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The map label for this gene is nqrA [H]

Identifier: 147674300

GI number: 147674300

Start: 2002774

End: 2004162

Strand: Reverse

Name: nqrA [H]

Synonym: VC0395_A1884

Alternate gene names: 147674300

Gene position: 2004162-2002774 (Counterclockwise)

Preceding gene: 147674547

Following gene: 147674588

Centisome position: 66.27

GC content: 48.45

Gene sequence:

>1389_bases
TTGCGCAATGAAAGAATCTTTTTCCCGATAAAAGTAGTGCAAGTGCGTATGATTACAATAAAAAAGGGATTGGACCTTCC
TATCGCAGGAACTCCTTCCCAGGTGATTAGTGATGGTAAAGCCATCAAAAAAGTCGCCTTGCTTGGCGAAGAGTACGTTG
GCATGCGTCCTACTATGCATGTCCGCGTAGGTGATGAAGTAAAAAAAGCTCAGATTCTTTTTGAAGATAAGAAGAATCCG
GGTGTGAAATTTACTTCACCAGTCAGCGGTAAAGTGGTTGAAATCAATCGTGGTGCAAAGCGCGTTCTTCAGTCTGTAGT
GATTGAAGTGGCGGGTGATGACCAAGTGACCTTCGACAAGTTTGAAGCCAATCAATTAGCCAGTTTGAATCGCGATGCGA
TCAAAACTCAGCTGGTTGAGTCTGGTCTTTGGACTGCTTTCCGTACTCGTCCGTTCAGCAAGGTTCCAGCCATTGATTCC
ACTTCTGAAGCCATTTTTGTCACTGCTATGGATACCAATCCGTTGGCAGCTGAGCCGACCGTTGTGATCAATGAACAATC
TGAAGCCTTCGTTGCTGGTCTAGATGTGCTTTCCGCACTGACAACTGGCAAAGTGTACGTTTGTAAAAAAGGCACCAGCT
TGCCACGTTCTCAACAGCCGAATGTTGAAGAACATGTCTTTGACGGCCCACATCCTGCAGGCTTAGCTGGCACTCACATG
CATTTCCTCTATCCAGTAAGTGCAGACCACGTGGCGTGGAGCATCAACTATCAGGACGTGATCGCAGTAGGTCAACTGTT
CCTGACGGGCGAGCTATACACCCAGCGTGTGGTTTCTCTTGCCGGCCCGGTGGTGAACAAACCTCGTTTGGTTCGCACTG
TCATGGGCGCATCACTAGAGCAACTGGTGGACAGCGAAATCATGCCTGGCGAAGTACGCATCATCTCTGGCTCTGTGCTG
TCTGGTACGAAAGCCACTGGACCACACGCTTATCTTGGTCGTTACCACCTACAGGTCTCTGTTCTTCGTGAAGGACGTGA
TAAAGAACTGTTTGGTTGGGCGATGCCGGGTAAGAACAAGTTCTCTGTGACTCGCTCTTTCCTTGGTCACCTATTCAAGG
GCCAAGTGTACAACATGACCACAACCACTAATGGTAGTGATCGATCTATGGTTCCAATCGGTAACTATGAGAAGGTCATG
CCACTAGATATGGAGCCAACCTTGTTGCTTCGTGATCTGTGTGCTGGTGACAGTGACAGCGCGGTTCGCTTAGGTGCTTT
AGAGCTGGATGAAGAAGATCTAGCACTGTGTACGTTCGTTTGCCCAGGCAAATACGAGTACGGTCAGCTCCTGCGTGAGT
GCTTAGACAAGATCGAGAAAGAAGGGTAA

Upstream 100 bases:

>100_bases
CCATTAAAAACGGACACAAACAATGTCGTGTCTACCGAGGTAAGGATTCCGCTAGCGTTGTTCAGTTGTAAGGACAAGGC
AAACGGAGTGCGCCTCGAAT

Downstream 100 bases:

>100_bases
TTTCCATGGGCCTTAAAAAGTTTCTTGAAGACATCGAGCATCATTTTGAGCCAGGCGGCAAACACGAGAAGTGGTTTGCC
CTGTATGAAGCAGCGGCGAC

Product: Na(+)-translocating NADH-quinone reductase subunit A

Products: NA

Alternate protein names: Na(+)-NQR subunit A; Na(+)-translocating NQR subunit A; NQR complex subunit A; NQR-1 subunit A [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MRNERIFFPIKVVQVRMITIKKGLDLPIAGTPSQVISDGKAIKKVALLGEEYVGMRPTMHVRVGDEVKKAQILFEDKKNP
GVKFTSPVSGKVVEINRGAKRVLQSVVIEVAGDDQVTFDKFEANQLASLNRDAIKTQLVESGLWTAFRTRPFSKVPAIDS
TSEAIFVTAMDTNPLAAEPTVVINEQSEAFVAGLDVLSALTTGKVYVCKKGTSLPRSQQPNVEEHVFDGPHPAGLAGTHM
HFLYPVSADHVAWSINYQDVIAVGQLFLTGELYTQRVVSLAGPVVNKPRLVRTVMGASLEQLVDSEIMPGEVRIISGSVL
SGTKATGPHAYLGRYHLQVSVLREGRDKELFGWAMPGKNKFSVTRSFLGHLFKGQVYNMTTTTNGSDRSMVPIGNYEKVM
PLDMEPTLLLRDLCAGDSDSAVRLGALELDEEDLALCTFVCPGKYEYGQLLRECLDKIEKEG

Sequences:

>Translated_462_residues
MRNERIFFPIKVVQVRMITIKKGLDLPIAGTPSQVISDGKAIKKVALLGEEYVGMRPTMHVRVGDEVKKAQILFEDKKNP
GVKFTSPVSGKVVEINRGAKRVLQSVVIEVAGDDQVTFDKFEANQLASLNRDAIKTQLVESGLWTAFRTRPFSKVPAIDS
TSEAIFVTAMDTNPLAAEPTVVINEQSEAFVAGLDVLSALTTGKVYVCKKGTSLPRSQQPNVEEHVFDGPHPAGLAGTHM
HFLYPVSADHVAWSINYQDVIAVGQLFLTGELYTQRVVSLAGPVVNKPRLVRTVMGASLEQLVDSEIMPGEVRIISGSVL
SGTKATGPHAYLGRYHLQVSVLREGRDKELFGWAMPGKNKFSVTRSFLGHLFKGQVYNMTTTTNGSDRSMVPIGNYEKVM
PLDMEPTLLLRDLCAGDSDSAVRLGALELDEEDLALCTFVCPGKYEYGQLLRECLDKIEKEG
>Mature_462_residues
MRNERIFFPIKVVQVRMITIKKGLDLPIAGTPSQVISDGKAIKKVALLGEEYVGMRPTMHVRVGDEVKKAQILFEDKKNP
GVKFTSPVSGKVVEINRGAKRVLQSVVIEVAGDDQVTFDKFEANQLASLNRDAIKTQLVESGLWTAFRTRPFSKVPAIDS
TSEAIFVTAMDTNPLAAEPTVVINEQSEAFVAGLDVLSALTTGKVYVCKKGTSLPRSQQPNVEEHVFDGPHPAGLAGTHM
HFLYPVSADHVAWSINYQDVIAVGQLFLTGELYTQRVVSLAGPVVNKPRLVRTVMGASLEQLVDSEIMPGEVRIISGSVL
SGTKATGPHAYLGRYHLQVSVLREGRDKELFGWAMPGKNKFSVTRSFLGHLFKGQVYNMTTTTNGSDRSMVPIGNYEKVM
PLDMEPTLLLRDLCAGDSDSAVRLGALELDEEDLALCTFVCPGKYEYGQLLRECLDKIEKEG

Specific function: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to nqrE are probably involved in the second step, the conversion of ubisemiqui

COG id: COG1726

COG function: function code C; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nqrA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008703
- InterPro:   IPR022615 [H]

Pfam domain/function: PF05896 NQRA; PF11973 NQRA_SLBB [H]

EC number: NA

Molecular weight: Translated: 50639; Mature: 50639

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNERIFFPIKVVQVRMITIKKGLDLPIAGTPSQVISDGKAIKKVALLGEEYVGMRPTMH
CCCCEEEEEEEEEEEEEEEEECCCCCCCCCCCHHHHCCCHHHHHHHHHCHHHCCCCCEEE
VRVGDEVKKAQILFEDKKNPGVKFTSPVSGKVVEINRGAKRVLQSVVIEVAGDDQVTFDK
EEECCCCCEEEEEEECCCCCCCEEECCCCCEEEEECCHHHHHHHHHHEEECCCCCEEEEH
FEANQLASLNRDAIKTQLVESGLWTAFRTRPFSKVPAIDSTSEAIFVTAMDTNPLAAEPT
HCCHHHHHCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCE
VVINEQSEAFVAGLDVLSALTTGKVYVCKKGTSLPRSQQPNVEEHVFDGPHPAGLAGTHM
EEEECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCCE
HFLYPVSADHVAWSINYQDVIAVGQLFLTGELYTQRVVSLAGPVVNKPRLVRTVMGASLE
EEEEEECCCCEEEEECHHHHHHHHHHEEEHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHH
QLVDSEIMPGEVRIISGSVLSGTKATGPHAYLGRYHLQVSVLREGRDKELFGWAMPGKNK
HHHCCCCCCCEEEEEECCEECCCCCCCCCHHHEEEEEEEEEECCCCCCCEEEEECCCCCH
FSVTRSFLGHLFKGQVYNMTTTTNGSDRSMVPIGNYEKVMPLDMEPTLLLRDLCAGDSDS
HHHHHHHHHHHHCCEEEEEEEECCCCCCEEEECCCCCEEEECCCCHHHHHHHHHCCCCCC
AVRLGALELDEEDLALCTFVCPGKYEYGQLLRECLDKIEKEG
EEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRNERIFFPIKVVQVRMITIKKGLDLPIAGTPSQVISDGKAIKKVALLGEEYVGMRPTMH
CCCCEEEEEEEEEEEEEEEEECCCCCCCCCCCHHHHCCCHHHHHHHHHCHHHCCCCCEEE
VRVGDEVKKAQILFEDKKNPGVKFTSPVSGKVVEINRGAKRVLQSVVIEVAGDDQVTFDK
EEECCCCCEEEEEEECCCCCCCEEECCCCCEEEEECCHHHHHHHHHHEEECCCCCEEEEH
FEANQLASLNRDAIKTQLVESGLWTAFRTRPFSKVPAIDSTSEAIFVTAMDTNPLAAEPT
HCCHHHHHCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCE
VVINEQSEAFVAGLDVLSALTTGKVYVCKKGTSLPRSQQPNVEEHVFDGPHPAGLAGTHM
EEEECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCCE
HFLYPVSADHVAWSINYQDVIAVGQLFLTGELYTQRVVSLAGPVVNKPRLVRTVMGASLE
EEEEEECCCCEEEEECHHHHHHHHHHEEEHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHH
QLVDSEIMPGEVRIISGSVLSGTKATGPHAYLGRYHLQVSVLREGRDKELFGWAMPGKNK
HHHCCCCCCCEEEEEECCEECCCCCCCCCHHHEEEEEEEEEECCCCCCCEEEEECCCCCH
FSVTRSFLGHLFKGQVYNMTTTTNGSDRSMVPIGNYEKVMPLDMEPTLLLRDLCAGDSDS
HHHHHHHHHHHHCCEEEEEEEECCCCCCEEEECCCCCEEEECCCCHHHHHHHHHCCCCCC
AVRLGALELDEEDLALCTFVCPGKYEYGQLLRECLDKIEKEG
EEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10077658; 10952301 [H]