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The map label for this gene is degP [H]

Identifier: 146341072

GI number: 146341072

Start: 4338757

End: 4340097

Strand: Reverse

Name: degP [H]

Synonym: BRADO4143

Alternate gene names: 146341072

Gene position: 4340097-4338757 (Counterclockwise)

Preceding gene: 146341073

Following gene: 146341071

Centisome position: 58.2

GC content: 66.52

Gene sequence:

>1341_bases
TTGATTTCAGCGTTGGTTCGATCCGTGCGCGCGCTGTGGCACAGCGCTATCATCATCGCCCTGTGCGGTGCCTGCGCTGG
CCTTGCATCACCGGCCGCGGCTCAGGGCGTTCCCGGTGCCGAAACCGTCTACGCGTCCGCGCCGCCGCGCCTGCTGCAGA
TCCGTACCTTGCTGGCCGATGCCGGCCGTCAGACCTCGACCGGGTCCGGCTTCCTGGTTTCCGCCGACGGGCTCGCGATC
ACCAACTACCACGTCGTCTCCGACGCGGCGTTGGAGCCGAAGACCTATCGTCTCGAATATACGGGCGCCGACGGCACACA
GGGGAATGTGACTCTGCTCGCGGTCGATCTGCCCAACGACCTCGCATTGATCCGCGTGGACAAGCAGGAGGCGCCGTTCT
TCACCTTCGACAAGGCGGCGCTCGACGGCACGCTGGCGAAGGGCGAGCGGCTCTATTCCCTGGGCAATCCGCTCGATCTC
GGCTTCACCATCATCGAGGGCACGTATAACGGCCTTGTCGAGCACAGCTACAACGACCACATCCACTTCACCGGCGCGCT
CAATCCCGGAATGAGCGGCGGCCCCGCGGTCAACGCGCAGGGGCAGGTGGTCGGCATCAACGTCGCCACGCGCCGCGGTG
GTCAGCTGATCAGCTTCCTGGTGCCGGCGCGATTCGCCGCCGCGCTGCTGGCGCGCGGCCGCGAGGCAAGCCCTGCGGCC
GGCGACCTGCGCAAGGACGTGATCGCCCAGCTCGCGAGCTGGCGCGGCGCGCTCTACAAATCGCTGGGGGACGAGGGGTT
TCGTGATCGCGTGTTCGGCTCCTATCAAGCCCCCGAAACGCGCTCGGCATGGTTCGAATGCTGGGCGAGCACCAACGCCA
GCGCATCGCCCAAGCCGCGCGCCAGCATCAACTCGACGAGCTGCAAGGCGGATGCGAGCGTCTATGTCGCCTCCGACCTC
AACACCGGCACGGTGGAGGTCAATCACTCCTATGCGAAGTCGATCGACCTCAATCAATTCCAGTTCGCGACGGTGCTGAC
GCAGCTGGCGCAGCCGCGACTGACCATGGGCGGCTCGTTCCGCAAATGGTACACGCCGCAGCATTGCCACGAGGATTTCG
TCGGCGTCACGCCGGCGGCCGAGCATCCGTCCTTGCGCGTCATGTGGTGCGCCCAGGGCTATCGCGAGTTCGACGGCCTG
TACGACGTCGCCGTGGTGGCGGTGACGCAGGACCGCGCCGACGAGGCGCTGGTGTCGCGGCTCAATCTGCAGGCGATCGC
CTATAACGATGCGCTGCGGATCGGCGCGAGCTTCCTCCAACGGCTGCAGGTCGTCCGATGA

Upstream 100 bases:

>100_bases
GGTTGCAACGCAGGCCTGTTTTCGATATTGGCCGAACCGCCGGATTGATCGATCGTGGGCGCAGGACGTCGGCAGCCGAC
GACGTGTTGCGGGGGCGTCA

Downstream 100 bases:

>100_bases
TCTGGATCGAGATCCTCTCCAGGCATCGCGACGTCACCGGCCGCTTCCGCGTCGATGCCGCCGAGATCCATGTCGGCCGC
GGCTACGACAACCACGTCAT

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MISALVRSVRALWHSAIIIALCGACAGLASPAAAQGVPGAETVYASAPPRLLQIRTLLADAGRQTSTGSGFLVSADGLAI
TNYHVVSDAALEPKTYRLEYTGADGTQGNVTLLAVDLPNDLALIRVDKQEAPFFTFDKAALDGTLAKGERLYSLGNPLDL
GFTIIEGTYNGLVEHSYNDHIHFTGALNPGMSGGPAVNAQGQVVGINVATRRGGQLISFLVPARFAAALLARGREASPAA
GDLRKDVIAQLASWRGALYKSLGDEGFRDRVFGSYQAPETRSAWFECWASTNASASPKPRASINSTSCKADASVYVASDL
NTGTVEVNHSYAKSIDLNQFQFATVLTQLAQPRLTMGGSFRKWYTPQHCHEDFVGVTPAAEHPSLRVMWCAQGYREFDGL
YDVAVVAVTQDRADEALVSRLNLQAIAYNDALRIGASFLQRLQVVR

Sequences:

>Translated_446_residues
MISALVRSVRALWHSAIIIALCGACAGLASPAAAQGVPGAETVYASAPPRLLQIRTLLADAGRQTSTGSGFLVSADGLAI
TNYHVVSDAALEPKTYRLEYTGADGTQGNVTLLAVDLPNDLALIRVDKQEAPFFTFDKAALDGTLAKGERLYSLGNPLDL
GFTIIEGTYNGLVEHSYNDHIHFTGALNPGMSGGPAVNAQGQVVGINVATRRGGQLISFLVPARFAAALLARGREASPAA
GDLRKDVIAQLASWRGALYKSLGDEGFRDRVFGSYQAPETRSAWFECWASTNASASPKPRASINSTSCKADASVYVASDL
NTGTVEVNHSYAKSIDLNQFQFATVLTQLAQPRLTMGGSFRKWYTPQHCHEDFVGVTPAAEHPSLRVMWCAQGYREFDGL
YDVAVVAVTQDRADEALVSRLNLQAIAYNDALRIGASFLQRLQVVR
>Mature_446_residues
MISALVRSVRALWHSAIIIALCGACAGLASPAAAQGVPGAETVYASAPPRLLQIRTLLADAGRQTSTGSGFLVSADGLAI
TNYHVVSDAALEPKTYRLEYTGADGTQGNVTLLAVDLPNDLALIRVDKQEAPFFTFDKAALDGTLAKGERLYSLGNPLDL
GFTIIEGTYNGLVEHSYNDHIHFTGALNPGMSGGPAVNAQGQVVGINVATRRGGQLISFLVPARFAAALLARGREASPAA
GDLRKDVIAQLASWRGALYKSLGDEGFRDRVFGSYQAPETRSAWFECWASTNASASPKPRASINSTSCKADASVYVASDL
NTGTVEVNHSYAKSIDLNQFQFATVLTQLAQPRLTMGGSFRKWYTPQHCHEDFVGVTPAAEHPSLRVMWCAQGYREFDGL
YDVAVVAVTQDRADEALVSRLNLQAIAYNDALRIGASFLQRLQVVR

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=224, Percent_Identity=31.25, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI22129776, Length=168, Percent_Identity=34.5238095238095, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI24308541, Length=178, Percent_Identity=31.4606741573034, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI7019477, Length=192, Percent_Identity=32.8125, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786356, Length=174, Percent_Identity=31.6091954022989, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646839, Length=179, Percent_Identity=31.8435754189944, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 47712; Mature: 47712

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISALVRSVRALWHSAIIIALCGACAGLASPAAAQGVPGAETVYASAPPRLLQIRTLLAD
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEECCCCCHHHHHHHHHHH
AGRQTSTGSGFLVSADGLAITNYHVVSDAALEPKTYRLEYTGADGTQGNVTLLAVDLPND
CCCCCCCCCEEEEECCCEEEEEEEEEECCCCCCCEEEEEECCCCCCCCCEEEEEEECCCC
LALIRVDKQEAPFFTFDKAALDGTLAKGERLYSLGNPLDLGFTIIEGTYNGLVEHSYNDH
EEEEEECCCCCCEEEECHHHHCCCHHCCCEEEECCCCCCCCEEEEECCCCCCEECCCCCE
IHFTGALNPGMSGGPAVNAQGQVVGINVATRRGGQLISFLVPARFAAALLARGREASPAA
EEEEEECCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
GDLRKDVIAQLASWRGALYKSLGDEGFRDRVFGSYQAPETRSAWFECWASTNASASPKPR
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
ASINSTSCKADASVYVASDLNTGTVEVNHSYAKSIDLNQFQFATVLTQLAQPRLTMGGSF
CCCCCCCCCCCCEEEEEECCCCCEEEECCHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCC
RKWYTPQHCHEDFVGVTPAAEHPSLRVMWCAQGYREFDGLYDVAVVAVTQDRADEALVSR
CCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHCCCEEEEEEEEECCCHHHHHHHH
LNLQAIAYNDALRIGASFLQRLQVVR
HCEEEEEECHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MISALVRSVRALWHSAIIIALCGACAGLASPAAAQGVPGAETVYASAPPRLLQIRTLLAD
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEECCCCCHHHHHHHHHHH
AGRQTSTGSGFLVSADGLAITNYHVVSDAALEPKTYRLEYTGADGTQGNVTLLAVDLPND
CCCCCCCCCEEEEECCCEEEEEEEEEECCCCCCCEEEEEECCCCCCCCCEEEEEEECCCC
LALIRVDKQEAPFFTFDKAALDGTLAKGERLYSLGNPLDLGFTIIEGTYNGLVEHSYNDH
EEEEEECCCCCCEEEECHHHHCCCHHCCCEEEECCCCCCCCEEEEECCCCCCEECCCCCE
IHFTGALNPGMSGGPAVNAQGQVVGINVATRRGGQLISFLVPARFAAALLARGREASPAA
EEEEEECCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
GDLRKDVIAQLASWRGALYKSLGDEGFRDRVFGSYQAPETRSAWFECWASTNASASPKPR
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
ASINSTSCKADASVYVASDLNTGTVEVNHSYAKSIDLNQFQFATVLTQLAQPRLTMGGSF
CCCCCCCCCCCCEEEEEECCCCCEEEECCHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCC
RKWYTPQHCHEDFVGVTPAAEHPSLRVMWCAQGYREFDGLYDVAVVAVTQDRADEALVSR
CCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHCCCEEEEEEEEECCCHHHHHHHH
LNLQAIAYNDALRIGASFLQRLQVVR
HCEEEEEECHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]