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The map label for this gene is lpxD [H]

Identifier: 146341060

GI number: 146341060

Start: 4325476

End: 4326543

Strand: Reverse

Name: lpxD [H]

Synonym: BRADO4131

Alternate gene names: 146341060

Gene position: 4326543-4325476 (Counterclockwise)

Preceding gene: 146341061

Following gene: 146341059

Centisome position: 58.02

GC content: 66.1

Gene sequence:

>1068_bases
ATGGCCCAGCCGACCTTTTTCCAATCTCCACCTCCGATGACGCTGGCGGCAATCGCAGCGAAGGCCAAGGCGGAGCTCGC
CGATGTCTCGCAGGGCGACAAGGTGATCAAGGGACTGGCCGCGCTCGACGAAGCCGGTCCGATGCACCTGGCGTTCTTCG
ACAACCTCAAATACGCCGACCAGCTGGCCCGGACCAATGCCGGGGCCTGCCTCGTGAGCCCGCGCTTCGAGGCGCGCGTG
CCCGGCCATGTCGTGGTGGTGAGGGCCAACCAGCCTTTCCGCGCCTTCGTGCAACTGGCCCGCGAGTTCCATGCCGACGC
GCTGCGTCCACAGCCCTGGTTCGGCGATGACGGTATCTCGCCTCAGGCGATCATCGATCCCACTGCACGGCTGGAGGACG
GCGTGATCGTCGAGCCGCTGGCGGTGATCGGCGCCCATGTCGAGATCGGCGCAGGGACCATCGTCGGCGCCGGCGCGGTG
ATCGGTCCACACGTCAAGGTCGGCCGCGACTGCAATGTCGGCGCCCGCACGGTCATCCAATGTTCGCTGATCGGCAACGA
CGTGCTGATCCATCCCGGCTGCAGCATCGGCCAGGACGGCTATGGCTTCATCTTCTTCGGGGCCAACGGGCACACCAAGG
TGCCGCAGACCGGCCGGGTGATCATCCAGAACCATGTCGAGGTCGGCGCCGGCACGACGATCGACCGCGGCAGCCTGCGT
GACACCGTGATCGGCGAGGGCACCAAAATCGACAACCAGGTGCAGATCGGCCACAATGTCACAATCGGCCGGCATTGCCT
GCTGGCGGCCCAGATCGGGCTGGCAGGAAGCCTCACGATCGGCGACAACGTCGCGCTTGGGGCGAAGGTCGGCATCAACA
ATCACCTGACGATCGGCGATGGGGCGCAGGTCACCGCGATGAGCGGTGTCAAGGACGATATCCCGCCGAACGGCCGGTGG
GGCGGCTTCTTCGCCAAGCCGACCAAGCAGTGGTTCCGCGAGATCGTTGCGGTGGAACGGCTGGTACGCGATCAGACGGC
GACGAGCAGGGACGAAGGACGGGAGTGA

Upstream 100 bases:

>100_bases
CGAATCCGGGTTGGCGTGGACCAACCCAGCCGGTGTAAGAGATGAGAGCTCGGTTCCGGGAGACTGGAGCCGGGCTCTGA
CGTTTTGAGAGTGTGACGGG

Downstream 100 bases:

>100_bases
TGGAGGAGTCACCCATCAAGTTTGCGGACATCGACATCAACGAGATTCTGAAGACGCTGCCGCACCGCAACCCGTTTCTC
CTGATCGACCGCGTGAAGAA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MAQPTFFQSPPPMTLAAIAAKAKAELADVSQGDKVIKGLAALDEAGPMHLAFFDNLKYADQLARTNAGACLVSPRFEARV
PGHVVVVRANQPFRAFVQLAREFHADALRPQPWFGDDGISPQAIIDPTARLEDGVIVEPLAVIGAHVEIGAGTIVGAGAV
IGPHVKVGRDCNVGARTVIQCSLIGNDVLIHPGCSIGQDGYGFIFFGANGHTKVPQTGRVIIQNHVEVGAGTTIDRGSLR
DTVIGEGTKIDNQVQIGHNVTIGRHCLLAAQIGLAGSLTIGDNVALGAKVGINNHLTIGDGAQVTAMSGVKDDIPPNGRW
GGFFAKPTKQWFREIVAVERLVRDQTATSRDEGRE

Sequences:

>Translated_355_residues
MAQPTFFQSPPPMTLAAIAAKAKAELADVSQGDKVIKGLAALDEAGPMHLAFFDNLKYADQLARTNAGACLVSPRFEARV
PGHVVVVRANQPFRAFVQLAREFHADALRPQPWFGDDGISPQAIIDPTARLEDGVIVEPLAVIGAHVEIGAGTIVGAGAV
IGPHVKVGRDCNVGARTVIQCSLIGNDVLIHPGCSIGQDGYGFIFFGANGHTKVPQTGRVIIQNHVEVGAGTTIDRGSLR
DTVIGEGTKIDNQVQIGHNVTIGRHCLLAAQIGLAGSLTIGDNVALGAKVGINNHLTIGDGAQVTAMSGVKDDIPPNGRW
GGFFAKPTKQWFREIVAVERLVRDQTATSRDEGRE
>Mature_354_residues
AQPTFFQSPPPMTLAAIAAKAKAELADVSQGDKVIKGLAALDEAGPMHLAFFDNLKYADQLARTNAGACLVSPRFEARVP
GHVVVVRANQPFRAFVQLAREFHADALRPQPWFGDDGISPQAIIDPTARLEDGVIVEPLAVIGAHVEIGAGTIVGAGAVI
GPHVKVGRDCNVGARTVIQCSLIGNDVLIHPGCSIGQDGYGFIFFGANGHTKVPQTGRVIIQNHVEVGAGTTIDRGSLRD
TVIGEGTKIDNQVQIGHNVTIGRHCLLAAQIGLAGSLTIGDNVALGAKVGINNHLTIGDGAQVTAMSGVKDDIPPNGRWG
GFFAKPTKQWFREIVAVERLVRDQTATSRDEGRE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=347, Percent_Identity=36.0230547550432, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1786378, Length=218, Percent_Identity=27.5229357798165, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 37426; Mature: 37295

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQPTFFQSPPPMTLAAIAAKAKAELADVSQGDKVIKGLAALDEAGPMHLAFFDNLKYAD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHH
QLARTNAGACLVSPRFEARVPGHVVVVRANQPFRAFVQLAREFHADALRPQPWFGDDGIS
HHHHCCCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PQAIIDPTARLEDGVIVEPLAVIGAHVEIGAGTIVGAGAVIGPHVKVGRDCNVGARTVIQ
CCEEECCHHHCCCCEEECCHHHHCCEEEECCCEEEECCCEECCCEEECCCCCCCCEEEEE
CSLIGNDVLIHPGCSIGQDGYGFIFFGANGHTKVPQTGRVIIQNHVEVGAGTTIDRGSLR
EEEECCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECEEECCCCEECCCCCC
DTVIGEGTKIDNQVQIGHNVTIGRHCLLAAQIGLAGSLTIGDNVALGAKVGINNHLTIGD
CCCCCCCCCCCCEEEECCCEEHHHHEEEEEHHCCCEEEEECCCEEEEEEECCCCEEEECC
GAQVTAMSGVKDDIPPNGRWGGFFAKPTKQWFREIVAVERLVRDQTATSRDEGRE
CCEEEEECCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AQPTFFQSPPPMTLAAIAAKAKAELADVSQGDKVIKGLAALDEAGPMHLAFFDNLKYAD
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHH
QLARTNAGACLVSPRFEARVPGHVVVVRANQPFRAFVQLAREFHADALRPQPWFGDDGIS
HHHHCCCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PQAIIDPTARLEDGVIVEPLAVIGAHVEIGAGTIVGAGAVIGPHVKVGRDCNVGARTVIQ
CCEEECCHHHCCCCEEECCHHHHCCEEEECCCEEEECCCEECCCEEECCCCCCCCEEEEE
CSLIGNDVLIHPGCSIGQDGYGFIFFGANGHTKVPQTGRVIIQNHVEVGAGTTIDRGSLR
EEEECCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECEEECCCCEECCCCCC
DTVIGEGTKIDNQVQIGHNVTIGRHCLLAAQIGLAGSLTIGDNVALGAKVGINNHLTIGD
CCCCCCCCCCCCEEEECCCEEHHHHEEEEEHHCCCEEEEECCCEEEEEEECCCCEEEECC
GAQVTAMSGVKDDIPPNGRWGGFFAKPTKQWFREIVAVERLVRDQTATSRDEGRE
CCEEEEECCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA