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The map label for this gene is maeA [H]

Identifier: 146342172

GI number: 146342172

Start: 5538080

End: 5539711

Strand: Direct

Name: maeA [H]

Synonym: BRADO5322

Alternate gene names: 146342172

Gene position: 5538080-5539711 (Clockwise)

Preceding gene: 146342171

Following gene: 146342174

Centisome position: 74.27

GC content: 66.54

Gene sequence:

>1632_bases
ATGAGCGCACCGACGCACTCAACCCATTCCCCGCGCGGCCTGACGCTGCTGCGCGACCCGCTGCTCAACAAGGGCACCGG
CTTCACCGAGCAGGAGCGCGACGCGCTCGGCCTGCGCGGCTTCCTGCCCGCAGGCGTCATGTCGATGCAGGCCCAGGCCG
AGCGTATCCTGGTCAATCTGCGCAGCCTGTCGAACGACCTGGAGAAGTACGTCGCGCTGAACGCGCTGCACGACCGCAAC
GAGGCGCTGTTCTTCCGGGTGGTCTGCGACAACATCGACGAGATCCAGCCGCTGATCTACACGCCGACCGTCGGCCTCGC
CTGTCAGAAATACGGCCTGATCTTCCAGCGTCCGCGCGGCCTGTTCATCTCGGCCAATGATCGCGGGCGGATCGCGGAGA
TCCTCGCCAATTGGCCGTATCGCGCCAGGCTGATCGTCGTCACCGACGGCGAGCGTATTCTCGGCCTCGGCGATCTCGGC
GCCAACGGCATGGGCATCCCGGTCGGCAAGCTGTCGCTGTACTCGGCCTGCGCCGGCATTCACCCTGAGGAATGCCTTCC
GGTCATGCTCGACGTCGGCACCAACAATGAGGAGCTGCTCGCCGATCCCTACTACATCGGACTGCGCCAGAAGCGCCTGA
CCGGCGAAGCCTACGACGCCTTCGTCGACGAATTCATGACCGCCGCCCGAACGGCCTTCCCCGGCGTGCTGATCCAGTTC
GAGGATTTCGCCAACCACGCCGCGTTCAAGCTGCTGCACAAATATCGCGACGAGGCCTGCGTCTTCAACGACGACATCCA
GGGCACCGCGGCAGTCGCGCTCGCCGGGCTTTTCTCCGCTCTGCGCATCACCGGCGGCAAGCTGCGCGATCAGACCGTGC
TGTTTCTCGGCGCCGGCGAGGCGGCGACCGGCATTGCCGATCTCGTCGTCTCGGCGATGATGGCCGAGGGGCTGTCCGAG
GCCGAGGCGCTGCGGCGCAACTGGCTGACGGATTCGCGCGGCCTCGTCATCAAGGGGCGCGAGAATCTGCACGGCCACAA
GCTGCGTTATGCGCACGACCAGGCGCCGATCGGCGATTTCCTGTCCGCGATCAAGACGCTCAAGCCGACGGCGATTATCG
GCGTGGCCGCGGTCGGCGGCGCCTTCACGCCGGAGGTGCTGCAGGCGATGGCGGAGCTCAACGAGCGCCCGATCATCTTT
GCGCTGTCGAACCCGACCTCGAAGGCGGAATGCTCGGCGGAGGCCGCCTATCGCTACACGCAGGGACGCGCGCTGTTCGC
CTGCGGCAGTCCGTATGATTCGGTCAAGCTCGACGGCAAGACCTTCGTGCCGCGCCAGGGCAACAACTCCTACATCTTTC
CCGGCGTCGGCCTCGGCGCCATCGCCAGCGGCGCGCGGCTGGTGACTGACGAGATGTTCATGGCGGCGGCTCATACGCTT
GCGAACTGCGTCACGGGTGCCGATCTCGAACAGGGCAGCCTGTATCCGGCCCTGCCGCGCATCCGCGAGGTGTCCGCCCA
TATCGGTGCGGCCGTCGCCGGCGTCGCCTATCAGAACGGGCTCGCCACCGGCCCTGCACCGAACGATCTGCTCGGCTTCG
TCGAGTCGAAGATGTACGACGCGCGCTACTGA

Upstream 100 bases:

>100_bases
GCCATCCCGCCGCTGTTGATGCCGATCAACGCCGGCGCGCTCCGGAATGGCGAGGCTCGAACAAAGGACCTCGGAGACTG
CCTTGACCCAACCGCAACGT

Downstream 100 bases:

>100_bases
TCGCGCTCGCGCGGATGCCTTGCAAAAGAGGCATCCGCGTCTCCACGACCCGCCGAAGGCACCCGGCTATTGATCCGGCA
CGATCGCATTGGTCGGGGTG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MSAPTHSTHSPRGLTLLRDPLLNKGTGFTEQERDALGLRGFLPAGVMSMQAQAERILVNLRSLSNDLEKYVALNALHDRN
EALFFRVVCDNIDEIQPLIYTPTVGLACQKYGLIFQRPRGLFISANDRGRIAEILANWPYRARLIVVTDGERILGLGDLG
ANGMGIPVGKLSLYSACAGIHPEECLPVMLDVGTNNEELLADPYYIGLRQKRLTGEAYDAFVDEFMTAARTAFPGVLIQF
EDFANHAAFKLLHKYRDEACVFNDDIQGTAAVALAGLFSALRITGGKLRDQTVLFLGAGEAATGIADLVVSAMMAEGLSE
AEALRRNWLTDSRGLVIKGRENLHGHKLRYAHDQAPIGDFLSAIKTLKPTAIIGVAAVGGAFTPEVLQAMAELNERPIIF
ALSNPTSKAECSAEAAYRYTQGRALFACGSPYDSVKLDGKTFVPRQGNNSYIFPGVGLGAIASGARLVTDEMFMAAAHTL
ANCVTGADLEQGSLYPALPRIREVSAHIGAAVAGVAYQNGLATGPAPNDLLGFVESKMYDARY

Sequences:

>Translated_543_residues
MSAPTHSTHSPRGLTLLRDPLLNKGTGFTEQERDALGLRGFLPAGVMSMQAQAERILVNLRSLSNDLEKYVALNALHDRN
EALFFRVVCDNIDEIQPLIYTPTVGLACQKYGLIFQRPRGLFISANDRGRIAEILANWPYRARLIVVTDGERILGLGDLG
ANGMGIPVGKLSLYSACAGIHPEECLPVMLDVGTNNEELLADPYYIGLRQKRLTGEAYDAFVDEFMTAARTAFPGVLIQF
EDFANHAAFKLLHKYRDEACVFNDDIQGTAAVALAGLFSALRITGGKLRDQTVLFLGAGEAATGIADLVVSAMMAEGLSE
AEALRRNWLTDSRGLVIKGRENLHGHKLRYAHDQAPIGDFLSAIKTLKPTAIIGVAAVGGAFTPEVLQAMAELNERPIIF
ALSNPTSKAECSAEAAYRYTQGRALFACGSPYDSVKLDGKTFVPRQGNNSYIFPGVGLGAIASGARLVTDEMFMAAAHTL
ANCVTGADLEQGSLYPALPRIREVSAHIGAAVAGVAYQNGLATGPAPNDLLGFVESKMYDARY
>Mature_542_residues
SAPTHSTHSPRGLTLLRDPLLNKGTGFTEQERDALGLRGFLPAGVMSMQAQAERILVNLRSLSNDLEKYVALNALHDRNE
ALFFRVVCDNIDEIQPLIYTPTVGLACQKYGLIFQRPRGLFISANDRGRIAEILANWPYRARLIVVTDGERILGLGDLGA
NGMGIPVGKLSLYSACAGIHPEECLPVMLDVGTNNEELLADPYYIGLRQKRLTGEAYDAFVDEFMTAARTAFPGVLIQFE
DFANHAAFKLLHKYRDEACVFNDDIQGTAAVALAGLFSALRITGGKLRDQTVLFLGAGEAATGIADLVVSAMMAEGLSEA
EALRRNWLTDSRGLVIKGRENLHGHKLRYAHDQAPIGDFLSAIKTLKPTAIIGVAAVGGAFTPEVLQAMAELNERPIIFA
LSNPTSKAECSAEAAYRYTQGRALFACGSPYDSVKLDGKTFVPRQGNNSYIFPGVGLGAIASGARLVTDEMFMAAAHTLA
NCVTGADLEQGSLYPALPRIREVSAHIGAAVAGVAYQNGLATGPAPNDLLGFVESKMYDARY

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=546, Percent_Identity=54.9450549450549, Blast_Score=621, Evalue=1e-178,
Organism=Homo sapiens, GI62420882, Length=557, Percent_Identity=53.3213644524237, Blast_Score=599, Evalue=1e-171,
Organism=Homo sapiens, GI62420880, Length=557, Percent_Identity=53.3213644524237, Blast_Score=599, Evalue=1e-171,
Organism=Homo sapiens, GI239049447, Length=557, Percent_Identity=53.3213644524237, Blast_Score=599, Evalue=1e-171,
Organism=Homo sapiens, GI4505145, Length=540, Percent_Identity=51.6666666666667, Blast_Score=541, Evalue=1e-154,
Organism=Homo sapiens, GI270265879, Length=457, Percent_Identity=54.4857768052516, Blast_Score=485, Evalue=1e-137,
Organism=Escherichia coli, GI87081919, Length=541, Percent_Identity=43.8077634011091, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1788806, Length=416, Percent_Identity=28.6057692307692, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17537199, Length=547, Percent_Identity=51.3711151736746, Blast_Score=551, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322823, Length=557, Percent_Identity=38.0610412926391, Blast_Score=347, Evalue=2e-96,
Organism=Drosophila melanogaster, GI281362672, Length=537, Percent_Identity=54.1899441340782, Blast_Score=603, Evalue=1e-172,
Organism=Drosophila melanogaster, GI281362674, Length=537, Percent_Identity=54.1899441340782, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI21356279, Length=537, Percent_Identity=54.1899441340782, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24646388, Length=536, Percent_Identity=54.4776119402985, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24646386, Length=536, Percent_Identity=54.4776119402985, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI78707242, Length=525, Percent_Identity=43.047619047619, Blast_Score=437, Evalue=1e-122,
Organism=Drosophila melanogaster, GI78707238, Length=525, Percent_Identity=43.047619047619, Blast_Score=437, Evalue=1e-122,
Organism=Drosophila melanogaster, GI78707240, Length=501, Percent_Identity=43.9121756487026, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI281363505, Length=524, Percent_Identity=41.6030534351145, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI78707236, Length=524, Percent_Identity=41.6030534351145, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI281363503, Length=522, Percent_Identity=41.3793103448276, Blast_Score=425, Evalue=1e-119,
Organism=Drosophila melanogaster, GI78707232, Length=500, Percent_Identity=42.2, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI19922384, Length=534, Percent_Identity=36.7041198501873, Blast_Score=359, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 58455; Mature: 58323

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPTHSTHSPRGLTLLRDPLLNKGTGFTEQERDALGLRGFLPAGVMSMQAQAERILVNL
CCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
RSLSNDLEKYVALNALHDRNEALFFRVVCDNIDEIQPLIYTPTVGLACQKYGLIFQRPRG
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHCCCEEECCCCCHHHHHCCCEEECCCC
LFISANDRGRIAEILANWPYRARLIVVTDGERILGLGDLGANGMGIPVGKLSLYSACAGI
EEEECCCCCHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHCCC
HPEECLPVMLDVGTNNEELLADPYYIGLRQKRLTGEAYDAFVDEFMTAARTAFPGVLIQF
CHHHCCEEEEECCCCCCCEEECCEEECCCHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEE
EDFANHAAFKLLHKYRDEACVFNDDIQGTAAVALAGLFSALRITGGKLRDQTVLFLGAGE
HHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCC
AATGIADLVVSAMMAEGLSEAEALRRNWLTDSRGLVIKGRENLHGHKLRYAHDQAPIGDF
HHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEEEECCCCCCCCEEEECCCCCCHHHH
LSAIKTLKPTAIIGVAAVGGAFTPEVLQAMAELNERPIIFALSNPTSKAECSAEAAYRYT
HHHHHHCCCHHEEEEHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHCHHHHHEEE
QGRALFACGSPYDSVKLDGKTFVPRQGNNSYIFPGVGLGAIASGARLVTDEMFMAAAHTL
CCCEEEEECCCCCCEEECCCEECCCCCCCCEEECCCCHHHHHCCCCHHHHHHHHHHHHHH
ANCVTGADLEQGSLYPALPRIREVSAHIGAAVAGVAYQNGLATGPAPNDLLGFVESKMYD
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
ARY
CCC
>Mature Secondary Structure 
SAPTHSTHSPRGLTLLRDPLLNKGTGFTEQERDALGLRGFLPAGVMSMQAQAERILVNL
CCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
RSLSNDLEKYVALNALHDRNEALFFRVVCDNIDEIQPLIYTPTVGLACQKYGLIFQRPRG
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHCCCEEECCCCCHHHHHCCCEEECCCC
LFISANDRGRIAEILANWPYRARLIVVTDGERILGLGDLGANGMGIPVGKLSLYSACAGI
EEEECCCCCHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHCCC
HPEECLPVMLDVGTNNEELLADPYYIGLRQKRLTGEAYDAFVDEFMTAARTAFPGVLIQF
CHHHCCEEEEECCCCCCCEEECCEEECCCHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEE
EDFANHAAFKLLHKYRDEACVFNDDIQGTAAVALAGLFSALRITGGKLRDQTVLFLGAGE
HHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCC
AATGIADLVVSAMMAEGLSEAEALRRNWLTDSRGLVIKGRENLHGHKLRYAHDQAPIGDF
HHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEEEECCCCCCCCEEEECCCCCCHHHH
LSAIKTLKPTAIIGVAAVGGAFTPEVLQAMAELNERPIIFALSNPTSKAECSAEAAYRYT
HHHHHHCCCHHEEEEHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHCHHHHHEEE
QGRALFACGSPYDSVKLDGKTFVPRQGNNSYIFPGVGLGAIASGARLVTDEMFMAAAHTL
CCCEEEEECCCCCCEEECCCEECCCCCCCCEEECCCCHHHHHCCCCHHHHHHHHHHHHHH
ANCVTGADLEQGSLYPALPRIREVSAHIGAAVAGVAYQNGLATGPAPNDLLGFVESKMYD
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
ARY
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA