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The map label for this gene is lrp [H]

Identifier: 146343716

GI number: 146343716

Start: 7249318

End: 7249797

Strand: Direct

Name: lrp [H]

Synonym: BRADO6962

Alternate gene names: 146343716

Gene position: 7249318-7249797 (Clockwise)

Preceding gene: 146343714

Following gene: 146343717

Centisome position: 97.22

GC content: 64.17

Gene sequence:

>480_bases
ATGATTTCGGTCGACAGCTTCGATCTCCGCATCCTGGCCGCGCTGCAGGACGATGGCCGGCTGACCAACCAGGAACTGGC
AGATCTCGCCGGCCTCTCTGCCTCGCAATGCTCGCGTCGTCGGATGCGGCTGGAGGAGGACGGCGTCATCGCCGGCTACC
GCGCCCAGCTTGCGAGCCAGGCGCTCGGCTTCGAACTGATCGCCTTCATCCAGATCACCCTGGCCACCCACTCGCCCGAC
AATGCCCAGAAGTTTCGCGCACTGGTCAACCGTGTCGATGACATCCAGGAGGCCTACGCTCTGACCGGCGACTCCGACTA
TCTCCTCAAGGTCGTGCTGCGCGACCTCAAGAGCCTGTCGGACATCGTCAACAATGTGCTGATGCCGCATCAGAGCGTCG
CCCATGTGCGCTCCTCGATCGTGCTCGACCGGCTGAAGGAGAGCGCGAAGCTGCCGCTGGCGTCGCTGCCGACGAGCTGA

Upstream 100 bases:

>100_bases
ATCGAGCCATGATCTCTCCAATTCGGCGCATGGAGCATGCAAACCATTGTCATTTTCGCCAAGATATGCACGATCCGTGC
ATGACCTCGGAGATTGCCGC

Downstream 100 bases:

>100_bases
CGGGAGGGCGCGAATCGAGGGAACTTCGGCATTCACCCCCACGCGGGCTTTTGCGACAGTCGCCGCGCTCCAAATTTTGC
GAGACGACCATGGCGCTGCA

Product: AsnC/Lrp family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MISVDSFDLRILAALQDDGRLTNQELADLAGLSASQCSRRRMRLEEDGVIAGYRAQLASQALGFELIAFIQITLATHSPD
NAQKFRALVNRVDDIQEAYALTGDSDYLLKVVLRDLKSLSDIVNNVLMPHQSVAHVRSSIVLDRLKESAKLPLASLPTS

Sequences:

>Translated_159_residues
MISVDSFDLRILAALQDDGRLTNQELADLAGLSASQCSRRRMRLEEDGVIAGYRAQLASQALGFELIAFIQITLATHSPD
NAQKFRALVNRVDDIQEAYALTGDSDYLLKVVLRDLKSLSDIVNNVLMPHQSVAHVRSSIVLDRLKESAKLPLASLPTS
>Mature_159_residues
MISVDSFDLRILAALQDDGRLTNQELADLAGLSASQCSRRRMRLEEDGVIAGYRAQLASQALGFELIAFIQITLATHSPD
NAQKFRALVNRVDDIQEAYALTGDSDYLLKVVLRDLKSLSDIVNNVLMPHQSVAHVRSSIVLDRLKESAKLPLASLPTS

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=152, Percent_Identity=35.5263157894737, Blast_Score=103, Evalue=4e-24,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=29.3333333333333, Blast_Score=85, Evalue=2e-18,
Organism=Escherichia coli, GI1790182, Length=141, Percent_Identity=29.0780141843972, Blast_Score=61, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17476; Mature: 17476

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVDSFDLRILAALQDDGRLTNQELADLAGLSASQCSRRRMRLEEDGVIAGYRAQLASQ
CCCCCCCCHHHEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCEEHHHHHHHHHH
ALGFELIAFIQITLATHSPDNAQKFRALVNRVDDIQEAYALTGDSDYLLKVVLRDLKSLS
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
DIVNNVLMPHQSVAHVRSSIVLDRLKESAKLPLASLPTS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MISVDSFDLRILAALQDDGRLTNQELADLAGLSASQCSRRRMRLEEDGVIAGYRAQLASQ
CCCCCCCCHHHEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCEEHHHHHHHHHH
ALGFELIAFIQITLATHSPDNAQKFRALVNRVDDIQEAYALTGDSDYLLKVVLRDLKSLS
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
DIVNNVLMPHQSVAHVRSSIVLDRLKESAKLPLASLPTS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11157937; 11481430 [H]