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The map label for this gene is ipdC [H]

Identifier: 146343769

GI number: 146343769

Start: 7317180

End: 7318817

Strand: Reverse

Name: ipdC [H]

Synonym: BRADO7016

Alternate gene names: 146343769

Gene position: 7318817-7317180 (Counterclockwise)

Preceding gene: 146343770

Following gene: 146343767

Centisome position: 98.15

GC content: 67.4

Gene sequence:

>1638_bases
ATGCCCGCTCTTGCTCATGCGCTGCTCGTCGCCCTGAAGGATCATGGCGCGCGCGAGATCTTCGGCATCCCCGGCGATTT
CGTTCTGCCGCTGTTCAGGGTCATCGAGGAGAGCAACATCCTGCCGAGCGTCACGCTCAGCCATGAGCCGGCGGTCGGCT
TCGCGGCGGATGCGGCCGCGCGCTATCATGGCGGGCTCGGTGTCGCCGTCGTGACCTATGGCGCGGGTGCCTTCAATGTC
GTCAACGCGGTCGCCGGCGCCTATGCCGAGCGCTCGCCGGTTGTCGTGATCGCCGGTGCGCCCGGCGCGCGCGAGCGCCT
TTCCGGCTTCCTGCTGCATCATCAGGCCCGCACCGTCGACACCCAGCTTGCGGTCTTCAAGGAGATCACCTGCGACCAGG
CCGTGCTGTCGGATCCCGCGACGGCACCTGCCCAGATCGCCCGCGTGCTGCGCAGCGCCAGGGAGATGTCGCTGCCGGTC
TATCTGGAATTCCCGCGCGACATGGTCGATGCCGAGGTCGAGGCGGTGGTGCCGCTGCCGCCGCGAACGGCGAACCGGGA
GGCGCTCGACGAATGCGTCGACGAGATCCTCGCGCGCATTGCACAAGCGCAGCGTCCCGTGATCGTCGTGGATGTTGAGA
TCCGTCGCTACGGCGTCGAGGACCAGATCGCCGCACTTGCCCGCAAGCTTGGCCTGCCGCTGGTCACGACCTTCATGGGG
CGTGGTCTGCTAGACAACGCGGACGATGTCGTCGCCGGAACCTACCTCGGCGCTGCCGGCAATCCCGCGATCACGCAACT
GGTCGAGGAGGCGGACCTCGTGCTGATGCTGGGCGTCATCCTGTCCGACACCAATTTCGCGCTATCGAACCGCGCGCCGG
ATCCGCGCCGCATGATCCTGGCATCCAGCCGCGAGGTGCAGATCGGACACCATGCCTATCGCGACATGCCGCTCCGCGAC
CTGATCGATGCGCTTGCGCAGCGTGCCGCGCCGCGGGCCGCTCAGCCCGGAACGCCGCGGCAGCGCTCTTCCTATCCGCG
CCGACTGAGCTCCGATGATCAGCCGATCGCGCCTTCGGATATCGCGACCGCGATCAACGACATGTTCGACCGCCACGGCC
GGATGCCGATGACCTCCGATATCGGCGACTGCCTGTTCACGGCGATGGAGATCGACAACACCGCGCTGGCGGCGCCCGGC
TATTACGCCGGGATGGGATTCGGTGTGCCGGCCGGGATCGGCGTGGCCGCGACTGGCCTGCGGCCGTTGATCCTGGTCGG
CGACGGCGCCTTCCAGATGACCGGCTGGGAGCTCGGCAATTGCCGCCGCTACGGGCTCGATCCGATCGTCGTGCTGTTCA
ACAATTGCAGCTGGGAGATGCTGCGCGTGTTCCAGCCGGAATCGCGCTTCAACGATCTCGACGACTGGCATTATGCCGAC
GTCGCCAACGCGATCGGCGGCGCCGGCGAGCGCGTCGCCACTCGCGCCGCGCTCGTCGCGGCATTGGAGCGCGCGGTGCA
GCGGCGTGGACAATTTTCGCTGGTCGAAGTGATGCTGCCGCGGGGCAAGACATCTGACACGCTGGCGCGCTTTGTCGCCG
GATTCAAATCGGCGCGCGAACGGATGGCCAAGGCGTGA

Upstream 100 bases:

>100_bases
GCATGCCGGCAAGGCTTCGGATCACGCGGCTTCGTGATTGGCAGTGGCGGCGTCCTCGTGTAGCACCGGATGGAAAGCCA
CGCTGTATCGGAGGCTCCTG

Downstream 100 bases:

>100_bases
ACCAAATGACTGATCGGGAGACTGTCAGACGCCGATCGGCGCCTGTCGGTCCATTGGTCTATGGGCCAGCCTTTTCGTGG
TTGGCGAGGCCGATCGCCTT

Product: indole-3-pyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MPALAHALLVALKDHGAREIFGIPGDFVLPLFRVIEESNILPSVTLSHEPAVGFAADAAARYHGGLGVAVVTYGAGAFNV
VNAVAGAYAERSPVVVIAGAPGARERLSGFLLHHQARTVDTQLAVFKEITCDQAVLSDPATAPAQIARVLRSAREMSLPV
YLEFPRDMVDAEVEAVVPLPPRTANREALDECVDEILARIAQAQRPVIVVDVEIRRYGVEDQIAALARKLGLPLVTTFMG
RGLLDNADDVVAGTYLGAAGNPAITQLVEEADLVLMLGVILSDTNFALSNRAPDPRRMILASSREVQIGHHAYRDMPLRD
LIDALAQRAAPRAAQPGTPRQRSSYPRRLSSDDQPIAPSDIATAINDMFDRHGRMPMTSDIGDCLFTAMEIDNTALAAPG
YYAGMGFGVPAGIGVAATGLRPLILVGDGAFQMTGWELGNCRRYGLDPIVVLFNNCSWEMLRVFQPESRFNDLDDWHYAD
VANAIGGAGERVATRAALVAALERAVQRRGQFSLVEVMLPRGKTSDTLARFVAGFKSARERMAKA

Sequences:

>Translated_545_residues
MPALAHALLVALKDHGAREIFGIPGDFVLPLFRVIEESNILPSVTLSHEPAVGFAADAAARYHGGLGVAVVTYGAGAFNV
VNAVAGAYAERSPVVVIAGAPGARERLSGFLLHHQARTVDTQLAVFKEITCDQAVLSDPATAPAQIARVLRSAREMSLPV
YLEFPRDMVDAEVEAVVPLPPRTANREALDECVDEILARIAQAQRPVIVVDVEIRRYGVEDQIAALARKLGLPLVTTFMG
RGLLDNADDVVAGTYLGAAGNPAITQLVEEADLVLMLGVILSDTNFALSNRAPDPRRMILASSREVQIGHHAYRDMPLRD
LIDALAQRAAPRAAQPGTPRQRSSYPRRLSSDDQPIAPSDIATAINDMFDRHGRMPMTSDIGDCLFTAMEIDNTALAAPG
YYAGMGFGVPAGIGVAATGLRPLILVGDGAFQMTGWELGNCRRYGLDPIVVLFNNCSWEMLRVFQPESRFNDLDDWHYAD
VANAIGGAGERVATRAALVAALERAVQRRGQFSLVEVMLPRGKTSDTLARFVAGFKSARERMAKA
>Mature_544_residues
PALAHALLVALKDHGAREIFGIPGDFVLPLFRVIEESNILPSVTLSHEPAVGFAADAAARYHGGLGVAVVTYGAGAFNVV
NAVAGAYAERSPVVVIAGAPGARERLSGFLLHHQARTVDTQLAVFKEITCDQAVLSDPATAPAQIARVLRSAREMSLPVY
LEFPRDMVDAEVEAVVPLPPRTANREALDECVDEILARIAQAQRPVIVVDVEIRRYGVEDQIAALARKLGLPLVTTFMGR
GLLDNADDVVAGTYLGAAGNPAITQLVEEADLVLMLGVILSDTNFALSNRAPDPRRMILASSREVQIGHHAYRDMPLRDL
IDALAQRAAPRAAQPGTPRQRSSYPRRLSSDDQPIAPSDIATAINDMFDRHGRMPMTSDIGDCLFTAMEIDNTALAAPGY
YAGMGFGVPAGIGVAATGLRPLILVGDGAFQMTGWELGNCRRYGLDPIVVLFNNCSWEMLRVFQPESRFNDLDDWHYADV
ANAIGGAGERVATRAALVAALERAVQRRGQFSLVEVMLPRGKTSDTLARFVAGFKSARERMAKA

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=545, Percent_Identity=25.6880733944954, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87081685, Length=566, Percent_Identity=24.0282685512367, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790104, Length=479, Percent_Identity=25.678496868476, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1786717, Length=567, Percent_Identity=21.6931216931217, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788716, Length=561, Percent_Identity=22.4598930481283, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323073, Length=547, Percent_Identity=26.1425959780622, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6323163, Length=553, Percent_Identity=26.2206148282098, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6321524, Length=546, Percent_Identity=25.4578754578755, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6320123, Length=572, Percent_Identity=23.0769230769231, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6320588, Length=580, Percent_Identity=24.6551724137931, Blast_Score=143, Evalue=8e-35,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017765
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 58605; Mature: 58474

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALAHALLVALKDHGAREIFGIPGDFVLPLFRVIEESNILPSVTLSHEPAVGFAADAAA
CCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHH
RYHGGLGVAVVTYGAGAFNVVNAVAGAYAERSPVVVIAGAPGARERLSGFLLHHQARTVD
HHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
TQLAVFKEITCDQAVLSDPATAPAQIARVLRSAREMSLPVYLEFPRDMVDAEVEAVVPLP
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHHCCCCEEEECCC
PRTANREALDECVDEILARIAQAQRPVIVVDVEIRRYGVEDQIAALARKLGLPLVTTFMG
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCHHHHHHHHHHHCCHHHHHHHC
RGLLDNADDVVAGTYLGAAGNPAITQLVEEADLVLMLGVILSDTNFALSNRAPDPRRMIL
CCCCCCCCCHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHEEE
ASSREVQIGHHAYRDMPLRDLIDALAQRAAPRAAQPGTPRQRSSYPRRLSSDDQPIAPSD
ECCCCEEECHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCHH
IATAINDMFDRHGRMPMTSDIGDCLFTAMEIDNTALAAPGYYAGMGFGVPAGIGVAATGL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEECCCCHHCCCCCCCCCCCCHHCCC
RPLILVGDGAFQMTGWELGNCRRYGLDPIVVLFNNCSWEMLRVFQPESRFNDLDDWHYAD
CEEEEEECCCEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHCCCHHHCCCCCCCHHHH
VANAIGGAGERVATRAALVAALERAVQRRGQFSLVEVMLPRGKTSDTLARFVAGFKSARE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHH
RMAKA
HHHCC
>Mature Secondary Structure 
PALAHALLVALKDHGAREIFGIPGDFVLPLFRVIEESNILPSVTLSHEPAVGFAADAAA
CHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHH
RYHGGLGVAVVTYGAGAFNVVNAVAGAYAERSPVVVIAGAPGARERLSGFLLHHQARTVD
HHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
TQLAVFKEITCDQAVLSDPATAPAQIARVLRSAREMSLPVYLEFPRDMVDAEVEAVVPLP
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHHCCCCEEEECCC
PRTANREALDECVDEILARIAQAQRPVIVVDVEIRRYGVEDQIAALARKLGLPLVTTFMG
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCHHHHHHHHHHHCCHHHHHHHC
RGLLDNADDVVAGTYLGAAGNPAITQLVEEADLVLMLGVILSDTNFALSNRAPDPRRMIL
CCCCCCCCCHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHEEE
ASSREVQIGHHAYRDMPLRDLIDALAQRAAPRAAQPGTPRQRSSYPRRLSSDDQPIAPSD
ECCCCEEECHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCHH
IATAINDMFDRHGRMPMTSDIGDCLFTAMEIDNTALAAPGYYAGMGFGVPAGIGVAATGL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEECCCCHHCCCCCCCCCCCCHHCCC
RPLILVGDGAFQMTGWELGNCRRYGLDPIVVLFNNCSWEMLRVFQPESRFNDLDDWHYAD
CEEEEEECCCEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHCCCHHHCCCCCCCHHHH
VANAIGGAGERVATRAALVAALERAVQRRGQFSLVEVMLPRGKTSDTLARFVAGFKSARE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHH
RMAKA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8202090 [H]