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The map label for this gene is pqqL [C]

Identifier: 146342890

GI number: 146342890

Start: 6296238

End: 6297623

Strand: Direct

Name: pqqL [C]

Synonym: BRADO6070

Alternate gene names: 146342890

Gene position: 6296238-6297623 (Clockwise)

Preceding gene: 146342889

Following gene: 146342891

Centisome position: 84.44

GC content: 66.52

Gene sequence:

>1386_bases
ATGATGTCCTCGCACCGGTTCACCTCTGCCGCCGCCGCGCTCGTCTCCCTCCTGGCGTTCACGGCCGGCGCTTCGGCGCA
AACGACGTTCGCCTCCGACCCCCCGGCCAGCTTCACCCTGCCCAACGGCCTGCAGGTCGTCGTCATCCAGGATCACCGCA
CGCCGGTGGTGACGCAGATGATCTGGTACAAGGTCGGCTCCGCCGACGAGACGCCCGGCAAATCGGGGCTGGCGCATTTC
CTCGAGCACCTGATGTTCAAGGGCACCGAGGCGCATCCCGCCGGCGAGTTCTCCAAAACCGTGCTGAAGATCGGCGGCAA
CGAGAACGCCTTCACCTCGGTCGACTACACCGGCTACTTCCAGCGCGTGCCGCGCGACCAGTTGCCGAAGATGATGGAGT
TCGAGGCCGACCGCATGACCGGCCTGGTTCTCAAAGATGAGAACGTGCTGCCCGAGCGCGACGTCGTGCTCGAGGAGTAC
AACATGCGCGTCGCCAACTCGCCGGAGGCCCGCCTCAACGAGCAGATCATGGCGGCGCTCTACGTCAACCATCCCTATGG
CCGTCCCGTCATCGGCTGGAGACCGGAGATCGAGAAGCTCAGCCGCGAGGACGCGCTGGCGTTCTATCGCCGTTTTTACG
CGCCCAACAACGCGATCCTGGTGATCGCCGGCGACACCGACGCCAAGGAAGTCCGCCCGCTGGTCGAGCAGACCTTTGCC
AAGGTTCCCTCGCAGCCCGATATCCCCGCGCGTCGCCTGCGGCCGCAGGAGCCCGAGCCGATCGCGCCGCGCACCGTCAC
TCTGGCCGATCCGCATGTCGAGCAGCCCTCGATGCGCCGTTTCTATCTGGTGCCCTCGGCGACCACGGCCGCGCCTGGTG
AATCCGCCGCGCTCGACGTGCTGGCGCAGCTGATGGGCAGCGGCAGCAACTCCTATCTCTACCGCGCGCTCGTCGTCGAC
AAGCCGCTCGCGGTCAATGCCAGTGCGTCCTATCAGGGGACCTCGCTCGACCCGAGCCAGTTCTCGGTCGCGGTCGCGCC
GCGGCCGGGCGTCGATTTCGCCCAGGTCGAGGCCGTCGTCGACGGCGTCATCGCCGAGATCGCCCAGAACCCGGTGCGAT
CAGAGGATCTCGAGCGCGTGAAGACGCAGCTGATCGCGGAAGCGATCTACGCCAACGACAACCAGGCGACGATGGCGCGC
TGGTATGGCGGCGGCCTCACCACCGGATTGAGCATCGAGGATATCAGAAGCTGGCCCGACCGCATCCGCGCCGTGACAGC
CGAGCAAGTCCGCGCCGCCGCGCAGAAATGGCTCGACAAGAAGCGCTCGGTCACGGGCTATCTGATCAAGGACAATGCGG
CCAAGCGCGAGGAGAAGCGGTCGTGA

Upstream 100 bases:

>100_bases
GCACCATGTCGCCGTTTTGTGACGCCGGGCTCAGTCCGGCGCGATGTAACATGCTGCGCTCAAACCCGATCGCCCCGCCC
CGCGGGCCTTCAGAAGGATC

Downstream 100 bases:

>100_bases
TGAGCACAATCACCTTCGCCCGCCGCCTCGCCTGCGTTCTCAGCGTCGCCGCCGCGGCGCTGACGCTCGCCCCGGCCGCC
CATGCCGCGACCAAGATCCA

Product: putative Zn-dependent protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MMSSHRFTSAAAALVSLLAFTAGASAQTTFASDPPASFTLPNGLQVVVIQDHRTPVVTQMIWYKVGSADETPGKSGLAHF
LEHLMFKGTEAHPAGEFSKTVLKIGGNENAFTSVDYTGYFQRVPRDQLPKMMEFEADRMTGLVLKDENVLPERDVVLEEY
NMRVANSPEARLNEQIMAALYVNHPYGRPVIGWRPEIEKLSREDALAFYRRFYAPNNAILVIAGDTDAKEVRPLVEQTFA
KVPSQPDIPARRLRPQEPEPIAPRTVTLADPHVEQPSMRRFYLVPSATTAAPGESAALDVLAQLMGSGSNSYLYRALVVD
KPLAVNASASYQGTSLDPSQFSVAVAPRPGVDFAQVEAVVDGVIAEIAQNPVRSEDLERVKTQLIAEAIYANDNQATMAR
WYGGGLTTGLSIEDIRSWPDRIRAVTAEQVRAAAQKWLDKKRSVTGYLIKDNAAKREEKRS

Sequences:

>Translated_461_residues
MMSSHRFTSAAAALVSLLAFTAGASAQTTFASDPPASFTLPNGLQVVVIQDHRTPVVTQMIWYKVGSADETPGKSGLAHF
LEHLMFKGTEAHPAGEFSKTVLKIGGNENAFTSVDYTGYFQRVPRDQLPKMMEFEADRMTGLVLKDENVLPERDVVLEEY
NMRVANSPEARLNEQIMAALYVNHPYGRPVIGWRPEIEKLSREDALAFYRRFYAPNNAILVIAGDTDAKEVRPLVEQTFA
KVPSQPDIPARRLRPQEPEPIAPRTVTLADPHVEQPSMRRFYLVPSATTAAPGESAALDVLAQLMGSGSNSYLYRALVVD
KPLAVNASASYQGTSLDPSQFSVAVAPRPGVDFAQVEAVVDGVIAEIAQNPVRSEDLERVKTQLIAEAIYANDNQATMAR
WYGGGLTTGLSIEDIRSWPDRIRAVTAEQVRAAAQKWLDKKRSVTGYLIKDNAAKREEKRS
>Mature_461_residues
MMSSHRFTSAAAALVSLLAFTAGASAQTTFASDPPASFTLPNGLQVVVIQDHRTPVVTQMIWYKVGSADETPGKSGLAHF
LEHLMFKGTEAHPAGEFSKTVLKIGGNENAFTSVDYTGYFQRVPRDQLPKMMEFEADRMTGLVLKDENVLPERDVVLEEY
NMRVANSPEARLNEQIMAALYVNHPYGRPVIGWRPEIEKLSREDALAFYRRFYAPNNAILVIAGDTDAKEVRPLVEQTFA
KVPSQPDIPARRLRPQEPEPIAPRTVTLADPHVEQPSMRRFYLVPSATTAAPGESAALDVLAQLMGSGSNSYLYRALVVD
KPLAVNASASYQGTSLDPSQFSVAVAPRPGVDFAQVEAVVDGVIAEIAQNPVRSEDLERVKTQLIAEAIYANDNQATMAR
WYGGGLTTGLSIEDIRSWPDRIRAVTAEQVRAAAQKWLDKKRSVTGYLIKDNAAKREEKRS

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI46593007, Length=421, Percent_Identity=25.6532066508314, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI94538354, Length=214, Percent_Identity=28.5046728971963, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI155969707, Length=222, Percent_Identity=26.5765765765766, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1787770, Length=215, Percent_Identity=29.7674418604651, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI2367164, Length=216, Percent_Identity=27.3148148148148, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71999683, Length=204, Percent_Identity=24.5098039215686, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994338, Length=245, Percent_Identity=26.530612244898, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25146563, Length=245, Percent_Identity=26.530612244898, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32566665, Length=245, Percent_Identity=26.530612244898, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25146566, Length=245, Percent_Identity=26.530612244898, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17553678, Length=243, Percent_Identity=25.1028806584362, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323192, Length=419, Percent_Identity=26.0143198090692, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323421, Length=234, Percent_Identity=27.3504273504274, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21357875, Length=206, Percent_Identity=28.1553398058252, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646943, Length=206, Percent_Identity=28.1553398058252, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221513245, Length=282, Percent_Identity=24.468085106383, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 50718; Mature: 50718

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSSHRFTSAAAALVSLLAFTAGASAQTTFASDPPASFTLPNGLQVVVIQDHRTPVVTQM
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCCHHHHH
IWYKVGSADETPGKSGLAHFLEHLMFKGTEAHPAGEFSKTVLKIGGNENAFTSVDYTGYF
HHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEECCCCCCEEECCCCHHH
QRVPRDQLPKMMEFEADRMTGLVLKDENVLPERDVVLEEYNMRVANSPEARLNEQIMAAL
HHCCHHHCCHHHHHCHHHHEEEEEECCCCCCCHHHHHHHHCCEECCCCHHHHHHHHHHHH
YVNHPYGRPVIGWRPEIEKLSREDALAFYRRFYAPNNAILVIAGDTDAKEVRPLVEQTFA
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHH
KVPSQPDIPARRLRPQEPEPIAPRTVTLADPHVEQPSMRRFYLVPSATTAAPGESAALDV
HCCCCCCCCHHHCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
LAQLMGSGSNSYLYRALVVDKPLAVNASASYQGTSLDPSQFSVAVAPRPGVDFAQVEAVV
HHHHHCCCCCCEEEEEEEECCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHH
DGVIAEIAQNPVRSEDLERVKTQLIAEAIYANDNQATMARWYGGGLTTGLSIEDIRSWPD
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
RIRAVTAEQVRAAAQKWLDKKRSVTGYLIKDNAAKREEKRS
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHCCC
>Mature Secondary Structure
MMSSHRFTSAAAALVSLLAFTAGASAQTTFASDPPASFTLPNGLQVVVIQDHRTPVVTQM
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCCHHHHH
IWYKVGSADETPGKSGLAHFLEHLMFKGTEAHPAGEFSKTVLKIGGNENAFTSVDYTGYF
HHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEECCCCCCEEECCCCHHH
QRVPRDQLPKMMEFEADRMTGLVLKDENVLPERDVVLEEYNMRVANSPEARLNEQIMAAL
HHCCHHHCCHHHHHCHHHHEEEEEECCCCCCCHHHHHHHHCCEECCCCHHHHHHHHHHHH
YVNHPYGRPVIGWRPEIEKLSREDALAFYRRFYAPNNAILVIAGDTDAKEVRPLVEQTFA
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHH
KVPSQPDIPARRLRPQEPEPIAPRTVTLADPHVEQPSMRRFYLVPSATTAAPGESAALDV
HCCCCCCCCHHHCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
LAQLMGSGSNSYLYRALVVDKPLAVNASASYQGTSLDPSQFSVAVAPRPGVDFAQVEAVV
HHHHHCCCCCCEEEEEEEECCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHH
DGVIAEIAQNPVRSEDLERVKTQLIAEAIYANDNQATMARWYGGGLTTGLSIEDIRSWPD
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
RIRAVTAEQVRAAAQKWLDKKRSVTGYLIKDNAAKREEKRS
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]