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The map label for this gene is lpxK

Identifier: 146342914

GI number: 146342914

Start: 6323185

End: 6324192

Strand: Reverse

Name: lpxK

Synonym: BRADO6095

Alternate gene names: 146342914

Gene position: 6324192-6323185 (Counterclockwise)

Preceding gene: 146342915

Following gene: 146342912

Centisome position: 84.81

GC content: 68.35

Gene sequence:

>1008_bases
ATGCGTGAGCCGGCCTTCTGGCATCGGCCCCCCTCCTGGCAATCGCATCTGTTGTCTCCGCTGTCGATGCTGTACGGCGC
CGTCGCTGCGCGCCGCATGGCGCAGCCTGGCATCAAGGCGGGCGTGCCCGTGATCTGCGTCGGCAACTACCATGTCGGCG
GCGCCGGCAAGACGCCGACGGTGTTGGCGTTGACCGCGTTGCTCCGCGGGCAGGGTGAGCAGCCGGTCGTGCTGAGCCGC
GGTTATGGCGGCCGGTTGCCAGGGCCCGTCCTGGTCGATCCAGCCGCTCATGGCGCAGCCGATGTCGGCGACGAGCCGTT
GATGATGGCCGCGCATGTCCCGGTGGTGGTCTCGCGCGCGCGCGCCGACGGTGTCGGACTCGCGAAGGCGCATCGCGCAT
CCGTCATTCTGATGGATGATGGATTTCAGAATCCGTCGATCACAAAGGATCTCGCGCTGATCGTCGTCGATGGCGGGCGC
GGGCTCGGCAATGCTCGGGTGTTTCCCGCCGGACCGCTGCGCACGCCGCTGCCACCGCAACTGGCGCGGACCGACGCCTT
GATGATCATCGGACGAGGTGAGGCCGGCGAAGCCGTCGCCTCACGCGTGGCCGCGGCGGGCAAGCCAGTGTTCAGGGCGC
AGCTGCAGCCCGATGCGGGCGTCGTCGCGTCGCTCGCCGGCCGGCCCCTCCTGGCCTTCGCAGGCATCGGCGATCCCCAA
CGCTTCTTCAGGAGCTTGCGAGCCAGCGGGCTCGAGATCAGGGCCGAGCGGCCGTTTCCCGATCATCATCCGTTCACAGA
CGGTGACATCAAGGCGCTCGTGGACCAAGCCACGCGTGAGCAGCTCGCTCTGGTCACCACAGAGAAGGATCTCGTCCGGC
TGCGCGGCCGCGGATGGGATCATCCGGAGCTTGCGCCCATGGCGTTTCCGGTGACCTTGCAGTTCGATGATGAGACGGCG
GTACGTTCCCTCGTGGCGCGACGGCTGTCAGCGGCGCGTGCGTCCTAG

Upstream 100 bases:

>100_bases
TCGCGCGTCGTCGACCAGCTCGGCGGCGCGCTGGAGCGGACGATGGCCGCGCTCGAGCCTTATCTTTTGCAGGTCAGGCT
CGAGATGGGGGCCGCCGGCG

Downstream 100 bases:

>100_bases
CCGTTCGCCTTGAGCGCGCCGGGGTAGTGCCGCTGCAGCACGGCGCTCGGCAACGCATAGGCTTCCTGGAGGTCGACGCT
CCAATATTTCAGCTCGTCGA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MREPAFWHRPPSWQSHLLSPLSMLYGAVAARRMAQPGIKAGVPVICVGNYHVGGAGKTPTVLALTALLRGQGEQPVVLSR
GYGGRLPGPVLVDPAAHGAADVGDEPLMMAAHVPVVVSRARADGVGLAKAHRASVILMDDGFQNPSITKDLALIVVDGGR
GLGNARVFPAGPLRTPLPPQLARTDALMIIGRGEAGEAVASRVAAAGKPVFRAQLQPDAGVVASLAGRPLLAFAGIGDPQ
RFFRSLRASGLEIRAERPFPDHHPFTDGDIKALVDQATREQLALVTTEKDLVRLRGRGWDHPELAPMAFPVTLQFDDETA
VRSLVARRLSAARAS

Sequences:

>Translated_335_residues
MREPAFWHRPPSWQSHLLSPLSMLYGAVAARRMAQPGIKAGVPVICVGNYHVGGAGKTPTVLALTALLRGQGEQPVVLSR
GYGGRLPGPVLVDPAAHGAADVGDEPLMMAAHVPVVVSRARADGVGLAKAHRASVILMDDGFQNPSITKDLALIVVDGGR
GLGNARVFPAGPLRTPLPPQLARTDALMIIGRGEAGEAVASRVAAAGKPVFRAQLQPDAGVVASLAGRPLLAFAGIGDPQ
RFFRSLRASGLEIRAERPFPDHHPFTDGDIKALVDQATREQLALVTTEKDLVRLRGRGWDHPELAPMAFPVTLQFDDETA
VRSLVARRLSAARAS
>Mature_335_residues
MREPAFWHRPPSWQSHLLSPLSMLYGAVAARRMAQPGIKAGVPVICVGNYHVGGAGKTPTVLALTALLRGQGEQPVVLSR
GYGGRLPGPVLVDPAAHGAADVGDEPLMMAAHVPVVVSRARADGVGLAKAHRASVILMDDGFQNPSITKDLALIVVDGGR
GLGNARVFPAGPLRTPLPPQLARTDALMIIGRGEAGEAVASRVAAAGKPVFRAQLQPDAGVVASLAGRPLLAFAGIGDPQ
RFFRSLRASGLEIRAERPFPDHHPFTDGDIKALVDQATREQLALVTTEKDLVRLRGRGWDHPELAPMAFPVTLQFDDETA
VRSLVARRLSAARAS

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=315, Percent_Identity=35.5555555555556, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_BRASO (A4Z0S1)

Other databases:

- EMBL:   CU234118
- RefSeq:   YP_001207962.1
- STRING:   A4Z0S1
- GeneID:   5117205
- GenomeReviews:   CU234118_GR
- KEGG:   bra:BRADO6095
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- ProtClustDB:   PRK00652
- BioCyc:   BSP376:BRADO6095-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 35392; Mature: 35392

Theoretical pI: Translated: 10.71; Mature: 10.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREPAFWHRPPSWQSHLLSPLSMLYGAVAARRMAQPGIKAGVPVICVGNYHVGGAGKTPT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEECCCCCCHH
VLALTALLRGQGEQPVVLSRGYGGRLPGPVLVDPAAHGAADVGDEPLMMAAHVPVVVSRA
HHHHHHHHHCCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCCCEEEEECCCHHEEHH
RADGVGLAKAHRASVILMDDGFQNPSITKDLALIVVDGGRGLGNARVFPAGPLRTPLPPQ
CCCCCCEEECCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCEECCCCCCCCCCCHH
LARTDALMIIGRGEAGEAVASRVAAAGKPVFRAQLQPDAGVVASLAGRPLLAFAGIGDPQ
HHCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCCEEEEECCCCHH
RFFRSLRASGLEIRAERPFPDHHPFTDGDIKALVDQATREQLALVTTEKDLVRLRGRGWD
HHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECHHHHHHHHCCCCC
HPELAPMAFPVTLQFDDETAVRSLVARRLSAARAS
CCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MREPAFWHRPPSWQSHLLSPLSMLYGAVAARRMAQPGIKAGVPVICVGNYHVGGAGKTPT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEECCCCCCHH
VLALTALLRGQGEQPVVLSRGYGGRLPGPVLVDPAAHGAADVGDEPLMMAAHVPVVVSRA
HHHHHHHHHCCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCCCEEEEECCCHHEEHH
RADGVGLAKAHRASVILMDDGFQNPSITKDLALIVVDGGRGLGNARVFPAGPLRTPLPPQ
CCCCCCEEECCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCEECCCCCCCCCCCHH
LARTDALMIIGRGEAGEAVASRVAAAGKPVFRAQLQPDAGVVASLAGRPLLAFAGIGDPQ
HHCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCCEEEEECCCCHH
RFFRSLRASGLEIRAERPFPDHHPFTDGDIKALVDQATREQLALVTTEKDLVRLRGRGWD
HHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECHHHHHHHHCCCCC
HPELAPMAFPVTLQFDDETAVRSLVARRLSAARAS
CCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA