Click here to switch to the map view.

The map label for this gene is nuoD [H]

Identifier: 146341112

GI number: 146341112

Start: 4385083

End: 4386279

Strand: Reverse

Name: nuoD [H]

Synonym: BRADO4183

Alternate gene names: 146341112

Gene position: 4386279-4385083 (Counterclockwise)

Preceding gene: 146341113

Following gene: 146341111

Centisome position: 58.82

GC content: 64.33

Gene sequence:

>1197_bases
ATGAACGAGCAGAGCCCAGCACTCCGCAACTTCACGATCAATTTCGGTCCGCAGCATCCGGCGGCGCACGGCGTGCTTCG
TCTCGTCCTTGAACTCGATGGCGAGGTCGTGGAGCGCGTCGATCCGCATATCGGCCTGTTGCATCGTGGCACCGAGAAGC
TGATCGAGACCAAGACCTATCTGCAAGCCATGCCTTACTTCGATCGGCTCGACTATGTCGCGCCGATGAACCAGGAGCAT
GCGTTCTGCCTGGCTGCCGAGCGGCTGCTCGGCATCGAGGTGCCGCGCCGCGGCCAGTTGATCCGCGTGCTGTACTCCGA
GATCGGCCGTCTGCTGTCGCATCTTCTGAACGTGACCACGCAGGCGATGGACGTCGGCGCGCTGACCCCGCCGCTGTGGG
GATTCGAGGAGCGCGAGAAGCTGATGGTGTTCTATGAGCGGGCCTCCGGCTCGCGCATGCACGCCAACTACTTCCGCATC
GGCGGCGTCCACCAGGACCTGCCGCCGAAGCTGGTCGACGACATCGACGCGTTCTGCGATCCCTTCCTCAAGGTGGTCGA
CGATCTCGACCAGCTCTTGACCGGCAACCGCATCTTCAAGCAGCGCAACGTCGACATCGGCGTCGTCACGCTCAAGCAGG
CCTGGGAGTGGGGCTTCTCCGGCGTCATGGTGCGCGGCTCGGGCGCGGCCTGGGACCTGCGCAAGTCGCAGCCTTACGAC
GTCTATGCCGAGATGGAGTTCGACATTCCCATCGGCAAGAACGGCGACTGCTACGACCGCTATCTGATCCGCATGGAAGA
GATGCGCCAGTCCGTGCGCATCATGAAGCAGTGCATCGCCAAGCTGCGCGCGCCGGACGGGCAGGGGCCGGTGCTGATCA
CCGACAACAAGATCGCGCCGCCGCGCCGTGGCGAGATGAAGCGCTCGATGGAAGCGCTGATCCATCACTTCAAGCTCTAT
ACCGAGGGCGTTCACGTGCCGGCCGGCGAGATCTATGCCGCCGTCGAGGCGCCGAAGGGCGAGTTCGGCGTCTACCTCGT
CGCCGACGGCACCAACAAGCCGTACAAGTGCAAGATCCGCGCGCCGGGCTTCGCCCATCTGCAGGCGATGGACTTCCTGT
GCCGCGGCCATCTGCTGGCCGACGTCTCGGCCATCCTCGGCTCGCTCGACATCGTGTTCGGAGAGGTGGATCGCTGA

Upstream 100 bases:

>100_bases
ACCAGGAATTCCGCAGGTTCGATTTCCTCTCGCCCTGGGAAGGCGCGGACTATCCGCTGCCGGGCGATGAGAAGGCGACG
AAGTGAATGGGAGCGAAGGC

Downstream 100 bases:

>100_bases
TGGGCCATGCGCCGATCCAGTTCGATCGTGCATCCGGAGCGCTCGAAGGAGCGAACCTCTGGGAGCGCACGGCTGCATTG
GCGCTGTCCACCGGCTCGAA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MNEQSPALRNFTINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIETKTYLQAMPYFDRLDYVAPMNQEH
AFCLAAERLLGIEVPRRGQLIRVLYSEIGRLLSHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERASGSRMHANYFRI
GGVHQDLPPKLVDDIDAFCDPFLKVVDDLDQLLTGNRIFKQRNVDIGVVTLKQAWEWGFSGVMVRGSGAAWDLRKSQPYD
VYAEMEFDIPIGKNGDCYDRYLIRMEEMRQSVRIMKQCIAKLRAPDGQGPVLITDNKIAPPRRGEMKRSMEALIHHFKLY
TEGVHVPAGEIYAAVEAPKGEFGVYLVADGTNKPYKCKIRAPGFAHLQAMDFLCRGHLLADVSAILGSLDIVFGEVDR

Sequences:

>Translated_398_residues
MNEQSPALRNFTINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIETKTYLQAMPYFDRLDYVAPMNQEH
AFCLAAERLLGIEVPRRGQLIRVLYSEIGRLLSHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERASGSRMHANYFRI
GGVHQDLPPKLVDDIDAFCDPFLKVVDDLDQLLTGNRIFKQRNVDIGVVTLKQAWEWGFSGVMVRGSGAAWDLRKSQPYD
VYAEMEFDIPIGKNGDCYDRYLIRMEEMRQSVRIMKQCIAKLRAPDGQGPVLITDNKIAPPRRGEMKRSMEALIHHFKLY
TEGVHVPAGEIYAAVEAPKGEFGVYLVADGTNKPYKCKIRAPGFAHLQAMDFLCRGHLLADVSAILGSLDIVFGEVDR
>Mature_398_residues
MNEQSPALRNFTINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIETKTYLQAMPYFDRLDYVAPMNQEH
AFCLAAERLLGIEVPRRGQLIRVLYSEIGRLLSHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERASGSRMHANYFRI
GGVHQDLPPKLVDDIDAFCDPFLKVVDDLDQLLTGNRIFKQRNVDIGVVTLKQAWEWGFSGVMVRGSGAAWDLRKSQPYD
VYAEMEFDIPIGKNGDCYDRYLIRMEEMRQSVRIMKQCIAKLRAPDGQGPVLITDNKIAPPRRGEMKRSMEALIHHFKLY
TEGVHVPAGEIYAAVEAPKGEFGVYLVADGTNKPYKCKIRAPGFAHLQAMDFLCRGHLLADVSAILGSLDIVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=391, Percent_Identity=64.9616368286445, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI260898743, Length=385, Percent_Identity=64.1558441558442, Blast_Score=514, Evalue=1e-146,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=39.2764857881137, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1789076, Length=391, Percent_Identity=25.5754475703325, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1788832, Length=387, Percent_Identity=26.6149870801034, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17568379, Length=397, Percent_Identity=60.2015113350126, Blast_Score=506, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17555284, Length=391, Percent_Identity=61.8925831202046, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24638644, Length=392, Percent_Identity=62.7551020408163, Blast_Score=526, Evalue=1e-150,
Organism=Drosophila melanogaster, GI221459469, Length=392, Percent_Identity=56.1224489795918, Blast_Score=469, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44948; Mature: 44948

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00535 COMPLEX1_49K ; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQSPALRNFTINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIETKTY
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHCCHHHHHHHHHH
LQAMPYFDRLDYVAPMNQEHAFCLAAERLLGIEVPRRGQLIRVLYSEIGRLLSHLLNVTT
HHHCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QAMDVGALTPPLWGFEEREKLMVFYERASGSRMHANYFRIGGVHQDLPPKLVDDIDAFCD
HHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCEEEECCCCCCCCHHHHHHHHHHHH
PFLKVVDDLDQLLTGNRIFKQRNVDIGVVTLKQAWEWGFSGVMVRGSGAAWDLRKSQPYD
HHHHHHHHHHHHHCCCHHHHHCCCCEEEEEEHHHHCCCCCCEEEECCCCEEECCCCCCCE
VYAEMEFDIPIGKNGDCYDRYLIRMEEMRQSVRIMKQCIAKLRAPDGQGPVLITDNKIAP
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCC
PRRGEMKRSMEALIHHFKLYTEGVHVPAGEIYAAVEAPKGEFGVYLVADGTNKPYKCKIR
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEE
APGFAHLQAMDFLCRGHLLADVSAILGSLDIVFGEVDR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCC
>Mature Secondary Structure
MNEQSPALRNFTINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIETKTY
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHCCHHHHHHHHHH
LQAMPYFDRLDYVAPMNQEHAFCLAAERLLGIEVPRRGQLIRVLYSEIGRLLSHLLNVTT
HHHCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QAMDVGALTPPLWGFEEREKLMVFYERASGSRMHANYFRIGGVHQDLPPKLVDDIDAFCD
HHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCEEEECCCCCCCCHHHHHHHHHHHH
PFLKVVDDLDQLLTGNRIFKQRNVDIGVVTLKQAWEWGFSGVMVRGSGAAWDLRKSQPYD
HHHHHHHHHHHHHCCCHHHHHCCCCEEEEEEHHHHCCCCCCEEEECCCCEEECCCCCCCE
VYAEMEFDIPIGKNGDCYDRYLIRMEEMRQSVRIMKQCIAKLRAPDGQGPVLITDNKIAP
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCC
PRRGEMKRSMEALIHHFKLYTEGVHVPAGEIYAAVEAPKGEFGVYLVADGTNKPYKCKIR
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEE
APGFAHLQAMDFLCRGHLLADVSAILGSLDIVFGEVDR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]