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The map label for this gene is macA [H]

Identifier: 146342764

GI number: 146342764

Start: 6155170

End: 6156465

Strand: Reverse

Name: macA [H]

Synonym: BRADO5938

Alternate gene names: 146342764

Gene position: 6156465-6155170 (Counterclockwise)

Preceding gene: 146342769

Following gene: 146342763

Centisome position: 82.56

GC content: 68.75

Gene sequence:

>1296_bases
GTGCGCCGGGCGCCATCTGTAATGACGGACATGGTCGATCAAGCCGCAGCCCTCCCGCGCCAGAGCAGCAAATCCTCTTC
GAAGGTCTGGTCCGCGCTTGTCGCGCATCGCTGGTTCATTCTCGCGGTGATCCTGCTGCTCGGCCTCGGCGGCTGGCAGA
GCGTGCGTGTCATGCTCGGCCCGGCGGTCGTGGTCGATCAGGTGCGGAGCGGTGATCTCGTCGAGACGGTGGTCGCCAGC
GGCCATGTCGAGACGCCGTTTCGCGTCGAGATCGGCAGCCAGATCACCGGCACGGTCGATGAGGTCCTTGTGCTCGAAGG
CCAGCGCGTGACCAGGGGCCAGCCGCTGATCTCGCTGGAGTCGCGCGAGCTCAAGGCCGCGGTGGTCCAGGCGCAGGGCC
AGGTGGCGCAGGCCGAAGCGCGGATGCGCCAGCTCGCCGAATTGACCCTCCCGTCGGCTAAGGAGGCGCTGCGCCAGGCC
CAGGCGACGCTGCTCAACGCGCAGCAGACCTACGACCGGACATCGCTGCTGACGGCCAACGGCTATGCCACGCGGGCCTC
GCTCGACGAGGCGCAGAAGACGCTCGACATCGCGCTGGCGCAGGAGCGCGCGGCCGAATTCCAGGTCTTCACCGCGAGCC
CCGGCGGCAGCGACTACGTCATGGCGGAGACGCAGCTGAATCAGGCGCGCGCCACGCTCGACACGGCGCAGTCGCGGCTC
GGCTATGCGACGATCTCGGCGCCGCGCGACGGCGTGCTGATCACGCGCAATGTCGAGAAGGGCACCGTGGCGCAGCCCGG
CAAGGCGCTGCTCGTTCTCGCGCCCGCCGGCGATGTCCAGCTCGTGCTGCAGATCGATGAGCGCAATCTCGGCAAGCTGG
CGCTGGGGCAGACGGCGCTGGCCTCGGCCGATGCCTATCCGGACAAGCGTTTTCCCGCCGTGCTCAGCTACATCAATCCC
GGCGTTGATCTCTCGCGCGCCTCGGTGCAGGTCAAACTGATCGTCAAGGACCCGCCGGACTATCTGCGCCAGGACATGAC
GGTGTCGGTCGACATCGAGGTCGCGTCCCGCAAGGATACGCTGGAGCTGCCCGTCCGCTCGGTTCATGATCTCACCTCCG
GGCAGCCCTGGGTGCTCGGCGAGAAGGACGGCCGCGCGGTCAAGCGCCCGGTGCGCGCCGGCATCCGTGGCAACAGCCAT
GTCGAGATCGTCGATGGCCTGAGTGCCGGCGACATCGCGGTGCCCGCCAGCTCCGGCCTCGTCACTGGCCAGCGCTTCCG
TCCGGTGCTGCCGTGA

Upstream 100 bases:

>100_bases
TTGACCTAGCGCAACATCCTGATGCGCGCATGACCTAGGCTGCTCGAGAACACGCCGTGGGGCGGACGGCTGAGGATTCA
CGAGGACGACATCCCGCCCG

Downstream 100 bases:

>100_bases
ACCGCTGGCTGCCGTTCGAATGGGTCGCGGCGGTGCGCTTCCTGCGCGAGGGCCGGCTGCAGACCCTGTTCATCATCGGC
GGCATCGCGATCGGCGTCGC

Product: putative efflux transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MRRAPSVMTDMVDQAAALPRQSSKSSSKVWSALVAHRWFILAVILLLGLGGWQSVRVMLGPAVVVDQVRSGDLVETVVAS
GHVETPFRVEIGSQITGTVDEVLVLEGQRVTRGQPLISLESRELKAAVVQAQGQVAQAEARMRQLAELTLPSAKEALRQA
QATLLNAQQTYDRTSLLTANGYATRASLDEAQKTLDIALAQERAAEFQVFTASPGGSDYVMAETQLNQARATLDTAQSRL
GYATISAPRDGVLITRNVEKGTVAQPGKALLVLAPAGDVQLVLQIDERNLGKLALGQTALASADAYPDKRFPAVLSYINP
GVDLSRASVQVKLIVKDPPDYLRQDMTVSVDIEVASRKDTLELPVRSVHDLTSGQPWVLGEKDGRAVKRPVRAGIRGNSH
VEIVDGLSAGDIAVPASSGLVTGQRFRPVLP

Sequences:

>Translated_431_residues
MRRAPSVMTDMVDQAAALPRQSSKSSSKVWSALVAHRWFILAVILLLGLGGWQSVRVMLGPAVVVDQVRSGDLVETVVAS
GHVETPFRVEIGSQITGTVDEVLVLEGQRVTRGQPLISLESRELKAAVVQAQGQVAQAEARMRQLAELTLPSAKEALRQA
QATLLNAQQTYDRTSLLTANGYATRASLDEAQKTLDIALAQERAAEFQVFTASPGGSDYVMAETQLNQARATLDTAQSRL
GYATISAPRDGVLITRNVEKGTVAQPGKALLVLAPAGDVQLVLQIDERNLGKLALGQTALASADAYPDKRFPAVLSYINP
GVDLSRASVQVKLIVKDPPDYLRQDMTVSVDIEVASRKDTLELPVRSVHDLTSGQPWVLGEKDGRAVKRPVRAGIRGNSH
VEIVDGLSAGDIAVPASSGLVTGQRFRPVLP
>Mature_431_residues
MRRAPSVMTDMVDQAAALPRQSSKSSSKVWSALVAHRWFILAVILLLGLGGWQSVRVMLGPAVVVDQVRSGDLVETVVAS
GHVETPFRVEIGSQITGTVDEVLVLEGQRVTRGQPLISLESRELKAAVVQAQGQVAQAEARMRQLAELTLPSAKEALRQA
QATLLNAQQTYDRTSLLTANGYATRASLDEAQKTLDIALAQERAAEFQVFTASPGGSDYVMAETQLNQARATLDTAQSRL
GYATISAPRDGVLITRNVEKGTVAQPGKALLVLAPAGDVQLVLQIDERNLGKLALGQTALASADAYPDKRFPAVLSYINP
GVDLSRASVQVKLIVKDPPDYLRQDMTVSVDIEVASRKDTLELPVRSVHDLTSGQPWVLGEKDGRAVKRPVRAGIRGNSH
VEIVDGLSAGDIAVPASSGLVTGQRFRPVLP

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=387, Percent_Identity=27.390180878553, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789900, Length=331, Percent_Identity=25.0755287009063, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787013, Length=284, Percent_Identity=27.8169014084507, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 46139; Mature: 46139

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRAPSVMTDMVDQAAALPRQSSKSSSKVWSALVAHRWFILAVILLLGLGGWQSVRVMLG
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEC
PAVVVDQVRSGDLVETVVASGHVETPFRVEIGSQITGTVDEVLVLEGQRVTRGQPLISLE
CHHHHHHCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCHHHEEEECCCCCCCCCCEEEEC
SRELKAAVVQAQGQVAQAEARMRQLAELTLPSAKEALRQAQATLLNAQQTYDRTSLLTAN
CHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
GYATRASLDEAQKTLDIALAQERAAEFQVFTASPGGSDYVMAETQLNQARATLDTAQSRL
CCEEHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHC
GYATISAPRDGVLITRNVEKGTVAQPGKALLVLAPAGDVQLVLQIDERNLGKLALGQTAL
CEEEECCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCCEECCCHHH
ASADAYPDKRFPAVLSYINPGVDLSRASVQVKLIVKDPPDYLRQDMTVSVDIEVASRKDT
HCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHCCCEEEEEEEECCCCCC
LELPVRSVHDLTSGQPWVLGEKDGRAVKRPVRAGIRGNSHVEIVDGLSAGDIAVPASSGL
CCCCHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCCCCEEEEEECCCCCCEEECCCCCC
VTGQRFRPVLP
EECCCCCCCCC
>Mature Secondary Structure
MRRAPSVMTDMVDQAAALPRQSSKSSSKVWSALVAHRWFILAVILLLGLGGWQSVRVMLG
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEC
PAVVVDQVRSGDLVETVVASGHVETPFRVEIGSQITGTVDEVLVLEGQRVTRGQPLISLE
CHHHHHHCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCHHHEEEECCCCCCCCCCEEEEC
SRELKAAVVQAQGQVAQAEARMRQLAELTLPSAKEALRQAQATLLNAQQTYDRTSLLTAN
CHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
GYATRASLDEAQKTLDIALAQERAAEFQVFTASPGGSDYVMAETQLNQARATLDTAQSRL
CCEEHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHC
GYATISAPRDGVLITRNVEKGTVAQPGKALLVLAPAGDVQLVLQIDERNLGKLALGQTAL
CEEEECCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCCEECCCHHH
ASADAYPDKRFPAVLSYINPGVDLSRASVQVKLIVKDPPDYLRQDMTVSVDIEVASRKDT
HCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHCCCEEEEEEEECCCCCC
LELPVRSVHDLTSGQPWVLGEKDGRAVKRPVRAGIRGNSHVEIVDGLSAGDIAVPASSGL
CCCCHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCCCCEEEEEECCCCCCEEECCCCCC
VTGQRFRPVLP
EECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]