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The map label for this gene is cvrA [H]

Identifier: 147674441

GI number: 147674441

Start: 226672

End: 228468

Strand: Direct

Name: cvrA [H]

Synonym: VC0395_A0220

Alternate gene names: 147674441

Gene position: 226672-228468 (Clockwise)

Preceding gene: 147674079

Following gene: 147673776

Centisome position: 7.5

GC content: 50.97

Gene sequence:

>1797_bases
ATGCACGAAGAGTCTATTGCTCTGACTATCGCTGCGGTTGGCGTAGTCGGTTTAGGATGTCAGTGGTTAGCCTGGCGGTT
ACGTCTGCCAGCCATCTTATTTTTGCTGTTGGCGGGGATTTTAGCTGGCCCAGTGTTTGGGGTGTTAAACCCGGAAGCCT
TGATGGGGGATTTGCTCTTTCCGCTTGTTTCACTTGCCGTGGCGGTGATTTTGTTTGAAGGCAGCCTCACTCTAAATTTC
AAAGAGATCCGCGGCGTCAGTAATACAGTGTGGAGCATTGTCACGGTTGGCGCACTCGTCTCATGGGGGATCACCAGCAC
GGCTGCGCATTGGTTGCTTGGCTTTGAATGGCCGTTAGCACTGATGTTTGGCAGTTTGACTGTGGTCACGGGTCCAACCG
TGATTGTGCCTTTGCTGCGCACAGTACGCCCAACCGCACGTTTAGCGAATATTCTGCGTTGGGAGGGGATTTTAATCGAC
CCACTTGGTGCACTGTTTGTGGTGATGGTGTATGAATTCATTGTATCCAGCAGCCATGCTCATAGCCTAGAAGTGTTTAG
CCTGATTTTATTGGTCGGTTTTTCGATTGGTATCGCTTCTGGAGTAGCGGTGGCGGCGGTACTGCGCAGAGGCTTGTTGC
CGGAGTACTTGCAGCCGTTTGCGGTGCTGAGTGTCGTGCTCGGTGTGTTTGCTGCGTCTAATGCCTTGGAGTCCGAATCT
GGCCTACTGACAGTGACAGTCATGGGGATGTGGCTGGCGAATGCCAAAGGGGTCAATATTCAGCACATCTTGCACTTTAA
AGAGCACTTAACGATTTTGCTGATCACAGGGCTGTTTATTCTGCTCGCGGCTCGGATTGAAGTGGCGGATTTCCAAGCGT
TGGGCTGGAGCGCCTTGGGGCTGTTTGTGGTGATGCAACTGCTGGCTCGCCCTGCGTCTATCTTCATTTCAACGTTGCGT
AGCACGCTCAACGTTCGTGAAAAAGCCTTTTTAGCTTGGGTGGCTCCGCGCGGGATTGTGGCCGCTTCGATCTCTTCTCT
GTTTGCCATCAAATTGATGGAGTTTGGCATCGCTGATGCCAAGCTATTAGTGCCGCTGACCTTTATGGTGATCATTGGCA
CTGTCGTGCTGCAAAGTGCGACTGCTCGACCAATGGCGTTGGCATTGAAAGTGTCAGAACCTGCGCCGAAAGGCTTCTTG
ATCATCGGTGCCAATGATGTGGCGCGTCAGGTCGGTTTAGCGATCGCTAAGTACGATTGTCGAGTGGTGGTGACGGATTC
CAACTGGGACTACATTCGCCAAGCAAGAATGGCCGGGCTTGAGCATTATTACGGCAACCCGATTTCCAGCCATGCTGAGG
ATTACCTGAATTTGATTGGGATTGGGCATGTGTTGGCACTGAGCCCTGATAAACACTTCAACATCATGGCCTGTATGCAG
TTTTTATCGGATTTTGGCGATAAGCGTGTGTTTTGCCTCAACGATAATCCAACCAATAACGTCAGTGAAAAGCATCTCGT
CGCTCAGGAATATCATGGCTTGCCGTTTCTAGGTGGTGAAGTGAGTTACAAAAAACTGGCGAGTTTGGTCGGCCAAGGTG
CGGAAGTGAAGCACACCAAATTGAGCGAAAACTTCACTTATCAGGATTATCAGCAAACCCACAAAGAGAGTTTTGTTTTG
CCGCTGTTTTTAGTCGACAGTCGTGGGCGGGTGCAGATGTGTCAGGATGTGGCGAGTTTTGCGCCGAAAGAGGGCGAAAT
TGTCGTGTCTCTGATCAAAAGTCACGAGAGCCCATAG

Upstream 100 bases:

>100_bases
TGAAGGAATTTGTGAAGGTACAGAGCAGGCGCAGCGTTTTCGTATGGAGTGGCAACGCGGTTGGAATGAGTACAATCAAT
AACCGATAAGAGGTGCAATC

Downstream 100 bases:

>100_bases
GGCTCTCGTTTTGCTCTGGCTAATTACTCTTCGTGCTCTTCCATGGCGCGGCGTAAGAAGCCGTCCGACTGCGAGAGTTT
CGCGGTCGCTTGCTCGTAGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MHEESIALTIAAVGVVGLGCQWLAWRLRLPAILFLLLAGILAGPVFGVLNPEALMGDLLFPLVSLAVAVILFEGSLTLNF
KEIRGVSNTVWSIVTVGALVSWGITSTAAHWLLGFEWPLALMFGSLTVVTGPTVIVPLLRTVRPTARLANILRWEGILID
PLGALFVVMVYEFIVSSSHAHSLEVFSLILLVGFSIGIASGVAVAAVLRRGLLPEYLQPFAVLSVVLGVFAASNALESES
GLLTVTVMGMWLANAKGVNIQHILHFKEHLTILLITGLFILLAARIEVADFQALGWSALGLFVVMQLLARPASIFISTLR
STLNVREKAFLAWVAPRGIVAASISSLFAIKLMEFGIADAKLLVPLTFMVIIGTVVLQSATARPMALALKVSEPAPKGFL
IIGANDVARQVGLAIAKYDCRVVVTDSNWDYIRQARMAGLEHYYGNPISSHAEDYLNLIGIGHVLALSPDKHFNIMACMQ
FLSDFGDKRVFCLNDNPTNNVSEKHLVAQEYHGLPFLGGEVSYKKLASLVGQGAEVKHTKLSENFTYQDYQQTHKESFVL
PLFLVDSRGRVQMCQDVASFAPKEGEIVVSLIKSHESP

Sequences:

>Translated_598_residues
MHEESIALTIAAVGVVGLGCQWLAWRLRLPAILFLLLAGILAGPVFGVLNPEALMGDLLFPLVSLAVAVILFEGSLTLNF
KEIRGVSNTVWSIVTVGALVSWGITSTAAHWLLGFEWPLALMFGSLTVVTGPTVIVPLLRTVRPTARLANILRWEGILID
PLGALFVVMVYEFIVSSSHAHSLEVFSLILLVGFSIGIASGVAVAAVLRRGLLPEYLQPFAVLSVVLGVFAASNALESES
GLLTVTVMGMWLANAKGVNIQHILHFKEHLTILLITGLFILLAARIEVADFQALGWSALGLFVVMQLLARPASIFISTLR
STLNVREKAFLAWVAPRGIVAASISSLFAIKLMEFGIADAKLLVPLTFMVIIGTVVLQSATARPMALALKVSEPAPKGFL
IIGANDVARQVGLAIAKYDCRVVVTDSNWDYIRQARMAGLEHYYGNPISSHAEDYLNLIGIGHVLALSPDKHFNIMACMQ
FLSDFGDKRVFCLNDNPTNNVSEKHLVAQEYHGLPFLGGEVSYKKLASLVGQGAEVKHTKLSENFTYQDYQQTHKESFVL
PLFLVDSRGRVQMCQDVASFAPKEGEIVVSLIKSHESP
>Mature_598_residues
MHEESIALTIAAVGVVGLGCQWLAWRLRLPAILFLLLAGILAGPVFGVLNPEALMGDLLFPLVSLAVAVILFEGSLTLNF
KEIRGVSNTVWSIVTVGALVSWGITSTAAHWLLGFEWPLALMFGSLTVVTGPTVIVPLLRTVRPTARLANILRWEGILID
PLGALFVVMVYEFIVSSSHAHSLEVFSLILLVGFSIGIASGVAVAAVLRRGLLPEYLQPFAVLSVVLGVFAASNALESES
GLLTVTVMGMWLANAKGVNIQHILHFKEHLTILLITGLFILLAARIEVADFQALGWSALGLFVVMQLLARPASIFISTLR
STLNVREKAFLAWVAPRGIVAASISSLFAIKLMEFGIADAKLLVPLTFMVIIGTVVLQSATARPMALALKVSEPAPKGFL
IIGANDVARQVGLAIAKYDCRVVVTDSNWDYIRQARMAGLEHYYGNPISSHAEDYLNLIGIGHVLALSPDKHFNIMACMQ
FLSDFGDKRVFCLNDNPTNNVSEKHLVAQEYHGLPFLGGEVSYKKLASLVGQGAEVKHTKLSENFTYQDYQQTHKESFVL
PLFLVDSRGRVQMCQDVASFAPKEGEIVVSLIKSHESP

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=323, Percent_Identity=26.9349845201238, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 64857; Mature: 64857

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEESIALTIAAVGVVGLGCQWLAWRLRLPAILFLLLAGILAGPVFGVLNPEALMGDLLF
CCCCHHEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
PLVSLAVAVILFEGSLTLNFKEIRGVSNTVWSIVTVGALVSWGITSTAAHWLLGFEWPLA
HHHHHHHHHHHCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
LMFGSLTVVTGPTVIVPLLRTVRPTARLANILRWEGILIDPLGALFVVMVYEFIVSSSHA
HHHCCHHEECCCHHHHHHHHHCCHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHCCCCC
HSLEVFSLILLVGFSIGIASGVAVAAVLRRGLLPEYLQPFAVLSVVLGVFAASNALESES
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
GLLTVTVMGMWLANAKGVNIQHILHFKEHLTILLITGLFILLAARIEVADFQALGWSALG
CEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LFVVMQLLARPASIFISTLRSTLNVREKAFLAWVAPRGIVAASISSLFAIKLMEFGIADA
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCCCH
KLLVPLTFMVIIGTVVLQSATARPMALALKVSEPAPKGFLIIGANDVARQVGLAIAKYDC
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHEEECC
RVVVTDSNWDYIRQARMAGLEHYYGNPISSHAEDYLNLIGIGHVLALSPDKHFNIMACMQ
EEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHH
FLSDFGDKRVFCLNDNPTNNVSEKHLVAQEYHGLPFLGGEVSYKKLASLVGQGAEVKHTK
HHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEEE
LSENFTYQDYQQTHKESFVLPLFLVDSRGRVQMCQDVASFAPKEGEIVVSLIKSHESP
CCCCCCHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MHEESIALTIAAVGVVGLGCQWLAWRLRLPAILFLLLAGILAGPVFGVLNPEALMGDLLF
CCCCHHEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
PLVSLAVAVILFEGSLTLNFKEIRGVSNTVWSIVTVGALVSWGITSTAAHWLLGFEWPLA
HHHHHHHHHHHCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
LMFGSLTVVTGPTVIVPLLRTVRPTARLANILRWEGILIDPLGALFVVMVYEFIVSSSHA
HHHCCHHEECCCHHHHHHHHHCCHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHCCCCC
HSLEVFSLILLVGFSIGIASGVAVAAVLRRGLLPEYLQPFAVLSVVLGVFAASNALESES
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
GLLTVTVMGMWLANAKGVNIQHILHFKEHLTILLITGLFILLAARIEVADFQALGWSALG
CEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LFVVMQLLARPASIFISTLRSTLNVREKAFLAWVAPRGIVAASISSLFAIKLMEFGIADA
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCCCH
KLLVPLTFMVIIGTVVLQSATARPMALALKVSEPAPKGFLIIGANDVARQVGLAIAKYDC
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHEEECC
RVVVTDSNWDYIRQARMAGLEHYYGNPISSHAEDYLNLIGIGHVLALSPDKHFNIMACMQ
EEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHH
FLSDFGDKRVFCLNDNPTNNVSEKHLVAQEYHGLPFLGGEVSYKKLASLVGQGAEVKHTK
HHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEEE
LSENFTYQDYQQTHKESFVLPLFLVDSRGRVQMCQDVASFAPKEGEIVVSLIKSHESP
CCCCCCHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]