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The map label for this gene is proC [H]

Identifier: 146342855

GI number: 146342855

Start: 6259505

End: 6260332

Strand: Direct

Name: proC [H]

Synonym: BRADO6035

Alternate gene names: 146342855

Gene position: 6259505-6260332 (Clockwise)

Preceding gene: 146342854

Following gene: 146342860

Centisome position: 83.95

GC content: 71.86

Gene sequence:

>828_bases
GTGACTTCCGTGGGCAACAACGAACTCCAACACACCACCGGCACCATCGTGCTGGCCGGTGCCGGCAAGATGGGCGGCGC
GATGCTGAGCGGCTGGCTGGCCGGCGGGCTCGATCCGGCGCGGGTGGTGGTGATCGAGCCGATGCCGTCGGCCGAGATCA
CGGCGCTGGTGGCCAAGGGTGTGCGGCTCAATCCGGCCGATGCCGCACCGGCCGAGGTCGTCATCCTCGCCGTCAAGCCG
CAGATGTTCCGCGAAGCCGGACCGGCGCTGAAGCGGTGGGTGGGCGGCGCCACGCTGGTGCTGTCGATCATGGCCGGCAC
CACGATCGCCAGCCTGCAGGATGTGGTGGGCGGCGCCGTGGTGCGCGCGATGCCCAACACGCCGGCCGCGATCGGCCGCG
GCATCACGGTCGCCGTACCCGCCGCCAATGTCAGCGCCAGCCAGCGCGCGCTGACCGATGCGCTGCTGCGCGCGACCGGG
GCGGTCGAATGGGTGGATGACGAGATGCTGATGGACGCGGTCACCGCGGTCTCCGGCTCCGGCCCCGCTTATGTCTTCCT
GCTCGCGGAGGAGCTCGCGCGCGCCGGCGTCGCCGCTGGCCTGCCCGAGGCGCTGGCGACGAAGCTGGCACGCGACACGG
TGTCCGGCGCGGGCGAGCTGCTGCATCGCTCGGATCTCTCATCTGCGACATTGCGGCGGAACGTCACCTCGCCCGGGGGC
ACGACCGCGGCCGCACTCTCGGTGCTGATGGCCGCGGACGGCTTCCAGCCGCTGCTGGAGCGCGCGGTGGCCGCGGCGAC
GGCAAGGTCGAAGGAATTGGCCAAATAG

Upstream 100 bases:

>100_bases
GCCCATGTCGCCCGCGATGCTTGTCGCTCTGCCCTCGCTCCACTAGAACCGCCTGTGGTTATGGATCCCGGCTCAAGGCC
GGGACGACAGCTTTTGTGCG

Downstream 100 bases:

>100_bases
CTCCTCCACCCTCCGCCGTCATTGCGAGCGCAGCGAAGCAATCCAGGGCCACGCCCGCGGCCCTGGATTGCTTCGTCGCG
GAGCTTGTCATCGGGCCGCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MTSVGNNELQHTTGTIVLAGAGKMGGAMLSGWLAGGLDPARVVVIEPMPSAEITALVAKGVRLNPADAAPAEVVILAVKP
QMFREAGPALKRWVGGATLVLSIMAGTTIASLQDVVGGAVVRAMPNTPAAIGRGITVAVPAANVSASQRALTDALLRATG
AVEWVDDEMLMDAVTAVSGSGPAYVFLLAEELARAGVAAGLPEALATKLARDTVSGAGELLHRSDLSSATLRRNVTSPGG
TTAAALSVLMAADGFQPLLERAVAAATARSKELAK

Sequences:

>Translated_275_residues
MTSVGNNELQHTTGTIVLAGAGKMGGAMLSGWLAGGLDPARVVVIEPMPSAEITALVAKGVRLNPADAAPAEVVILAVKP
QMFREAGPALKRWVGGATLVLSIMAGTTIASLQDVVGGAVVRAMPNTPAAIGRGITVAVPAANVSASQRALTDALLRATG
AVEWVDDEMLMDAVTAVSGSGPAYVFLLAEELARAGVAAGLPEALATKLARDTVSGAGELLHRSDLSSATLRRNVTSPGG
TTAAALSVLMAADGFQPLLERAVAAATARSKELAK
>Mature_274_residues
TSVGNNELQHTTGTIVLAGAGKMGGAMLSGWLAGGLDPARVVVIEPMPSAEITALVAKGVRLNPADAAPAEVVILAVKPQ
MFREAGPALKRWVGGATLVLSIMAGTTIASLQDVVGGAVVRAMPNTPAAIGRGITVAVPAANVSASQRALTDALLRATGA
VEWVDDEMLMDAVTAVSGSGPAYVFLLAEELARAGVAAGLPEALATKLARDTVSGAGELLHRSDLSSATLRRNVTSPGGT
TAAALSVLMAADGFQPLLERAVAAATARSKELAK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=35.4477611940299, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=35.4477611940299, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI21361454, Length=264, Percent_Identity=34.469696969697, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI198041662, Length=263, Percent_Identity=30.4182509505703, Blast_Score=104, Evalue=7e-23,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=33.0827067669173, Blast_Score=117, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=33.5820895522388, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17540664, Length=284, Percent_Identity=30.6338028169014, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320861, Length=261, Percent_Identity=32.5670498084291, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=34.7014925373134, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24647700, Length=155, Percent_Identity=42.5806451612903, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24648116, Length=216, Percent_Identity=34.7222222222222, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27661; Mature: 27530

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVGNNELQHTTGTIVLAGAGKMGGAMLSGWLAGGLDPARVVVIEPMPSAEITALVAKG
CCCCCCCCCEECCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCC
VRLNPADAAPAEVVILAVKPQMFREAGPALKRWVGGATLVLSIMAGTTIASLQDVVGGAV
CEECCCCCCCCEEEEEEECHHHHHHCCHHHHHHHCHHHHHHHHHHCCHHHHHHHHHCCHH
VRAMPNTPAAIGRGITVAVPAANVSASQRALTDALLRATGAVEWVDDEMLMDAVTAVSGS
EEECCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCC
GPAYVFLLAEELARAGVAAGLPEALATKLARDTVSGAGELLHRSDLSSATLRRNVTSPGG
CCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCC
TTAAALSVLMAADGFQPLLERAVAAATARSKELAK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSVGNNELQHTTGTIVLAGAGKMGGAMLSGWLAGGLDPARVVVIEPMPSAEITALVAKG
CCCCCCCCEECCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCC
VRLNPADAAPAEVVILAVKPQMFREAGPALKRWVGGATLVLSIMAGTTIASLQDVVGGAV
CEECCCCCCCCEEEEEEECHHHHHHCCHHHHHHHCHHHHHHHHHHCCHHHHHHHHHCCHH
VRAMPNTPAAIGRGITVAVPAANVSASQRALTDALLRATGAVEWVDDEMLMDAVTAVSGS
EEECCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCC
GPAYVFLLAEELARAGVAAGLPEALATKLARDTVSGAGELLHRSDLSSATLRRNVTSPGG
CCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCC
TTAAALSVLMAADGFQPLLERAVAAATARSKELAK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]