAGCCAAAAGA
AGCGGCGGAAGTGA

Upstream 100 bases:

>100_bases
ACACTAATCGCGGCAGCCATGGCTTTTCCTCGACAATCACGACATGAATCCGATATGATCCCTGTAGTCACTATAGGGTC
AAGCGATGTCAGGTGGATTT

Downstream 100 bases:

>100_bases
CGAGAGGTTTCATTGAGGGCGGGGCAGATCCCGCATGAGCCAGATTCCTGATCCGGCCACGAGGACCGCCGTGATCCAGA
GCGTCGGAAGGGTTGCCTGC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 137; Mature: 136

Protein sequence:

>137_residues
MAIGELGRQTATRVETIRYYERIGLLPAPARTAGNYRAYGPEHLNRLSFIRRSRDLGFSLDQVRALLDLADERARSCEAV
DAIARDHLAEIDRKIADLRALRRELGNMISQCRQGTVAECRIIDALSPGASQKKRRK

Sequences:

>Translated_137_residues
MAIGELGRQTATRVETIRYYERIGLLPAPARTAGNYRAYGPEHLNRLSFIRRSRDLGFSLDQVRALLDLADERARSCEAV
DAIARDHLAEIDRKIADLRALRRELGNMISQCRQGTVAECRIIDALSPGASQKKRRK
>Mature_136_residues
AIGELGRQTATRVETIRYYERIGLLPAPARTAGNYRAYGPEHLNRLSFIRRSRDLGFSLDQVRALLDLADERARSCEAVD
AIARDHLAEIDRKIADLRALRRELGNMISQCRQGTVAECRIIDALSPGASQKKRRK

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=132, Percent_Identity=36.3636363636364, Blast_Score=90, Evalue=6e-20,
Organism=Escherichia coli, GI1786695, Length=127, Percent_Identity=33.0708661417323, Blast_Score=82, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15463; Mature: 15332

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIGELGRQTATRVETIRYYERIGLLPAPARTAGNYRAYGPEHLNRLSFIRRSRDLGFSL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCH
DQVRALLDLADERARSCEAVDAIARDHLAEIDRKIADLRALRRELGNMISQCRQGTVAEC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RIIDALSPGASQKKRRK
HHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AIGELGRQTATRVETIRYYERIGLLPAPARTAGNYRAYGPEHLNRLSFIRRSRDLGFSL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCH
DQVRALLDLADERARSCEAVDAIARDHLAEIDRKIADLRALRRELGNMISQCRQGTVAEC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RIIDALSPGASQKKRRK
HHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]