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The map label for this gene is serS [H]

Identifier: 146340973

GI number: 146340973

Start: 4231910

End: 4233238

Strand: Reverse

Name: serS [H]

Synonym: BRADO4044

Alternate gene names: 146340973

Gene position: 4233238-4231910 (Counterclockwise)

Preceding gene: 146340974

Following gene: 146340972

Centisome position: 56.77

GC content: 67.34

Gene sequence:

>1329_bases
ATGCACGACATCAAATCGATCCGCGACAATCCGCAAGATTTCGATGCAGCGCTGACTCGCCGGGGTCTGTCGCCGCTGTC
GTCGCAGCTGCTCGCCATCGACGAGCGCCGCCGCGCGGCGATCCTGGCGTCGGAGCAGGCGCAGGCGCGGCGCAACGCGG
CCTCCAGGGAGATCGGCGAGGCCAAGAAGGCCAAGGACGAGGGACGCGCGTCCGCGCTGATGGAGGAGGTCGCCAAGCTC
AAGACCACGATGCCGGAGCTCGAGGCGGCTGCGAAGCAGGCCGACGAGGAGCTGGCGCGCGAGCTGTCGGCGATCCCCAA
TCTTCCGCTCGACGAGGTGCCGGACGGCAAGGACGAGCATGACAACGTCGAGCGTCATGTGTTTGGCGCCCGCCGCAACT
ACGCCTTCGCGCCCAAGGCGCATGACGATATCGGGACGGCTCTTGGCATGGACTTCGAGTCGGCGGCGAAGCTGTCCGGC
GCGCGCTTCGTCGTGCTGAAGAAGGGGCTCGCGCGACTCGAGCGCGCGATCGGGCAGTTCATGCTCGACCTCCACACCAC
CGAGCATGGCTACACCGAGGTCAACCCGCCGCTCCTGGTGCGCAACGACGTCATGTTCGGCACCGGCCAATTGCCGAAGT
TCGAGGACGACCAGTTCTGGGCGGTCAGGGGCGAGCTGCTGATCGCGCCCGATGAGCGTCTGAAGGCCGAACGGCTCGGT
CTCATTCCCACCGCCGAGGTCGCGCTCACAAACCTCGTGCGCGAATCGATCGTCGACGAAAAGGAGCTGCCGATGCGGCT
CACCGCGCTCACGCCGTGCTTCCGCGCCGAGGCCGGCGCGGCTGGGCGCGACACCCGCGGCATGATCCGGCAGCATCAGT
TCACCAAGGTGGAGCTGGTCTCGATCACGACGCCGGAGACGAGCAAGGACGAGCACGAGCGGATGCTGGCCTGCGCCGAG
GAGGTGCTGCGCCGGCTCGATCTGCACTACCGCGTGATCACGCTGTGCACCGGCGACATGGGCTTCTCGTCGCAGAAGAC
CTACGACATCGAGGTCTGGATGCCCGGGCAGGGCGACGGCGGCGCCTTCCGCGAGATCTCCAGCTGTTCGGTCTGCGGCG
ACTTCCAGGCCCGCCGCATGGATGCGCGCTATCGCGCCAGCGACGGCAAGCCGCGCTTCGTGCACACATTGAACGGCTCG
GGCACGGCCGTCGGTCGCGCGTTGATCGCTGTGATGGAGACCTATCAGCAGGCCGACGGCTCGATCGCCGTGCCGGACGT
GTTGCAGCCCTACATGGGGGGCCTCAAGGTCGTTGCCGCGGATTCATAG

Upstream 100 bases:

>100_bases
GCCTTGCCTGTTCCCAACCGCTGCCATTCGCGGTAGTGCAAGCCGACCTGCGACCCAGGGCGACTCGCGAGCACCATTTC
GTTCCCAGGACCGAACGACC

Downstream 100 bases:

>100_bases
AGGAGCGGCAAATTGCATCCATGCCGGTCGCCGCAATTGCGCCGCGACCGGCAGATCGTATCCTGCGGTTCCGCCAGCAC
GCGCGTTTCAGAACCGGCAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MHDIKSIRDNPQDFDAALTRRGLSPLSSQLLAIDERRRAAILASEQAQARRNAASREIGEAKKAKDEGRASALMEEVAKL
KTTMPELEAAAKQADEELARELSAIPNLPLDEVPDGKDEHDNVERHVFGARRNYAFAPKAHDDIGTALGMDFESAAKLSG
ARFVVLKKGLARLERAIGQFMLDLHTTEHGYTEVNPPLLVRNDVMFGTGQLPKFEDDQFWAVRGELLIAPDERLKAERLG
LIPTAEVALTNLVRESIVDEKELPMRLTALTPCFRAEAGAAGRDTRGMIRQHQFTKVELVSITTPETSKDEHERMLACAE
EVLRRLDLHYRVITLCTGDMGFSSQKTYDIEVWMPGQGDGGAFREISSCSVCGDFQARRMDARYRASDGKPRFVHTLNGS
GTAVGRALIAVMETYQQADGSIAVPDVLQPYMGGLKVVAADS

Sequences:

>Translated_442_residues
MHDIKSIRDNPQDFDAALTRRGLSPLSSQLLAIDERRRAAILASEQAQARRNAASREIGEAKKAKDEGRASALMEEVAKL
KTTMPELEAAAKQADEELARELSAIPNLPLDEVPDGKDEHDNVERHVFGARRNYAFAPKAHDDIGTALGMDFESAAKLSG
ARFVVLKKGLARLERAIGQFMLDLHTTEHGYTEVNPPLLVRNDVMFGTGQLPKFEDDQFWAVRGELLIAPDERLKAERLG
LIPTAEVALTNLVRESIVDEKELPMRLTALTPCFRAEAGAAGRDTRGMIRQHQFTKVELVSITTPETSKDEHERMLACAE
EVLRRLDLHYRVITLCTGDMGFSSQKTYDIEVWMPGQGDGGAFREISSCSVCGDFQARRMDARYRASDGKPRFVHTLNGS
GTAVGRALIAVMETYQQADGSIAVPDVLQPYMGGLKVVAADS
>Mature_442_residues
MHDIKSIRDNPQDFDAALTRRGLSPLSSQLLAIDERRRAAILASEQAQARRNAASREIGEAKKAKDEGRASALMEEVAKL
KTTMPELEAAAKQADEELARELSAIPNLPLDEVPDGKDEHDNVERHVFGARRNYAFAPKAHDDIGTALGMDFESAAKLSG
ARFVVLKKGLARLERAIGQFMLDLHTTEHGYTEVNPPLLVRNDVMFGTGQLPKFEDDQFWAVRGELLIAPDERLKAERLG
LIPTAEVALTNLVRESIVDEKELPMRLTALTPCFRAEAGAAGRDTRGMIRQHQFTKVELVSITTPETSKDEHERMLACAE
EVLRRLDLHYRVITLCTGDMGFSSQKTYDIEVWMPGQGDGGAFREISSCSVCGDFQARRMDARYRASDGKPRFVHTLNGS
GTAVGRALIAVMETYQQADGSIAVPDVLQPYMGGLKVVAADS

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI225579074, Length=425, Percent_Identity=30.8235294117647, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI8923421, Length=424, Percent_Identity=30.4245283018868, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI16306548, Length=441, Percent_Identity=31.5192743764172, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1787120, Length=444, Percent_Identity=51.8018018018018, Blast_Score=411, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17539260, Length=458, Percent_Identity=31.0043668122271, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17542084, Length=390, Percent_Identity=28.4615384615385, Blast_Score=147, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6321799, Length=395, Percent_Identity=30.379746835443, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6320226, Length=406, Percent_Identity=29.064039408867, Blast_Score=179, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24581334, Length=363, Percent_Identity=32.7823691460055, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI17737985, Length=372, Percent_Identity=31.989247311828, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48731; Mature: 48731

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIKSIRDNPQDFDAALTRRGLSPLSSQLLAIDERRRAAILASEQAQARRNAASREIGE
CCCHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKKAKDEGRASALMEEVAKLKTTMPELEAAAKQADEELARELSAIPNLPLDEVPDGKDEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DNVERHVFGARRNYAFAPKAHDDIGTALGMDFESAAKLSGARFVVLKKGLARLERAIGQF
CCHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHH
MLDLHTTEHGYTEVNPPLLVRNDVMFGTGQLPKFEDDQFWAVRGELLIAPDERLKAERLG
HHHHHCCCCCCCCCCCCEEEECCEEECCCCCCCCCCCCEEEEECCEEECCHHHHHHHHCC
LIPTAEVALTNLVRESIVDEKELPMRLTALTPCFRAEAGAAGRDTRGMIRQHQFTKVELV
CCCHHHHHHHHHHHHHHCCCCCCCEEHHHHCHHHHHCCCCCCCCHHHHHHHCCCCEEEEE
SITTPETSKDEHERMLACAEEVLRRLDLHYRVITLCTGDMGFSSQKTYDIEVWMPGQGDG
EEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCCC
GAFREISSCSVCGDFQARRMDARYRASDGKPRFVHTLNGSGTAVGRALIAVMETYQQADG
CHHHHHCCCCCCCCHHHHHHCCHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCC
SIAVPDVLQPYMGGLKVVAADS
CEECHHHHHHHHCCEEEEEECC
>Mature Secondary Structure
MHDIKSIRDNPQDFDAALTRRGLSPLSSQLLAIDERRRAAILASEQAQARRNAASREIGE
CCCHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKKAKDEGRASALMEEVAKLKTTMPELEAAAKQADEELARELSAIPNLPLDEVPDGKDEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DNVERHVFGARRNYAFAPKAHDDIGTALGMDFESAAKLSGARFVVLKKGLARLERAIGQF
CCHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHH
MLDLHTTEHGYTEVNPPLLVRNDVMFGTGQLPKFEDDQFWAVRGELLIAPDERLKAERLG
HHHHHCCCCCCCCCCCCEEEECCEEECCCCCCCCCCCCEEEEECCEEECCHHHHHHHHCC
LIPTAEVALTNLVRESIVDEKELPMRLTALTPCFRAEAGAAGRDTRGMIRQHQFTKVELV
CCCHHHHHHHHHHHHHHCCCCCCCEEHHHHCHHHHHCCCCCCCCHHHHHHHCCCCEEEEE
SITTPETSKDEHERMLACAEEVLRRLDLHYRVITLCTGDMGFSSQKTYDIEVWMPGQGDG
EEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCCC
GAFREISSCSVCGDFQARRMDARYRASDGKPRFVHTLNGSGTAVGRALIAVMETYQQADG
CHHHHHCCCCCCCCHHHHHHCCHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCC
SIAVPDVLQPYMGGLKVVAADS
CEECHHHHHHHHCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA