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The map label for this gene is serA [H]

Identifier: 146340756

GI number: 146340756

Start: 3982302

End: 3983300

Strand: Reverse

Name: serA [H]

Synonym: BRADO3813

Alternate gene names: 146340756

Gene position: 3983300-3982302 (Counterclockwise)

Preceding gene: 146340757

Following gene: 146340755

Centisome position: 53.42

GC content: 67.37

Gene sequence:

>999_bases
ATGACCACCAGGACGGCAACGAACAAGAACAAGATCCTCGTCACGCAATCCTTCTCGGCCAAGGGGCGCGCGCTGCTGTC
GGCGCGCGAGGACGTCGAGATGATCGAATTCCCCAACATGATCTCGGCGGCGGATTTCTCCGCGCTGCTCAGCTCGCATG
CGCCCGTGCACGGCGTCGCGCTCGGCGCCACGCGATTCGGCGAGCCGGAACTGCTCGCCGCCGGCGACATGAAGGTCGTC
ACCCGGATCGGCGTCGGCTTCGACGCGGTCGACGTACCCGCGCTCTCCAGGCACAAGGTGCCGCTGATGGTCGCGGGGAC
CGCCAACTCGCCCTCGGTGGCCGAGCAGGCGTTGTTCATGATGCTGACCTTGGCCAAGCGCGCCAGCGAGATGCATGCGA
TGGTCAAGGACGGCACCTGGGGCTCCCGCCTCGGCGTGCTGCCGTTCGACCTCTACGGCAAGACCGTGCTGATCATCGGC
TTCGGCCGCATCGGCACCCGCACCGCCAAGCGCTGTCTCGCGATGGAGATGCAGGTCCTGGTCTACGACCCCTACAAGCC
CGCCGCCGAGATTACCGCGGCCGGCTGCGAGCCGGTTGCCGACCTCGACGCCGCGCTGCCGCGCGCCGATTTCGTCAGCA
TCCACTGTCCAAAAACGCAAGAGACCATCGGCCTGTTCAACGCCGCGCGTCTCCGTCTGATGAAGCCGACCGCGTACCTG
ATCAACACCGCGCGCGGCGGCCTGATCGACGAGGCCGCGCTGTATGACGCGCTGTCAACGGGCCGGCTCGCCGGGGCCGG
TCTCGACGTGTTCGAGCAGGAGCCGCCGCCGGTCGGTCACGCGCTGCATGCGCTGCCCAACGTGATCATGGCGCCGCACG
TCGCCGGCGTCACCCGCGAGGCAGTCGACCGGATGAGCGAGCAGACCGCGCGCAACATTCTCAGCGTGCTCGATCGCGAG
CCGATTCGGCAAAACGTGATCAATCAGGACGTGCTCTGA

Upstream 100 bases:

>100_bases
AGCCCCCTGCGCATGGCAATGGACCTCAACAACATGCACCTGTTAAATGAGGCGACCGGGCTCGTGATCTGACGAGCACA
AGAAGCTTCAAGGGCAGGAC

Downstream 100 bases:

>100_bases
ACGCGTGGGGTTCCATCATGCCGGTCCTCCGCCGGCAGCGAGAGGACCGGATCAGAGGTGACATGACGGGCTCATTCATC
CACCGCTTTGTTGCCCAAAT

Product: putative phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTTRTATNKNKILVTQSFSAKGRALLSAREDVEMIEFPNMISAADFSALLSSHAPVHGVALGATRFGEPELLAAGDMKVV
TRIGVGFDAVDVPALSRHKVPLMVAGTANSPSVAEQALFMMLTLAKRASEMHAMVKDGTWGSRLGVLPFDLYGKTVLIIG
FGRIGTRTAKRCLAMEMQVLVYDPYKPAAEITAAGCEPVADLDAALPRADFVSIHCPKTQETIGLFNAARLRLMKPTAYL
INTARGGLIDEAALYDALSTGRLAGAGLDVFEQEPPPVGHALHALPNVIMAPHVAGVTREAVDRMSEQTARNILSVLDRE
PIRQNVINQDVL

Sequences:

>Translated_332_residues
MTTRTATNKNKILVTQSFSAKGRALLSAREDVEMIEFPNMISAADFSALLSSHAPVHGVALGATRFGEPELLAAGDMKVV
TRIGVGFDAVDVPALSRHKVPLMVAGTANSPSVAEQALFMMLTLAKRASEMHAMVKDGTWGSRLGVLPFDLYGKTVLIIG
FGRIGTRTAKRCLAMEMQVLVYDPYKPAAEITAAGCEPVADLDAALPRADFVSIHCPKTQETIGLFNAARLRLMKPTAYL
INTARGGLIDEAALYDALSTGRLAGAGLDVFEQEPPPVGHALHALPNVIMAPHVAGVTREAVDRMSEQTARNILSVLDRE
PIRQNVINQDVL
>Mature_331_residues
TTRTATNKNKILVTQSFSAKGRALLSAREDVEMIEFPNMISAADFSALLSSHAPVHGVALGATRFGEPELLAAGDMKVVT
RIGVGFDAVDVPALSRHKVPLMVAGTANSPSVAEQALFMMLTLAKRASEMHAMVKDGTWGSRLGVLPFDLYGKTVLIIGF
GRIGTRTAKRCLAMEMQVLVYDPYKPAAEITAAGCEPVADLDAALPRADFVSIHCPKTQETIGLFNAARLRLMKPTAYLI
NTARGGLIDEAALYDALSTGRLAGAGLDVFEQEPPPVGHALHALPNVIMAPHVAGVTREAVDRMSEQTARNILSVLDREP
IRQNVINQDVL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=325, Percent_Identity=32.9230769230769, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI61743967, Length=265, Percent_Identity=33.9622641509434, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI4557497, Length=265, Percent_Identity=33.9622641509434, Blast_Score=141, Evalue=7e-34,
Organism=Homo sapiens, GI6912396, Length=318, Percent_Identity=30.5031446540881, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI145580578, Length=305, Percent_Identity=31.1475409836066, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI4557499, Length=305, Percent_Identity=31.1475409836066, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI145580575, Length=265, Percent_Identity=31.6981132075472, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI87082289, Length=258, Percent_Identity=34.8837209302326, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789279, Length=290, Percent_Identity=31.7241379310345, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787645, Length=263, Percent_Identity=32.319391634981, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI87081824, Length=256, Percent_Identity=29.6875, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788660, Length=242, Percent_Identity=31.404958677686, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=248, Percent_Identity=36.6935483870968, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=257, Percent_Identity=31.1284046692607, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=259, Percent_Identity=32.046332046332, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320925, Length=259, Percent_Identity=31.6602316602317, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6324964, Length=262, Percent_Identity=30.1526717557252, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324055, Length=261, Percent_Identity=30.6513409961686, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324980, Length=196, Percent_Identity=31.6326530612245, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6325144, Length=169, Percent_Identity=28.9940828402367, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921140, Length=270, Percent_Identity=35.9259259259259, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI45552429, Length=327, Percent_Identity=32.7217125382263, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574284, Length=327, Percent_Identity=32.7217125382263, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45551003, Length=327, Percent_Identity=32.7217125382263, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24585514, Length=325, Percent_Identity=31.0769230769231, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574282, Length=325, Percent_Identity=31.0769230769231, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574286, Length=271, Percent_Identity=32.4723247232472, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI28571528, Length=250, Percent_Identity=36, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646446, Length=305, Percent_Identity=31.1475409836066, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646448, Length=305, Percent_Identity=31.1475409836066, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646452, Length=305, Percent_Identity=31.1475409836066, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646450, Length=305, Percent_Identity=31.1475409836066, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI62472511, Length=265, Percent_Identity=31.3207547169811, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24585516, Length=252, Percent_Identity=26.5873015873016, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 35566; Mature: 35435

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRTATNKNKILVTQSFSAKGRALLSAREDVEMIEFPNMISAADFSALLSSHAPVHGVA
CCCCCCCCCCEEEEEECCCCCCHHHHHHHCCHHHHHCCCHHHHHHHHHHHHCCCCCCEEE
LGATRFGEPELLAAGDMKVVTRIGVGFDAVDVPALSRHKVPLMVAGTANSPSVAEQALFM
ECCCCCCCCCEEECCCCEEEHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHH
MLTLAKRASEMHAMVKDGTWGSRLGVLPFDLYGKTVLIIGFGRIGTRTAKRCLAMEMQVL
HHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHEEEE
VYDPYKPAAEITAAGCEPVADLDAALPRADFVSIHCPKTQETIGLFNAARLRLMKPTAYL
EECCCCCHHHHHHCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHEEEECCHHHH
INTARGGLIDEAALYDALSTGRLAGAGLDVFEQEPPPVGHALHALPNVIMAPHVAGVTRE
HCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
AVDRMSEQTARNILSVLDREPIRQNVINQDVL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
>Mature Secondary Structure 
TTRTATNKNKILVTQSFSAKGRALLSAREDVEMIEFPNMISAADFSALLSSHAPVHGVA
CCCCCCCCCEEEEEECCCCCCHHHHHHHCCHHHHHCCCHHHHHHHHHHHHCCCCCCEEE
LGATRFGEPELLAAGDMKVVTRIGVGFDAVDVPALSRHKVPLMVAGTANSPSVAEQALFM
ECCCCCCCCCEEECCCCEEEHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHH
MLTLAKRASEMHAMVKDGTWGSRLGVLPFDLYGKTVLIIGFGRIGTRTAKRCLAMEMQVL
HHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHEEEE
VYDPYKPAAEITAAGCEPVADLDAALPRADFVSIHCPKTQETIGLFNAARLRLMKPTAYL
EECCCCCHHHHHHCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHEEEECCHHHH
INTARGGLIDEAALYDALSTGRLAGAGLDVFEQEPPPVGHALHALPNVIMAPHVAGVTRE
HCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
AVDRMSEQTARNILSVLDREPIRQNVINQDVL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]