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The map label for this gene is ispU [H]

Identifier: 146341065

GI number: 146341065

Start: 4332699

End: 4333457

Strand: Reverse

Name: ispU [H]

Synonym: BRADO4136

Alternate gene names: 146341065

Gene position: 4333457-4332699 (Counterclockwise)

Preceding gene: 146341066

Following gene: 146341064

Centisome position: 58.12

GC content: 67.85

Gene sequence:

>759_bases
ATGTCCAAAGCCGCGGCCCCGGTGAAGGAAGCGCCGGACCGGTCCGACGCACCGGCCCATGTTGCCATTATCATGGATGG
CAACGGCCGCTGGGCTGCGGCCCGTGGCTTGCCGCGCGCGGAGGGACATCGCCGCGGCGTCGAGGCGCTGCGTCGCGTGG
TGCGCGCCTCTGATGAGCTCGGCATTCGTTATCTCACCATCTTCTCGTTCTCGTCGGAGAACTGGTCGCGGCCCGCCAGC
GAGATCGGCGATCTCTTCGGCCTGTTGCGTCGCTTCATCCGCAACGATCTGGCCACGCTGCATCGCGATGGCGTCCGCGT
CCGGGTGATCGGCGAGCGCGCGGGCCTCGAGCCCGACATCTGCGCGCTGCTCAGCGAGGCCGAGGAGCTCACGCGGGCCA
ACACCAAGCTGACACTGGTGGTGGCGTTCAACTACGGCTCGCGCCAGGAGATCGCGCGCGCCGCTCAGAATCTCGCGCGC
GAAGTCGCCGAGGGAAGGCGCGATCCCGCTTCGATCGATGCGGACGCCATCGGCGCGCATCTCGATGTGCCCGACATTCC
CGATCCCGATCTGATCATCCGGACCAGCGGCGAGCAGCGGCTGTCGAACTTCCTGATGTGGCAGGCCGCCTATAGCGAGC
TGGTGTTCGTGCCCCAGCATTGGCCTGACTTCGACAAGGCGGCGCTGGAAGGCGCGATCGCCGAGTTCGGCCGGCGTGAA
CGCCGCTTCGGCGGCCTCGTGGCGAAAACCGCCTCGTGA

Upstream 100 bases:

>100_bases
CGGCGACGTGCAGAAGGCGACCGACAGCGTGATCTCGGAGATCGACCAGCTGCTGGCGGCGAAGGAAAAGGAAATCCTCA
CCGTCTGAAGGATGCGCCTG

Downstream 100 bases:

>100_bases
GCAAACCGGACACCGCAGCCGTGGCGGACGCGCAGCCGAAAAAGGCGGCGCCGAGCAATCTTCTGCTGCGCATCGCGGCG
GCGCTCGTGCTGGTGCCCCT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 2; Di-trans,poly-cis-decaprenylcistransferase 2; Undecaprenyl diphosphate synthase 2; UDS 2 [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSKAAAPVKEAPDRSDAPAHVAIIMDGNGRWAAARGLPRAEGHRRGVEALRRVVRASDELGIRYLTIFSFSSENWSRPAS
EIGDLFGLLRRFIRNDLATLHRDGVRVRVIGERAGLEPDICALLSEAEELTRANTKLTLVVAFNYGSRQEIARAAQNLAR
EVAEGRRDPASIDADAIGAHLDVPDIPDPDLIIRTSGEQRLSNFLMWQAAYSELVFVPQHWPDFDKAALEGAIAEFGRRE
RRFGGLVAKTAS

Sequences:

>Translated_252_residues
MSKAAAPVKEAPDRSDAPAHVAIIMDGNGRWAAARGLPRAEGHRRGVEALRRVVRASDELGIRYLTIFSFSSENWSRPAS
EIGDLFGLLRRFIRNDLATLHRDGVRVRVIGERAGLEPDICALLSEAEELTRANTKLTLVVAFNYGSRQEIARAAQNLAR
EVAEGRRDPASIDADAIGAHLDVPDIPDPDLIIRTSGEQRLSNFLMWQAAYSELVFVPQHWPDFDKAALEGAIAEFGRRE
RRFGGLVAKTAS
>Mature_251_residues
SKAAAPVKEAPDRSDAPAHVAIIMDGNGRWAAARGLPRAEGHRRGVEALRRVVRASDELGIRYLTIFSFSSENWSRPASE
IGDLFGLLRRFIRNDLATLHRDGVRVRVIGERAGLEPDICALLSEAEELTRANTKLTLVVAFNYGSRQEIARAAQNLARE
VAEGRRDPASIDADAIGAHLDVPDIPDPDLIIRTSGEQRLSNFLMWQAAYSELVFVPQHWPDFDKAALEGAIAEFGRRER
RFGGLVAKTAS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=236, Percent_Identity=38.5593220338983, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI45580738, Length=236, Percent_Identity=38.5593220338983, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=45.575221238938, Blast_Score=212, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=35.6828193832599, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=34.8837209302326, Blast_Score=119, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=232, Percent_Identity=28.0172413793103, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18857969, Length=226, Percent_Identity=39.3805309734513, Blast_Score=140, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27763; Mature: 27632

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAAAPVKEAPDRSDAPAHVAIIMDGNGRWAAARGLPRAEGHRRGVEALRRVVRASDEL
CCCCCCCHHCCCCCCCCCEEEEEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCCC
GIRYLTIFSFSSENWSRPASEIGDLFGLLRRFIRNDLATLHRDGVRVRVIGERAGLEPDI
CEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHH
CALLSEAEELTRANTKLTLVVAFNYGSRQEIARAAQNLAREVAEGRRDPASIDADAIGAH
HHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCC
LDVPDIPDPDLIIRTSGEQRLSNFLMWQAAYSELVFVPQHWPDFDKAALEGAIAEFGRRE
CCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHH
RRFGGLVAKTAS
HHHCCCEECCCC
>Mature Secondary Structure 
SKAAAPVKEAPDRSDAPAHVAIIMDGNGRWAAARGLPRAEGHRRGVEALRRVVRASDEL
CCCCCCHHCCCCCCCCCEEEEEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCCC
GIRYLTIFSFSSENWSRPASEIGDLFGLLRRFIRNDLATLHRDGVRVRVIGERAGLEPDI
CEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHH
CALLSEAEELTRANTKLTLVVAFNYGSRQEIARAAQNLAREVAEGRRDPASIDADAIGAH
HHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCC
LDVPDIPDPDLIIRTSGEQRLSNFLMWQAAYSELVFVPQHWPDFDKAALEGAIAEFGRRE
CCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHH
RRFGGLVAKTAS
HHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]