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The map label for this gene is dht [H]

Identifier: 146342980

GI number: 146342980

Start: 6389175

End: 6390629

Strand: Direct

Name: dht [H]

Synonym: BRADO6163

Alternate gene names: 146342980

Gene position: 6389175-6390629 (Clockwise)

Preceding gene: 146342979

Following gene: 146342981

Centisome position: 85.68

GC content: 67.49

Gene sequence:

>1455_bases
ATGTCCCTGTTCATCCGTGGCGGCACGGTGGTGAACCACGATCATTCCCGCCGCGCCGACGTGCTCATCCAAAGCGGGAC
GATCGTTGCCGTCGGCACCGCGATCGAGCCGCCGCTGTCGGCCGAGGTGATCGATGCCGATGGCTGCTATGTGCTTCCTG
GCGGCATCGATCCGCACACCCATCTCGAGCTCGGCTTCATGGGAACGGTGTCGGCCGACGATTTCGAATGGGGCACTAAG
GCGGGGCTGTCAGGCGGCACCACAATGGTGGTGGATTTCTGCATCCCCGACCCCGGGCAGTCGATGCTCGCGGCCTATCA
GGACTGGCGGCGCAAATCGGAGAAGGCTGCGGCCGACTACGGCTTCCACATGGCCGTGACCTCCTGGTCGAAGCAGGTGT
TCGACGAGATGGAGGTGGTGGTCAAGACCTACGGCATCAACACCTTCAAGCATTTCATGGCCTACAAGGGCGCGCTGATG
GTGAATGACGACGAGTTGTACAACTCGTTCGCGCGTTGCGCAGCGCTCGGCGCAATGCCGCTGGTCCATGCCGAGAACGG
CGACGTCGTCGCACGCATGCAGGAGGCGATACTGGCGCGCGGCATCGACGGGCCGGAGGGCCACGCGTTCTCGCGCCCAC
CGGAGGTCGAGGGCGAGGCGACCAGCCGCGCGATCATGATCGCCGACATGACGGGCGCGCCGCTCTATGTCGTGCACACC
AGCTGCCGCCAGTCGCACGAGGCGATCGCGCGCGCCCGCGCCGCCGGCCAGCGCGTCTATGGCGAGCCGCTGATCCAGCA
TCTGCTGCTCGACGACAGCGAATATCGCCGTGACGACTGGGACCATGCCGCGGCCTGCGTGATGTCGCCGCCGTTCCGCG
ACCGGGCGCATCAGGACAGCCTGTGGGCCGGACTGCAATCGGGCTCGCTGCAGGTGGTCGCGACCGATCATTGCGCCTTC
ACGCTGGCGCAGAAGCGCCTCGGCCGCGGCGACTTCCGCAGGATTCCGAACGGCACCGGCGGGCTCGAGGACCGGATGCC
GCTGCTGTGGACGGCCGGCGTCGGCACCGGACGGCTGACCAAGGAGGAGTTCGTCGCGGTCACCTCGGCGAATATCGCGC
GCATCCTCAATATCTTCCCGCGCAAGGGCGCGATCATGGCGGGCTCCGATGCTGACCTGGTGGTGTGGGACCCGGCCGCC
CACAAGACGATCCGCGCCAGCCGTCAGGTCAGCCGCATCGACTACAACGTCTTCGAAGGCTTCACCTGCACCGGCGGCCC
CGCCATGACGGTGTCGCGTGGACGCATCGCCTGGCGCGACGGCGAGTTGCGCGCGCAAGCCGGCGACGGCCGCTATGTCG
AGCGGCCGGCCTTTCCGTCCGTGCATGTCGCCAATTCCACCTGGAAGGAGATCACCGCGCCGCGCGCCGTCGCGCGCGAG
ATGGTCACGCCCTAG

Upstream 100 bases:

>100_bases
CGCTCCTGGTCAAATTTTGATCAGCGCGAGTCGGCGCGGCCGCGCTAGATTCAAGATGCGGCGTCCTGCAACTGCGTCGC
GACGAGCGCGAGGCCAGCCC

Downstream 100 bases:

>100_bases
ACGATCGGCTTCCGAAGTCCTGTCGGAAGTGATCCGCGGCCATCCCGCCCTCCGCTGTCATCGTCGGCGGAGGCGCAGCG
GCGAATTGCTCGCCTCAGAT

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSLFIRGGTVVNHDHSRRADVLIQSGTIVAVGTAIEPPLSAEVIDADGCYVLPGGIDPHTHLELGFMGTVSADDFEWGTK
AGLSGGTTMVVDFCIPDPGQSMLAAYQDWRRKSEKAAADYGFHMAVTSWSKQVFDEMEVVVKTYGINTFKHFMAYKGALM
VNDDELYNSFARCAALGAMPLVHAENGDVVARMQEAILARGIDGPEGHAFSRPPEVEGEATSRAIMIADMTGAPLYVVHT
SCRQSHEAIARARAAGQRVYGEPLIQHLLLDDSEYRRDDWDHAAACVMSPPFRDRAHQDSLWAGLQSGSLQVVATDHCAF
TLAQKRLGRGDFRRIPNGTGGLEDRMPLLWTAGVGTGRLTKEEFVAVTSANIARILNIFPRKGAIMAGSDADLVVWDPAA
HKTIRASRQVSRIDYNVFEGFTCTGGPAMTVSRGRIAWRDGELRAQAGDGRYVERPAFPSVHVANSTWKEITAPRAVARE
MVTP

Sequences:

>Translated_484_residues
MSLFIRGGTVVNHDHSRRADVLIQSGTIVAVGTAIEPPLSAEVIDADGCYVLPGGIDPHTHLELGFMGTVSADDFEWGTK
AGLSGGTTMVVDFCIPDPGQSMLAAYQDWRRKSEKAAADYGFHMAVTSWSKQVFDEMEVVVKTYGINTFKHFMAYKGALM
VNDDELYNSFARCAALGAMPLVHAENGDVVARMQEAILARGIDGPEGHAFSRPPEVEGEATSRAIMIADMTGAPLYVVHT
SCRQSHEAIARARAAGQRVYGEPLIQHLLLDDSEYRRDDWDHAAACVMSPPFRDRAHQDSLWAGLQSGSLQVVATDHCAF
TLAQKRLGRGDFRRIPNGTGGLEDRMPLLWTAGVGTGRLTKEEFVAVTSANIARILNIFPRKGAIMAGSDADLVVWDPAA
HKTIRASRQVSRIDYNVFEGFTCTGGPAMTVSRGRIAWRDGELRAQAGDGRYVERPAFPSVHVANSTWKEITAPRAVARE
MVTP
>Mature_483_residues
SLFIRGGTVVNHDHSRRADVLIQSGTIVAVGTAIEPPLSAEVIDADGCYVLPGGIDPHTHLELGFMGTVSADDFEWGTKA
GLSGGTTMVVDFCIPDPGQSMLAAYQDWRRKSEKAAADYGFHMAVTSWSKQVFDEMEVVVKTYGINTFKHFMAYKGALMV
NDDELYNSFARCAALGAMPLVHAENGDVVARMQEAILARGIDGPEGHAFSRPPEVEGEATSRAIMIADMTGAPLYVVHTS
CRQSHEAIARARAAGQRVYGEPLIQHLLLDDSEYRRDDWDHAAACVMSPPFRDRAHQDSLWAGLQSGSLQVVATDHCAFT
LAQKRLGRGDFRRIPNGTGGLEDRMPLLWTAGVGTGRLTKEEFVAVTSANIARILNIFPRKGAIMAGSDADLVVWDPAAH
KTIRASRQVSRIDYNVFEGFTCTGGPAMTVSRGRIAWRDGELRAQAGDGRYVERPAFPSVHVANSTWKEITAPRAVAREM
VTP

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=462, Percent_Identity=48.4848484848485, Blast_Score=454, Evalue=1e-127,
Organism=Homo sapiens, GI4503377, Length=459, Percent_Identity=45.3159041394335, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI190194363, Length=459, Percent_Identity=46.1873638344227, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI4503051, Length=459, Percent_Identity=43.7908496732026, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI62422571, Length=459, Percent_Identity=43.7908496732026, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI4503379, Length=484, Percent_Identity=41.7355371900826, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI19923821, Length=459, Percent_Identity=44.0087145969499, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI18105007, Length=427, Percent_Identity=24.5901639344262, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI87082175, Length=464, Percent_Identity=40.301724137931, Blast_Score=341, Evalue=6e-95,
Organism=Escherichia coli, GI1786722, Length=450, Percent_Identity=25.7777777777778, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17539558, Length=456, Percent_Identity=47.5877192982456, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71989490, Length=483, Percent_Identity=43.6853002070393, Blast_Score=425, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI86575075, Length=444, Percent_Identity=32.2072072072072, Blast_Score=229, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6322218, Length=436, Percent_Identity=26.605504587156, Blast_Score=109, Evalue=9e-25,
Organism=Drosophila melanogaster, GI221377917, Length=463, Percent_Identity=44.9244060475162, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI17137462, Length=461, Percent_Identity=44.468546637744, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24644287, Length=296, Percent_Identity=45.6081081081081, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI24644289, Length=246, Percent_Identity=47.1544715447154, Blast_Score=234, Evalue=7e-62,
Organism=Drosophila melanogaster, GI24642586, Length=439, Percent_Identity=25.9681093394077, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI18859883, Length=241, Percent_Identity=24.4813278008299, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 52674; Mature: 52543

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFIRGGTVVNHDHSRRADVLIQSGTIVAVGTAIEPPLSAEVIDADGCYVLPGGIDPHT
CEEEEECCEEEECCCCCCEEEEEECCCEEEEECCCCCCCCCEEECCCCCEEECCCCCCCC
HLELGFMGTVSADDFEWGTKAGLSGGTTMVVDFCIPDPGQSMLAAYQDWRRKSEKAAADY
EEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
GFHMAVTSWSKQVFDEMEVVVKTYGINTFKHFMAYKGALMVNDDELYNSFARCAALGAMP
CEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCCC
LVHAENGDVVARMQEAILARGIDGPEGHAFSRPPEVEGEATSRAIMIADMTGAPLYVVHT
EEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEC
SCRQSHEAIARARAAGQRVYGEPLIQHLLLDDSEYRRDDWDHAAACVMSPPFRDRAHQDS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHCCCCHHHHHHEECCCCCCCCCCCCH
LWAGLQSGSLQVVATDHCAFTLAQKRLGRGDFRRIPNGTGGLEDRMPLLWTAGVGTGRLT
HHHCCCCCCEEEEEECCHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCEEEECCCCCCCCC
KEEFVAVTSANIARILNIFPRKGAIMAGSDADLVVWDPAAHKTIRASRQVSRIDYNVFEG
HHHEEEEHHHHHHHHHHHCCCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHCCHHHHCC
FTCTGGPAMTVSRGRIAWRDGELRAQAGDGRYVERPAFPSVHVANSTWKEITAPRAVARE
EEECCCCEEEEECCEEEEECCCEEEECCCCCEEECCCCCCEEECCCCHHHHCCHHHHHHH
MVTP
HCCC
>Mature Secondary Structure 
SLFIRGGTVVNHDHSRRADVLIQSGTIVAVGTAIEPPLSAEVIDADGCYVLPGGIDPHT
EEEEECCEEEECCCCCCEEEEEECCCEEEEECCCCCCCCCEEECCCCCEEECCCCCCCC
HLELGFMGTVSADDFEWGTKAGLSGGTTMVVDFCIPDPGQSMLAAYQDWRRKSEKAAADY
EEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
GFHMAVTSWSKQVFDEMEVVVKTYGINTFKHFMAYKGALMVNDDELYNSFARCAALGAMP
CEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCCC
LVHAENGDVVARMQEAILARGIDGPEGHAFSRPPEVEGEATSRAIMIADMTGAPLYVVHT
EEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEC
SCRQSHEAIARARAAGQRVYGEPLIQHLLLDDSEYRRDDWDHAAACVMSPPFRDRAHQDS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHCCCCHHHHHHEECCCCCCCCCCCCH
LWAGLQSGSLQVVATDHCAFTLAQKRLGRGDFRRIPNGTGGLEDRMPLLWTAGVGTGRLT
HHHCCCCCCEEEEEECCHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCEEEECCCCCCCCC
KEEFVAVTSANIARILNIFPRKGAIMAGSDADLVVWDPAAHKTIRASRQVSRIDYNVFEG
HHHEEEEHHHHHHHHHHHCCCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHCCHHHHCC
FTCTGGPAMTVSRGRIAWRDGELRAQAGDGRYVERPAFPSVHVANSTWKEITAPRAVARE
EEECCCCEEEEECCEEEEECCCEEEECCCCCEEECCCCCCEEECCCCHHHHCCHHHHHHH
MVTP
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]