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The map label for this gene is dsdC [H]

Identifier: 147673540

GI number: 147673540

Start: 334446

End: 335378

Strand: Direct

Name: dsdC [H]

Synonym: VC0395_A0314

Alternate gene names: 147673540

Gene position: 334446-335378 (Clockwise)

Preceding gene: 147673392

Following gene: 147674137

Centisome position: 11.06

GC content: 51.02

Gene sequence:

>933_bases
ATGTTAAAAAGCCAGCAAGTTGCCAGTCTGCATACTTTTATGCAGGTAGCTCAATACACCAGCTTTAGTTTAGCTGCTGC
GGCTCTCCATCTCACCACGGGGGCGATCAGCCAACAAATGTTGCAGTTAGAAGCGCAGTTGGGTTTTAGCTTATTTGAAC
GGCACTCTCGCGGGGTACGTTTAACTGAGGCAGGACGAATCTTACTGACAACGGTGCAACGTAGCTATCAAGATATTGAG
CAGACAATTCACAGTTTAGTGCCATCAACGGAGCGAAAAGAGATCCGGCTGAAACTGACGCCATCATTTGCGTTTAAATG
GTTGGTTCCGCGGCTAGAGGACTTTTATCGCCGTCATCCTGAGATTCAGATTCAGACGTTCGCGGAAGGCGCGTTGGTCG
ATAGTGAGCGGCGTGATTACGATCTGGCGATTGATTATGGCGCGTTACCTTATCCACGGCGAGATGCGCAGTTATTGATG
GAGGAGTGGTTATTGCCCGTGATGAGCACGAACTATCTCGCAGCCCATTCTTGGTTACAGGAGGATTGGGCTAACTCCGA
AGCTTGGCAGCAAGTGGTTTTATTGCATGATGCAATGCCGTGGGCGAATGCGGCACGCGACCAAGAGTGGCACTACTGGG
CTCACCAGATGGGAATTACCTTGCCTGAGCGGCGTGATCACTACTTCAACCGCACGGATATGGCGATGTCAGCTGCAGAG
GCCGGAGTGGGGATTGCAATGGCGCGTACTGCCTTACTTTCAAACGAACTCGATACAGGGCGTTTGGTTACCCCGTTTGC
TCCCATTCGAGCCAAGGCTGGCTACTTTTTGATTACTCACCAAGCCACTGACGCGACGCAAGTTTTTTGCCAGTGGTTGC
AAAAGCAAATTCCGGTGCAGGTTAGCCAAACCGATCGCGATTCTACGCTATAG

Upstream 100 bases:

>100_bases
TGACTCCTTGCTTCATTTTCGGCTCAGTTTCGGAGGTTTACTTTTCATTAACAATCGATAAAAATTATCACCACCCTTTA
GTAAAACTAAAAGCAAGTCC

Downstream 100 bases:

>100_bases
GGGCGGTGTATTTTGCACTCTCGTTCGAAGAAATCGACCTTATTGTGCAAATTCGACTGCTGATATTGTGTTTAGTGTAG
CGCTATGCTGACCTCGTCCT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: D-serine deaminase activator [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MLKSQQVASLHTFMQVAQYTSFSLAAAALHLTTGAISQQMLQLEAQLGFSLFERHSRGVRLTEAGRILLTTVQRSYQDIE
QTIHSLVPSTERKEIRLKLTPSFAFKWLVPRLEDFYRRHPEIQIQTFAEGALVDSERRDYDLAIDYGALPYPRRDAQLLM
EEWLLPVMSTNYLAAHSWLQEDWANSEAWQQVVLLHDAMPWANAARDQEWHYWAHQMGITLPERRDHYFNRTDMAMSAAE
AGVGIAMARTALLSNELDTGRLVTPFAPIRAKAGYFLITHQATDATQVFCQWLQKQIPVQVSQTDRDSTL

Sequences:

>Translated_310_residues
MLKSQQVASLHTFMQVAQYTSFSLAAAALHLTTGAISQQMLQLEAQLGFSLFERHSRGVRLTEAGRILLTTVQRSYQDIE
QTIHSLVPSTERKEIRLKLTPSFAFKWLVPRLEDFYRRHPEIQIQTFAEGALVDSERRDYDLAIDYGALPYPRRDAQLLM
EEWLLPVMSTNYLAAHSWLQEDWANSEAWQQVVLLHDAMPWANAARDQEWHYWAHQMGITLPERRDHYFNRTDMAMSAAE
AGVGIAMARTALLSNELDTGRLVTPFAPIRAKAGYFLITHQATDATQVFCQWLQKQIPVQVSQTDRDSTL
>Mature_310_residues
MLKSQQVASLHTFMQVAQYTSFSLAAAALHLTTGAISQQMLQLEAQLGFSLFERHSRGVRLTEAGRILLTTVQRSYQDIE
QTIHSLVPSTERKEIRLKLTPSFAFKWLVPRLEDFYRRHPEIQIQTFAEGALVDSERRDYDLAIDYGALPYPRRDAQLLM
EEWLLPVMSTNYLAAHSWLQEDWANSEAWQQVVLLHDAMPWANAARDQEWHYWAHQMGITLPERRDHYFNRTDMAMSAAE
AGVGIAMARTALLSNELDTGRLVTPFAPIRAKAGYFLITHQATDATQVFCQWLQKQIPVQVSQTDRDSTL

Specific function: Regulates the expression of the dsd operon for D-serine deaminase (dsdA) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788706, Length=301, Percent_Identity=33.5548172757475, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789173, Length=292, Percent_Identity=31.1643835616438, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786448, Length=295, Percent_Identity=31.864406779661, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI157672245, Length=211, Percent_Identity=33.175355450237, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI145693193, Length=299, Percent_Identity=25.4180602006689, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787589, Length=149, Percent_Identity=32.8859060402685, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790262, Length=151, Percent_Identity=32.4503311258278, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786401, Length=261, Percent_Identity=23.3716475095785, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011781
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35551; Mature: 35551

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSQQVASLHTFMQVAQYTSFSLAAAALHLTTGAISQQMLQLEAQLGFSLFERHSRGVR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
LTEAGRILLTTVQRSYQDIEQTIHSLVPSTERKEIRLKLTPSFAFKWLVPRLEDFYRRHP
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCC
EIQIQTFAEGALVDSERRDYDLAIDYGALPYPRRDAQLLMEEWLLPVMSTNYLAAHSWLQ
CEEEEEECCCCEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
EDWANSEAWQQVVLLHDAMPWANAARDQEWHYWAHQMGITLPERRDHYFNRTDMAMSAAE
HHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHH
AGVGIAMARTALLSNELDTGRLVTPFAPIRAKAGYFLITHQATDATQVFCQWLQKQIPVQ
CCCHHHHHHHHHHHCCCCCCCEECCCCCHHCCCCEEEEEECCCHHHHHHHHHHHHHCCEE
VSQTDRDSTL
EECCCCCCCC
>Mature Secondary Structure
MLKSQQVASLHTFMQVAQYTSFSLAAAALHLTTGAISQQMLQLEAQLGFSLFERHSRGVR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
LTEAGRILLTTVQRSYQDIEQTIHSLVPSTERKEIRLKLTPSFAFKWLVPRLEDFYRRHP
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCC
EIQIQTFAEGALVDSERRDYDLAIDYGALPYPRRDAQLLMEEWLLPVMSTNYLAAHSWLQ
CEEEEEECCCCEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
EDWANSEAWQQVVLLHDAMPWANAARDQEWHYWAHQMGITLPERRDHYFNRTDMAMSAAE
HHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHH
AGVGIAMARTALLSNELDTGRLVTPFAPIRAKAGYFLITHQATDATQVFCQWLQKQIPVQ
CCCHHHHHHHHHHHCCCCCCCEECCCCCHHCCCCEEEEEECCCHHHHHHHHHHHHHCCEE
VSQTDRDSTL
EECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592420; 9205837; 9278503 [H]