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The map label for this gene is ahcY [H]

Identifier: 146342095

GI number: 146342095

Start: 5450141

End: 5451553

Strand: Reverse

Name: ahcY [H]

Synonym: BRADO5238

Alternate gene names: 146342095

Gene position: 5451553-5450141 (Counterclockwise)

Preceding gene: 146342096

Following gene: 146342088

Centisome position: 73.11

GC content: 63.48

Gene sequence:

>1413_bases
ATGACCGCCTTCAACGACTACATCGTCAAGGACATTTCGCTCGCCGAGTTCGGCCGCAAGGAGATCTCGCTCGCTGAGAC
CGAGATGCCCGGCCTGATGGCGACGCGCGAGGAGTATGGCCCGAAGCAGCCGCTGAAGGGCGCGCGGATCGCAGGCTCCC
TGCACATGACCATCCAGACCGCGGTGCTGATCGAGACGCTGAAGGCGCTCGGCGCCGACATCCGCTGGGTCTCCTGCAAC
ATCTATTCGACGCAGGACCATGCCGCCGCGGCGATCGCCGCCGCCGGCATTCCGGTGTTCGCCGTCAAGGGCGAGACCCT
GGTCGACTACTGGGACTACACTGCCAAGCTGTTCGACTGGCATGGCGGCGGCCATCCCAACATGATCCTGGATGACGGCG
GCGACGCCACCATGTACGTCCATCTCGGTCTCAAGGCCGAGAACGGCGACGCGGCGTTCCTCGACAAGCCCGGCTCGGAA
GAGGAGGAGGTGTTCTTCGCGCTCCTGAAGAAGCAGCTCAAGGAGAAGCCGAAGGGCTACTTCGCCGAGATCGCCAAGTC
GATCAAGGGCGTCTCCGAGGAGACCACCACGGGCGTGCATCGTCTCTACGACATGCAGAAGGCCGGCACGCTGCTGTGGC
CCGCGATCAACGTCAATGACAGCGTCACCAAGTCGAAGTTCGACAATCTTTATGGCTGCCGCGAGTCGCTGGTCGACGGC
ATCCGCCGCGGCACCGACGTGATGATGTCGGGCAAGGTCGCGATGGTCGCGGGCTTCGGCGACGTCGGCAAGGGCTCGGC
CGCCTCGCTGCGCCAGGCCGGCTGCCGCGTCATGGTCTCCGAGATCGATCCGATCTGCGCGCTGCAGGCATCGATGGAGG
GCTATGAGGTGACGACGATGGAGGACGCCGCGCCCCGCGCCGACATCTTTGTGACCGCCACCGGCAACAAGGACATCATC
ACCATCGAGCACATGCGCGCGATGAAGGATCGCGCCATCGTCTGCAACATCGGCCACTTCGACAACGAGATCCAGGTCGC
CTCGCTGAAGAACCTGAAGTGGACCAACATCAAGCCGCAGGTCGACGAGATCACCTTCCCCGACGGCAAGCGCATGATCC
TGCTGTCCGAAGGCCGGCTCGTGAACCTCGGCAATGCGATGGGCCATCCGTCCTTCGTGATGTCGGCGTCATTCACCAAC
CAGACCCTGGCGCAGATCGAGCTCTACGCCAACAACAAGGACGGCAAGTACAAGAAGGAAGTCTACGTGCTGCCGAAGTC
GCTCGACGAGAAGGTCGCGCGCCTGCACCTCGCCAAGATCGGCGTCAAGCTCACCGAGCTGCGCCCCGACCAGGCCGCCT
ATATCGGCGTCAAGCCGGAAGGCCCGTTCAAGTCGGAGCACTACCGTTATTGA

Upstream 100 bases:

>100_bases
CTCTCCCCGCCGGATCGGGGGAGAGTGATCCAGACAGCGCTGCGACGCGTCTCGTTCAATCGTTACAACCCGTTCGAATT
CATCCGACCAGGAACCCCAC

Downstream 100 bases:

>100_bases
GCTGCACTCAAGCGCGGTGGAGATGACGAAGGCCGGGGCATCGCCCCGGCCTTTTGCTTGATCGCGTACTTGATTAGCTA
TCAGCAGTTCTGCGATGAGC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MTAFNDYIVKDISLAEFGRKEISLAETEMPGLMATREEYGPKQPLKGARIAGSLHMTIQTAVLIETLKALGADIRWVSCN
IYSTQDHAAAAIAAAGIPVFAVKGETLVDYWDYTAKLFDWHGGGHPNMILDDGGDATMYVHLGLKAENGDAAFLDKPGSE
EEEVFFALLKKQLKEKPKGYFAEIAKSIKGVSEETTTGVHRLYDMQKAGTLLWPAINVNDSVTKSKFDNLYGCRESLVDG
IRRGTDVMMSGKVAMVAGFGDVGKGSAASLRQAGCRVMVSEIDPICALQASMEGYEVTTMEDAAPRADIFVTATGNKDII
TIEHMRAMKDRAIVCNIGHFDNEIQVASLKNLKWTNIKPQVDEITFPDGKRMILLSEGRLVNLGNAMGHPSFVMSASFTN
QTLAQIELYANNKDGKYKKEVYVLPKSLDEKVARLHLAKIGVKLTELRPDQAAYIGVKPEGPFKSEHYRY

Sequences:

>Translated_470_residues
MTAFNDYIVKDISLAEFGRKEISLAETEMPGLMATREEYGPKQPLKGARIAGSLHMTIQTAVLIETLKALGADIRWVSCN
IYSTQDHAAAAIAAAGIPVFAVKGETLVDYWDYTAKLFDWHGGGHPNMILDDGGDATMYVHLGLKAENGDAAFLDKPGSE
EEEVFFALLKKQLKEKPKGYFAEIAKSIKGVSEETTTGVHRLYDMQKAGTLLWPAINVNDSVTKSKFDNLYGCRESLVDG
IRRGTDVMMSGKVAMVAGFGDVGKGSAASLRQAGCRVMVSEIDPICALQASMEGYEVTTMEDAAPRADIFVTATGNKDII
TIEHMRAMKDRAIVCNIGHFDNEIQVASLKNLKWTNIKPQVDEITFPDGKRMILLSEGRLVNLGNAMGHPSFVMSASFTN
QTLAQIELYANNKDGKYKKEVYVLPKSLDEKVARLHLAKIGVKLTELRPDQAAYIGVKPEGPFKSEHYRY
>Mature_469_residues
TAFNDYIVKDISLAEFGRKEISLAETEMPGLMATREEYGPKQPLKGARIAGSLHMTIQTAVLIETLKALGADIRWVSCNI
YSTQDHAAAAIAAAGIPVFAVKGETLVDYWDYTAKLFDWHGGGHPNMILDDGGDATMYVHLGLKAENGDAAFLDKPGSEE
EEVFFALLKKQLKEKPKGYFAEIAKSIKGVSEETTTGVHRLYDMQKAGTLLWPAINVNDSVTKSKFDNLYGCRESLVDGI
RRGTDVMMSGKVAMVAGFGDVGKGSAASLRQAGCRVMVSEIDPICALQASMEGYEVTTMEDAAPRADIFVTATGNKDIIT
IEHMRAMKDRAIVCNIGHFDNEIQVASLKNLKWTNIKPQVDEITFPDGKRMILLSEGRLVNLGNAMGHPSFVMSASFTNQ
TLAQIELYANNKDGKYKKEVYVLPKSLDEKVARLHLAKIGVKLTELRPDQAAYIGVKPEGPFKSEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=467, Percent_Identity=57.6017130620985, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI239937451, Length=445, Percent_Identity=57.752808988764, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI298286489, Length=468, Percent_Identity=49.1452991452991, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI195539349, Length=468, Percent_Identity=49.1452991452991, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI24308043, Length=468, Percent_Identity=49.1452991452991, Blast_Score=454, Evalue=1e-127,
Organism=Homo sapiens, GI195539337, Length=468, Percent_Identity=49.1452991452991, Blast_Score=454, Evalue=1e-127,
Organism=Homo sapiens, GI21361647, Length=471, Percent_Identity=48.1953290870488, Blast_Score=430, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17506425, Length=467, Percent_Identity=59.5289079229122, Blast_Score=527, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6320882, Length=481, Percent_Identity=58.6278586278586, Blast_Score=511, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24642172, Length=466, Percent_Identity=60.9442060085837, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24656245, Length=472, Percent_Identity=48.5169491525424, Blast_Score=440, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45553387, Length=467, Percent_Identity=48.3940042826552, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45553385, Length=466, Percent_Identity=48.2832618025751, Blast_Score=416, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51617; Mature: 51486

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFNDYIVKDISLAEFGRKEISLAETEMPGLMATREEYGPKQPLKGARIAGSLHMTIQT
CCCCCCHHHCCCCHHHCCCCCEEEHHCCCCCCCHHHHHCCCCCCCCCCEEECEEEEHHHH
AVLIETLKALGADIRWVSCNIYSTQDHAAAAIAAAGIPVFAVKGETLVDYWDYTAKLFDW
HHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCEEEEHHCCEEEEEEC
HGGGHPNMILDDGGDATMYVHLGLKAENGDAAFLDKPGSEEEEVFFALLKKQLKEKPKGY
CCCCCCCEEEECCCCEEEEEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCHH
FAEIAKSIKGVSEETTTGVHRLYDMQKAGTLLWPAINVNDSVTKSKFDNLYGCRESLVDG
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
IRRGTDVMMSGKVAMVAGFGDVGKGSAASLRQAGCRVMVSEIDPICALQASMEGYEVTTM
HHCCCCEEEECCEEEEEECCCCCCCCHHHHHHCCCEEEEECCCCCEEEHHCCCCEEEEEE
EDAAPRADIFVTATGNKDIITIEHMRAMKDRAIVCNIGHFDNEIQVASLKNLKWTNIKPQ
CCCCCCCCEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEECCCCCC
VDEITFPDGKRMILLSEGRLVNLGNAMGHPSFVMSASFTNQTLAQIELYANNKDGKYKKE
CCEEECCCCCEEEEEECCCEEECCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCEEEE
VYVLPKSLDEKVARLHLAKIGVKLTELRPDQAAYIGVKPEGPFKSEHYRY
EEEECCHHHHHHHHHHHHHHCEEEEECCCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TAFNDYIVKDISLAEFGRKEISLAETEMPGLMATREEYGPKQPLKGARIAGSLHMTIQT
CCCCCHHHCCCCHHHCCCCCEEEHHCCCCCCCHHHHHCCCCCCCCCCEEECEEEEHHHH
AVLIETLKALGADIRWVSCNIYSTQDHAAAAIAAAGIPVFAVKGETLVDYWDYTAKLFDW
HHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCEEEEHHCCEEEEEEC
HGGGHPNMILDDGGDATMYVHLGLKAENGDAAFLDKPGSEEEEVFFALLKKQLKEKPKGY
CCCCCCCEEEECCCCEEEEEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCHH
FAEIAKSIKGVSEETTTGVHRLYDMQKAGTLLWPAINVNDSVTKSKFDNLYGCRESLVDG
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
IRRGTDVMMSGKVAMVAGFGDVGKGSAASLRQAGCRVMVSEIDPICALQASMEGYEVTTM
HHCCCCEEEECCEEEEEECCCCCCCCHHHHHHCCCEEEEECCCCCEEEHHCCCCEEEEEE
EDAAPRADIFVTATGNKDIITIEHMRAMKDRAIVCNIGHFDNEIQVASLKNLKWTNIKPQ
CCCCCCCCEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEECCCCCC
VDEITFPDGKRMILLSEGRLVNLGNAMGHPSFVMSASFTNQTLAQIELYANNKDGKYKKE
CCEEECCCCCEEEEEECCCEEECCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCEEEE
VYVLPKSLDEKVARLHLAKIGVKLTELRPDQAAYIGVKPEGPFKSEHYRY
EEEECCHHHHHHHHHHHHHHCEEEEECCCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]