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The map label for this gene is lysA [H]

Identifier: 146343265

GI number: 146343265

Start: 6735293

End: 6736633

Strand: Reverse

Name: lysA [H]

Synonym: BRADO6485

Alternate gene names: 146343265

Gene position: 6736633-6735293 (Counterclockwise)

Preceding gene: 146343266

Following gene: 146343264

Centisome position: 90.34

GC content: 67.71

Gene sequence:

>1341_bases
TTGACAATCCCTGCCATTTCCCGGCAATTCGCCGCCACAATCACTCACTCGCAAGCCGCGCGCGGACACGAACCCATGAA
CCATTTCGACTACCGCGACGGCGTGCTGCACGCCGAGGCCGTCAATCTCGCCGAGCTCGCGAGCCGCGTCGGCACCCCGT
TCTACTGCTACTCCACCGCCACCCTGGAGCGGCATTACCGCGTGTTCGCGGACGCCTTCGCCGGCCAGGACGTCTTGATC
TGCTACGCGATGAAGGCCAATTCCAACCAGTCGGTGCTGCGCACGCTCGCAAAGCTGGGCGCCGGCGCCGACGTCGTCTC
CGGCGGCGAATTGAAGCGCGCGCTGGCCGCCGGCATCCCCTCGCGCAAGATCGTATTTTCCGGCGTCGGCAAGACCGAGG
CCGAGCTGCGCGCCGCGCTCGCGGCCGACATCCACTGCCTCAACATCGAATCCGAGCCCGAGCTCGATCTGCTGGCGCGC
CTCGCCGTGGAGACCGGCCACACCGCCCGCATCTCCATCCGCGTCAACCCGGATGTCGATGCCGGCACGCACGCAAAAAT
CTCGACCGGCAAGTCGGAGAACAAGTTCGGCATCCCGCTCGACCACGCCCGCCGCGTCTACGCCCGCGCGGCGAAGATGA
AGGGCATCAAGGTCACCGGCGTCGACGTCCATATCGGCAGCCAGATCACCGATCTCGGCCCGATGGAGACCGCCTTCCGC
ATCCTCACCGAATTCGTGCAGACGCTCCGCGCCGACGGCCACGACATCTCCCATGTCGATTTCGGCGGCGGCCTCGGCAT
CCCCTATCACATGGACCGCGCCGTGCCGCCGGAGCCCGCCGCCTACGCCGCGATGGTCAAGCGCGTGTCGCACAATCTCG
GCTGCACCCTGATGTTCGAGCCCGGCCGCATGATCGTCGGCAATGCCGGCATCCTCCTCGCCAAGGTGATCTATGTGAAG
CACGGCGAGGCCAAGAACTTCGTCATCATCGACGCCGCGATGAACGACCTGATCCGCCCGACGCTCTACGAGGCGCATCA
CGACATCCTGCCCGTGAAGCAGGCCCCGCCGGACGCGCCCGCCTTCGTGGCCGACGTCGTCGGCCCGGTCTGCGAAAGCG
GCGACTACCTCGCCCTCGACCGGGCGCTGCCCGAGCCCGCGCCCGGCGACCTCCTCGCCATCATGACCGCAGGCGCCTAC
GGCGCCGTGCAGGCCTGCACGTACAATACCCGCGCGCTGGTGCCCGAGGTGCTGGTGAAGGGCGACCAGGCGGCGGTGAT
CCGGCCGAGGATCGAGGTCGAGCAGCTGATCGCGATGGATACGCCGGCGCCGTGGTTGTGA

Upstream 100 bases:

>100_bases
AGATGTTCACCCTCATGGTGAGGAGCGCCGCGCGCGGCGCGTCTCGAACCATGAGGCCTGGACGGCGCGGCAACTGCCTC
GGCGAGGACCGCGGCCTCAA

Downstream 100 bases:

>100_bases
GGCGGGCTGCGTTCCTTTCCTTGATGCGTGAGTAAGCGTTCTCACCGCACGACGATCCGGGCATGTAAGCCCCACTGTCA
TCGTCCGCGAAAGCGGACGA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTIPAISRQFAATITHSQAARGHEPMNHFDYRDGVLHAEAVNLAELASRVGTPFYCYSTATLERHYRVFADAFAGQDVLI
CYAMKANSNQSVLRTLAKLGAGADVVSGGELKRALAAGIPSRKIVFSGVGKTEAELRAALAADIHCLNIESEPELDLLAR
LAVETGHTARISIRVNPDVDAGTHAKISTGKSENKFGIPLDHARRVYARAAKMKGIKVTGVDVHIGSQITDLGPMETAFR
ILTEFVQTLRADGHDISHVDFGGGLGIPYHMDRAVPPEPAAYAAMVKRVSHNLGCTLMFEPGRMIVGNAGILLAKVIYVK
HGEAKNFVIIDAAMNDLIRPTLYEAHHDILPVKQAPPDAPAFVADVVGPVCESGDYLALDRALPEPAPGDLLAIMTAGAY
GAVQACTYNTRALVPEVLVKGDQAAVIRPRIEVEQLIAMDTPAPWL

Sequences:

>Translated_446_residues
MTIPAISRQFAATITHSQAARGHEPMNHFDYRDGVLHAEAVNLAELASRVGTPFYCYSTATLERHYRVFADAFAGQDVLI
CYAMKANSNQSVLRTLAKLGAGADVVSGGELKRALAAGIPSRKIVFSGVGKTEAELRAALAADIHCLNIESEPELDLLAR
LAVETGHTARISIRVNPDVDAGTHAKISTGKSENKFGIPLDHARRVYARAAKMKGIKVTGVDVHIGSQITDLGPMETAFR
ILTEFVQTLRADGHDISHVDFGGGLGIPYHMDRAVPPEPAAYAAMVKRVSHNLGCTLMFEPGRMIVGNAGILLAKVIYVK
HGEAKNFVIIDAAMNDLIRPTLYEAHHDILPVKQAPPDAPAFVADVVGPVCESGDYLALDRALPEPAPGDLLAIMTAGAY
GAVQACTYNTRALVPEVLVKGDQAAVIRPRIEVEQLIAMDTPAPWL
>Mature_445_residues
TIPAISRQFAATITHSQAARGHEPMNHFDYRDGVLHAEAVNLAELASRVGTPFYCYSTATLERHYRVFADAFAGQDVLIC
YAMKANSNQSVLRTLAKLGAGADVVSGGELKRALAAGIPSRKIVFSGVGKTEAELRAALAADIHCLNIESEPELDLLARL
AVETGHTARISIRVNPDVDAGTHAKISTGKSENKFGIPLDHARRVYARAAKMKGIKVTGVDVHIGSQITDLGPMETAFRI
LTEFVQTLRADGHDISHVDFGGGLGIPYHMDRAVPPEPAAYAAMVKRVSHNLGCTLMFEPGRMIVGNAGILLAKVIYVKH
GEAKNFVIIDAAMNDLIRPTLYEAHHDILPVKQAPPDAPAFVADVVGPVCESGDYLALDRALPEPAPGDLLAIMTAGAYG
AVQACTYNTRALVPEVLVKGDQAAVIRPRIEVEQLIAMDTPAPWL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=350, Percent_Identity=27.1428571428571, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI16506287, Length=393, Percent_Identity=25.1908396946565, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1789203, Length=413, Percent_Identity=33.8983050847458, Blast_Score=177, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562780, Length=344, Percent_Identity=24.1279069767442, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322664, Length=354, Percent_Identity=24.2937853107345, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24586472, Length=338, Percent_Identity=25.7396449704142, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24586474, Length=342, Percent_Identity=26.0233918128655, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47814; Mature: 47682

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPAISRQFAATITHSQAARGHEPMNHFDYRDGVLHAEAVNLAELASRVGTPFYCYSTA
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHCCHHHHHHHHCCCEEEEEHH
TLERHYRVFADAFAGQDVLICYAMKANSNQSVLRTLAKLGAGADVVSGGELKRALAAGIP
HHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
SRKIVFSGVGKTEAELRAALAADIHCLNIESEPELDLLARLAVETGHTARISIRVNPDVD
CCEEEEECCCCCHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCCCC
AGTHAKISTGKSENKFGIPLDHARRVYARAAKMKGIKVTGVDVHIGSQITDLGPMETAFR
CCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHHHH
ILTEFVQTLRADGHDISHVDFGGGLGIPYHMDRAVPPEPAAYAAMVKRVSHNLGCTLMFE
HHHHHHHHHHCCCCCCCEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
PGRMIVGNAGILLAKVIYVKHGEAKNFVIIDAAMNDLIRPTLYEAHHDILPVKQAPPDAP
CCEEEEECCHHEEEEEEEEECCCCCCEEEEEHHHHHHHCHHHHHHHCCEECCCCCCCCCC
AFVADVVGPVCESGDYLALDRALPEPAPGDLLAIMTAGAYGAVQACTYNTRALVPEVLVK
HHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHC
GDQAAVIRPRIEVEQLIAMDTPAPWL
CCCEEEEECCCCHHHHHCCCCCCCCC
>Mature Secondary Structure 
TIPAISRQFAATITHSQAARGHEPMNHFDYRDGVLHAEAVNLAELASRVGTPFYCYSTA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHCCHHHHHHHHCCCEEEEEHH
TLERHYRVFADAFAGQDVLICYAMKANSNQSVLRTLAKLGAGADVVSGGELKRALAAGIP
HHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
SRKIVFSGVGKTEAELRAALAADIHCLNIESEPELDLLARLAVETGHTARISIRVNPDVD
CCEEEEECCCCCHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCCCC
AGTHAKISTGKSENKFGIPLDHARRVYARAAKMKGIKVTGVDVHIGSQITDLGPMETAFR
CCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHHHH
ILTEFVQTLRADGHDISHVDFGGGLGIPYHMDRAVPPEPAAYAAMVKRVSHNLGCTLMFE
HHHHHHHHHHCCCCCCCEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
PGRMIVGNAGILLAKVIYVKHGEAKNFVIIDAAMNDLIRPTLYEAHHDILPVKQAPPDAP
CCEEEEECCHHEEEEEEEEECCCCCCEEEEEHHHHHHHCHHHHHHHCCEECCCCCCCCCC
AFVADVVGPVCESGDYLALDRALPEPAPGDLLAIMTAGAYGAVQACTYNTRALVPEVLVK
HHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHC
GDQAAVIRPRIEVEQLIAMDTPAPWL
CCCEEEEECCCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]