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The map label for this gene is hisG [H]

Identifier: 146342926

GI number: 146342926

Start: 6334171

End: 6335148

Strand: Direct

Name: hisG [H]

Synonym: BRADO6107

Alternate gene names: 146342926

Gene position: 6334171-6335148 (Clockwise)

Preceding gene: 146342925

Following gene: 146342927

Centisome position: 84.95

GC content: 68.1

Gene sequence:

>978_bases
ATGAGCGGCCCCCTCGTCCTCGCCGTTCCTTCCAAGGGTCGCCTGCAGGAGAACGCGGAGGCGTTCTTCGGCCGCGCCGG
GCTGAACCTGTCCAAGCCGGGCGGCGCGCGCGACTATCGCGGCACGATCTCCGGTCTCGACAATGTCGAGATCGCCTATC
TCTCTGCGAGTGACATCGCCTCGCAACTGGCACGCGGCACCGTGCATCTCGGCGTCACCGGCGAGGACCTCGTGCGCGAG
GAAATCACCGATGCCGACAAGCGCGTGCTGCTGATCGACACGCTCGGCTTCGGCGGCGCCAATGTCGTGGTCGCCGTGCC
GCAGGCCTGGATCGACGTCCGCACCATGGCCGATCTCGACGATGTCGCCAGCGGCTTCCGCGCGCAGCACAATCGCCGCA
TGCGCGTCGCCACCAAGTACATCAATTTGACGCGGGGCTTCTTCGCCAGCCACGGCATCGTCGACTACCGCATCGTCGAG
AGCGCCGGCGCCACCGAGGGCGCGCCGGCCGTCGGCACCGCCGAGCTGATCGTCGACATCACCTCAACCGGCTCGACGCT
GGTTGCGAACGGGCTGAAGGTGCTCGACGACGGCGTCATCCTGCGCAGCCAGGCCAATCTCGTCGCGTCGCGCGACGCCG
ACTGGTCGGAGGGTCCGCGCGAGAGCGCCCGCATCATCCTCGACCATATCCATGCCCGCGCGCGCGCCAGCAAGTACCGC
GAGGTCCGCACCCGCTTCAAAGGTTGCGACGCAGCAATGCTGACCGAGGCGCACAACCGCTTCGGGGTCGTCGCGCCGTT
CGGCGGCCCGACATCGTCGGGCATGCTGACCCTGCATTGCCCGCCGGCGCAGATCTACTCGCTCGGCAGCTTCCTCCGCG
CGCATGGGGCGGAGACGGTGTCGGTCGCCTCGCTCGACTACGTGCTCGACCGCGAGAATCCGCTGTTTGCCCGCCTCGAA
GCCTTCCTGCGATCATAA

Upstream 100 bases:

>100_bases
TCGGCGCCGCGTCCTTCATTCCGGCCGTCGGCTTCTCGATCTGGATCGAGCGGCTGGCGCAGAGCAGCACGGCGGGCAAG
GCCGCGCGCGGGAGAGCATC

Downstream 100 bases:

>100_bases
ATCGCCGTTCATCGTAGCGACAGGCAGCGGCAGCTACCATATGTTGGTGGGCGAACGAGGATGCTGAGCAATGCTGGGAA
CTGACGTGTCCGACCTGACC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSGPLVLAVPSKGRLQENAEAFFGRAGLNLSKPGGARDYRGTISGLDNVEIAYLSASDIASQLARGTVHLGVTGEDLVRE
EITDADKRVLLIDTLGFGGANVVVAVPQAWIDVRTMADLDDVASGFRAQHNRRMRVATKYINLTRGFFASHGIVDYRIVE
SAGATEGAPAVGTAELIVDITSTGSTLVANGLKVLDDGVILRSQANLVASRDADWSEGPRESARIILDHIHARARASKYR
EVRTRFKGCDAAMLTEAHNRFGVVAPFGGPTSSGMLTLHCPPAQIYSLGSFLRAHGAETVSVASLDYVLDRENPLFARLE
AFLRS

Sequences:

>Translated_325_residues
MSGPLVLAVPSKGRLQENAEAFFGRAGLNLSKPGGARDYRGTISGLDNVEIAYLSASDIASQLARGTVHLGVTGEDLVRE
EITDADKRVLLIDTLGFGGANVVVAVPQAWIDVRTMADLDDVASGFRAQHNRRMRVATKYINLTRGFFASHGIVDYRIVE
SAGATEGAPAVGTAELIVDITSTGSTLVANGLKVLDDGVILRSQANLVASRDADWSEGPRESARIILDHIHARARASKYR
EVRTRFKGCDAAMLTEAHNRFGVVAPFGGPTSSGMLTLHCPPAQIYSLGSFLRAHGAETVSVASLDYVLDRENPLFARLE
AFLRS
>Mature_324_residues
SGPLVLAVPSKGRLQENAEAFFGRAGLNLSKPGGARDYRGTISGLDNVEIAYLSASDIASQLARGTVHLGVTGEDLVREE
ITDADKRVLLIDTLGFGGANVVVAVPQAWIDVRTMADLDDVASGFRAQHNRRMRVATKYINLTRGFFASHGIVDYRIVES
AGATEGAPAVGTAELIVDITSTGSTLVANGLKVLDDGVILRSQANLVASRDADWSEGPRESARIILDHIHARARASKYRE
VRTRFKGCDAAMLTEAHNRFGVVAPFGGPTSSGMLTLHCPPAQIYSLGSFLRAHGAETVSVASLDYVLDRENPLFARLEA
FLRS

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=315, Percent_Identity=25.0793650793651, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 34790; Mature: 34659

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPLVLAVPSKGRLQENAEAFFGRAGLNLSKPGGARDYRGTISGLDNVEIAYLSASDIA
CCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCEEEEEEEHHHHH
SQLARGTVHLGVTGEDLVREEITDADKRVLLIDTLGFGGANVVVAVPQAWIDVRTMADLD
HHHHCCEEEEECCHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEECCHHHHHHHHHCCHH
DVASGFRAQHNRRMRVATKYINLTRGFFASHGIVDYRIVESAGATEGAPAVGTAELIVDI
HHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCEEEEEEEE
TSTGSTLVANGLKVLDDGVILRSQANLVASRDADWSEGPRESARIILDHIHARARASKYR
ECCCCHHHHCCCEEECCCEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EVRTRFKGCDAAMLTEAHNRFGVVAPFGGPTSSGMLTLHCPPAQIYSLGSFLRAHGAETV
HHHHHHCCCCHHHHHHHCCCEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEE
SVASLDYVLDRENPLFARLEAFLRS
EEEEEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SGPLVLAVPSKGRLQENAEAFFGRAGLNLSKPGGARDYRGTISGLDNVEIAYLSASDIA
CCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCEEEEEEEHHHHH
SQLARGTVHLGVTGEDLVREEITDADKRVLLIDTLGFGGANVVVAVPQAWIDVRTMADLD
HHHHCCEEEEECCHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEECCHHHHHHHHHCCHH
DVASGFRAQHNRRMRVATKYINLTRGFFASHGIVDYRIVESAGATEGAPAVGTAELIVDI
HHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCEEEEEEEE
TSTGSTLVANGLKVLDDGVILRSQANLVASRDADWSEGPRESARIILDHIHARARASKYR
ECCCCHHHHCCCEEECCCEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EVRTRFKGCDAAMLTEAHNRFGVVAPFGGPTSSGMLTLHCPPAQIYSLGSFLRAHGAETV
HHHHHHCCCCHHHHHHHCCCEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEE
SVASLDYVLDRENPLFARLEAFLRS
EEEEEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA