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The map label for this gene is pdhA [H]

Identifier: 146341016

GI number: 146341016

Start: 4277214

End: 4278236

Strand: Reverse

Name: pdhA [H]

Synonym: BRADO4087

Alternate gene names: 146341016

Gene position: 4278236-4277214 (Counterclockwise)

Preceding gene: 146341017

Following gene: 146341015

Centisome position: 57.38

GC content: 64.91

Gene sequence:

>1023_bases
ATGGCCGCACCGAAGAAGACCGCCGCAAAGGAACAAGGGCAGGACAAGGACAACGGCCCGCCGCCGGAATTCACCAAGGA
GCAAGAACTCGCAGCGCTGCGCGACATGCTGCTGATCCGCCGCTTTGAGGAAAAGGCGGGTCAGCTTTATGGCATGGGTG
CGATCGGCGGCTTCTGCCATCTCTACATCGGCCAGGAGGCCGTGGTGGTCGGCATGCAGATGGCGCTGAAGCAGGGCGAC
CAGGTCATCACCGGCTATCGCGATCACGGCCACATGCTGGCGACCGGCATGGATGCCAAGGGCGTCATGGCCGAGCTCAC
CGGACGCCGCGGCGGTTACTCCAAGGGCAAGGGCGGCTCCATGCACATGTTCAGCATGGAGAAGAACTTCTTCGGCGGCC
ACGGCATCGTCGGCGCGCAGGTCTCCCTCGGCACGGGGCTCGCGCTCGCCAACCGCTATCGCGGCAATGATTCGGTCAGC
GTCGCCTATTTCGGTGACGGCGCGGCCAACCAGGGCCAGGTCTATGAGAGCTTCAACATGGCGGAGCTCTGGAAGCTGCC
GGTGATCTACGTGATCGAGAACAACCGCTATGCGATGGGCACGGCGGTGTCGCGCGCCTCGGCGCAGACCGACTTCTCCA
AGCGCGGCCTCTCCTTCAACATTCCCGGCGAGCAGGTCGACGGCATGGACGTCCGCGCCGTGAAGGCCGCCGGCGAGAAG
GCCGTGGCGTGGTGCCGCGAGGGCAAGGGGCCTTTCATCCTGGAAATGCAGACCTACCGCTATCGCGGCCATTCAATGTC
GGATCCGGCGAAGTACCGCACCCGCGAGGAGGTCGAGAAGGTCCGCCACGACCAGGATCCGATCGAGCAGGTGCGCAACC
GCCTGCTGGCGGCCAAGGTCAGCGAGCAGGATCTCAAGGCGATCGATGCCGACGTGCGCAAGATCGTCAACGAGGCCGCC
GATTTCGCGCAGGCCGATCCCGAGCCGGATCCCGCCGAGCTCTACACCGACGTCTATCGCTAA

Upstream 100 bases:

>100_bases
CACTGCGGCAAAAGCAAAGTGAACCGCGGTTCACGGGGTCCTTTTACGTGCCGTGGAGTTGAGCTACAGAAAGCTACTTT
TTCTCTCATCCGGAATTGCC

Downstream 100 bases:

>100_bases
TCGCGCGCGCAAGCTGATTTCCCTGGAGCTGATATGCCTATTCAAGTTTTGATGCCTGCGCTGTCGCCCACGATGGAGAA
GGGCAACCTCGCCAAATGGC

Product: pyruvate dehydrogenase E1 component subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MAAPKKTAAKEQGQDKDNGPPPEFTKEQELAALRDMLLIRRFEEKAGQLYGMGAIGGFCHLYIGQEAVVVGMQMALKQGD
QVITGYRDHGHMLATGMDAKGVMAELTGRRGGYSKGKGGSMHMFSMEKNFFGGHGIVGAQVSLGTGLALANRYRGNDSVS
VAYFGDGAANQGQVYESFNMAELWKLPVIYVIENNRYAMGTAVSRASAQTDFSKRGLSFNIPGEQVDGMDVRAVKAAGEK
AVAWCREGKGPFILEMQTYRYRGHSMSDPAKYRTREEVEKVRHDQDPIEQVRNRLLAAKVSEQDLKAIDADVRKIVNEAA
DFAQADPEPDPAELYTDVYR

Sequences:

>Translated_340_residues
MAAPKKTAAKEQGQDKDNGPPPEFTKEQELAALRDMLLIRRFEEKAGQLYGMGAIGGFCHLYIGQEAVVVGMQMALKQGD
QVITGYRDHGHMLATGMDAKGVMAELTGRRGGYSKGKGGSMHMFSMEKNFFGGHGIVGAQVSLGTGLALANRYRGNDSVS
VAYFGDGAANQGQVYESFNMAELWKLPVIYVIENNRYAMGTAVSRASAQTDFSKRGLSFNIPGEQVDGMDVRAVKAAGEK
AVAWCREGKGPFILEMQTYRYRGHSMSDPAKYRTREEVEKVRHDQDPIEQVRNRLLAAKVSEQDLKAIDADVRKIVNEAA
DFAQADPEPDPAELYTDVYR
>Mature_339_residues
AAPKKTAAKEQGQDKDNGPPPEFTKEQELAALRDMLLIRRFEEKAGQLYGMGAIGGFCHLYIGQEAVVVGMQMALKQGDQ
VITGYRDHGHMLATGMDAKGVMAELTGRRGGYSKGKGGSMHMFSMEKNFFGGHGIVGAQVSLGTGLALANRYRGNDSVSV
AYFGDGAANQGQVYESFNMAELWKLPVIYVIENNRYAMGTAVSRASAQTDFSKRGLSFNIPGEQVDGMDVRAVKAAGEKA
VAWCREGKGPFILEMQTYRYRGHSMSDPAKYRTREEVEKVRHDQDPIEQVRNRLLAAKVSEQDLKAIDADVRKIVNEAAD
FAQADPEPDPAELYTDVYR

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=327, Percent_Identity=52.5993883792049, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI291084742, Length=327, Percent_Identity=53.5168195718654, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI4505685, Length=327, Percent_Identity=53.5168195718654, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI291084744, Length=334, Percent_Identity=52.3952095808383, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI291084757, Length=327, Percent_Identity=48.0122324159021, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI11386135, Length=331, Percent_Identity=30.2114803625378, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI258645172, Length=331, Percent_Identity=30.5135951661631, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI32564172, Length=327, Percent_Identity=52.2935779816514, Blast_Score=333, Evalue=9e-92,
Organism=Caenorhabditis elegans, GI17536047, Length=327, Percent_Identity=52.2935779816514, Blast_Score=333, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI86563355, Length=278, Percent_Identity=28.4172661870504, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI86563357, Length=278, Percent_Identity=28.4172661870504, Blast_Score=107, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6321026, Length=327, Percent_Identity=49.5412844036697, Blast_Score=321, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24639740, Length=327, Percent_Identity=51.6819571865443, Blast_Score=327, Evalue=7e-90,
Organism=Drosophila melanogaster, GI24639744, Length=327, Percent_Identity=51.6819571865443, Blast_Score=327, Evalue=7e-90,
Organism=Drosophila melanogaster, GI28571106, Length=327, Percent_Identity=51.6819571865443, Blast_Score=327, Evalue=7e-90,
Organism=Drosophila melanogaster, GI24639746, Length=306, Percent_Identity=52.6143790849673, Blast_Score=317, Evalue=9e-87,
Organism=Drosophila melanogaster, GI24639748, Length=329, Percent_Identity=51.6717325227964, Blast_Score=312, Evalue=2e-85,
Organism=Drosophila melanogaster, GI21355903, Length=340, Percent_Identity=26.4705882352941, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37349; Mature: 37218

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPKKTAAKEQGQDKDNGPPPEFTKEQELAALRDMLLIRRFEEKAGQLYGMGAIGGFCH
CCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCHHCCEEE
LYIGQEAVVVGMQMALKQGDQVITGYRDHGHMLATGMDAKGVMAELTGRRGGYSKGKGGS
EEECCHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCHHHHHCCCCCCCCCCCCCC
MHMFSMEKNFFGGHGIVGAQVSLGTGLALANRYRGNDSVSVAYFGDGAANQGQVYESFNM
EEEEEECCCCCCCCCEEEEEEECCCCHHHHHHCCCCCCEEEEEECCCCCCCCCHHHCCCH
AELWKLPVIYVIENNRYAMGTAVSRASAQTDFSKRGLSFNIPGEQVDGMDVRAVKAAGEK
HHHHCCCEEEEEECCCEEEHHHHHHHHHHCCHHHCCCEECCCCCCCCCCCEEHHHHCCHH
AVAWCREGKGPFILEMQTYRYRGHSMSDPAKYRTREEVEKVRHDQDPIEQVRNRLLAAKV
HHHHHHCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
SEQDLKAIDADVRKIVNEAADFAQADPEPDPAELYTDVYR
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
AAPKKTAAKEQGQDKDNGPPPEFTKEQELAALRDMLLIRRFEEKAGQLYGMGAIGGFCH
CCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCHHCCEEE
LYIGQEAVVVGMQMALKQGDQVITGYRDHGHMLATGMDAKGVMAELTGRRGGYSKGKGGS
EEECCHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCHHHHHCCCCCCCCCCCCCC
MHMFSMEKNFFGGHGIVGAQVSLGTGLALANRYRGNDSVSVAYFGDGAANQGQVYESFNM
EEEEEECCCCCCCCCEEEEEEECCCCHHHHHHCCCCCCEEEEEECCCCCCCCCHHHCCCH
AELWKLPVIYVIENNRYAMGTAVSRASAQTDFSKRGLSFNIPGEQVDGMDVRAVKAAGEK
HHHHCCCEEEEEECCCEEEHHHHHHHHHHCCHHHCCCEECCCCCCCCCCCEEHHHHCCHH
AVAWCREGKGPFILEMQTYRYRGHSMSDPAKYRTREEVEKVRHDQDPIEQVRNRLLAAKV
HHHHHHCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
SEQDLKAIDADVRKIVNEAADFAQADPEPDPAELYTDVYR
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]