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The map label for this gene is algD [H]

Identifier: 146343798

GI number: 146343798

Start: 7358495

End: 7359805

Strand: Direct

Name: algD [H]

Synonym: BRADO7047

Alternate gene names: 146343798

Gene position: 7358495-7359805 (Clockwise)

Preceding gene: 146343797

Following gene: 146343799

Centisome position: 98.68

GC content: 61.1

Gene sequence:

>1311_bases
ATGAATATCAGTATCTTCGGCCTGGGCTATGTTGGAACCGTCTGTGCGGCCTGTCTGGCCGAGCTCGGACACCACATCAT
CGGCGTCGACAAGGCAGGTGCCAAGGTTGAACTGATCCAGGCAGGCCAGTCCCCGGTCATCGAACCCGGAATCTCCGAAA
AGGTCGCGGCAGCCGTGGCTGCCGGCCGCCTGACCGCTTCGACCGATGCAACGGCGGCAATCGCTGCCACCGACATCTCG
ATGATCTGCGTCGGAACCCCTTCCGCGGCTTCGGGAGACCTCGACCTGACCGCCATTCGTCAAGTCGCAGCCGAAATCGG
CCACGGCCTCAGAGAGAAGCCCACGTCCCATCTCGTGGTCATCCGATCGACGGTCCTGCCAGGGACGTCCCAAAGGATTG
TCGTTCCTCTGATCGAGGAGGCCTCGGGAAAGAAGGCCGGGACCGATTTTGAGATCAGCTTCAATCCGGAGTTCCTCCGG
GAGGGATGCGCAATCGCGGACTTCAACTCCCCGTCCAAGACGGTTGTCGGCGCTGACCGCAGCGAGACGGCCGCACGCAT
TCTCTCGCTCTATGAGCAGCTCCCCGGCGCCAAGATCGCGGCCTCGATCGAAACTGCCGAACTCGCGAAGTACATCGATA
ATACCTGGCATGCGCTCAAGGTCGCATTTGCCAACGAGGTCGGCGTGATCGCCAAGACGTTGGATATCGATAGCCGCGAG
GTCATCGACATTTTCCTGCAGGATACCCGCCTGAATATATCAGCCGCCTATCTTCGACCAGGCTTCGCCTTCGGCGGCTC
GTGTCTCCCCAAGGATATCAAGGCGCTCAAGCACCTCGCTGGTCGTCATGGACTGAGCGTCCCGGTCATCGAGAACGTCC
TGCCGAGCAACGACATGGTGATGTCGCGTGGTGTCGATTGGATTCTGGCTCAGCCGGGCCGAAAGGTGGCGTTTCTCGGC
ATCAGCTTCAAGGCCGGCACCGACGATGTTCGCGAAAGCCCGTTCGTTCTTTTGGTCAACGGGCTGCTGAGCCGAGACCG
CGAGGTCCGCGTCTACGATCCCAATGTGCGCCTGTCCCAACTGATCGGTGCCAACAGGGACTTCCTCATGCGCAACCGGC
AGATCGCCGATATTCTCGTCGATGATGTCGCTGAGACGATCGACTGGGCCGACATCATCGTGCTGACCACCAATGATCCG
CGCTTCATCGATGCCCTGCGCAGCACACGCGCCGACCAGACCGTCCTCGAACTGACGGAGGCCCGGCTGCCGGCGGATGT
CCAGGCGACCGTGAAAGGCTTCCACTGGTGA

Upstream 100 bases:

>100_bases
GAATGATTTCCACCGATTCGTTGGGCCTGTGCTATCAGCGATCCCAAGACTTTTTCCCTTGCCGCCGGACGGTTCGTCCG
AAGGCTACGAAACCATAACG

Downstream 100 bases:

>100_bases
ACATGCGGGGCCCGAACGACGAGATGCGTCGTCGGCCGGCGATCGATTTCCACGACAATATTGCCGCCAACTGGGAGACG
CTGCACCGGAGCCGGACGTT

Product: GDP-mannose 6-dehydrogenase

Products: NA

Alternate protein names: GMD [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNISIFGLGYVGTVCAACLAELGHHIIGVDKAGAKVELIQAGQSPVIEPGISEKVAAAVAAGRLTASTDATAAIAATDIS
MICVGTPSAASGDLDLTAIRQVAAEIGHGLREKPTSHLVVIRSTVLPGTSQRIVVPLIEEASGKKAGTDFEISFNPEFLR
EGCAIADFNSPSKTVVGADRSETAARILSLYEQLPGAKIAASIETAELAKYIDNTWHALKVAFANEVGVIAKTLDIDSRE
VIDIFLQDTRLNISAAYLRPGFAFGGSCLPKDIKALKHLAGRHGLSVPVIENVLPSNDMVMSRGVDWILAQPGRKVAFLG
ISFKAGTDDVRESPFVLLVNGLLSRDREVRVYDPNVRLSQLIGANRDFLMRNRQIADILVDDVAETIDWADIIVLTTNDP
RFIDALRSTRADQTVLELTEARLPADVQATVKGFHW

Sequences:

>Translated_436_residues
MNISIFGLGYVGTVCAACLAELGHHIIGVDKAGAKVELIQAGQSPVIEPGISEKVAAAVAAGRLTASTDATAAIAATDIS
MICVGTPSAASGDLDLTAIRQVAAEIGHGLREKPTSHLVVIRSTVLPGTSQRIVVPLIEEASGKKAGTDFEISFNPEFLR
EGCAIADFNSPSKTVVGADRSETAARILSLYEQLPGAKIAASIETAELAKYIDNTWHALKVAFANEVGVIAKTLDIDSRE
VIDIFLQDTRLNISAAYLRPGFAFGGSCLPKDIKALKHLAGRHGLSVPVIENVLPSNDMVMSRGVDWILAQPGRKVAFLG
ISFKAGTDDVRESPFVLLVNGLLSRDREVRVYDPNVRLSQLIGANRDFLMRNRQIADILVDDVAETIDWADIIVLTTNDP
RFIDALRSTRADQTVLELTEARLPADVQATVKGFHW
>Mature_436_residues
MNISIFGLGYVGTVCAACLAELGHHIIGVDKAGAKVELIQAGQSPVIEPGISEKVAAAVAAGRLTASTDATAAIAATDIS
MICVGTPSAASGDLDLTAIRQVAAEIGHGLREKPTSHLVVIRSTVLPGTSQRIVVPLIEEASGKKAGTDFEISFNPEFLR
EGCAIADFNSPSKTVVGADRSETAARILSLYEQLPGAKIAASIETAELAKYIDNTWHALKVAFANEVGVIAKTLDIDSRE
VIDIFLQDTRLNISAAYLRPGFAFGGSCLPKDIKALKHLAGRHGLSVPVIENVLPSNDMVMSRGVDWILAQPGRKVAFLG
ISFKAGTDDVRESPFVLLVNGLLSRDREVRVYDPNVRLSQLIGANRDFLMRNRQIADILVDDVAETIDWADIIVLTTNDP
RFIDALRSTRADQTVLELTEARLPADVQATVKGFHW

Specific function: Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and ant

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=382, Percent_Identity=26.4397905759162, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI296040438, Length=233, Percent_Identity=28.755364806867, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI296040443, Length=223, Percent_Identity=29.5964125560538, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1788340, Length=402, Percent_Identity=29.1044776119403, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI48994968, Length=374, Percent_Identity=28.8770053475936, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17560350, Length=379, Percent_Identity=28.7598944591029, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI17136908, Length=384, Percent_Identity=26.3020833333333, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.132 [H]

Molecular weight: Translated: 46653; Mature: 46653

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISIFGLGYVGTVCAACLAELGHHIIGVDKAGAKVELIQAGQSPVIEPGISEKVAAAVA
CCEEEEECHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHH
AGRLTASTDATAAIAATDISMICVGTPSAASGDLDLTAIRQVAAEIGHGLREKPTSHLVV
HCCEECCCCCCEEEEEECEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHCCCCCEEEE
IRSTVLPGTSQRIVVPLIEEASGKKAGTDFEISFNPEFLREGCAIADFNSPSKTVVGADR
EEEEECCCCCCEEEEEEEECCCCCCCCCEEEEEECHHHHHCCCEEEECCCCCCEEEECCC
SETAARILSLYEQLPGAKIAASIETAELAKYIDNTWHALKVAFANEVGVIAKTLDIDSRE
HHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCHHEEEEEECCCCCEEEEEECCCCHH
VIDIFLQDTRLNISAAYLRPGFAFGGSCLPKDIKALKHLAGRHGLSVPVIENVLPSNDMV
HEEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEE
MSRGVDWILAQPGRKVAFLGISFKAGTDDVRESPFVLLVNGLLSRDREVRVYDPNVRLSQ
HHCCCCEEEECCCCEEEEEEEEEECCCCCHHCCCEEEEEEHHHCCCCEEEEECCCCHHHH
LIGANRDFLMRNRQIADILVDDVAETIDWADIIVLTTNDPRFIDALRSTRADQTVLELTE
HHCCCHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCHHHHHHHHH
ARLPADVQATVKGFHW
HCCCCCHHHHHCCCCC
>Mature Secondary Structure
MNISIFGLGYVGTVCAACLAELGHHIIGVDKAGAKVELIQAGQSPVIEPGISEKVAAAVA
CCEEEEECHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHH
AGRLTASTDATAAIAATDISMICVGTPSAASGDLDLTAIRQVAAEIGHGLREKPTSHLVV
HCCEECCCCCCEEEEEECEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHCCCCCEEEE
IRSTVLPGTSQRIVVPLIEEASGKKAGTDFEISFNPEFLREGCAIADFNSPSKTVVGADR
EEEEECCCCCCEEEEEEEECCCCCCCCCEEEEEECHHHHHCCCEEEECCCCCCEEEECCC
SETAARILSLYEQLPGAKIAASIETAELAKYIDNTWHALKVAFANEVGVIAKTLDIDSRE
HHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCHHEEEEEECCCCCEEEEEECCCCHH
VIDIFLQDTRLNISAAYLRPGFAFGGSCLPKDIKALKHLAGRHGLSVPVIENVLPSNDMV
HEEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEE
MSRGVDWILAQPGRKVAFLGISFKAGTDDVRESPFVLLVNGLLSRDREVRVYDPNVRLSQ
HHCCCCEEEECCCCEEEEEEEEEECCCCCHHCCCEEEEEEHHHCCCCEEEEECCCCHHHH
LIGANRDFLMRNRQIADILVDDVAETIDWADIIVLTTNDPRFIDALRSTRADQTVLELTE
HHCCCHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCHHHHHHHHH
ARLPADVQATVKGFHW
HCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3108855; 10984043; 2470755; 1370473; 8294014; 12135385; 12705829 [H]