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The map label for this gene is lpxC

Identifier: 147675593

GI number: 147675593

Start: 2117265

End: 2118182

Strand: Reverse

Name: lpxC

Synonym: VC0395_A1974

Alternate gene names: 147675593

Gene position: 2118182-2117265 (Counterclockwise)

Preceding gene: 147674018

Following gene: 147673246

Centisome position: 70.04

GC content: 47.17

Gene sequence:

>918_bases
ATGATCAGACAACGTACTCTGAAAGAAATAGTGAAAACAACTGGGGTGGGCTTACACTCTGGTCGTAAAGTTACGCTGAC
TCTTCGCCCGGCCGCAGCCAATACGGGGATTATTTATCGTCGTACTGACGTCAACCCACCGGTTGATTTTCCTGCCGATC
CGGCTTCTGTGCGTGACACCATGCTTTGTACCGCTTTGGTTAATGATCAAGGTGTACGAATCTCTACCGTAGAGCATCTT
AATGCTGCTTTAGCAGGGATGGGGATCGACAATGCGATTATCGAAGTGGATGCACCCGAAATTCCAATTATGGATGGCAG
TGCGAGTCCTTTTGTTTACTTGCTGCAACAAGCGGGTATTCAAACACTCAATGCACCAAAACGCTTCATCCGTATCAAGA
AACCTGTACGCATTGAAGATGGCGATAAGTGGGCTGAATTTGTTCCATTTAACGGCTTCCGTATGGATTTCGAAATTGAG
TTCAACCACCCAGCGATTGATGGCGATGACCAACGCCTCGTGTTTGATTTTTCTTCACAGGGTTTTGTGAAAGAAATCTC
TCGTGCGCGTACCTTTGGTTTTATGCGTGATATCGAATATCTGCAATCACAAAACCTCTGCTTAGGTGGTAGCTTTGATT
GCGCGATCGTGCTGGATGATTACCGTATCCTGAATGAAGAAGGACTGCGTTTCGATAACGAGTTTGTGACTCATAAAGTG
CTGGATGCGATTGGTGATCTCTACATGGCTGGTCATGCGATTGTTGGTGAGTTCCGTGCCTACAAATCAGGCCACGGCTT
GAACAACCAACTGCTGCGTGCGGTATTGGCCGATCAAGAAGCATGGGAATGGGCAACCTTCGAAGAAGAAGTGGGTTCAC
CTGTTGCTTTTGCTGAACCGAACATGGTTCTCGCGTAA

Upstream 100 bases:

>100_bases
TAAAATATCAGCGTAATTTGACAGTGTTCAGAATTCTGGTAGGATGTCGGTCGGTGTTATGCCGGCCGTTCATTGTGGCT
AAATAAATCGAGGCAACTAG

Downstream 100 bases:

>100_bases
GCCATTCAGAAAGAACAATCATAATAAAGCCAGACAGATGTCTGGCTTTATTTTTTCTTTTAAATTCAATGATATTTAAA
CGCTATTCTGTGAGTGTAAC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MIRQRTLKEIVKTTGVGLHSGRKVTLTLRPAAANTGIIYRRTDVNPPVDFPADPASVRDTMLCTALVNDQGVRISTVEHL
NAALAGMGIDNAIIEVDAPEIPIMDGSASPFVYLLQQAGIQTLNAPKRFIRIKKPVRIEDGDKWAEFVPFNGFRMDFEIE
FNHPAIDGDDQRLVFDFSSQGFVKEISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEEGLRFDNEFVTHKV
LDAIGDLYMAGHAIVGEFRAYKSGHGLNNQLLRAVLADQEAWEWATFEEEVGSPVAFAEPNMVLA

Sequences:

>Translated_305_residues
MIRQRTLKEIVKTTGVGLHSGRKVTLTLRPAAANTGIIYRRTDVNPPVDFPADPASVRDTMLCTALVNDQGVRISTVEHL
NAALAGMGIDNAIIEVDAPEIPIMDGSASPFVYLLQQAGIQTLNAPKRFIRIKKPVRIEDGDKWAEFVPFNGFRMDFEIE
FNHPAIDGDDQRLVFDFSSQGFVKEISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEEGLRFDNEFVTHKV
LDAIGDLYMAGHAIVGEFRAYKSGHGLNNQLLRAVLADQEAWEWATFEEEVGSPVAFAEPNMVLA
>Mature_305_residues
MIRQRTLKEIVKTTGVGLHSGRKVTLTLRPAAANTGIIYRRTDVNPPVDFPADPASVRDTMLCTALVNDQGVRISTVEHL
NAALAGMGIDNAIIEVDAPEIPIMDGSASPFVYLLQQAGIQTLNAPKRFIRIKKPVRIEDGDKWAEFVPFNGFRMDFEIE
FNHPAIDGDDQRLVFDFSSQGFVKEISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEEGLRFDNEFVTHKV
LDAIGDLYMAGHAIVGEFRAYKSGHGLNNQLLRAVLADQEAWEWATFEEEVGSPVAFAEPNMVLA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=305, Percent_Identity=73.1147540983607, Blast_Score=485, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_VIBC3 (A5F5P3)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F5P3
- SMR:   A5F5P3
- STRING:   A5F5P3
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A1974
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- ProtClustDB:   PRK13186
- BioCyc:   VCHO345073:VC0395_A1974-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33968; Mature: 33968

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRQRTLKEIVKTTGVGLHSGRKVTLTLRPAAANTGIIYRRTDVNPPVDFPADPASVRDT
CCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCHHHHHH
MLCTALVNDQGVRISTVEHLNAALAGMGIDNAIIEVDAPEIPIMDGSASPFVYLLQQAGI
EEEEEEECCCCCEEEHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCHHHHHHHHCCC
QTLNAPKRFIRIKKPVRIEDGDKWAEFVPFNGFRMDFEIEFNHPAIDGDDQRLVFDFSSQ
CCCCCCHHHEEECCCEEECCCCCHHHCCCCCCEEEEEEEEECCCCCCCCCCEEEEEECCC
GFVKEISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEEGLRFDNEFVTHKV
CHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECEEEECCCCCCCCHHHHHHHH
LDAIGDLYMAGHAIVGEFRAYKSGHGLNNQLLRAVLADQEAWEWATFEEEVGSPVAFAEP
HHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCEEECCC
NMVLA
CEEEC
>Mature Secondary Structure
MIRQRTLKEIVKTTGVGLHSGRKVTLTLRPAAANTGIIYRRTDVNPPVDFPADPASVRDT
CCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCHHHHHH
MLCTALVNDQGVRISTVEHLNAALAGMGIDNAIIEVDAPEIPIMDGSASPFVYLLQQAGI
EEEEEEECCCCCEEEHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCHHHHHHHHCCC
QTLNAPKRFIRIKKPVRIEDGDKWAEFVPFNGFRMDFEIEFNHPAIDGDDQRLVFDFSSQ
CCCCCCHHHEEECCCEEECCCCCHHHCCCCCCEEEEEEEEECCCCCCCCCCEEEEEECCC
GFVKEISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEEGLRFDNEFVTHKV
CHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECEEEECCCCCCCCHHHHHHHH
LDAIGDLYMAGHAIVGEFRAYKSGHGLNNQLLRAVLADQEAWEWATFEEEVGSPVAFAEP
HHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCEEECCC
NMVLA
CEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA