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The map label for this gene is cya1 [H]

Identifier: 146343845

GI number: 146343845

Start: 7407684

End: 7409777

Strand: Reverse

Name: cya1 [H]

Synonym: BRADO7095

Alternate gene names: 146343845

Gene position: 7409777-7407684 (Counterclockwise)

Preceding gene: 146343850

Following gene: 146343843

Centisome position: 99.37

GC content: 69.29

Gene sequence:

>2094_bases
GTGACGGCGACCCCAGGCTCATCGCCCACCCCCGCGCAGCGCTCCGAGCAGCTGACGGTCAGCATCCGCTTCGCGGTGTC
CGCGCTCGTCCTGGCCGCGATCCTGCTCACGGCCTTTGGCTCCAGCCTGCTGTGGTGGCGGACGTCGGAGGCGATCAGCC
GGCAGCTCGCCAGCACCATCAACAGCCAGATTGCCGGAGCGGTGCGCAAGGAGGTGACGGCGATCGTCGGCGAGGCGCAA
GCCGCGCACACCGCGATCCGCACCCTGTTTCTGCAGAACGTGCTCGACACCCGCGAGGCCGACAAGCGCGAGTTCGTGTT
CCTGTCGCAGCTGCAGTCGCAGGCGACGATCTCGTGGGCGGCGTTCGGCTGGCCGGACGGCTCGTTCTTCGCCGCGCACA
AGCTCGGCGATCAGCGCCTCGAAATGATGGAGATCTCGCTGACCGATCATCCGGGCCAGCGCCGTGTCGACGCGTATGAC
GTCGTGCCCGGCGACATCGAATTTACCTCGCGCCGGTTCGAGCCGACCAGCTTCAAGGTCGCCGATCAGCCCTGGTTCAA
GCAGGGTCTCGCCGCCGACGAGCCGCGCTGGTTCAGCGTCGATCAGCATCCGGTGGGACGACGTCCCGCGATCGCGCTGG
CAGGGCCGATCGATGTCTACCAGGAGCGGCAGGGCGTGCTCGCCATCATCGTCGAGCATGCGCGGATCGCACGCTTTCTC
GCCCAGCTGCAGGTCGGCCAGACCGGCAGCGCCTTCATCCTGGAACGTGATGGCGCGGTGGTGGCCGCGCCCGATGCCGA
TGCGGACGAGGAACATGCCGGACGAGACCGTCAGCCGCTGCTGCCGGTCGCACAGCAGGCGATGCGCTCCGCGGTCGAGG
GTGACGAGGCCTGGCGAGGCCGGGTGCAATCGGGTGACGGCGCGTTCGAGGTCGCGCGTACGCCGCTGCCGTTCCCGGGC
TGGTCGCTCGTCACGGTGATTCCGGAAGCCGAATTTCTCGGCCCGGTCGATGCCGCGCTGCGACGGGTGATCATCGGCCT
CGGTATCGGCGCGGTGCTCGCCGCGCTCGCCTCCGCCGCGCTGGCGCGCGCGGTGATCGCGGCGCCGCTCGGCCGCGTCG
TCGCCGAGCTGCGCCATGTCGAGGCGTTCGCGCTCGCGCAAGTCCGCCGCCATCCCTCGCGGCTGCGCGAGATCGCGAGC
CTGTCCGGGGCCATCGCCGAGATGGCCGGCGGGCTGTCGTCGTTCGGCAAGTTCATTCCGGCTGATCTCGTCCGGCAATT
GCTGCGCCAAGGCGTCGACGCCAGGCCCGGCGGTCACCTCCAGGAGCTCAGCGTGATGTTCATCGACATCGCCGGCTTTA
CCGGCCTGTCGGAGCGGATGGGCGATCGCGTCGTGCCGCTGCTGTCACGCTATCTCGATCTGATCTCGACCGTCATCGTC
GATCATGGCGGCACGATCGACAAGTTCATCGGCGATGCGGTGATGGCGTTCTGGGGCGCGCCCGCGGCGCAGCCGGATCA
TGCCGTGCTGTGCTGCCGCGCCGCGCTGGCCTGCCGGGCGGCGGTCGAGGGCAGCGACCTCCGCGACGAGGATGGGCAGC
CGCTGCGCATCCGCATCGGTATCAATTCCGGCCGCATGCTGGTCGGCAATATCGGCTCCGAGCTGCGGCTCAACTACACC
GTGATCGGCGATGCCGTGAACGTGGCGAGCCGGCTGGAAGGCGCCAACAAGACCTATGGCACGACGATCCTGATCGGTGA
GGCCACGGCGCGGCTTTCCGGCGATGCGTTCGTGGCTCGCGAGATCGACCGCATCGCCGTCTACGGCCGCGAGGAAGGCC
TGGCGGTGCACGAGCTCGTCGGGCTGGCCGAGGACGTTGGCGCGCAGCAGCGGAGCTGGATCGCGCATTATGCCCGCGGG
CTTCGCGACTATCGCGCGCGCGATTTCGAGGCTGCCATCGTCGCCTTCGAAGCCGTGGTGGCGCTCAAGCCCGGCGATCG
CGCCGCCGAGGTCATGATCGCGCGCTGCCGGACATGGGCCGAGACGCAGCCGGATCAGCATTGGCGCGCCGTCACCGCGC
TGACGAGCAAATAG

Upstream 100 bases:

>100_bases
GGGCAATGCTGATAGCTCGTTGTTGCCGCGAGCGAACCGCGCGACGGATCGGCCGATCATATGCCCGGCGCGGCCGTCCG
GTGGGAGGGACAGACCTGCA

Downstream 100 bases:

>100_bases
AGCGTGCGGCGATCAGGCCGATTTGAGCTTGCCGCGCAGCGGCCGCCGTCCGGCGAATACGGCGGCGAGATCCTGGGTCG
GCGCGGCCTCGTCCTCGTCG

Product: putative adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1 [H]

Number of amino acids: Translated: 697; Mature: 696

Protein sequence:

>697_residues
MTATPGSSPTPAQRSEQLTVSIRFAVSALVLAAILLTAFGSSLLWWRTSEAISRQLASTINSQIAGAVRKEVTAIVGEAQ
AAHTAIRTLFLQNVLDTREADKREFVFLSQLQSQATISWAAFGWPDGSFFAAHKLGDQRLEMMEISLTDHPGQRRVDAYD
VVPGDIEFTSRRFEPTSFKVADQPWFKQGLAADEPRWFSVDQHPVGRRPAIALAGPIDVYQERQGVLAIIVEHARIARFL
AQLQVGQTGSAFILERDGAVVAAPDADADEEHAGRDRQPLLPVAQQAMRSAVEGDEAWRGRVQSGDGAFEVARTPLPFPG
WSLVTVIPEAEFLGPVDAALRRVIIGLGIGAVLAALASAALARAVIAAPLGRVVAELRHVEAFALAQVRRHPSRLREIAS
LSGAIAEMAGGLSSFGKFIPADLVRQLLRQGVDARPGGHLQELSVMFIDIAGFTGLSERMGDRVVPLLSRYLDLISTVIV
DHGGTIDKFIGDAVMAFWGAPAAQPDHAVLCCRAALACRAAVEGSDLRDEDGQPLRIRIGINSGRMLVGNIGSELRLNYT
VIGDAVNVASRLEGANKTYGTTILIGEATARLSGDAFVAREIDRIAVYGREEGLAVHELVGLAEDVGAQQRSWIAHYARG
LRDYRARDFEAAIVAFEAVVALKPGDRAAEVMIARCRTWAETQPDQHWRAVTALTSK

Sequences:

>Translated_697_residues
MTATPGSSPTPAQRSEQLTVSIRFAVSALVLAAILLTAFGSSLLWWRTSEAISRQLASTINSQIAGAVRKEVTAIVGEAQ
AAHTAIRTLFLQNVLDTREADKREFVFLSQLQSQATISWAAFGWPDGSFFAAHKLGDQRLEMMEISLTDHPGQRRVDAYD
VVPGDIEFTSRRFEPTSFKVADQPWFKQGLAADEPRWFSVDQHPVGRRPAIALAGPIDVYQERQGVLAIIVEHARIARFL
AQLQVGQTGSAFILERDGAVVAAPDADADEEHAGRDRQPLLPVAQQAMRSAVEGDEAWRGRVQSGDGAFEVARTPLPFPG
WSLVTVIPEAEFLGPVDAALRRVIIGLGIGAVLAALASAALARAVIAAPLGRVVAELRHVEAFALAQVRRHPSRLREIAS
LSGAIAEMAGGLSSFGKFIPADLVRQLLRQGVDARPGGHLQELSVMFIDIAGFTGLSERMGDRVVPLLSRYLDLISTVIV
DHGGTIDKFIGDAVMAFWGAPAAQPDHAVLCCRAALACRAAVEGSDLRDEDGQPLRIRIGINSGRMLVGNIGSELRLNYT
VIGDAVNVASRLEGANKTYGTTILIGEATARLSGDAFVAREIDRIAVYGREEGLAVHELVGLAEDVGAQQRSWIAHYARG
LRDYRARDFEAAIVAFEAVVALKPGDRAAEVMIARCRTWAETQPDQHWRAVTALTSK
>Mature_696_residues
TATPGSSPTPAQRSEQLTVSIRFAVSALVLAAILLTAFGSSLLWWRTSEAISRQLASTINSQIAGAVRKEVTAIVGEAQA
AHTAIRTLFLQNVLDTREADKREFVFLSQLQSQATISWAAFGWPDGSFFAAHKLGDQRLEMMEISLTDHPGQRRVDAYDV
VPGDIEFTSRRFEPTSFKVADQPWFKQGLAADEPRWFSVDQHPVGRRPAIALAGPIDVYQERQGVLAIIVEHARIARFLA
QLQVGQTGSAFILERDGAVVAAPDADADEEHAGRDRQPLLPVAQQAMRSAVEGDEAWRGRVQSGDGAFEVARTPLPFPGW
SLVTVIPEAEFLGPVDAALRRVIIGLGIGAVLAALASAALARAVIAAPLGRVVAELRHVEAFALAQVRRHPSRLREIASL
SGAIAEMAGGLSSFGKFIPADLVRQLLRQGVDARPGGHLQELSVMFIDIAGFTGLSERMGDRVVPLLSRYLDLISTVIVD
HGGTIDKFIGDAVMAFWGAPAAQPDHAVLCCRAALACRAAVEGSDLRDEDGQPLRIRIGINSGRMLVGNIGSELRLNYTV
IGDAVNVASRLEGANKTYGTTILIGEATARLSGDAFVAREIDRIAVYGREEGLAVHELVGLAEDVGAQQRSWIAHYARGL
RDYRARDFEAAIVAFEAVVALKPGDRAAEVMIARCRTWAETQPDQHWRAVTALTSK

Specific function: Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP [H]

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

Organism=Homo sapiens, GI24497587, Length=156, Percent_Identity=32.6923076923077, Blast_Score=68, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71989805, Length=166, Percent_Identity=30.1204819277108, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71989822, Length=166, Percent_Identity=30.1204819277108, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508769, Length=139, Percent_Identity=30.9352517985612, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17534659, Length=161, Percent_Identity=31.6770186335404, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI62484298, Length=282, Percent_Identity=29.0780141843972, Blast_Score=78, Evalue=3e-14,
Organism=Drosophila melanogaster, GI62484477, Length=230, Percent_Identity=29.5652173913043, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI116008008, Length=170, Percent_Identity=32.9411764705882, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI62473752, Length=167, Percent_Identity=26.9461077844311, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137448, Length=167, Percent_Identity=26.9461077844311, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 75232; Mature: 75100

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS50125 GUANYLATE_CYCLASES_2 ; PS00398 RECOMBINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATPGSSPTPAQRSEQLTVSIRFAVSALVLAAILLTAFGSSLLWWRTSEAISRQLASTI
CCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHH
NSQIAGAVRKEVTAIVGEAQAAHTAIRTLFLQNVLDTREADKREFVFLSQLQSQATISWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEE
AFGWPDGSFFAAHKLGDQRLEMMEISLTDHPGQRRVDAYDVVPGDIEFTSRRFEPTSFKV
EECCCCCCEEHHHHCCHHHHHEEEEEECCCCCCCCCCEEECCCCCCHHCCCCCCCCCEEE
ADQPWFKQGLAADEPRWFSVDQHPVGRRPAIALAGPIDVYQERQGVLAIIVEHARIARFL
CCCCHHHCCCCCCCCCEEECCCCCCCCCCCEEEECCHHHHHHCCCCEEHHHHHHHHHHHH
AQLQVGQTGSAFILERDGAVVAAPDADADEEHAGRDRQPLLPVAQQAMRSAVEGDEAWRG
HHHHCCCCCCEEEEECCCCEEECCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCHHHCC
RVQSGDGAFEVARTPLPFPGWSLVTVIPEAEFLGPVDAALRRVIIGLGIGAVLAALASAA
CCCCCCCCEEEECCCCCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHH
LARAVIAAPLGRVVAELRHVEAFALAQVRRHPSRLREIASLSGAIAEMAGGLSSFGKFIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHCCH
ADLVRQLLRQGVDARPGGHLQELSVMFIDIAGFTGLSERMGDRVVPLLSRYLDLISTVIV
HHHHHHHHHCCCCCCCCCCHHHHHEEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHH
DHGGTIDKFIGDAVMAFWGAPAAQPDHAVLCCRAALACRAAVEGSDLRDEDGQPLRIRIG
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEE
INSGRMLVGNIGSELRLNYTVIGDAVNVASRLEGANKTYGTTILIGEATARLSGDAFVAR
CCCCCEEEECCCCCEEEEEEEECHHHHHHHHHCCCCCCCCCEEEEECCHHHCCCCHHHHH
EIDRIAVYGREEGLAVHELVGLAEDVGAQQRSWIAHYARGLRDYRARDFEAAIVAFEAVV
HHHHHEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHE
ALKPGDRAAEVMIARCRTWAETQPDQHWRAVTALTSK
EECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TATPGSSPTPAQRSEQLTVSIRFAVSALVLAAILLTAFGSSLLWWRTSEAISRQLASTI
CCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHH
NSQIAGAVRKEVTAIVGEAQAAHTAIRTLFLQNVLDTREADKREFVFLSQLQSQATISWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEE
AFGWPDGSFFAAHKLGDQRLEMMEISLTDHPGQRRVDAYDVVPGDIEFTSRRFEPTSFKV
EECCCCCCEEHHHHCCHHHHHEEEEEECCCCCCCCCCEEECCCCCCHHCCCCCCCCCEEE
ADQPWFKQGLAADEPRWFSVDQHPVGRRPAIALAGPIDVYQERQGVLAIIVEHARIARFL
CCCCHHHCCCCCCCCCEEECCCCCCCCCCCEEEECCHHHHHHCCCCEEHHHHHHHHHHHH
AQLQVGQTGSAFILERDGAVVAAPDADADEEHAGRDRQPLLPVAQQAMRSAVEGDEAWRG
HHHHCCCCCCEEEEECCCCEEECCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCHHHCC
RVQSGDGAFEVARTPLPFPGWSLVTVIPEAEFLGPVDAALRRVIIGLGIGAVLAALASAA
CCCCCCCCEEEECCCCCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHH
LARAVIAAPLGRVVAELRHVEAFALAQVRRHPSRLREIASLSGAIAEMAGGLSSFGKFIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHCCH
ADLVRQLLRQGVDARPGGHLQELSVMFIDIAGFTGLSERMGDRVVPLLSRYLDLISTVIV
HHHHHHHHHCCCCCCCCCCHHHHHEEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHH
DHGGTIDKFIGDAVMAFWGAPAAQPDHAVLCCRAALACRAAVEGSDLRDEDGQPLRIRIG
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEE
INSGRMLVGNIGSELRLNYTVIGDAVNVASRLEGANKTYGTTILIGEATARLSGDAFVAR
CCCCCEEEECCCCCEEEEEEEECHHHHHHHHHCCCCCCCCCEEEEECCHHHCCCCHHHHH
EIDRIAVYGREEGLAVHELVGLAEDVGAQQRSWIAHYARGLRDYRARDFEAAIVAFEAVV
HHHHHEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHE
ALKPGDRAAEVMIARCRTWAETQPDQHWRAVTALTSK
EECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 1970565 [H]