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The map label for this gene is glmS [H]

Identifier: 146340711

GI number: 146340711

Start: 3928493

End: 3930319

Strand: Direct

Name: glmS [H]

Synonym: BRADO3763

Alternate gene names: 146340711

Gene position: 3928493-3930319 (Clockwise)

Preceding gene: 146340709

Following gene: 146340712

Centisome position: 52.68

GC content: 65.52

Gene sequence:

>1827_bases
ATGTGCGGAATCATCGGGATCCTGGGACGCGGGCCGGTTGCCGAGCATCTCGTCGATTCCCTGAAACGTCTTGAGTATCG
CGGCTACGACTCTGCTGGCGTTGCGACGCTCGAGGGCGATCAGATCGATCGCCGACGTGCCGAGGGCAAGCTGAAGAATC
TCGAGAAGCGCCTGGAGCGCGAGCCGCTCAAGGGCCATGCCGGCATCGGCCATACCCGCTGGGCGACGCATGGCAAGCCG
ACTGAGAGCAACGCCCATCCGCACGCAACTGATAACGTCGCGGTCGTCCACAACGGCATCATCGAGAACTTCCGCGAGCT
CCGCGCCGAGCTCGAGAAGCAGGGCGCCAAGTTCGCCTCCGAGACCGACACCGAGACGGTCGTCCATCTCGTCAACTCCT
ACCTGCTCAAAGGTCATACGCCGCAGCAGGCGGTCGCCGCTTCACTGCCGCATTTGAAGGGCGCGTTCGCACTCGCCTTT
CTGTTCAAGGGTCATGGCGATCTCCTGATCGGTGCCCGCAAGGGCTCTCCGTTGGCGATGGGCTATGGCGATGGCGAGAT
GTTCCTCGGCTCCGACGCGATCGCGCTGGCGCCGTTCACGGATACGATCAGCTATCTCGACGATGGCGACTGGGTCGAGA
TCACCCGCGACTCCGGCATCATCCACGACGCCTCGGGCGCGGTGGTGAAGCGCGAGGTGCTGAAGTCAGGCGCATCGTCG
TTCCTGGTCGACAAGGCGAACTATCGCCACTTCATGGCCAAGGAAATCCACGAGCAGCCGGAGGTGGTCGGCCACACGCT
GGCGCGCTATGTCGACATGGGCACCGAGCGCGTCGCGCTGCCGGCGCGGCTGCCGTTCGACTTCACCGACATCCAGCGCA
TCTCGATCACCGCCTGCGGCACCGCGAGCTATGCCGGCTTCGTCGCCAAATACTGGTTCGAGCGCTTCGCGCGGGTGCCG
GTCGAGCTCGATGTCGCCTCGGAATTCCGCTACCGCGAGGCGCCGCTGCGCAAGGGCGATCTCGCCATCTTCATCTCTCA
GTCGGGCGAGACCGCCGACACCCTGGCGGCGCTGCGCTATGCCAAGTCACAGGGCGTGCACACGCTCTCGGTCGTCAACG
TGCCGACCTCGACGATCGCGCGCGAGAGCGAGATCGTGATGCCGACGCTCGCCGGTCCCGAGATCGGCGTCGCCTCGACC
AAGGCGTTCACCTGCCAGCTGATGGTGCTCGCGGCGCTGGCGATCGCCGCCGGCCGTGGCCGCGGCGAACTCTCCGAAGC
CGACGAGACCAAGCTGGTGCATGGTCTCGTCGAGGTGCCGCGCCTGATCGCGTCAGCGCTGACGACGGAGCCGCAGATCG
AGAAGCTGGCGCGCGAGATCGCCAAGTCCAAGGATGTGCTGTATCTCGGCCGCGGCACCTCCTATCCGCTGGCGCTCGAA
GGCGCGCTGAAGCTGAAGGAGATCTCCTACATCCACGCCGAGGGCTATGCCGCCGGTGAGCTCAAGCACGGTCCGATCGC
GCTGATCGACGAGACCATGCCGGTCGTCGTGATCGCGCCCTATGACAAGGTGTTCGAGAAGACCGTGTCGAACATGCAAG
AGGTCGCCGCGCGCGGCGGCAACATCATCCTGATGACCGACGCCAAGGGCGCCGAGGAGGCGACCGTGGACTCGCTGGTC
ACGATCACCATGCCCGACATGGCCGCGACCTTCACGCCGATCGTCTACGCGATCCCGGTGCAGCTGCTGGCCTATCACAC
GGCGGTCGTGATGGGCACCGACGTCGACCAGCCGCGCAATCTGGCGAAGTCGGTGACGGTGGAGTAG

Upstream 100 bases:

>100_bases
TCGCAATCCGCAATAATTATTGAATCCTGAAAGCGCGCGGTTTTCGTTAAGACAATGCCACGCATTTGAATCTCTCTCGA
CGATTTGGGGACTAGCGCTG

Downstream 100 bases:

>100_bases
GGCAGGCCGCCTCCACACACTCTGCGTCATCCCGGCGAAAGCCGGGATCCATAACCACCGTCCTCGGTGGTTTGCAGCTC
TGGTAGCTCCAGCGTGCCGC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MCGIIGILGRGPVAEHLVDSLKRLEYRGYDSAGVATLEGDQIDRRRAEGKLKNLEKRLEREPLKGHAGIGHTRWATHGKP
TESNAHPHATDNVAVVHNGIIENFRELRAELEKQGAKFASETDTETVVHLVNSYLLKGHTPQQAVAASLPHLKGAFALAF
LFKGHGDLLIGARKGSPLAMGYGDGEMFLGSDAIALAPFTDTISYLDDGDWVEITRDSGIIHDASGAVVKREVLKSGASS
FLVDKANYRHFMAKEIHEQPEVVGHTLARYVDMGTERVALPARLPFDFTDIQRISITACGTASYAGFVAKYWFERFARVP
VELDVASEFRYREAPLRKGDLAIFISQSGETADTLAALRYAKSQGVHTLSVVNVPTSTIARESEIVMPTLAGPEIGVAST
KAFTCQLMVLAALAIAAGRGRGELSEADETKLVHGLVEVPRLIASALTTEPQIEKLAREIAKSKDVLYLGRGTSYPLALE
GALKLKEISYIHAEGYAAGELKHGPIALIDETMPVVVIAPYDKVFEKTVSNMQEVAARGGNIILMTDAKGAEEATVDSLV
TITMPDMAATFTPIVYAIPVQLLAYHTAVVMGTDVDQPRNLAKSVTVE

Sequences:

>Translated_608_residues
MCGIIGILGRGPVAEHLVDSLKRLEYRGYDSAGVATLEGDQIDRRRAEGKLKNLEKRLEREPLKGHAGIGHTRWATHGKP
TESNAHPHATDNVAVVHNGIIENFRELRAELEKQGAKFASETDTETVVHLVNSYLLKGHTPQQAVAASLPHLKGAFALAF
LFKGHGDLLIGARKGSPLAMGYGDGEMFLGSDAIALAPFTDTISYLDDGDWVEITRDSGIIHDASGAVVKREVLKSGASS
FLVDKANYRHFMAKEIHEQPEVVGHTLARYVDMGTERVALPARLPFDFTDIQRISITACGTASYAGFVAKYWFERFARVP
VELDVASEFRYREAPLRKGDLAIFISQSGETADTLAALRYAKSQGVHTLSVVNVPTSTIARESEIVMPTLAGPEIGVAST
KAFTCQLMVLAALAIAAGRGRGELSEADETKLVHGLVEVPRLIASALTTEPQIEKLAREIAKSKDVLYLGRGTSYPLALE
GALKLKEISYIHAEGYAAGELKHGPIALIDETMPVVVIAPYDKVFEKTVSNMQEVAARGGNIILMTDAKGAEEATVDSLV
TITMPDMAATFTPIVYAIPVQLLAYHTAVVMGTDVDQPRNLAKSVTVE
>Mature_608_residues
MCGIIGILGRGPVAEHLVDSLKRLEYRGYDSAGVATLEGDQIDRRRAEGKLKNLEKRLEREPLKGHAGIGHTRWATHGKP
TESNAHPHATDNVAVVHNGIIENFRELRAELEKQGAKFASETDTETVVHLVNSYLLKGHTPQQAVAASLPHLKGAFALAF
LFKGHGDLLIGARKGSPLAMGYGDGEMFLGSDAIALAPFTDTISYLDDGDWVEITRDSGIIHDASGAVVKREVLKSGASS
FLVDKANYRHFMAKEIHEQPEVVGHTLARYVDMGTERVALPARLPFDFTDIQRISITACGTASYAGFVAKYWFERFARVP
VELDVASEFRYREAPLRKGDLAIFISQSGETADTLAALRYAKSQGVHTLSVVNVPTSTIARESEIVMPTLAGPEIGVAST
KAFTCQLMVLAALAIAAGRGRGELSEADETKLVHGLVEVPRLIASALTTEPQIEKLAREIAKSKDVLYLGRGTSYPLALE
GALKLKEISYIHAEGYAAGELKHGPIALIDETMPVVVIAPYDKVFEKTVSNMQEVAARGGNIILMTDAKGAEEATVDSLV
TITMPDMAATFTPIVYAIPVQLLAYHTAVVMGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=692, Percent_Identity=36.849710982659, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI205277386, Length=692, Percent_Identity=37.4277456647399, Blast_Score=401, Evalue=1e-112,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=49.7553017944535, Blast_Score=584, Evalue=1e-168,
Organism=Escherichia coli, GI1788651, Length=223, Percent_Identity=30.4932735426009, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI87082251, Length=314, Percent_Identity=21.9745222929936, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=720, Percent_Identity=35.5555555555556, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17532899, Length=720, Percent_Identity=33.8888888888889, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17532897, Length=429, Percent_Identity=37.7622377622378, Blast_Score=286, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6322745, Length=475, Percent_Identity=37.6842105263158, Blast_Score=290, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6323731, Length=431, Percent_Identity=32.9466357308585, Blast_Score=200, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6323730, Length=208, Percent_Identity=36.0576923076923, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21357745, Length=685, Percent_Identity=36.6423357664234, Blast_Score=410, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65715; Mature: 65715

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGILGRGPVAEHLVDSLKRLEYRGYDSAGVATLEGDQIDRRRAEGKLKNLEKRLER
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHC
EPLKGHAGIGHTRWATHGKPTESNAHPHATDNVAVVHNGIIENFRELRAELEKQGAKFAS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCC
ETDTETVVHLVNSYLLKGHTPQQAVAASLPHLKGAFALAFLFKGHGDLLIGARKGSPLAM
CCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEE
GYGDGEMFLGSDAIALAPFTDTISYLDDGDWVEITRDSGIIHDASGAVVKREVLKSGASS
ECCCCCEEECCCCEEEECCHHHHHHCCCCCEEEEECCCCEEECCCCHHHHHHHHHCCCHH
FLVDKANYRHFMAKEIHEQPEVVGHTLARYVDMGTERVALPARLPFDFTDIQRISITACG
EEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEEECC
TASYAGFVAKYWFERFARVPVELDVASEFRYREAPLRKGDLAIFISQSGETADTLAALRY
CHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHH
AKSQGVHTLSVVNVPTSTIARESEIVMPTLAGPEIGVASTKAFTCQLMVLAALAIAAGRG
HHHCCCEEEEEEECCHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
RGELSEADETKLVHGLVEVPRLIASALTTEPQIEKLAREIAKSKDVLYLGRGTSYPLALE
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEC
GALKLKEISYIHAEGYAAGELKHGPIALIDETMPVVVIAPYDKVFEKTVSNMQEVAARGG
CCEEEEHEEEEEECCEECCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCC
NIILMTDAKGAEEATVDSLVTITMPDMAATFTPIVYAIPVQLLAYHTAVVMGTDVDQPRN
CEEEEECCCCCCHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHH
LAKSVTVE
HHHHCCCC
>Mature Secondary Structure
MCGIIGILGRGPVAEHLVDSLKRLEYRGYDSAGVATLEGDQIDRRRAEGKLKNLEKRLER
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHC
EPLKGHAGIGHTRWATHGKPTESNAHPHATDNVAVVHNGIIENFRELRAELEKQGAKFAS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCC
ETDTETVVHLVNSYLLKGHTPQQAVAASLPHLKGAFALAFLFKGHGDLLIGARKGSPLAM
CCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEE
GYGDGEMFLGSDAIALAPFTDTISYLDDGDWVEITRDSGIIHDASGAVVKREVLKSGASS
ECCCCCEEECCCCEEEECCHHHHHHCCCCCEEEEECCCCEEECCCCHHHHHHHHHCCCHH
FLVDKANYRHFMAKEIHEQPEVVGHTLARYVDMGTERVALPARLPFDFTDIQRISITACG
EEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEEECC
TASYAGFVAKYWFERFARVPVELDVASEFRYREAPLRKGDLAIFISQSGETADTLAALRY
CHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHH
AKSQGVHTLSVVNVPTSTIARESEIVMPTLAGPEIGVASTKAFTCQLMVLAALAIAAGRG
HHHCCCEEEEEEECCHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
RGELSEADETKLVHGLVEVPRLIASALTTEPQIEKLAREIAKSKDVLYLGRGTSYPLALE
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEC
GALKLKEISYIHAEGYAAGELKHGPIALIDETMPVVVIAPYDKVFEKTVSNMQEVAARGG
CCEEEEHEEEEEECCEECCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCC
NIILMTDAKGAEEATVDSLVTITMPDMAATFTPIVYAIPVQLLAYHTAVVMGTDVDQPRN
CEEEEECCCCCCHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHH
LAKSVTVE
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]