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The map label for this gene is cobW [H]

Identifier: 146341789

GI number: 146341789

Start: 5109391

End: 5110428

Strand: Reverse

Name: cobW [H]

Synonym: BRADO4908

Alternate gene names: 146341789

Gene position: 5110428-5109391 (Counterclockwise)

Preceding gene: 146341790

Following gene: 146341788

Centisome position: 68.54

GC content: 66.86

Gene sequence:

>1038_bases
ATGACGACATCGTTCGCCAAGACGCCTTGCACCATCGTCACCGGCTTCCTCGGTGCCGGCAAGACCACGCTGGTGCGCAA
TCTGATCGAGACGGCGAACGGCCGCCGTCTCGCGATCATCGTCAACGAGTTCGGCGATGTCGGGATCGACGGCGATATCC
TGAAGGGTTGCGGCGTGCCGGATTGCCCGGAGGACCGCATCGTCGAGCTGTCCAATGGCTGCCTGTGCTGCACCGTCGCC
GACGATTTCGTCCCGGCGCTCAAGAGCCTGCTGGACCAGAAGGAGCCGCCCGAGCATATCGTGATCGAGACCTCCGGCCT
CGCCTTGCCGAAGCCGCTGGTGCAGGCGTTCAACTGGCCCGAGATCGCGACGCGCGTCACGGTCGATGGCGTCGTCGCGG
TGGTCGATGGCCCGGCCGTGGTCGCCGGCCGTTTCGCCGATGATCCGGAGGCGCTCGCCGCTCAGCGCGCGGCCGACGAT
TCGCTCGATCACGACAATCCGCTCGAGGAGGTCTATGAGGATCAGCTGCTGTGCGCCGACCTCGTGGTCATGAACAAGAG
CGACCTCATGAGCGATGACGAGCGCAAGGCGGTTGCATCCGAGATCGCTGCCAAAGTAACACGCGCGGTCAAGGTGATCG
CGACCGAGCATGGCCAGCTCTCGGCCTCCGTCCTGCTCGGACTTGGCGCCGCAGCCGAGGACGATCTCGCGGCGCGGCCG
TCGCATCACGACAACGAGGCCGATCACGACCACGACGATTTCGAGAGCTTCGTGCTCGACGTCCCGGCGCAGACCTCGCC
CGACGCGCTCGTCCACCGTATCGCGGCCGCTGTCGATGCGCATGACGTGCTGCGCGTGAAAGGCTTCGTCGAAATTGCCG
GCAAGCCGCTGCGCCTGCTGGTGCAGGCGGTCGGCAGCCGGATCCAGCATCAGTTCGAGCGGCCGTGGCGCGCGGGCGAA
TCGCGACAGGGCCGGCTCGTCGTGATCGGCGAGCGCGGCCTCGACGAGGCCGCGATCAGAACCCTGATCGCGGGCTAG

Upstream 100 bases:

>100_bases
GGGCCTGCCGGCATGGCGCGAGCGTCCTGAGTACATCCGCAAGAACACGGTCGCCCGCGTGCCTGCGTTGCCGATACTGC
GCTGAAGACCGGAGATCGCA

Downstream 100 bases:

>100_bases
GCGGGAGCGATGCACCTCCTGGCGACATCCGGCGCTGACATCGACGACCTCGAGCAGGCCGTCGATCTCGCGCAGTCGCC
GGCGGAGGTCGTCATACTGT

Product: putative cobalamin synthesis protein cobW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTTSFAKTPCTIVTGFLGAGKTTLVRNLIETANGRRLAIIVNEFGDVGIDGDILKGCGVPDCPEDRIVELSNGCLCCTVA
DDFVPALKSLLDQKEPPEHIVIETSGLALPKPLVQAFNWPEIATRVTVDGVVAVVDGPAVVAGRFADDPEALAAQRAADD
SLDHDNPLEEVYEDQLLCADLVVMNKSDLMSDDERKAVASEIAAKVTRAVKVIATEHGQLSASVLLGLGAAAEDDLAARP
SHHDNEADHDHDDFESFVLDVPAQTSPDALVHRIAAAVDAHDVLRVKGFVEIAGKPLRLLVQAVGSRIQHQFERPWRAGE
SRQGRLVVIGERGLDEAAIRTLIAG

Sequences:

>Translated_345_residues
MTTSFAKTPCTIVTGFLGAGKTTLVRNLIETANGRRLAIIVNEFGDVGIDGDILKGCGVPDCPEDRIVELSNGCLCCTVA
DDFVPALKSLLDQKEPPEHIVIETSGLALPKPLVQAFNWPEIATRVTVDGVVAVVDGPAVVAGRFADDPEALAAQRAADD
SLDHDNPLEEVYEDQLLCADLVVMNKSDLMSDDERKAVASEIAAKVTRAVKVIATEHGQLSASVLLGLGAAAEDDLAARP
SHHDNEADHDHDDFESFVLDVPAQTSPDALVHRIAAAVDAHDVLRVKGFVEIAGKPLRLLVQAVGSRIQHQFERPWRAGE
SRQGRLVVIGERGLDEAAIRTLIAG
>Mature_344_residues
TTSFAKTPCTIVTGFLGAGKTTLVRNLIETANGRRLAIIVNEFGDVGIDGDILKGCGVPDCPEDRIVELSNGCLCCTVAD
DFVPALKSLLDQKEPPEHIVIETSGLALPKPLVQAFNWPEIATRVTVDGVVAVVDGPAVVAGRFADDPEALAAQRAADDS
LDHDNPLEEVYEDQLLCADLVVMNKSDLMSDDERKAVASEIAAKVTRAVKVIATEHGQLSASVLLGLGAAAEDDLAARPS
HHDNEADHDHDDFESFVLDVPAQTSPDALVHRIAAAVDAHDVLRVKGFVEIAGKPLRLLVQAVGSRIQHQFERPWRAGES
RQGRLVVIGERGLDEAAIRTLIAG

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=358, Percent_Identity=28.2122905027933, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI33469141, Length=358, Percent_Identity=28.2122905027933, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI146231952, Length=362, Percent_Identity=28.1767955801105, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI148727351, Length=358, Percent_Identity=28.2122905027933, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI223941779, Length=358, Percent_Identity=28.2122905027933, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI223941776, Length=346, Percent_Identity=26.878612716763, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI119120938, Length=152, Percent_Identity=36.1842105263158, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI87082430, Length=343, Percent_Identity=30.0291545189504, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788499, Length=219, Percent_Identity=28.310502283105, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324356, Length=187, Percent_Identity=29.4117647058824, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 36817; Mature: 36686

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSFAKTPCTIVTGFLGAGKTTLVRNLIETANGRRLAIIVNEFGDVGIDGDILKGCGVP
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCCC
DCPEDRIVELSNGCLCCTVADDFVPALKSLLDQKEPPEHIVIETSGLALPKPLVQAFNWP
CCCCCCEEEECCCEEEEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHCCCC
EIATRVTVDGVVAVVDGPAVVAGRFADDPEALAAQRAADDSLDHDNPLEEVYEDQLLCAD
HHHHEEEECEEEEEECCCEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LVVMNKSDLMSDDERKAVASEIAAKVTRAVKVIATEHGQLSASVLLGLGAAAEDDLAARP
HHEECCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
SHHDNEADHDHDDFESFVLDVPAQTSPDALVHRIAAAVDAHDVLRVKGFVEIAGKPLRLL
CCCCCCCCCCHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VQAVGSRIQHQFERPWRAGESRQGRLVVIGERGLDEAAIRTLIAG
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure 
TTSFAKTPCTIVTGFLGAGKTTLVRNLIETANGRRLAIIVNEFGDVGIDGDILKGCGVP
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCCC
DCPEDRIVELSNGCLCCTVADDFVPALKSLLDQKEPPEHIVIETSGLALPKPLVQAFNWP
CCCCCCEEEECCCEEEEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHCCCC
EIATRVTVDGVVAVVDGPAVVAGRFADDPEALAAQRAADDSLDHDNPLEEVYEDQLLCAD
HHHHEEEECEEEEEECCCEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LVVMNKSDLMSDDERKAVASEIAAKVTRAVKVIATEHGQLSASVLLGLGAAAEDDLAARP
HHEECCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
SHHDNEADHDHDDFESFVLDVPAQTSPDALVHRIAAAVDAHDVLRVKGFVEIAGKPLRLL
CCCCCCCCCCHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VQAVGSRIQHQFERPWRAGESRQGRLVVIGERGLDEAAIRTLIAG
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]