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The map label for this gene is bla [H]

Identifier: 146340992

GI number: 146340992

Start: 4252784

End: 4253641

Strand: Direct

Name: bla [H]

Synonym: BRADO4063

Alternate gene names: 146340992

Gene position: 4252784-4253641 (Clockwise)

Preceding gene: 146340991

Following gene: 146341024

Centisome position: 57.03

GC content: 70.16

Gene sequence:

>858_bases
GTGACACGGCGGCAGGTGTTTCCGCTCGCGCTCGCACCTCTGTTCGTGAAGCCGGCGTTGGCTGCCGACTTCCAGGAGAC
CATCGCAGGCATCGAGGCCGACAGCGCCGGGCGGCTCGGCGTGGCCCTGCTGGACACCGCGAGCGGCGCACTCAGCGGCC
ACCGGCTCGACGAGCGGTTCCCGATGTGCAGCACCTTCAAGGCCCTGCTCGCGGCGGCGATCCTGACCAAGGTCGATGCC
GGTGCCGAGCAGCTCTCGCGGCGACTTCCGATCACGCAAGGCGACATCCTGTCCTACGCGCCGGTCACCAAGCTGCATGT
CGGCACCTCCGGCCTCTCGATCGGCGAACTCTGCGAGGCGACCGTCACGCTCAGCGACAACACGGCAGCGAACCTGCTGC
TGGCCACGCTTGACGGCCCGGCTGGGCTCACACGCGCGACCCGCGGCTTCGGTGACGCCATCACCCGGCTCGACCGCATC
GAGCCCGCGCTGAACGAAAGCGTGCCAGATGATCCCCGCGACACCACGACGCCGGCCGCAATGGCGCAGACCCTGGCGAA
GCTGACGACCGGAAATGCGTTGTCGACATCGTCGCGCGACGTCCTGAACGGCTGGCTGATCGGCTGCAAGACCGGGGCGG
CCAGGCTCCGCGCCGGCCTGCCCGCGTCATGGCGCGTCGGCGACAAGACCGGCTCCGGCGAGAACGGCAGCAGCAACGAT
GTTGCGGTGATCTGGCCGGCGGGGCGCGCGCCGGTGATCGTGACGAGCTATCTGACCGAAACCAAGGCGAGTGATGAGAA
GCGCAACGCCGCTCACGCCGCCGTCGGCCGCGCGGTCGCGGCGGCCCTCGGCGCCTGA

Upstream 100 bases:

>100_bases
GCTATGTCAGGGCTTGGGAGAAGCCGTCCGATCACGTCCCGGTGTGGGCCGATTTCGATCTGGAGACGGCGTAACGTTCA
AGGCAGGTCCGATGAGCTTC

Downstream 100 bases:

>100_bases
GCTGCGCGCGCGCCGAGATCGATCTCGCGAACGACGGCCGCGACCGCGTCGAAGCCGGCGCGCAGTTGGCGGACCTCGCG
CGCGGCGAACCGAACGCCGA

Product: putative beta-lactamase

Products: NA

Alternate protein names: Beta-lactamase MEN-1; Cefotaximase 1 [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MTRRQVFPLALAPLFVKPALAADFQETIAGIEADSAGRLGVALLDTASGALSGHRLDERFPMCSTFKALLAAAILTKVDA
GAEQLSRRLPITQGDILSYAPVTKLHVGTSGLSIGELCEATVTLSDNTAANLLLATLDGPAGLTRATRGFGDAITRLDRI
EPALNESVPDDPRDTTTPAAMAQTLAKLTTGNALSTSSRDVLNGWLIGCKTGAARLRAGLPASWRVGDKTGSGENGSSND
VAVIWPAGRAPVIVTSYLTETKASDEKRNAAHAAVGRAVAAALGA

Sequences:

>Translated_285_residues
MTRRQVFPLALAPLFVKPALAADFQETIAGIEADSAGRLGVALLDTASGALSGHRLDERFPMCSTFKALLAAAILTKVDA
GAEQLSRRLPITQGDILSYAPVTKLHVGTSGLSIGELCEATVTLSDNTAANLLLATLDGPAGLTRATRGFGDAITRLDRI
EPALNESVPDDPRDTTTPAAMAQTLAKLTTGNALSTSSRDVLNGWLIGCKTGAARLRAGLPASWRVGDKTGSGENGSSND
VAVIWPAGRAPVIVTSYLTETKASDEKRNAAHAAVGRAVAAALGA
>Mature_284_residues
TRRQVFPLALAPLFVKPALAADFQETIAGIEADSAGRLGVALLDTASGALSGHRLDERFPMCSTFKALLAAAILTKVDAG
AEQLSRRLPITQGDILSYAPVTKLHVGTSGLSIGELCEATVTLSDNTAANLLLATLDGPAGLTRATRGFGDAITRLDRIE
PALNESVPDDPRDTTTPAAMAQTLAKLTTGNALSTSSRDVLNGWLIGCKTGAARLRAGLPASWRVGDKTGSGENGSSNDV
AVIWPAGRAPVIVTSYLTETKASDEKRNAAHAAVGRAVAAALGA

Specific function: Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins [H]

COG id: COG2367

COG function: function code V; Beta-lactamase class A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-A beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR000871 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 29383; Mature: 29251

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRQVFPLALAPLFVKPALAADFQETIAGIEADSAGRLGVALLDTASGALSGHRLDERF
CCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCHHHC
PMCSTFKALLAAAILTKVDAGAEQLSRRLPITQGDILSYAPVTKLHVGTSGLSIGELCEA
CHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCE
TVTLSDNTAANLLLATLDGPAGLTRATRGFGDAITRLDRIEPALNESVPDDPRDTTTPAA
EEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCHHH
MAQTLAKLTTGNALSTSSRDVLNGWLIGCKTGAARLRAGLPASWRVGDKTGSGENGSSND
HHHHHHHHHCCCCCCCCCHHHHHHEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
VAVIWPAGRAPVIVTSYLTETKASDEKRNAAHAAVGRAVAAALGA
EEEEECCCCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TRRQVFPLALAPLFVKPALAADFQETIAGIEADSAGRLGVALLDTASGALSGHRLDERF
CCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCHHHC
PMCSTFKALLAAAILTKVDAGAEQLSRRLPITQGDILSYAPVTKLHVGTSGLSIGELCEA
CHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCE
TVTLSDNTAANLLLATLDGPAGLTRATRGFGDAITRLDRIEPALNESVPDDPRDTTTPAA
EEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCHHH
MAQTLAKLTTGNALSTSSRDVLNGWLIGCKTGAARLRAGLPASWRVGDKTGSGENGSSND
HHHHHHHHHCCCCCCCCCHHHHHHEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
VAVIWPAGRAPVIVTSYLTETKASDEKRNAAHAAVGRAVAAALGA
EEEEECCCCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8834913; 1633193 [H]